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All Journal Eksakta : Berkala Ilmiah Bidang MIPA MULTIPLE: Journal of Global and Multidisciplinary Jurnal Mitra Pengabdian Farmasi Science Get Journal
Resti Ariani
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Peningkatan Pemahaman Imunohematologi Bagi Petugas Bank Darah Rumah Sakit Melalui Pelatihan Pelayanan Darah Resti Ariani; Anna Kartika Yuli Astuti; Rina Puspita; Hendro Pratomo Setyo; Dea
urn:multiple://2988-7828multiple.v3i39
Publisher : Institute of Educational, Research, and Community Service

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Abstract

Pelayanan darah yang aman dan efektif sangat penting dalam dunia medis, terutama untuk mendukung keberhasilan berbagai prosedur medis seperti operasi besar dan perawatan pasien dengan penyakit kronis. Bank Darah Rumah Sakit (BDRS) memiliki peran krusial dalam memastikan kecocokan darah antara donor dan resipien. Imunohematologi, ilmu yang mempelajari interaksi golongan darah dan sistem imun tubuh, menjadi dasar penting dalam proses pencocokan darah yang tepat untuk mencegah reaksi transfusi yang berbahaya. Pengetahuan yang kurang memadai tentang imunohematologi dapat meningkatkan risiko kesalahan transfusi. Oleh karena itu, pelatihan bagi petugas BDRS sangat diperlukan untuk memperdalam pemahaman tentang konsep-konsep dasar imunohematologi dan prosedur transfusi yang aman. Penelitian ini mengkaji pelaksanaan pelatihan imunohematologi bagi petugas BDRS di PMI Kota Semarang, dengan tujuan meningkatkan pemahaman dan keterampilan praktis peserta. Pelatihan ini menggunakan metode pemaparan materi secara sistematis dan interaktif, dengan evaluasi menggunakan pre-test dan post-test untuk mengukur perubahan pemahaman peserta. Hasil pelatihan menunjukkan adanya peningkatan pemahaman yang signifikan tentang aspek teknis imunohematologi, seperti pencocokan darah dan penanganan reaksi transfusi. Pelatihan ini diharapkan dapat meningkatkan kualitas layanan darah di rumah sakit, mengurangi risiko kesalahan medis, serta meningkatkan keselamatan pasien dalam proses transfusi darah.
Implementasi Kesiapsiagaan Bencana Berbasis Masyarakat dan Penanganan Kedaruratan Medis di Lingkungan Tembalang Semarang Resti Ariani; Bajeng Nurul W; Mugiyanto
Jurnal Mitra Pengabdian Farmasi Vol. 1 No. 2 (2022): Februari 2022
Publisher : Akademi Farmasi YPPM Mandiri

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Abstract

The Semarang City continues make improvements to become a safe city. However, several natural disasters such as floods, tidal waves, and landslides are still an annual problem, especially during the rainy season. An alert and alert community needs to be nurtured and provided with sufficient education to take an active role in their environment. The service program in collaboration with PMI Semarang City is expected to be able to train the capabilities of the community who are prepared for disasters, as well as to form an alert character in dealing with medical emergencies. The method used in this service is in the form of training and knowledge sharing followed by question and answer. The training activity with material on Basic Life Support was attended by 30 participants consisting of RT representatives and community youth. Not only presentation of the material but also initial practical training such as Cardiopulmonary Resuscitation (CPR). At the end of the training, an evaluation of the material that has been delivered and how the level of understanding of the participants after attending the training is carried out. With the training, the people of Tembalang become more confident after carrying out the training, because they get new experience and knowledge that can be applied when a disaster occurs anytime.
Platelet-Rich Plasma (PRP) Allogenic: A Potential Challenge for Decreasing Random Blood Glucose, Uric Acid, and Cholesterol Levels in A Preliminary Pre and Post Test Study on Adult Subjects Diah Hastuti; Awal Prasetyo; Anzhari, Della Hashfi; Resti Ariani; Mutia Syafira; Anna Kartika Yuli Astuti; Rina Puspita
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 01 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss01/643

Abstract

Ideally, metabolic homeostasis is maintained through stable glucose regulation, balanced lipid metabolism, and effective uric acid clearance under conditions of minimal systemic inflammation. In real clinical conditions, aging and persistent low-grade inflammation frequently disrupt this balance, leading to hyperglycemia, dyslipidemia, and elevated uric acid levels. Current pharmacological management mainly emphasizes metabolic control and may not sufficiently address underlying tissue dysfunction or inflammatory processes. Platelet-rich plasma (PRP) is a blood-derived bioregenerative product containing growth factors with anti-inflammatory and regenerative properties, offering a potential supportive approach for metabolic regulation. Nevertheless, PRP administration has predominantly relied on invasive delivery methods. Nebulization provides a non-invasive pulmonary route that enables rapid systemic absorption, representing an alternative delivery strategy. Despite its potential advantages, clinical evidence regarding the metabolic effects of PRP delivered via nebulization remains limited, creating an urgent need for preliminary clinical evaluation. Therefore, this pre–post test study aimed to assess the effects of allogeneic PRP nebulization on random blood glucose, uric acid, and total cholesterol levels. Fourteen adult subjects received PRP nebulization for five consecutive days. The intervention resulted in a significant reduction in random blood glucose levels and mild decreasing trends in uric acid and total cholesterol without serious adverse events.
Exploration of CRISPR-Cas9 Gene Editing System Utilization for Targeted Induction of Apoptosis in Cancer Cells Resti Ariani; Eka Cahya Muliawati; Zola Efa Harnis
Science Journal Get Press Vol 3 No 1 (2026): January, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i1.436

Abstract

The CRISPR-Cas9 gene editing system represents a powerful approach for precision targeting of genetic determinants involved in cancer cell survival. This study evaluated the ability of CRISPR-Cas9 to induce apoptosis in cancer cells through targeted disruption of anti-apoptotic genes. Acute myeloid leukemia (HL-60 and KG-1) and anaplastic thyroid cancer (8505C and C643) cell lines were used to knockout BIRC5 (survivin) and MADD using specific single-guide RNAs. Efficient genome editing was achieved, with indel formation exceeding 50% across all models. Targeting BIRC5 and MADD significantly reduced cell viability to 39.8–54.6% of control levels and induced substantial apoptosis. Total apoptotic populations reached 52.8–60.1% following BIRC5 knockout and 45.3–50.6% following MADD knockout. Apoptosis induction was confirmed by caspase-3/7 activation, increased Sub-G1 accumulation, and cleavage of apoptosis-related proteins, indicating activation of the intrinsic apoptotic pathway.Notably, BIRC5 disruption consistently produced stronger pro-apoptotic effects than MADD across all cancer models. Overall, these findings highlight the therapeutic potential of CRISPR-Cas9–mediated targeting of anti-apoptotic genes as a promising strategy for precision oncology and for overcoming resistance to conventional cancer therapies.
Co-Authors Anna Kartika Yuli Astuti Anzhari, Della Hashfi Awal Prasetyo Bajeng Nurul W Dea Diah Hastuti Eka Cahya Muliawati Harnis, Zola Efa Hendro Pratomo Setyo Mugiyanto Mutia Syafira Rina Puspita