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Anzhari, Della Hashfi
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Medicine & Pharmacology

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EFFECT OF MEAL TIME BEFORE BLOOD DONATION ON PLASMA LIPEMIC LEVELS AND IN LIQUID PLASMA (LP) Anzhari, Della Hashfi; Ritchie, Ni Ken
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 3 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i3.3121

Abstract

Kondisi meningkatnya kadar lemak dalam darah akibat asupan makanan dapat mengindikasikan hiperlipidemia. Peningkatan kadar lemak dalam darah pasca makan merupakan respons fisiologis normal terhadap asupan lemak dari makanan. Lemak di dalam tubuh akan mengalami metabolisme dan membutuhkan waktu kembali ke keadaan basal. Hal ini dapat menyebabkan lipemik yang disebabkan oleh tingginya lipoprotein yang terdapat pada darah. Penelitian ini bertujuan untuk mengevaluasi pengaruh waktu makan sebelum donasi terhadap kadar trigliserida dan kejadian lipemik pada komponen LP. Metode studi eksperimen dilakukan pada 28 responden yang dibagi menjadi dua kelompok berdasarkan waktu makan terakhir (2 dan 3 jam sebelum donor). Darah donor yang terkumpul dibuat menjadi komponen darah Liquid Plasma (LP) dan Packed Red Cell (PRC) leukodepleted dilakukan pemeriksaan lipemik, kadar kolesterol,dan kadar trigliserida. Hasil penelitian menunjukkan tidak ditemukan pengaruh waktu makan 2 jam dan 3 jam terhadap kenaikan kadar kolesterol sebelum donor dengan darah donor maupun komponen LP (p=0,946, P=0,431). Ditemukan pengaruh waktu makan 2 jam dan 3 jam terhadap kenaikan kadar trigliserida sebelum donor dengan darah donor maupun komponen LP (p=0,002, p=0,003) dimana berdasarkan nilai mean selisih kenaikan cenderung lebih tinggi pada waktu makan 3 jam sebelum donor. Terdapat hubungan antara kadar trigliserida dan lipemik (p=0,000). Namun, tidak terdapat hubungan antara kadar kolesterol dengan lipemik yang terjadi pada komponen LP (p=0,229).
DONOR DARAH DENGAN HIPERLIPIDEMIA BERDAMPAK TERHADAP KUALITAS DARAH YANG DISUMBANGKAN: SYSTEMATIC REVIEW Anzhari, Della Hashfi; Ritchie, Ni Ken; Lubis, Anna Mira
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 4 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i4.2647

Abstract

Hyperlipidemia is currently suffered by many people, including those individuals who regularly donate blood. Hyperlipidemia occurs due to an unhealthy lifestyle. It was found that there was a decrease in the quality of donor blood, including a change in plasma color to a milky white, cloudy appearance known as lipemia, as well as a decrease in the function of platelet and erythrocyte components. The aim of this study was to determine the impact of hyperlipidemia in blood donors on the blood produced. This systematic literature review follows PRISMA guidelines, with article collection carried out using basic data from Science Direct, PubMed, Google Scholar, Research Gate and Sage Journal. The articles used were limited to publication years between 2014 and 2024. In this research, 7 articles were found that were suitable and selected. The results of this study show that there are several factors that cause an individual to experience hyperlipidemia, one of the factors that has a big influence is diet. In this study, it was discovered that donors with hyperlipidemia were more likely to produce blood products that had high levels of fat, in which case the plasma blood component became lipemic and level of hemolysis during storage was higher. Apart from that, hyperlipidemia also affects other blood products, namely the platelet component, which can produce platelets that have abnormalities in platelet composition and function. The impact of hyperlipidemia should not be ignored, better donor screening can provide better quality control to reduce the risk of this occurring.
Co-Authors Anna Mira Lubis Ni Ken Ritchie, Ni Ken