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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo Majalah Farmaseutik Media Ilmu Kesehatan Journal of Innovation in Community Empowerment (JICE) Journal of Pharmaceutical (JOP) JOURNAL OF PHILANTHROPY: The Journal of Community Service
Rusydan, Azka Muhammad
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Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Penyuluhan Hipertensi dan DAGUSIBU Obat Antihipertensi Puji Lestari, Mardiana; Rusydan, Azka Muhammad
The Journal of Innovation in Community Empowerment Vol 6 No 2 (2024): Journal of Innovation in Community Empowerment (JICE)
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jice.v6i2.1400

Abstract

Hipertensi merupakan penyakit tidak menular yang ditandai dengan tekanan darah sistolik diatas 140 mmHg atau tekanan darah diastolik diatas 90 mmHg pada pemeriksaan berulang. Penyakit ini termasuk penyakit degeneratif yang dapat mengakibatkan kerusakan organ vital tubuh seiring berjalannya waktu. Penderita hipertensi diperkirakan sebesar 22% dari total populasi di dunia. Hipertensi termasuk masalah kesehatan global yang cukup berbahaya, dan menjadi penyebab utama penyakit jantung koroner dan penyakit ginjal. Hipertensi atau tekanan darah tinggi juga dikenal sebagai silent killer karena pada kebanyakan kasus pasien tidak mengetahui kapan mengalami tekanan darah tinggi dikarenakan pada pemeriksaan fisik seringkali tidak menunjukkan tanda-tanda sampai terjadi komplikasi. Pencegahan dan penanganan yang tepat akan mengurangi dampak atau risiko terhadap terjadinya komplikasi yang tidak di inginkan. Kegiatan penyuluhan kesehatan ini bertujuan untuk meningkatkan pengetahuan dan pemahaman masyarakat Dukuh Beji tentang penyakit hipertensi dan DAGUSIBU obat antihipertensi sebagai upaya promotif dan preventif. Metode kegiatan penyuluhan diawali dengan pemeriksaan kesehatan yaitu pengukuran tekanan darah, selanjutnya dilakukan pretest yang kemudian dilanjutkan dengan penyampaian materi dan diskusi kemudian diakhiri dengan posttest. Hasil kegiatan penyuluhan dari 26 peserta diperoleh karakteristik peserta mayoritas berusia >61 sebanyak 50%, dengan jenis kelamin perempuan 69,2%, dan tekanan darah berada pada rentang tidak normal 69,2%. Pada evaluasi tingkat pengetahuan terjadi peningkatan pengetahuan peserta yang dilihat dari hasil pretest sebelum dilakukan penyuluhan masih ada masyarakat yang memiliki tingkat pengetahuan yang cukup sebanyak 15,4%, setelah diberikan penyuluhan dan diberikan postest diperoleh tingkat pengetahuan seluruh peserta 100% dalam kategori “Baik”.
Pengaruh Variasi Waktu Ekstraksi terhadap Aktivitas Peredaman Radikal Bebas DPPH Ekstrak Biji Kopi Robusta Lampung Barat Arifah, Mitsalina Fildzah; Rusydan, Azka Muhammad; Sayyidah Yahya, Fina Ummu; Pratama , Nofran Putra; Saputra, Diky Permana
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i2.1454

Abstract

Background: Robusta Coffee (Coffea canephora) has been cultivated in Indonesia, especially in the West Lampung area. Robusta coffee contains secondary metabolites that act as antioxidants, namely chlorogenic acid and other phenolic components. These secondary metabolites of robusta coffee bean can be obtained using the extraction method. The ultrasound-assisted extraction (UAE) is a well-known method to be more effective and lower temperature than other extraction methods. Variations in time impacted by the antioxidant activity of coffee bean extract. Research objective: To determine the effect of variation in extraction time on the free radical reduction activity of DPPH from West Lampung Robusta coffee bean extract. Research method: Robusta coffee beans were extracted by the UAE method using a 70% ethanol solvent (1:100). The variation in extraction time was 10, 20, and 30 minutes. Robusta coffee bean extract was subjected to organoleptic tests, phytochemical screening, and antioxidant activity in DPPH free radical scavenging. Research results: The yield results at 10, 20, and 30 minutes of robusta coffee bean extract were 24.04%, 35.71%, and 20.15%. The results of the organoleptic test of the extract produce a thick texture, brown color, and unique aroma. The results of the phytochemical screening of the extract contain alkaloids, phenolics, tannins, and flavonoids.  The IC50 values at the time variations of 10, 20, and 30 minutes, and quercetin were 29.97 ± 2.737 ppm; 30.5 ± 1.745 ppm; 23.31 ± 4.638 ppm; and 1.42 ± 0.440 ppm respectively, which were significantly different. Conclusion: The variation in extraction time affected the free radical reduction activity of DPPH was an extraction time of 30 minutes in the most optimal DPPH free radical scavenging activity  
Direct FTIR and Chemometrics for Authentication of Kratom Powder and Other Alkaloids-containing Plant Matters Rusydan, Azka Muhammad; Firdausia, Rizqa Salsabila
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i2, Special Edition.1482

