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Peran Polimorfisme GeN MMP-9-1562C/T Terhadap Kejadian Retinopati Diabetik Pada Pasien DM Ekawaty Suryani Mastari
Journal of Health and Medical Science Volume 1 Nomor 4 Oktober 2022
Publisher : CV. Pusdikra Mitra Jaya

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Abstract

Retinopati diabetik merupakan komplikasi neurovaskular pada diabetes yang melibatkan kerusakan sawar-darah retina. Peran matriks metalloproteinase dalam mendegradasi matriks ekstrasel memperantarai kerusakan sel endotel retina dan proliferasi vaskular. Matriks metalloproteinase-9 (MMP-9) telah diketahui berperan pada inflamasi dan neovaskularisasi retina. Oleh karenanya, polimorfisme MMP-9 -1562C/T dianggap berperan pada risiko terjadinya retinopati diabetik. Penelitian ini merupakan studi cross-sectional dengan 52 pasien retinopati diabetik dan 42 pasien DM tanpa komplikasi sebagai kontrol. Pemeriksaan polimorfisme gen MMP-9 -1562C/T dilakukan dengan teknik PCR-RFLP. Perbedaan frekuensi proporsi genotip dan alel kedua kelompok dianalisis dengan uji chi square. Diperoleh frekuensi genotip CC 75%, CT 23,1%, dan TT 1,9% pada kelompok kasus serta genotip CC 54,8%, CT 45,2% dan tidak dijumpai genotip TT pada kelompok kontrol. Uji keseimbangan Hardy-Weinberg pada frekeunsi genotip menunjukkan kesesuaian (p>0,05). Uji proporsi frekuensi genotip dan alel pada kelompok kontrol dan kelompok kasus menunjukkan tidak adanya perbedaan bermakna (p>0,05). Polimorfisme gen MMP-9 -1562C/T bukan merupakan faktor risiko utama terjadinya retinopati diabetik pada pasien DM
PENGARUH TERAPI AKUPRESUR TERHADAP PENURUNAN KADAR GULA DARAH PADA PASIEN DM TIPE II DI POLIKLINIK RUMAH SAKIT UMUM IMELDA PEKERJA INDONESIA MEDAN TAHUN 2022 Meriani Herlina; Heriaty Berutu; Ekawaty Suryani Mastari; Christine Handayani Siburian; Bernita Silalahi; Noradina Noradina; Ester Ria Simarmata
Jurnal Ilmiah Keperawatan IMELDA Vol. 9 No. 1 (2023): Jurnal Ilmiah Keperawatan IMELDA
Publisher : Program Studi S1/DIII-Keperawatan Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jikeperawatan.v9i1.1168

Abstract

Penyakit Diabetes Melitus (DM) adalah penyakit menahun (Kronis) berupa gangguan metabolik yang ditandai dengan kadar gula darah yang melebihi batas normal. Diabetes Melitus dikenal sebagai silent killer karna sering tidak disadari oleh penyandangnya dan saat diketahui sudah terjadi komplikasi. Penelitian ini bertujuan untuk mengetahui Pengaruh Terapi Akupresur terhadap penurunan kadar gula darah pasien DM Tipe II. Penelitian dilakukan di Poliklinik Rumah Sakit Umum Imelda Pekerja Indonesia Medan, pada bulan Juli 2022 sampai Agustus 2022. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian Quasy Eksperiment ini menggunakan pendekatan pre test and post test with control group design. Populasi pada penelitian ini adalah 40 responden dan sampel dalam penelitian ini adalah 20 responden yang diambil secara purposive sampling. Dan dianalisis secara Univariat dan Bivariat menggunakan uji wilcoxon dan Mann Whitney untuk mengetahui perbedaan antara dua kelompok terhadap pengaruh terapi akupresur. Hasil penelitian menunjukan bahwa pengaruh terapi akupresur terhadap penurunan kadar gula darah adalah p-value = 0,005 < 0,05 dapat disimpulkan adanya pengaruh terapi akupresur terhadap penurunan kadar gula darah pasien DM Tipe II di Poliklinik Rumah Sakit Umum Imelda Pekerja Indonesia Medan. Disarankan kepada hasil penelitian ini diharapkan sebagai informasi bagi pasien diabetes melitus untuk melakukan secara mandiri terapi akupresur dan bagi rumah sakit imelda pekerja indonesia untuk memasukan unsur terapi akupresur sebagai bahan kajian dalam pengelolaan pasien diabetes melitus tipe II.
EDUKASI KESEHATAN TENTANG FAKTOR RISIKO DAN PENCEGAHAN DIABETES DI KELURAHAN LABUHAN DELI, MEDAN MARELAN TAHUN 2022 Noradina Noradina; Meriani Herlina; Ekawaty Suryani Mastari; Christina Magdalena T.Bolon
Jurnal Pengabdian Ilmu Kesehatan Vol. 2 No. 2 (2022): Juli: Jurnal Pengabdian Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (550.565 KB) | DOI: 10.55606/jpikes.v2i2.283

