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AKTIVITAS PENANGKAPAN RADIKAL BEBAS PADA KOMBINASI EKSTRAK ETANOL DAUN MANGGA (Mangifera indica L.) DAN DAUN SIRSAK (Annona muricata L.) Endah Kurniawati; Fajar Setyo Wibowo; Rita Rusmeilina
Cendekia Journal of Pharmacy Vol 5, No 1 (2021): Cendekia Journal of Pharmacy
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v5i1.125

Antioksidan merupakan suatu senyawa yang bermanfaat dalam melawan kanker dan proses lain yang berpotensi mengarah pada penyakit-penyakit degeneratif seperti diabetes dan penyakit jantung. Antioksidan bekerja dengan cara menetralisasi radikal bebas menjadi bentuk non radikal. Banyak tanaman, termasuk buah dan sayur, merupakan antioksidan alami karena kandungan senyawa fenolik dan flavonoid yang berperan terhadap aktivitas tanaman sebagai antioksidan. Mangga dan sirsak merupakan salah satu tanaman yang tersebar luas di Indonesia. Daun mangga dan daun sirsak mengandung banyak zat aktif salah satunya adalah senyawa fenol yang menunjukkan aktivitas sebagai antioksidan, antiinflamasi dan antidiabetes. Kombinasi kedua tanaman tersebut berpotensi untuk dikembangkan aktivitas antioksidannya.Aktivitas antioksidan kombinasi ekstrak daun mangga dan daun sirsak dapat diamati dari aktivitas penangkapan radikal bebas menggunakan metode DPPH dengan pembanding vitamin C. Nilai IC50 digunakan sebagai parameter aktivitas penangkapan radikal bebas menggunakan metode DPPH. Kombinasi ekstrak daun mangga dan sirsak menunjukkan adanya aktivitas sebagai antioksidan. Hasil uji aktivitas penangkapan radikal bebas menunjukkan aktivitas kombinasi dua ekstrak tersebut lebih rendah dibandingkan dengan standar vitamin C yang memiliki nilai IC50 sebesar 35,50 ppm. Namun kombinasi kedua ekstrak tersebut memiliki potensi dikembangkan sebagai antioksidan. Kombinasi ekstrak etanol daun mangga dan daun sirsak dengan perbandingan 75:25 memiliki nilai IC50 paling baik yaitu sebesar 94,96 ppm, diikuti perbandingan 50:50 dengan nilai IC50 140,36 ppm, dan perbandingan 25:75 dengan nilai IC50 sebesar 207,79 ppm.

Peningkatan Kualitas Hidup Lansia dalam Penanganan Stroke bagi Kader PKK dan Kesehatan di Gilingan, Banjarsari, Surakarta Novena Yety Lindawati; Endah Kurniawati; Dian Puspitasari; Diah Pratimasari
Jurnal Surya Masyarakat Vol 1, No 2 (2019): Mei 2019
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.1.2.2019.139-145