Abstract

Kratom (Mitragyna speciosa), has gained attention for its use as stimulant and opioid-like analgesic effects. In Indonesia, its legal status remains uncertain in many regions, and concerns about its safety have led to increasing regulation. Even with uncertainty with its legal status, kratom remains easily accessed via online market.  However with Indonesia’s Ministry of Trade is set to regulate its export regulation, a method to quickly distinguish kratom venations is needed. This study explores the potential of Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy, combined with chemometric techniques like Principal Component Analysis (PCA), to differentiate between kratom venations and other alkaloid-containing plants. Direct ATR-FTIR analysis of ground kratom, tea, and coffee leaves revealed characteristic functional groups, with distinct spectral variations observed across the plant samples. Cluster variable analysis reduced the dimensionality of the spectral data by 98.6%, while maintaining 98% similarity level.  PCA highlighting key principal components (PC1 and PC2) responsible for 93.9% of the variance. The model successfully grouped the samples into five clusters with a similarity level of 88.3% and a cluster distance ratio > 1, confirming the method's ability to distinguish kratom venations and other plant materials. This study demonstrates that FTIR-PCA is an effective, rapid, and non-destructive tool for profiling plant materials, although further research with a larger and more diverse sample set is needed for more robust predictive modeling.
Formulasi Krim dan Analisa Potensi Antioksidan dari Fraksi Ekstrak Etanol Bawang Hitam Firdausia, Rizqa Salsabila; Kurniawati, Endah; Rusydan, Azka Muhammad; Ardianto, Lisman Septa
MEDIA ILMU KESEHATAN Vol 14 No 1 (2025): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v14i1.1476

Abstract

Background: Reactive oxygen species (ROS) are free radicals that can cause damage to skin tissue. ROS can be prevented by antioxidants in plants that contain phenolics and flavonoids such as in black garlic. To obtain more specific compounds, fractionation of black garlic extract was carried out using polar, semi-polar and non-polar solvents. Objective: This study aims to determine the antioxidant activity by the FRAP method, then make and evaluate cream products from fractions of black garlic ethanol extract. Methods: Black garlic is made by heating garlic using a rice cooker, then extracted by maceration method. The resulting extract was fractionated with 3 solvents namely water, ethyl acetate and n-hexane. Furthermore, phytochemical screening and antioxidant analysis with the FRAP method were conducted. Fractions with the highest antioxidant activity were formulated into 3 cream preparations with extract concentrations of 0.5; 1; 1.5% and evaluated.Results: The water fraction had higher antioxidant ability, 1.545 ± 0.128 mmol/g extract. The water fraction was then developed into a cream preparation and evaluated the physical properties of the three formulas.Conclusion: Based on the test results, the three cream formulas have good physical properties and are stable at room and low temperatures.
Edukasi Pemanfaatan Bahan Alam Sebagai Solusi Penanganan Penyakit Degeneratif pada Masyarakat Dusun Beji Sumberagung Bantul Rusydan, Azka Muhammad; Lestari, Mardiana Puji; Veriarini, Falaisa Ananda; Elipitaloka , Naftali
JOURNAL OF PHILANTHROPY: The Journal of Community Service Vol. 3 No. 1 (2025): Journal of Philanthropy, January 2025
Publisher : Samodra Ilmu: Lembaga Penelitian, Penerbitan, dan Jurnal Ilmiah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58353/jop.v3i1.235

