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All Journal Eksakta : Berkala Ilmiah Bidang MIPA Mestaka: Jurnal Pengabdian Kepada Masyarakat Media Penelitian dan Pengembangan Kesehatan Jurnal Penelitian dan Pengabdian Masyarakat
Anzhari, Della Hashfi
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EFFECT OF MEAL TIME BEFORE BLOOD DONATION ON PLASMA LIPEMIC LEVELS AND IN LIQUID PLASMA (LP) Anzhari, Della Hashfi; Ritchie, Ni Ken
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 3 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i3.3121

Abstract

Kondisi meningkatnya kadar lemak dalam darah akibat asupan makanan dapat mengindikasikan hiperlipidemia. Peningkatan kadar lemak dalam darah pasca makan merupakan respons fisiologis normal terhadap asupan lemak dari makanan. Lemak di dalam tubuh akan mengalami metabolisme dan membutuhkan waktu kembali ke keadaan basal. Hal ini dapat menyebabkan lipemik yang disebabkan oleh tingginya lipoprotein yang terdapat pada darah. Penelitian ini bertujuan untuk mengevaluasi pengaruh waktu makan sebelum donasi terhadap kadar trigliserida dan kejadian lipemik pada komponen LP. Metode studi eksperimen dilakukan pada 28 responden yang dibagi menjadi dua kelompok berdasarkan waktu makan terakhir (2 dan 3 jam sebelum donor). Darah donor yang terkumpul dibuat menjadi komponen darah Liquid Plasma (LP) dan Packed Red Cell (PRC) leukodepleted dilakukan pemeriksaan lipemik, kadar kolesterol,dan kadar trigliserida. Hasil penelitian menunjukkan tidak ditemukan pengaruh waktu makan 2 jam dan 3 jam terhadap kenaikan kadar kolesterol sebelum donor dengan darah donor maupun komponen LP (p=0,946, P=0,431). Ditemukan pengaruh waktu makan 2 jam dan 3 jam terhadap kenaikan kadar trigliserida sebelum donor dengan darah donor maupun komponen LP (p=0,002, p=0,003) dimana berdasarkan nilai mean selisih kenaikan cenderung lebih tinggi pada waktu makan 3 jam sebelum donor. Terdapat hubungan antara kadar trigliserida dan lipemik (p=0,000). Namun, tidak terdapat hubungan antara kadar kolesterol dengan lipemik yang terjadi pada komponen LP (p=0,229).
DONOR DARAH DENGAN HIPERLIPIDEMIA BERDAMPAK TERHADAP KUALITAS DARAH YANG DISUMBANGKAN: SYSTEMATIC REVIEW Anzhari, Della Hashfi; Ritchie, Ni Ken; Lubis, Anna Mira
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 4 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i4.2647

Abstract

Hyperlipidemia is currently suffered by many people, including those individuals who regularly donate blood. Hyperlipidemia occurs due to an unhealthy lifestyle. It was found that there was a decrease in the quality of donor blood, including a change in plasma color to a milky white, cloudy appearance known as lipemia, as well as a decrease in the function of platelet and erythrocyte components. The aim of this study was to determine the impact of hyperlipidemia in blood donors on the blood produced. This systematic literature review follows PRISMA guidelines, with article collection carried out using basic data from Science Direct, PubMed, Google Scholar, Research Gate and Sage Journal. The articles used were limited to publication years between 2014 and 2024. In this research, 7 articles were found that were suitable and selected. The results of this study show that there are several factors that cause an individual to experience hyperlipidemia, one of the factors that has a big influence is diet. In this study, it was discovered that donors with hyperlipidemia were more likely to produce blood products that had high levels of fat, in which case the plasma blood component became lipemic and level of hemolysis during storage was higher. Apart from that, hyperlipidemia also affects other blood products, namely the platelet component, which can produce platelets that have abnormalities in platelet composition and function. The impact of hyperlipidemia should not be ignored, better donor screening can provide better quality control to reduce the risk of this occurring.
Platelet-Rich Plasma (PRP) Allogenic: A Potential Challenge for Decreasing Random Blood Glucose, Uric Acid, and Cholesterol Levels in A Preliminary Pre and Post Test Study on Adult Subjects Diah Hastuti; Awal Prasetyo; Anzhari, Della Hashfi; Resti Ariani; Mutia Syafira; Anna Kartika Yuli Astuti; Rina Puspita
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 01 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss01/643