Stroke merupakan penyebab kecacatan nomor satu dan penyebab kematian nomor tiga setelah penyakit jantung dan kanker baik dinegara maju maupun berkembang. Di Indonesia, stroke merupakan penyebab kematian pada semua kelompok umur, dengan proporsi tertinggi pada usia 55-64 tahun mencapai, 26,8% baik diperkotaan maupun dipedesaan. Kegiatan pengabdian masyarakat dalam bentuk promotif, preventif, kuratif, dan rehabilitatif dengan memberikan penyuluhan tentang penyakit stroke dan penanganannya secara alami, workshop pembuatan minuman pencegah stroke, serta pelatihan senam pencegah stroke. Evaluasi kegiatan dilakukan dengan metode pretest dan postest terhadap materi penyuluhan yang diberikan serta kuisioner tentang pelaksanaan kegiatan yang telah dilakukan. Kegiatan pengabdian masyarakat diikuti oleh 43 peserta yang terdiri dari kader PKK dan kesehatan serta perwakilan lansia dari tiap RW di Gilingan, Banjarsari, Surakarta. Hasil kegiatan ini menunjukkan adanya peningkatan persentase tingkat pengetahuan dan pemahaman peserta mengenai penyakit stroke setelah pemberian penyuluhan “Mengenal Penyakit Stroke” dari 35% menjadi 95%. Peningkatan jumlah peserta yang memahami cara penanganan penyakit stroke secara alami juga terlihat setelah pemberian penyuluhan “Pemanfaatan Obat Alam Indonesia untuk Terapi Penyakit Stroke” dari 42% menjadi 93%. Evaluasi terhadap pelaksanaan kegiatan pengabdian ini juga menunjukkan hasil yang sangat baik terhadap tema yang diambil sebanyak 86,05% peserta memilih sangat menarik dan 13,95% memilih menarik. Kegiatan pengabdian ini meningkatkan pengetahuan, pemahaman, dan wawasan mengenai penyakit stroke dan penanganannya secara alami bagi Kader PKK dan Kesehatan serta perwakilan para lansia di Gilingan, Banjarsari, Surakarta sehingga dapat mensosialisasikan ke seluruh masyarakat serta mengurangi angka kejadian stroke di daerah tersebut.Kata Kunci : stroke, pencegahan dan penanganan alami stroke, kader PKK dan kesehatanAbstractStroke is one of the cause of disability and death (its rank is after heart disease and cancer) worldwide. In Indonesia, stroke is the cause of death in all age groups, with the highest proportion is at the age of 55-64 years reaching 26.8% both in urban and rural areas. Community service activities in stroke promotive, preventive, curative, and rehabilitative forms was held by providing counseling about stroke and how to handle it naturally, workshops on making health drinks to prevent strokes, as well as stroke prevention exercises. Evaluation of activities was carried out with the pretest and posttest method of counseling material provided as well as questionnaires about the implementation of activities that had been carried out. Community service activities were attended by 43 participants consisting of PKK workers (kader), community health workers (kader), and elderly representatives from each RW in Gilingan, Banjarsari, Surakarta. The results of this activity indicate an increase in the percentage of the level of knowledge and understanding of participants regarding stroke after giving counseling "Recognizing Stroke" from 35% to 95%. An increase in the number of participants who understand how to deal with stroke naturally is also seen after giving counseling "Utilization of Indonesian Natural Herbs for Stroke Therapy" from 42% to 93%. The evaluation of the implementation of this service activity also showed very good results on the theme taken as many as 86.05% of the participants chose very interesting and 13.95% chose interesting. This service activity increases knowledge, understanding, and insight into stroke and its handling naturally for PKK kader, community health kader and representatives of the elderly in Gilingan, Banjarsari, Surakarta so that they can socialize to the whole community and reduce the incidence of stroke in the area.

FORMULATION OF CHEWABLE TABLET PREPARATIONS FROM THE COMBINATION OF Azadirachta Indica A. Juss. AND Gynura Procumbens (Merr.) Nofran Putra Pratama; Kurnia Rahayu Purnomo Sari; Endah Kurniawati
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.5918

Azadirachta indica A. Juss. and Gynura procumbens (Merr.) are one type of potential medicinal plants because they have various properties. One of the properties of these two plants is as an antioxidant. The combination of the two plants has a strong category of antioxidant activity, does not cause death and physical changes in test animals. This study aimed to make an antioxidant chewable Tablet containing a combination of Azadirachta indica A. Juss. and Gynura procumbens (Merr.) extract with a variation of mannitol-sorbitol as a filler. This variation has the advantage of covering the bitter taste of the active substance so that it is expected to provide a pleasant taste and is easy to swallow. The extract obtained was formulated into chewable Tablets with variations of mannitol-sorbitol (90%:10%), (80%:20%), and (70%:30%). The method used is wet granulation. The granules obtained were tested for their physical properties, namely flow velocity, angle of repose, and compressibility. The physical properties of the Tablets tested included uniformity of weight, size, hardness, friability, disintegration time, quality of taste, shape, and odor. Based on the test results of the physical properties of the granules, the three formulas met the requirements. While the physical properties of Tablets that do not meet the criteria are uniformity of size and disintegration time. This research concludes that the extracts of Azadirachta indica A. Juss. and Gynura procumbens (Merr.) be formulated into chewable Tablets where formula two with variations of mannitol:sorbitol (80:20%) is the best formula by fulfilling 9 of 11 requirements

