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All Journal Jurnal Kedokteran Brawijaya The Journal of Society Medicine (JSOCMED)
Dalimunthe, Dina A
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Patch Test Analysis of Channa Striata Extract Biopolymer Dalimunthe, Dina A; Lubis, Flora Marita; Hazlianda, Cut Putri; Sinaga, Riana Miranda; Dhillon, Jesryn; Hutagalung, Patricia; Berlian, Guntur
Journal of Society Medicine Vol. 4 No. 6 (2025): June
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i6.217

Abstract

Introduction: Wound healing involves complex interactions between cells and mediators that occur immediately after the wound occurs and depends on nutritional factors and wound closure. Snakehead murrel fish (Channa striata) extract has been extensively researched to speed up the wound healing process because of its high amino acid content. Patch tests were carried out to assess the allergen potential of the Channa striata extract biopolymer in the form of wound dressings. Methods: Experimental study of 40 subjects who had admit patch test with various consentration of Channa striata extract biopolymer. The patch test materials divided of 5 grups. They were aquadest solution, Eucheuma cottonii biopolymer, Channa striata extract biopolymer concentrations of 5.4 g/mL, 10.8 g/mL, and 21.6 g/mL. All subjects had been assessed for skin reactions that occured after 48 hours, 72 hours, and 96 hours. Results: A total of 40 subjects met the inclusion criteria and completed informed consent.  There was minimum allergen reaction (+) in slight subject in all grups except aquadest grup after 48 hours. The allergic reaction dissolve in 72 and 96 hours. An irritant reaction (IR) occurred in among all grups but indicated to the  hypafix plaster. Conclusion: Patch test containing biopolymer Channa striata extract showed a minimal allergic reaction
Lichen Amyloidosis on the Back that improved with Methotrexate Administration: Case Report Dalimunthe, Dina A; Danil, Rezkyana
Jurnal Kedokteran Brawijaya Vol. 33 No. 4 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.04.10

Abstract

Lichen amyloidosis comprises a range of disorders characterized by amyloid protein deposits in tissues and organs. Several studies have shown that lichen amyloidosis is a form of localized primary cutaneous amyloidosis, often affecting the anterior legs and arms, but rarely found in the back, making such cases notable. A 75-year-old male presented with pruritic brown-black hyperkeratotic nodules on the back, which had increased over the past year. The patient had a history of psoriasis vulgaris and was being treated with methotrexate, cetirizine, and topical medications. Histopathology with Congo Red staining confirmed lichen amyloidosis, with amyloid deposits in the dermal papillae. Lichen amyloidosis, although typically localized to the lower extremities, may also appear on the back in rare cases. The amyloid deposition in the dermis may result from chronic friction or genetic factors. In addition, methotrexate's role in managing the condition is related to its immunosuppressive and anti-inflammatory effects. This case indicates the importance of recognizing atypical presentations of lichen amyloidosis. Early histopathological confirmation and tailored treatment, including methotrexate and topical corticosteroids, can aid symptom relief and prevent progression.
Co-Authors Berlian, Guntur Cut Putri Hazlianda Danil, Rezkyana Dhillon, Jesryn Hutagalung, Patricia Lubis, Flora Marita Sinaga, Riana Miranda