Abstract

Ideally, metabolic homeostasis is maintained through stable glucose regulation, balanced lipid metabolism, and effective uric acid clearance under conditions of minimal systemic inflammation. In real clinical conditions, aging and persistent low-grade inflammation frequently disrupt this balance, leading to hyperglycemia, dyslipidemia, and elevated uric acid levels. Current pharmacological management mainly emphasizes metabolic control and may not sufficiently address underlying tissue dysfunction or inflammatory processes. Platelet-rich plasma (PRP) is a blood-derived bioregenerative product containing growth factors with anti-inflammatory and regenerative properties, offering a potential supportive approach for metabolic regulation. Nevertheless, PRP administration has predominantly relied on invasive delivery methods. Nebulization provides a non-invasive pulmonary route that enables rapid systemic absorption, representing an alternative delivery strategy. Despite its potential advantages, clinical evidence regarding the metabolic effects of PRP delivered via nebulization remains limited, creating an urgent need for preliminary clinical evaluation. Therefore, this pre–post test study aimed to assess the effects of allogeneic PRP nebulization on random blood glucose, uric acid, and total cholesterol levels. Fourteen adult subjects received PRP nebulization for five consecutive days. The intervention resulted in a significant reduction in random blood glucose levels and mild decreasing trends in uric acid and total cholesterol without serious adverse events.
SOSIALISASI PLATELET RICH PLASMA (PRP) ALOGENIK SEBAGAI TERAPI PENDUKUNG DIABETES MELLITUS PADA TENAGA KESEHATAN DI FASILITAS KESEHATAN KOTA SEMARANG Anzhari, Della Hashfi; Syafira, Muthia; Ariani, Resti; Astuti, Anna Kartika Yuli; Lestari, Tulus Puji
JPMUJ Vol. 4 No. 1 (2026): SEMUA ARTIKEL TERBIT SECARA ONLINE
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat UIKA Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/jpmuj.v4i1.3247

Abstract

Diabetes mellitus is a non-communicable disease with an increasing prevalence and is often accompanied by chronic complications, one of which is diabetic foot ulcers that are difficult to heal and have a high risk of infection and amputation. Conventional management of diabetic wounds often fails to produce optimal results, necessitating innovative and evidence-based supportive therapies. Platelet-Rich Plasma (PRP) is a blood-derived product rich in growth factors that has the potential to accelerate wound healing. Although the potential of PRP has been widely reported, healthcare professionals' understanding and readiness to apply it remain limited, particularly in primary healthcare facilities. This community service activity aims to increase the knowledge and understanding of health workers regarding allogeneic PRP, including topical or spray formulations, as a supportive therapy in the treatment of diabetic wounds. The community service method was carried out through educational and knowledge dissemination activities, which included material presentations, interactive discussions, and demonstrations of the use of PRP on diabetic wounds using simulation media. The activity was carried out at the Indonesian Red Cross in Semarang City, involving health workers from the Indonesian Red Cross and affiliated health care facilities. The material presented covered the basic concepts of PRP, the mechanism of PRP in wound healing, the differences between autologous and allogeneic PRP, and the principles of using topical or spray PRP. Data were obtained through observation during the activity and participant responses, then analyzed using descriptive qualitative methods. The novelty of this activity was the introduction of allogeneic PRP in topical or spray form as a supportive therapy for diabetic wounds to health workers, which is still relatively rarely applied in health service practice. The results of the activity showed an increase in participants' understanding, enthusiasm, and readiness to consider the use of PRP as part of rational and safe diabetes wound management. It was concluded that this community service activity could increase healthcare workers' knowledge of the use of allogeneic PRP as a supportive therapy for diabetic wounds and has the potential to encourage the adoption of evidence-based regenerative therapies in healthcare facilities.
Sosialisasi dan Edukasi Pemanfaatan Platelet Rich Plasma (PRP) Metode Nebulisasi pada Paguyuban Lansia PMI Kota Semarang Syafira, Mutia; Anzhari, Della Hashfi; Ariani, Resti; Hastuti, Diah; Shafira, Chintya Meiska; Amirullah, Nafissa Naomi
Mestaka: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 1 (2026): Februari 2026
Publisher : Pakis Journal Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58184/mestaka.v5i1.865

Abstract

Based on the results of initial observations conducted with activity partners, it was found that the Semarang City PMI Elderly Association still has limited knowledge regarding innovations in the use of blood-based products, especially Platelet Rich Plasma (PRP), and its application methods in the health sector. The lack of information that is easily understood by the elderly group is one of the factors in low health literacy regarding the development of blood-based health technology. This community service activity aims to socialize and educate the Semarang City PMI Elderly Association regarding the concept, benefits, and basic principles of the use of Platelet Rich Plasma (PRP) with the nebulization method. The activity was implemented through educational and interactive material delivery, discussions, and evaluation of participant understanding. Based on the results of the community service activity, participants showed high enthusiasm and consistent attendance during the socialization process, marked by active participation in discussions and increased understanding of the material presented. This activity can be concluded as running well and showing a better understanding based on qualitative analysis and elderly awareness of the innovation of PRP use as part of health education. This community service activity is expected to support the role of universities in the implementation of Tridarma, especially community service in the health sector.
Co-Authors Amirullah, Nafissa Naomi Anna Kartika Yuli Astuti Anna Mira Lubis Ariani, Resti Astuti, Anna Kartika Yuli Awal Prasetyo Diah Hastuti Hastuti, Diah Lestari, Tulus Puji Mutia Syafira Ni Ken Ritchie, Ni Ken Resti Ariani Rina Puspita Shafira, Chintya Meiska Syafira, Muthia Syafira, Mutia