Edukasi Pengelolaan Stres Sebagai Upaya menjaga Kesehatan Kulit Rizqa Salsabila Firdausia; Endah Kurniawati; Mufrod
The Journal of Innovation in Community Empowerment Vol 5 No 1 (2023): Journal of Innovation in Community Empowerment (JICE)
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jice.v5i1.814

ABSTRACT Stress is a problem that often arises in this modern era. Stress can be acute or chronic and is determined by individual perceptions and the body's response to the pressure. Long-term exposure to continuous stress can lead to physical illness in the body (psychosomatic), one of them is skin. Unhealthy skin will also cause a decrease in self-confidence, causing stress. Therefore there is a need for psychotherapeutic intervention to overcome these disorders and to restore the body's condition. Strategies that can be done to deal with stress can include an active approach to the source of stress, seeking social support (emotional support or information from other people or seeing a psychologist) from the surrounding environment, building self-control (self-control) towards the source of the problem, as well as trying to find a positive side from stress. So that this service activity is expected to be able to educate the public, especially teenagers to be able to manage stress properly. The activity was carried out using the webinar method with 37 youth participants. The activity was carried out in 3 stages, namely pretest, limitation of material - discussion and post test. In the pretest and posttest stages the participants were given the same 5 questions. Based on the results of the pretest and posttest, it was found that there was an increase in the correct answers from 79.459% to 85.405%. This indicates that there is an increase in knowledge from the participants related to managing stress on skin health after the intervention. Based on this, it can be interpreted that community service activities with the theme "Stress Management Education as an Effort to Maintain Skin Health" can be carried out properly and increasing knowledge of participant.

Edukasi Dan Pelatihan Pembuatan Lipbalm sebagai Upaya Menjaga Kesehatan Kulit Endah Kurniawati
The Journal of Innovation in Community Empowerment Vol 5 No 2 (2023): Journal of Innovation in Community Empowerment (JICE)
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jice.v5i2.969

Bibir merupakan bagian dari kulit yang sangat tipis lapisannya jika dibandingkan dengan kulit wajah lainnya. Pengaruh adanya makanan dan minuman, radiasi UV dapat menyebabkan bibir kering, pecah-pecah, maupun kerutan pada bibir. Ketika bibir kering atau pecah-pecah, orang akan cenderung membasahi bibir dengan ludah untuk mengembalikan kelembaban bibir. Hal ini dapat memperparah kondisi karena saliva mengandung enzim pencernaan yang mengganggu lapisan pelindung bibir. Oleh karena itu, bibir harus dilembabkan dan dilindungi dengan penggunaan produk seperti lipbalm ketika keadaan tersebut muncul. Lipbalm termasuk kosmetik yang sering tertelan saat digunakan sehingga penting bagi para produsen dan konsumen/masyarakat untuk memperhatikan bahan-bahan penyusun di dalamnya. Adanya kegiatan pengabdian ini diharapkan dapat memberikan wawasan kepada masyarakat agar mampu memahami pentingnya kesehatan kulit bibir, mampu membuat lipbalm sederhana dengan komposisi bahan yang aman dan agar masyarakat bisa lebih pintar dalam memilih sediaan lipbalm yang sesuai dengan kondisi kulit. Kegiatan pengabdian masyarakat diikuti 15 peserta dan dilaksanakan secara tatap muka. Tahap kegiatan pengabdian terdiri dari pengerjaan pretest, penyampaian materi, praktek pembuatan lipbalm, pengerjaan posttest dan evaluasi kegiatan pengabdian. Berdasarkan hasil evaluasi pretest dan posttest, peserta mengalami peningkatan pemahaman terkait manfaat lipbalm, dan bahan penyusun lipbalm. Adanya kegiatan pengabdian kepada masyarakat ini mampu meningkatkan wawasan dan pemahaman masyarakat mengenai pentingnya kesehatan kulit khususnya area bibir, dan mampu membuat lipbalm sederhana dengan komposisi bahan yang aman.

