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All Journal Majalah Kedokteran Gigi Indonesia Jurnal Gizi Klinik Indonesia Oto Rhino Laryngologica Indonesiana
Soesatyo, Marsetyawan Heparis Nur Ekandaru
Departemen Histologi Dan Biologi Sel, Fakultas Kedokteran, Universitas Gadjah Mada, Yogyakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Penentuan konsentrasi stainless steel 316L dan kobalt kromium remanium GM-800 pada uji GPMT Ikmal Hafizi; W. Widjijono; Marsetyawan Heparis Nur Ekandaru Soesatyo
Majalah Kedokteran Gigi Indonesia Vol 2, No 3 (2016): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (654.181 KB) | DOI: 10.22146/majkedgiind.11386

Abstract

Concentration determination of stainless steel 316L and cobalt chromium remanium GM - 800 on GPMT test. Dentistry had used metals such as cobalt chromium and stainless steel in maxillofacial surgery, cardiovascular, and as a dental material. 316L stainless steel is austenistic stainless steel which has low carbon composition to improve the corrosion resistance as well as the content of molybdenum in the material. Cobalt chromium (CoCr) is a cobaltbased alloy with a mixture of chromium. Density of a metal cobalt chromium alloy is about 8-9 g/cm3 that caused metal interference relatively mild. Remanium GM-800 is one type of a cobalt chromium alloy with the advantages of having high resistance to fracture and high modulus of elasticity. This study aims to determine the exact concentration used in 316L stainless steel and cobalt chromium GM-800 as the GPMT test material. Subjects were cobalt chromium Remanium GM-800 and 316L stainless steel concentration of 5%, 10%, 20%, 40% and 80%. Patch containing stainless steel or cobalt chromium paste was af xed for 24 hours each on three experimental animals, then the erythema and edema were observed using the Magnusson and Kligman scale. In the study, concentration of 5% is the concentration recommended for stainless steel 316L and cobalt chromium GM-800 as material in challenge phase GPMT test, while the concentration of 40% is the concentration recommended for stainless steel 316L and cobalt chromium GM-800 in the induction phase.ABSTRAKDunia kedokteran gigi banyak menggunakan logam pada pembedahan maxillofacial, cardiovascular, dan sebagai material dental. Logam yang banyak digunakan antara lain adalah kobalt kromium dan stainless steel. Stainless steel 316L merupakan austenistic stainless steel yang memiliki komposisi karbon rendah sehingga dapat meningkatkan ketahanan terhadap korosi sama halnya dengan kandungan molybdenum pada material tersebut. Kobalt kromium (CoCr) adalah cobalt-based alloy dengan campuran chromium. Kepadatan (density) dari logam campur kobalt kromium adalah sekitar 8-9 gram/cm3 menyebabkan logam campur ini relatif sangat ringan. Remanium GM-800 merupakan salah satu jenis alloy kobalt kromium dengan kelebihan memiliki resistensi terhadap fraktur yang tinggi serta modulus elastisitas yang tinggi. Penelitian ini bertujuan untuk mengetahui konsentrasi tepat yang digunakan pada stainless steel 316L dan kobalt kromium GM-800 sebagai bahan uji GPMT. Subjek penelitian adalah kobalt kromium Remanium GM800 dan stainless steel 316L konsentrasi 5%, 10%, 20%, 40%, dan 80%. Patch berisi pasta stainless steel atau kobalt kromium ditempelkan selama 24 jam masing-masing pada 3 hewan coba, selanjutnya dilakukan observasi eritema dan edema dengan menggunakan skala Magnusson dan Kligman. Pada penelitian, konsentrasi 5% merupakan konsentrasi yang direkomendasikan untuk stainless steel 316L dan kobalt kromium GM-800 sebagai konsentrasi tahap challenge uji GPMT, sedangkan konsentrasi 40% merupakan konsentrasi yang direkomendasikan untuk logam stainless steel 316L dan kobalt kromium GM-800 tahap induksi.
Campuran kitosan dengan resin akrilik sebagai bahan gigi tiruan penghambat Candida albicans Titik Ismiyati; Widowati Siswomihardjo; Marsetyawan Heparis Nur Ekandaru Soesatyo; R. Rochmadi
Majalah Kedokteran Gigi Indonesia Vol 3, No 3 (2017): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (766.127 KB) | DOI: 10.22146/majkedgiind.23721