Abstract

Diabetes sebagai penyakit metabolik, merupakan penyakit yang berhubungan erat dengan gaya hidup masyarakat. Penyakit ini berhubungan dengan beban sosioekonomi yang tinggi secara global dan regional. Terjadinya diabetes dipengaruhi oleh faktor risiko yang dibagi menjadi faktor risiko yang dapat dimodifikasi dan faktor risiko yang tidak dapat dimodifikasi. Pencegahan penyakit diabetes melitus tipe 2 mengurangi risiko yang dapat dimodifikasi terutama kepada orang-orang yang memiliki risiko untuk menderita DM tipe 2. Penelitian di berbagai negara termasuk Indonesia menunjukkan bahwa pengetahuan masyarakat mengenai Diabetes Melitus masih belum optimal. Tujuan dari program pengabdian masyarakat ini adalah untuk meningkatkan pengetahuan tentang faktor risiko dan pencegahan diabetes pada masyarakat baik yang berisiko diabetes maupun yang tidak berisiko dengan memberikan edukasi di Kelurahan Labihan Deli, Medan Marelan.
Literature Review Role Of Matrix Metalloproteinase In Cancer Pain Ekawaty Suryani Mastari; Fitri Aidani Ulfa; Ningrum Wahyuni; Noradina Noradina; Meriani HS
The International Science of Health Journal Vol. 1 No. 4 (2023): December : The International Science of Health Journal
Publisher : Sekolah Tinggi Ilmu Kesehatan Kesdam IV, Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ishel.v1i4.890

Abstract

Cancer pain occurs in more than half of cancer patients and affects their quality of life. The complexities of proinflammatory molecules in the tumor microenvironment contribute to pain. The MMPs, as proteolytic enzymes involved in cancer cell migration towards the surrounding environment, demonstrate their connection to the development of pain in cancer. As complex molecules, MMPs can be influenced by various cytokines and chemokines, mainly throughout neuroinflammation, which decreases neuron sensitivity and boosts hyperexcitability in pain-controlling mechanisms.
FAKTOR RISIKO ACUTE KIDNEY INJURY (AKI) PADA PASIEN DENGAN KEGANASAN: RISK FACTORS FOR ACUTE KIDNEY INJURY (AKI) IN PATIENTS WITH MALIGNANCY Agustiawan; Mastari, Ekawaty Suryani; Anggraini , Tivalen Dwirara; Saragih, Ulfah Octavia
Jurnal Kedokteran Ibnu Nafis Vol. 13 No. 2 (2024): Desember 2024
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/jkin.v13i2.662

Abstract

Acute kidney injury (AKI) merupakan kondisi dimana seseorang mengalami penurunan fungsi ginjal secara tiba-tiba (<48 jam). Mereka dengan AKI mengalami peningkatan kadar serum kreatinin >0.3 mg/dl, kenaikan presentasi kreatinin serum ≥50% (1,5 kali dari nilai awal/normal), atau penurunan urine output. Penelitian sebelumnya menunjukkan bahwa AKI merupakan komplikasi umum dari kanker, dimana hampir separuh pasien neoplastik mengalami AKI selama perjalanan penyakit mereka. Hal ini tentunya berdampak besar pada prognosis keseluruhan, lama rawat inap, dan biaya pengobatan. Kejadian AKI pada pasien kanker merupakan hal yang umum, dimana AKI seringkali ditemukan dalam perjalanan penyakit pasien dengan keganasan. AKI dapat disebabkan oleh karena faktor pasien, tumor, maupun pengobatan. Pencegahan dan antisipasi harus dilakukan untuk meningkatkan luaran pasien.
Evaluasi Pola Penggunaan Obat Tradisional dan Swamedikasi di Desa Bireuen Meunasah Blang Muhammad Natsir Ilvira; Fahmi Irsan Nasution; Hanafis Sastra Winata; Bayu Irvia Satria; Ekawaty Suryani Mastari
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i4.501

Abstract

The use of traditional medicine has long been integral to Indonesian society, offering affordable and accessible healthcare options. This study evaluates the patterns of traditional medicine use in Bireuen Meunasah Blang Village, focusing on respondent demographics, self-medication practices, and perceptions of affordability, effectiveness, and accessibility. Using a descriptive quantitative design, data were collected from 97 respondents aged 18–60 years through structured questionnaires. Results indicate that 54.6% of respondents demonstrate adequate use of traditional medicine, while 76.3% follow appropriate usage guidelines. Perceptions of cost and availability were predominantly positive, with 48.5% finding traditional medicines affordable and 70.1% familiar with their names. However, knowledge of side effects and sources of information remains limited. These findings underline the need for targeted public health education to enhance safe and informed self-medication practices with traditional medicines.
Review Implementation Of Retention Of Medical Record Files Based On The Regulation Of National Standards For Hospital Accreditation (SNARS) Edition 1 MIRM 10 At RSUD Dr RM Djoelham Binjai 2021 Harefa, Sausan Mawaddah; Mastari , Ekawaty Suryani; Fajar Maulana
Jurnal Kesehatan, Rekam Medis dan Farmasi (JUK-Medifa) Vol. 2 No. 01 (2023): JUK-Medifa (Jurnal Kesehatan, Rekam Medis dan Farmasi), November 2023
Publisher : SEAN Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/juk-medifa.v2i01.101

