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All Journal Indonesian Journal of Global Health research The Journal of Society Medicine (JSOCMED)
Risanti, Rinda Chindra
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Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Relationship between Thioredoxin Reductase (TrxR) Levels and Melasma Risanti, Rinda Chindra; Jusuf, Nelva Karmila; Putra, Imam Budi
Journal of Society Medicine Vol. 3 No. 3 (2024): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i3.131

Abstract

Introduction: Melasma is a common condition of acquired hypermelanosis in dermatology that often occurs in areas of the body exposed to sunlight, especially the face. Thioredoxin Reductase (TrxR) is a key antioxidant system in defense against oxidative stress through disulfide reductase activity that regulates dithiol/disulfide protein balance. High levels/activity of TrxR correlate with melanin formation and tyrosinase activity which provides additional information about the role of cellular antioxidant proteins in melanogenesis which is suspected to be related to the occurrence of melasma. The aim of this study was to determine the relationship between TrxR levels and melasma Method: This study was an observational analytical study with cross-sectional design on 30 melasma patients and 30 controls. Each patient underwent anamnesis, dermatological examination, and blood sampling to assess TrxR levels by ELISA test. These data were analyzed statistically using the Mann Whitney test. Results: This study shows that the most common distribution pattern of melasma was centrofacial in 24 people (80%). The mean TrxR level in melasma was 12.73±11.66 ng/ml. The results of the study showed that there was a relationship between high TrxR levels and melasma (p<0.001). The TrxR mean level based on the duration of suffering from melasma at <5 years was 11.4±2.89, and ≥ 5 years was 14.0±3,18 Conclusion: There is a relationship between TrxR levels and melasma.
Multiple Manifestations of Cutaneous Larva Migrans: A Case Report Risanti, Rinda Chindra; Dalimunthe, Dina Arwina
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.6291

Abstract

Cutaneous larva migrans (CLM) is an infectious disease caused by hookworm larvae that live in animals where infected humans are the final hosts. Clinical symptoms are found serpiginous lesions accompanied by pruritus. Multiple manifestations of cutaneous larva migrans on the skin can occur, but such cases are infrequently reported. This article describes a case report that provides a detailed diagnosis, therapeutic approach, and follow-up care of a patient. A 44-year-old man presented with the primary complaint of multiple reddish bumps and raised skin lesions that spread in a winding pattern, accompanied by itching on the abdomen for the past week after he did physical activities by crawling on the ground without wearing clothes. The onset was marked by small reddish bumps on the abdomen, along with constant itching. Then the reddish bumps lengthened, spread to form winding lesions and left blackish spots. The patient was treated with albendazole 400 mg orally once a day for 7 days and cetirizine 10 mg once a day (at night) to relieve itching, and fusidic acid cream 2x1 in the area of the scratch wound. An evaluation was conducted after 7 days of treatment by assessing the clinical signs and the patient's complaints. The itching had decreased, and the rash appeared to be drying and shows good responses. The patient's history and dermatological examination led to the diagnosis of cutaneous larva migrans with multiple manifestations. Administering antihelminthic medication can speed up the progression of the illness and prevent potential complications. Topical or systemic treatment results in a cure rate approaching 100%. Early and appropriate identification and management can help prevent complications and recurrence.
Co-Authors Dina Arwina Dalimunthe, Dina Arwina Jusuf, Nelva Karmila Putra, Imam Budi