Abstract

The mixture of acrylic resin and chitosan as denture material to inhibit Candida albicans. The inhibition of Candida albicans in denture resin has an important role to prevent the development of denture stomatitis. Chitosan is a natural polymer compound derived from shrimp waste which can function as an antifungal Acrylik resin cannot be mixed with chitosan. To obtain a homogeneous mixture, the mixture was added a coupling agen acrylic acid and acetone. The research objective was to study the mixture of acrylic resin and chitosan with solvent acrylic acid and acetone as a denture that can inhibit the growth of Candida albicans. Methods: The samples used discs in 10 mm diameter and 2 mm thickness, made from heat cured acrylic resin mixed with chitosan dissolved in acrylat acid and acetone. They were divided into 4 groups. Group 1 was acrylic resin without chitosan as a control, group 2, 3 and 4 were the mixture of acrylic resin and 5 ml chitosan in 0.5%, 1%, and 2% concentration respectively. The fourier transform irfrared spectroscopy (FTIR) and the digital optical microscope were used to synthesize and analyze. The Kruskal Wallis was used to analyze the data. The results showed that the mixture of acrylic resin with chitosan significantly inhibited the growth of Candida albicans. Conclusion: a mixture of acrylic resins and chitosan can be fungistatic, so it can be developed as an antifungal denture material. ABSTRAKPenghambatan Candida albicans pada gigi tiruan resin akrilik dapat memainkan peran penting dalam mencegah perkembangan denture stomatitis. Kitosan adalah senyawa polimer alam yang berasal dari limbah udang yang dapat berfungsi sebagai antijamur. Resin akrilik tidak dapat bercampur dengan kitosan. Untuk mendapatkan campuran yang homogen, campuran tersebut ditambah coupling agent asam akrilat dan aseton. Penelitian ini bertujuan untuk mengkaji campuran resin akrilik dan kitosan dan asam akrilat pelarut aseton sebagai bahan gigi tiruan penghambat Candida albicans. Spesimen penelitian berbentuk cakram berdiameter 10 mm dan tebal 2 mm dibuat dari resin akrilik kuring panas (QC 20) dicampur dengan kitosan dari cangkang udang yang ditambahkan asam akrilat dalam pelarut aseton. Spesimen dibagi menjadi 4 kelompok. Kelompok 1 terdiri dari resin akrilik tanpa kitosan sebagai kontrol, sedangkan kelompok 2, 3, dan 4 terdiri dari campuran resin akrilik dengan kitosan 5 ml pada konsentrasi 0,5%, 1%, dan 2%, secara berurutan. Hasil campuran resin akrilik dengan kitosan dianalisis dengan menggunakan Fourier Transform Infrared spectroscopy (FTIR), dan digital mikroskop optik. Efek antijamur diuji dengan menggunakan metode dilusi. Data yang didapat dianalisis statistik dengan Kruskal Wallis. Hasil penelitian menunjukkan bahwa campuran resin akrilik dengan kitosan signifikan menghambat pertumbuhan Candida albicans. Berdasarkan hasil yang diperoleh, dapat disimpulkan bahwa campuran resin akrilik dan kitosan dapat bersifat fungistatik, sehingga dapat dikembangkan sebagai bahan gigi tiruan antijamur.
Peran neutral endopeptidase terhadap inflamasi saluran napas atas pada penderita obstructive sleep apnea Hatmansjah Hatmansjah; Marsetyawan Heparis Nur Ekandaru Soesaty; Bambang Hermani; Indwiani Astuti; Bambang Uji Djoko Rianto
Oto Rhino Laryngologica Indonesiana Vol 46, No 1 (2016): Volume 46, No. 1 January - June 2016
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1186.483 KB) | DOI: 10.32637/orli.v46i1.149

