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All Journal Eksakta : Berkala Ilmiah Bidang MIPA Media Penelitian dan Pengembangan Kesehatan
Anzhari, Della Hashfi
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology

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EFFECT OF MEAL TIME BEFORE BLOOD DONATION ON PLASMA LIPEMIC LEVELS AND IN LIQUID PLASMA (LP) Anzhari, Della Hashfi; Ritchie, Ni Ken
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 3 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i3.3121

Abstract

Kondisi meningkatnya kadar lemak dalam darah akibat asupan makanan dapat mengindikasikan hiperlipidemia. Peningkatan kadar lemak dalam darah pasca makan merupakan respons fisiologis normal terhadap asupan lemak dari makanan. Lemak di dalam tubuh akan mengalami metabolisme dan membutuhkan waktu kembali ke keadaan basal. Hal ini dapat menyebabkan lipemik yang disebabkan oleh tingginya lipoprotein yang terdapat pada darah. Penelitian ini bertujuan untuk mengevaluasi pengaruh waktu makan sebelum donasi terhadap kadar trigliserida dan kejadian lipemik pada komponen LP. Metode studi eksperimen dilakukan pada 28 responden yang dibagi menjadi dua kelompok berdasarkan waktu makan terakhir (2 dan 3 jam sebelum donor). Darah donor yang terkumpul dibuat menjadi komponen darah Liquid Plasma (LP) dan Packed Red Cell (PRC) leukodepleted dilakukan pemeriksaan lipemik, kadar kolesterol,dan kadar trigliserida. Hasil penelitian menunjukkan tidak ditemukan pengaruh waktu makan 2 jam dan 3 jam terhadap kenaikan kadar kolesterol sebelum donor dengan darah donor maupun komponen LP (p=0,946, P=0,431). Ditemukan pengaruh waktu makan 2 jam dan 3 jam terhadap kenaikan kadar trigliserida sebelum donor dengan darah donor maupun komponen LP (p=0,002, p=0,003) dimana berdasarkan nilai mean selisih kenaikan cenderung lebih tinggi pada waktu makan 3 jam sebelum donor. Terdapat hubungan antara kadar trigliserida dan lipemik (p=0,000). Namun, tidak terdapat hubungan antara kadar kolesterol dengan lipemik yang terjadi pada komponen LP (p=0,229).
DONOR DARAH DENGAN HIPERLIPIDEMIA BERDAMPAK TERHADAP KUALITAS DARAH YANG DISUMBANGKAN: SYSTEMATIC REVIEW Anzhari, Della Hashfi; Ritchie, Ni Ken; Lubis, Anna Mira
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 4 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i4.2647

Abstract

Hyperlipidemia is currently suffered by many people, including those individuals who regularly donate blood. Hyperlipidemia occurs due to an unhealthy lifestyle. It was found that there was a decrease in the quality of donor blood, including a change in plasma color to a milky white, cloudy appearance known as lipemia, as well as a decrease in the function of platelet and erythrocyte components. The aim of this study was to determine the impact of hyperlipidemia in blood donors on the blood produced. This systematic literature review follows PRISMA guidelines, with article collection carried out using basic data from Science Direct, PubMed, Google Scholar, Research Gate and Sage Journal. The articles used were limited to publication years between 2014 and 2024. In this research, 7 articles were found that were suitable and selected. The results of this study show that there are several factors that cause an individual to experience hyperlipidemia, one of the factors that has a big influence is diet. In this study, it was discovered that donors with hyperlipidemia were more likely to produce blood products that had high levels of fat, in which case the plasma blood component became lipemic and level of hemolysis during storage was higher. Apart from that, hyperlipidemia also affects other blood products, namely the platelet component, which can produce platelets that have abnormalities in platelet composition and function. The impact of hyperlipidemia should not be ignored, better donor screening can provide better quality control to reduce the risk of this occurring.
Platelet-Rich Plasma (PRP) Allogenic: A Potential Challenge for Decreasing Random Blood Glucose, Uric Acid, and Cholesterol Levels in A Preliminary Pre and Post Test Study on Adult Subjects Diah Hastuti; Awal Prasetyo; Anzhari, Della Hashfi; Resti Ariani; Mutia Syafira; Anna Kartika Yuli Astuti; Rina Puspita
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 01 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss01/643

Abstract

Ideally, metabolic homeostasis is maintained through stable glucose regulation, balanced lipid metabolism, and effective uric acid clearance under conditions of minimal systemic inflammation. In real clinical conditions, aging and persistent low-grade inflammation frequently disrupt this balance, leading to hyperglycemia, dyslipidemia, and elevated uric acid levels. Current pharmacological management mainly emphasizes metabolic control and may not sufficiently address underlying tissue dysfunction or inflammatory processes. Platelet-rich plasma (PRP) is a blood-derived bioregenerative product containing growth factors with anti-inflammatory and regenerative properties, offering a potential supportive approach for metabolic regulation. Nevertheless, PRP administration has predominantly relied on invasive delivery methods. Nebulization provides a non-invasive pulmonary route that enables rapid systemic absorption, representing an alternative delivery strategy. Despite its potential advantages, clinical evidence regarding the metabolic effects of PRP delivered via nebulization remains limited, creating an urgent need for preliminary clinical evaluation. Therefore, this pre–post test study aimed to assess the effects of allogeneic PRP nebulization on random blood glucose, uric acid, and total cholesterol levels. Fourteen adult subjects received PRP nebulization for five consecutive days. The intervention resulted in a significant reduction in random blood glucose levels and mild decreasing trends in uric acid and total cholesterol without serious adverse events.
Co-Authors Anna Kartika Yuli Astuti Anna Mira Lubis Awal Prasetyo Diah Hastuti Mutia Syafira Ni Ken Ritchie, Ni Ken Resti Ariani Rina Puspita