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All Journal The International Science of Health Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Ilmiah Kesehatan Mandira Cendikia
Ningrum Wahyuni
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Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Literature Review Role Of Matrix Metalloproteinase In Cancer Pain Ekawaty Suryani Mastari; Fitri Aidani Ulfa; Ningrum Wahyuni; Noradina Noradina; Meriani HS
The International Science of Health Journal Vol. 1 No. 4 (2023): December : The International Science of Health Journal
Publisher : Sekolah Tinggi Ilmu Kesehatan Kesdam IV, Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ishel.v1i4.890

Abstract

Cancer pain occurs in more than half of cancer patients and affects their quality of life. The complexities of proinflammatory molecules in the tumor microenvironment contribute to pain. The MMPs, as proteolytic enzymes involved in cancer cell migration towards the surrounding environment, demonstrate their connection to the development of pain in cancer. As complex molecules, MMPs can be influenced by various cytokines and chemokines, mainly throughout neuroinflammation, which decreases neuron sensitivity and boosts hyperexcitability in pain-controlling mechanisms.
Gambaran Status Gizi Balita Dilihat Dari Tingkat Pendidikan Dan Pola Asuh Ibu Dalam Pemberian Makan Anak Wan Tisya Muhaira; Ningrum Wahyuni
Jurnal Ilmiah Kesehatan Mandira Cendikia Vol. 3 No. 6 (2024)
Publisher : YAYASAN PENDIDIKAN MANDIRA CENDIKIA

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Abstract

Penelitian ini bertujuan adalah menganalisis pengaruh tingkat pendidikan ibu dan pola asuh pemberian makan dengan status gizi anak balita .Jenis penelitian Studi Korelasional. Pengumpulan data dengan kuesioner tentang pendidikan ibu, pola asuh pemberian makanan dan status gizi anak balita . Populasi seluruh ibu yang memiliki balita usia 2-5 tahun berjumlah 439 balita, tehnik sampling purposive sampling. Sampel 75 responden. Analisis menggunakan uji Spearman’s rank, berdasarkan hasil penelitian ada peroleh : ada pengaruh signifikan antara tingkat pendidikan ibu dengan status gizi anak balita (ρ = 0.000) dan tidak ada pengaruh yang signifikan antara pola asuh dalam pemberian makan dengan status gizi anak balita (ρ = 0.260). ada pengaruh tingkat pendidikan ibu dan status gizi anak balita , tidak ada pengaruh antara pola asuh dalam pemberian makan dengan status gizi anak balita
Uji Ekstrak N-Heksan Daun Kirinyuh (Chromolaena Odorata L.) Terhadap Model Hewan Luka Bakar Derajat IIA Wan Tisya Muhaira; Luthvia Luthvia; Ningrum Wahyuni; Indah Afriwanty Simatupang; Bayu Ariatama
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i4.514

Abstract

Chromolaena odorata referred to as Kirinyuh leaves, contains tannins, phenols, flavonoids, saponins, and steroids, which possess antibacterial properties against several pathogenic bacteria in humans, including Staphylococcus aureus, Escherichia coli, and Candida albicans. This investigation aimed to assess the moderate efficacy of the N-Hexan cream derived from Chromolaena odorata L. against Grade IIA burns in male Wistar rats. The research employed a laboratory experimental approach, encompassing the creation of an N-hexane extract from Chromolaena odorata L. and the formulation of various burn cream preparations of 20%, 25%, and 30% concentrations. Multiple tests are conducted: organoleptic assessment, homogeneity evaluation, and testing of pH, spreadability, adhesion, and burn. The research analysis employed a one-way ANOVA followed by the LSD test. The most effective dose for hastening burn wound healing is a 30% concentration of n-Hexan extract, resulting an average healing rate of 79%. The ANOVA test outcomes revealed a significant value of 0.000 (≤ 0.05) indicating a statistically significant difference in burn wound healing by day 21. The findings indicate that the N-Hexan extract from Chromolaena odorata L, exhibits a capacity to expedite the healing of burn wounds in male Wistar rats, as evidenced in both the 25% and the 30% concentration group.  
Co-Authors Bayu Ariatama Ekawaty Suryani Mastari Fitri Aidani Ulfa Indah Afriwanty Simatupang Luthvia Luthvia Meriani HS Noradina Wan Tisya Muhaira