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All Journal Jurnal Kedokteran Brawijaya The Journal of Society Medicine (JSOCMED) Media Dermato-Venereologica Indonesiana Cermin Dunia Kedokteran
Danil, Rezkyana
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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The Aryl Hydrocarbon Receptor (AhR) Level Based on Age and Clinical Type of Melasma Danil, Rezkyana; Jusuf, Nelva Karmila; Putra, Imam Budi
Journal of Society Medicine Vol. 3 No. 7 (2024): July
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i7.153

Abstract

Introduction: Melasma is the most common pigmentation condition on the face due to excessive melanin production and release. The main predisposing factor for melasma is UV exposure. Aryl Hydrocarbon Receptor (AhR) is a ligand-dependent transcription factor that regulates the expression of a very large number of target genes in humans. Facial hyperpigmentation is increased in people living in air-polluted areas with particulate matter2.5  (PM2.5) concentrations. Dioxin compounds contained in PM2.5  can activate AhR signaling. This study aims to determine the aryl hydrocarbon receptor (AhR) level based on age and clinical type of melasma. Methods: This study was an observational study with a cross-sectional design of 30 women with melasma at Prof. CPL Hospital. This study was conducted after obtaining ethical clearance from the Research Ethics Commission of the University of North Sumatra and has obtained permission from the research field of Prof. Chairuddin Panusunan Lubis Hospital. All subjects underwent history taking, physical examination, dermatological examination, and blood sampling to assess AhR levels by ELISA test. Data were analyzed with Chi square test to assess AhR levels based on age, and to assess AhR levels based on clinical type of melasma with Kruskal Wallis test. Results: This study shows that the majority of melasma age is 41-50 years with the highest mean AhR level is 882,61 ng/mL, while the lowest AhR level is in the age range of 20-30 years with a mean of 271,5 ng/mL. Chi square test showed that there was a significant relationship between AhR levels and age (p < 0,001). The highest mean AhR levels in melasma subjects were centrofacial type with a mean of 795,50 ng/mL, while the lowest mean AhR levels were found in melasma subjects with malar type with a mean of 623,36 ng/mL. The Kruskal Wallis test showed that there was no significant difference in AhR levels based on the clinical type of melasma (p = 0,930). Conclusion: That increased the age, the highest AhR levels. The highest average AhR level was centrofacial type of melasma. There was no significant difference in AhR levels based on the clinical type of melasma.
PREVALENSI 5 KELAINAN KULIT TERBANYAK POLIKLINIK DERMATOLOGI KOSMETIK RS USU TAHUN 2020 - 2022 Danil, Rezkyana; Jusuf, Nelva Karmila; Putra, Imam Budi
Media Dermato-Venereologica Indonesiana Vol 51 No 4 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i4.460

Abstract

   Pendahuluan: Dermatologi kosmetik merupakan bagian dari ilmu dermatologi yang terfokus pada permasalahan kulit dan kesehatannya. Tujuan: Mengetahui jumlah kunjungan pasien per tahun dan 5 kelainan kulit terbanyak di Poliklinik Dermatologi Kosmetik RS USU periode 2020 – 2022. Metode: Penelitian ini merupakan penelitian retrospektif dengan menggunakan data rekam medis di RS USU periode 2020 – 2022. Hasil: Jumlah pasien di Poliklinik Dermatologi Kosmetik RS USU pada tahun 2020 yaitu 342 pasien (21,8%), tahun 2021 sebanyak 811 pasien (40,8%), dan tahun 2022 sebanyak 640 pasien (26,5%). Kelainan kulit terbanyak pada tahun 2020 adalah akne vulgaris berjumlah 206 pasien (60,2%). Tahun 2021 didapatkan kelainan kulit terbanyak yaitu striae distensae berjumlah 281 pasien (34,6%). Kemudian tahun 2022 didapatkan kelainan kulit terbanyak yaitu akne vulgaris berjumlah 145 pasien (22,7%). Dalam rentang waktu tahun 2020 – 2022 didapatkan 5 kelainan kulit tertinggi dari total kunjungan pasien, yaitu akne vulgaris 527 pasien (29,4%), diikuti striae distensae 453 pasien (25,3%), penuaan kulit 211 pasien (11,7%), melasma 159 pasien (8,9%), dan selulit 120 pasien (6,7%). Kesimpulan: Penelitian ini memberikan gambaran 5 kelainan kulit tertinggi dari total kunjungan pasien di Poliklinik Dermatologi Kosmetik RS USU periode 2020 – 2022, dengan kunjungan pasien tertinggi di tahun 2021 sebanyak 811 pasien (40,8%). 
Lichen Amyloidosis on the Back that improved with Methotrexate Administration: Case Report Dalimunthe, Dina A; Danil, Rezkyana
Jurnal Kedokteran Brawijaya Vol. 33 No. 4 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.04.10

Abstract

Lichen amyloidosis comprises a range of disorders characterized by amyloid protein deposits in tissues and organs. Several studies have shown that lichen amyloidosis is a form of localized primary cutaneous amyloidosis, often affecting the anterior legs and arms, but rarely found in the back, making such cases notable. A 75-year-old male presented with pruritic brown-black hyperkeratotic nodules on the back, which had increased over the past year. The patient had a history of psoriasis vulgaris and was being treated with methotrexate, cetirizine, and topical medications. Histopathology with Congo Red staining confirmed lichen amyloidosis, with amyloid deposits in the dermal papillae. Lichen amyloidosis, although typically localized to the lower extremities, may also appear on the back in rare cases. The amyloid deposition in the dermis may result from chronic friction or genetic factors. In addition, methotrexate's role in managing the condition is related to its immunosuppressive and anti-inflammatory effects. This case indicates the importance of recognizing atypical presentations of lichen amyloidosis. Early histopathological confirmation and tailored treatment, including methotrexate and topical corticosteroids, can aid symptom relief and prevent progression.
Perkembangan Terkini Fotoproteksi: Analisis Danil, Rezkyana; Jufuf, Nelva Karmila
Cermin Dunia Kedokteran Vol 52 No 4 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i4.906

Abstract

Sunlight contains ultraviolet rays such as ultraviolet A (UVA) and ultraviolet B (UVB) rays have adverse effects on the skin such as photoaging, immunosuppression, photocarcinogenesis, and exacerbation of photodermatosis. Photoprotection is an important preventive measure. The use of sunscreen is an important and essential component; development of ultraviolet (UV) filters, sunscreens with topical antioxidants, and others, are current sunscreen innovations. However, sunscreens do not prevent visible light radiation hence the development of nontopical oral and subcutaneous photoprotection that has systemic effect. Development of physical photoprotection is by adjusting the type, color, and thickness of material. Other photoprotection is from ozone layer, weather, and selection of fabric or glass used as shades.
Co-Authors Dalimunthe, Dina A Jufuf, Nelva Karmila Jusuf, Nelva Karmila Putra, Imam Budi