Formulasi Dan Optimasi Sediaan Gel Ekstrak Etanol Kol Ungu (Brassica oleracea L. Var. Capitata F. Rubra) dengan Basis Carbomer pratama, nofran putra; Kurniawati, Endah; Oktapiya, Tira Risa; Rahmawati, Zerli; Wulandari, Septi
BENCOOLEN JOURNAL OF PHARMACY Vol. 4 No. 1 (2024): April
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v4i1.33999

Purple cabbage (Brassica oleracea L. Var. Capitata F. Rubra) is known to have anti-inflammatory activity, so it can be used as a medicine to treat inflammation, especially in breastfeeding mothers. To make it easier to use, it is made into a gel formulation. One of the compounds in purple cabbage is anthocyanin which is in the form of glycosides bound to sugar molecules (cyanidin-3 diglucoside-5-glucoside). These compounds have important effects on the body, one of which is anti-inflammatory. To make it easier to use, it is made into a gel formulation. One of the bases used in the formulation of gels is carbomer. Carbomer has better characteristic in terms of the release of active substances compared to other gel bases. The purpose of this study was to make a gel formulation and to determine the effect of purple cabbage extract gel characteristic on the stability of the physical properties of the preparation. The gel was made using a carbomer base with various extract concentrations of 2.5%, 5% and 7.5%. The gel was tested for its physical characteristic including organoleptic, viscosity, pH, dispersionfor 21 days as well as a preference test. The analytical method used is ANOVA with a 95% confidence level and a Likert scale as a comparative test for the formulation based on the respondents' preferences. The results of the gel formulation using a carbomer base with variations in the concentration of the extract showed that the physical characteristic test of all variables showed that all the formulas met the requirements of the physical preparation, namely homogeneous, viscosity with a value below 50,000 cps, a suitable pH of less than 6, and dispersion in line with the viscosity value. The results of the preference test showed that F2 had the best acceptance and many respondents chose it. The conclusion of this study is that all formulas show results that are in accordance with the requirements of the gel preparation. The difference in extract concentration did not show a significant difference to the length of storage time

Formulasi Dan Optimasi Sediaan Gel Ekstrak Etanol Kol Ungu (Brassica oleracea L. Var. Capitata F. Rubra) dengan Basis Carbomer pratama, nofran putra; Kurniawati, Endah; Oktapiya, Tira Risa; Rahmawati, Zerli; Wulandari, Septi
BENCOOLEN JOURNAL OF PHARMACY Vol. 4 No. 1 (2024): April
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v4i1.33999

Purple cabbage (Brassica oleracea L. Var. Capitata F. Rubra) is known to have anti-inflammatory activity, so it can be used as a medicine to treat inflammation, especially in breastfeeding mothers. To make it easier to use, it is made into a gel formulation. One of the compounds in purple cabbage is anthocyanin which is in the form of glycosides bound to sugar molecules (cyanidin-3 diglucoside-5-glucoside). These compounds have important effects on the body, one of which is anti-inflammatory. To make it easier to use, it is made into a gel formulation. One of the bases used in the formulation of gels is carbomer. Carbomer has better characteristic in terms of the release of active substances compared to other gel bases. The purpose of this study was to make a gel formulation and to determine the effect of purple cabbage extract gel characteristic on the stability of the physical properties of the preparation. The gel was made using a carbomer base with various extract concentrations of 2.5%, 5% and 7.5%. The gel was tested for its physical characteristic including organoleptic, viscosity, pH, dispersionfor 21 days as well as a preference test. The analytical method used is ANOVA with a 95% confidence level and a Likert scale as a comparative test for the formulation based on the respondents' preferences. The results of the gel formulation using a carbomer base with variations in the concentration of the extract showed that the physical characteristic test of all variables showed that all the formulas met the requirements of the physical preparation, namely homogeneous, viscosity with a value below 50,000 cps, a suitable pH of less than 6, and dispersion in line with the viscosity value. The results of the preference test showed that F2 had the best acceptance and many respondents chose it. The conclusion of this study is that all formulas show results that are in accordance with the requirements of the gel preparation. The difference in extract concentration did not show a significant difference to the length of storage time

The Effect of Variation in Solvent Concentration on Caffeine Content in Green Arabica Coffee Bean Extract (Coffea arabica) using UV-Vis Spectrophotometry Zulfaidah, Nanda Tsalasani; Kurniawati , Endah; Putri, Gita Herdittya; Widiani, Fitria
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.17983