Abstract

Latar belakang: Obstructive sleep apnea (OSA) pada anak yang berhubungan dengan excessivedaytime somnolance (EDS), gagal tumbuh, kelainan kardiovaskular, gagal napas, dan kematian,prevalensinya terus meningkat. Inflamasi berperan pada patogenesis penyakit tersebut.Tujuan:Mengetahui peran neutral endopetidase (NEP) terhadap inflamasi pada penderita OSA dan hubungannyadengan mediator inflamasi subtance P (SP), interleukin-4 (IL-4), dan tumor necrosis factor α (TNF-α).Metode: Penelitian potong lintang dilakukan pada pada 36 pasien hipertrofi tonsil dan adenoid selamaMei 2013-2015. Diagnosis OSA ditegakkan dengan polisomnografi, dan kadar NEP, SP, IL-4 dan TNF-αyang berasal dari tonsil maupun adenoid dengan imunohistokimia.Hasil: Terdapat 21 penderita OSA(58,3%) dan 15 subjek tidak OSA (41,7%), dari total 36 sampel. Dijumpai hubungan yang bermaknaantara SP tonsil dan SP adenoid dengan OSA, serta IL-4 tonsil dengan OSA (p<0,05). Walau kadar NEPtonsil dan NEP adenoid lebih sedikit pada OSA, serta IL-4 adenoid, TNF-α tonsil dan adenoid lebihbesar pada OSA, perbedaan tersebut tidak bermakna (P>0,05). Dijumpai juga hubungan yang bermaknaantara SP tonsil dengan IL-4 tonsil dan SP tonsil dengan TNF-α tonsil (p<0,05).Kesimpulan: Terdapathubungan yang tidak bermakna antara NEP dan OSA, namun ditemukan hubungan yang bermakna antaraSP dan IL-4 dengan OSA. Kata kunci : Obstructive sleep apnea, neutral endopeptidase, substance P, interleukin-4 ABSTRACTBackground: The prevalence of obstructive sleep apnea (OSA) in children, which can lead toexcessive daytime somnolance (EDS), failure to thrive, cardiovascular disorders and respiratory failureand death, continues to rise. Inflammation is associated with OSA. Purpose: To identify the role of neutralendopeptidase (NEP) to inflammation in obstructive sleep apnea (OSA), and its association to inflammatorymediator subtance P (SP), interleukin-4 (IL-4) and tumor necrosis factor-α (TNF-α). Methods: A crosssectionalstudy had been done to 36 adenotonsilar hypertrophy child patients with OSA during the periodof time from May 2013-2015. OSA was diagnosed based on polisomnografi and the level of NEP, SP, IL-4and TNF-α by imunohistochemistry. Results: We found 21 subjects had OSA (58.3%) and 15 subjects didnot have OSA (41.7%), from total sample 36. There were significant associations between SP tonsil, SPadenoid and IL-4 tonsil with OSA (p<0.05). Although the number of NEP level in OSA was smaller thannon OSA and IL-4 adenoid, TNF-α tonsil and TNF-α adenoid OSA were found greater than non OSA,but the difference between them were not significant (p>0.05). Conclusion: This study did not found asignificant correlation between NEP with OSA but there were significant correlations between SP andIL-4 with OSA. Keywords: Obstructive sleep apnea, neutral endopeptidase, substance P, interleukin-4 Alamat Korespondensi: Hatmansjah, SMF THT RSUP Persahabatan, Jl. Persahabatan Raya No. 1,Jakarta, Email: hatmansjah@yahoo.com
Peningkatan aktivitas fagositosis dan produksi nitrit oksida pada makrofag peritoneum tikus Sprague Dawley yang diberi Lactobacillus plantarum Mut7 dan ekstrak serat ubi jalar Lily Arsanti Lestari; Marsetyawan Heparis Nur Ekandaru Soesatyo; Susi Iravati; Eni Harmayani
Jurnal Gizi Klinik Indonesia Vol 9, No 2 (2012): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.15381

Abstract

Background: Macrophages play an important role as part of the innate immune response in the gut and they represent one of the first lines of nonspecific defense against bacterial invasion. Previous studies indicated that probiotics and prebiotics may act as an immunomodulator agents. Nevertheless, research on the immunomodulatory effect of local materials has never been performed.Objective: To study the effects of Lactobacillus plantarum Mut7 and sweet potato fiber on the activity and Nitric Oxide (NO) production of peritoneal macrophages of Sprague Dawley rats.Method: Ninety six Sprague Dawley rats aged 8 weeks were divided into two groups; A (not infected with Salmonella typhimurium) and B (infected with S. typhimurium). Each group was divided into 4 subgroups and assigned to standard AIN-93M diet (KON), 109 CFU/ml of L. plantarum Mut7 (PRO), modified AIN-93M diet with sweet potato fiber (PRE), and both component (SIN). After 3 weeks of treatment, 6 rats of each subgroup were sacrificed and the peritoneal macrophages were isolated and analysed for its activity and NO production. The rest of the rats continued the treatments for another 2 weeks. At the end of the experiment, they were sacrificed and the peritoneal macrophage were isolated and analysed for its activity and NO production.Results: Oral administration of  L. plantarum Mut7, sweet potato fiber, or both improve phagocytic activity of peritoneal macrophage which was indicated by an increase in the percentage of macrophages that phagocyte latex particles (p<0.05) and an increase in the number of latex particles engulfed by macrophages either after 3 or 5 weeks of treatment (p<0.05). Oral administration of L. plantarum Mut7, sweet potato fiber, or both were unable to increase the nitric oxide production after 3 weeks of treatment (p>0.05), but after 5 weeks of treatment the production of NO was significantly increased (p<0.05).Conclusion: L. plantarum Mut7, sweet potato fiber, or both increase the non specific immune response as they could improve the activity and NO production of peritoneal macrophages.
Co-Authors Bambang Hermani Bambang Uji Djoko Rianto Eni Harmayani Hatmansjah Hatmansjah Ikmal Hafizi Indwiani Astuti Lily Arsanti Lestari R. Rochmadi Susi Iravati Titik Ismiyati W. Widjijono Widowati Siswomihardjo