Abstract

Hypertension is a chronic disease and a major risk factor for cardiovascular disease, often referred to as a "silent killer" due to its asymptomatic nature. Its prevalence in Indonesia is increasing, reaching 34.1% among individuals aged 18 years and over in 2018. Traditional herbal medicine can treat degenerative diseases, but its use is still limited due to inadequate public knowledge. This community service program aims to provide education about hypertension and the use of traditional herbal medicine in Dusun Beji, Bantul, Yogyakarta. The program includes health education, blood pressure checks, and promotion of herbal medicine for hypertension management. A total of 34 participants (85% attendance) attended the session, with 26 completing pretest and posttest questionnaires to evaluate increased knowledge. The majority of participants were elderly (?61 years, 50%) and female (69.2%), with 69.2% showing abnormal blood pressure levels. Educational materials, including presentations and brochures, were provided along with live demonstrations of herbal preparations. Post-test results showed a slight increase in mean score from 7.73 to 7.88, with increased homogeneity of data and an increase in median from 7 to 8. Although paired t-test showed no statistically significant difference (P=0.885), descriptive analysis showed an increase in understanding and awareness. Active participation during the discussion, especially regarding herbal preparations, reflected the community's interest in adopting alternative approaches to hypertension management. This initiative has succeeded in increasing awareness of hypertension and the benefits of herbal medicines to effectively manage the chronic disease and its complications.
Enzymatic hydrolysis of chicken feet for bioactive peptides: method validation and protein quantification Rusydan, Azka Muhammad; Rahayu, Adelia Ragil; Rohmah, Siti Dzurriatur; Firdausia, Rizqa Salsabila
Acta Pharmaciae Indonesia Vol 12 No 2 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.2.13818

Abstract

Background: Stunting affects 21.5% of Indonesian children under five, primarily due to chronic nutritional deficiencies. Chicken feet, underutilized poultry byproducts rich in protein, represent potential sources of bioactive peptides for nutritional interventions. Objective: This study evaluated two enzymatic hydrolysis methods for producing bioactive peptides from chicken feet and validated analytical methods for protein quantification. Methods: Chicken feet were hydrolyzed using bromelain and sequential papain-alcalase treatments. Soluble proteins were quantified using the Biuret assay. Analytical methods were validated for accuracy, precision, and linearity according to ICH guidelines. Results: The analytical method demonstrated satisfactory performance with accuracy values of 98-102%, RSD values below 2%, and linearity (R² = 0.9977) across the 3-11 mg/mL range. Bromelain treatment significantly increased soluble protein content to 24.39 ± 0.65 mg/mL, representing a 1.71-fold increase compared to the non-hydrolyzed control (14.24 ± 0.20 mg/mL, p < 0.001). Conversely, papain-alcalase treatment decreased soluble protein content to 10.92 ± 0.05 mg/mL, likely due to excessive peptide degradation into free amino acids undetectable by the Biuret assay. Conclusion: Bromelain hydrolysis demonstrated superior protein solubilization efficiency compared to papain-alcalase treatment. These preliminary findings suggest bromelain’s potential for converting chicken feet into functional ingredients, though further peptide characterization and bioactivity assessment are required for nutritional applications.
An Integrated FTIR-TLC-PCA Approach for an Accurate Classification Model of Kratom Venation Rusydan, Azka Muhammad; Arifah, Mitsalina Fildzah; Lukitaningsih, Endang; Fakhrudin, Nanang
Majalah Farmaseutik Vol 21, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i3.101780

Abstract

Kratom (M. speciosa), has a long history of traditional use for various ailments as well as for recreational purposes due to its opioid and psychoactive effects. Nowadays kratom is easily accessible via online markets, with leaf powders commonly categorized by vein color, suggesting different effects despite minimal variations in alkaloid content. To improve the identification and characterization of kratom samples, fingerprinting methods using chemometric tools are increasingly applied in food and pharmaceutical analysis. This study explores a combination of Fourier Transform Infrared Spectroscopy (FTIR) and Thin-Layer Chromatography (TLC) densitometry data, analyzed with Principal Component Analysis (PCA), to develop a model for distinguishing kratom venation and other alkaloid-containing plants.The TLC chromatogram revealed six consistent peaks (Rf values of 0.17, 0.27, 0.42, 0.73, 0.8, and 0.9), correlating with alkaloids found in kratom. Using PCA, we combined FTIR absorbance values at selected wavenumbers with TLC chromatogram data, resulting in four principal components (PC1, PC2, PC3, and PC4) that explained 84.1%, 9.7%, 2.7%, and 2.5% of the variance, respectively. The resulting score plot demonstrated distinct clustering of samples, which was then verified with cluster analysis. The resulting analysis indicated effective differentiation between kratom vein colors and plant species. The developed FTIR-TLC-PCA model offers a promising approach for sample classification, potentially aiding quality control and authenticity verification in pharmaceutical applications.
Co-Authors Ardianto, Lisman Septa Arifah, Mitsalina Fildzah Elipitaloka , Naftali Endah Kurniawati Endang Lukitaningsih Lestari, Mardiana Puji Nanang Fakhrudin, Nanang Pratama, Nofran Putra Rahayu, Adelia Ragil Rizqa Salsabila Firdausia Rohmah, Siti Dzurriatur Saputra, Diky Permana Sayyidah Yahya, Fina Ummu Veriarini, Falaisa Ananda