Coffee is one type of beverage that is widely favoured by the community, Arabica coffee plants are a variant that grows a lot in Indonesia. Coffee beans contain various chemical compounds, one of which is caffeine. This study aims to determine the caffeine content with different solvent concentrations. Green Arabica coffee beans (Coffea arabica) were extracted using the maceration method. Ethanol extract 70% and ethanol extract 96% of green Arabica coffee beans were then fractionated in liquid-liquid extraction of chloroform and water phases. Then the analysis and determination of caffeine content were carried out with a UV-Vis Spectrophotometer. Qualitative tests were carried out using the Parry reagent color test showing positive results with a change in color to green. The results of the study in the form of a % caffeine content value to the weight of the extract sample, showed that in the 70% ethanol extract of green Arabica coffee beans contained a caffeine content of 10.115 ± 0.06% and the 96% ethanol extract of green Arabica coffee beans was 12.760 ± 0.580%. The results of the analysis showed that the amount of caffeine content had a significant difference with a p-value <0.05. So it can be concluded that the optimum solvent for extracting caffeine from green Arabica coffee bean extract is 96% solvent.

The Effect of Extraction Solvents towards Total Flavonoid Content and Total Phenolic Content of Butterfly Pea (Clitoria ternatea) Extract Kurniawati, Endah; Zulfaidah, Nanda Tsalasani; Amaliya, Siti Nur; Kurniawati, Siska Putri
Journal of Biotechnology and Natural Science Vol. 4 No. 2 (2024): December
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jbns.v4i2.12158

Butterfly pea flower (Clitoria ternatea) has many benefits including antioxidant. The antioxidant activity was contributed by flavonoid and phenolic components. The choice of solvent is important to obtain the metabolite components that contribute to antioxidant activity. Therefore this study was conducted to find the ability of different solvent to obtain total flavonoid content (TFC) and total phenolic content (TPC) in C. ternatea. The fine powder of dried flower was extracted by different solvents (ethanol 70%, ethanol 96%, and methanol). Quercetin was used as standard in determination of TFC and gallic acid was used as standard in determination of TPC. The TFC value of ethanol 70%, ethanol 96% and methanol extract were 46,23±0,39; 28,19±0,03; and 16,87±0,11 mg QE/g extract respectively. The TPC value of ethanol 70%, ethanol 96% and methanol extract were 93,91±0,16; 78,63±0,16; 84,46±0,16 mg GAE/g extract respectively. Ethanol 70% extract had the highest yield value and the highest amount of TPC and TFC compare to other solvents. Thus, the amount of flavonoid and phenolic in ethanol 70% extract showed the promising potential benefit of C. ternatea as antioxidant.

The Effect of Variation in Solvent Concentration on Caffeine Content in Green Arabica Coffee Bean Extract (Coffea arabica) using UV-Vis Spectrophotometry Zulfaidah, Nanda Tsalasani; Kurniawati , Endah; Putri, Gita Herdittya; Widiani, Fitria
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.17983

Coffee is one type of beverage that is widely favoured by the community, Arabica coffee plants are a variant that grows a lot in Indonesia. Coffee beans contain various chemical compounds, one of which is caffeine. This study aims to determine the caffeine content with different solvent concentrations. Green Arabica coffee beans (Coffea arabica) were extracted using the maceration method. Ethanol extract 70% and ethanol extract 96% of green Arabica coffee beans were then fractionated in liquid-liquid extraction of chloroform and water phases. Then the analysis and determination of caffeine content were carried out with a UV-Vis Spectrophotometer. Qualitative tests were carried out using the Parry reagent color test showing positive results with a change in color to green. The results of the study in the form of a % caffeine content value to the weight of the extract sample, showed that in the 70% ethanol extract of green Arabica coffee beans contained a caffeine content of 10.115 ± 0.06% and the 96% ethanol extract of green Arabica coffee beans was 12.760 ± 0.580%. The results of the analysis showed that the amount of caffeine content had a significant difference with a p-value <0.05. So it can be concluded that the optimum solvent for extracting caffeine from green Arabica coffee bean extract is 96% solvent.

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