Abstract

The quality of standardized hospitals in Indonesia can be determined from their alignment with the National Hospital Accreditation Service Standards (SNARS). Medical retention which is also important in hospital services is contained in SNARS First Edition MIRM 10. In MIRM 10 there are three assessments for meeting national hospital accreditation standards regarding retention of medical recovery. The purpose of this study was to determine the implementation of medical record retention at RSUD Dr RM RS Djoelham Binjai based on SNARS 1st Edition MIRM 10. This study used a qualitative descriptive method with a cross sectional design. The research was conducted at Dr.RM Hospital. Djoelham Binjai from June to September 2022. The population in this study were 4 officers and the entire population was sampled. The method used in this research is by interview and observation. Based on the results of the study, it was found that the fulfillment of the 1 MIRM 10 assessment element based on SNARS did not yet have an SOP. Assessment of element 2 has not been fully carried out. The absence of an individual officer for retention duties results in element 3 mismatch. This study concluded that the retention of medical records at RSUD Dr RM Djoelham Binjai had not been fully implemented based on SNARS 1st Edition MIRM 10
Dampak Penggunaan Gadget Pada Kesehatan Mental Remaja Di SMA Swasta Nur Ihsan Medan Ekawaty Suryani Mastari; Fitri Aidani Ulfa Hrp; Fahmi Irsan Nasution; Ahmad Yayang Saputra; Jane Alesha
Marsipature Hutanabe: Jurnal Pengabdian Kepada Masyarakat Vol. 1 No. 01 (2024): Marsipature Hutanabe: Jurnal Pengabdian Kepada Masyarakat
Publisher : CV. Devi Tara Innovations

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Abstract

Mental health problems have become an unresolved health problem in the midst of society, both at the global and national levels. Especially during the COVID-19 pandemic, mental health problems will be increasingly difficult to solve. The increasingly worrying condition of people's mental health will affect national productivity. According to WHO, mental health refers to a person's well-being condition, when a person is aware of his or her abilities, is able to manage his or her stress and adapts well, can work productively, and contributes to his environment. Current technological developments also affect mental health, including the use of gadgets. Gadgets make it easy to access information, communicate with others, and do various online activities. However, excessive use of gadgets can have a negative impact on the mental and physical health of users, especially at the age of children and adolescents, The influence of gadgets can result in children being hampered in interacting even in the family environment, easily bored and difficult to concentrate, especially in learning, and interfering with their cognitive development. According to a survey in Indonesia according to Research by Kominfo and the United Nations Children's Fund (2014), the use of social media and digital is an integrated part of the daily life of young people in Indonesia. The study found that 98% of the children and adolescents surveyed knew about the internet and that 79.5% of them were internet users. In addition, there are still few parents who supervise their children when accessing the internet or playing layer media. Prevention and handling of metal health disorders due to the use of gadgets requires the role of various parties, including government policies, parents and families, and the role of the school environment. Socialization in the environment around children, especially schools, is one of the keys.
Edukasi Pentingnya Menjaga Kesehatan Mental Pada Anak Remaja Di SMA Negeri 3 Binjai Fitri Aidani Ulfa Hrp; Ekawaty Suryani Mastari; Ningrum Wahyuni; Emilia Putri Tarigan; Farhah Kamilatun Nuha
Marsipature Hutanabe: Jurnal Pengabdian Kepada Masyarakat Vol. 1 No. 01 (2024): Marsipature Hutanabe: Jurnal Pengabdian Kepada Masyarakat
Publisher : CV. Devi Tara Innovations

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Abstract

Mental health problems have become unresolved health problems in society, both at the global and national levels. Especially during the COVID-19 pandemic, mental health problems will be more difficult to solve. The increasingly concerning condition of people's mental health will affect national productivity. This could hinder Indonesia from transitioning into a developed country by 2045. Mental health services are crucial and require the same attention as physical health. According to the Indonesia-National Adolescent Mental Health Survey 2022, 15.5 million (34.9 percent) adolescents experience mental problems and 2.45 million (5.5 percent) adolescents experience mental disorders. Of that number, only 2.6 percent accessed counseling services, both emotional and behavioral. The government has been thinking about mental health, but it has not been a priority. Access to mental health services is expensive and not inclusive. Meanwhile, attention to mental and physical health has not been equal in national health insurance. In Indonesia, we know many cases of adolescents aged 15-17 who experience excessive anxiety resulting in depression and suicide.
Eccrine Poroma pada Kulit Kepala: Laporan Kasus dan Tinjauan Histopatologis Ekawaty Suryani Mastari; Bayu Irvia Satria; Fahmi Irsan Nasution
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i2.6228

Abstract

Poromas are benign neoplasms composed of epithelial cells that show tubular differentiation, which arises from the intraepidermal part of the eccrine of the sweat glands. This lesion can resemble melanoma or non melanoma.1,2 Case description We reported a case of eccrine poroma in a man, Mr. ES, 50 years old, with complaints of a lump in the head of the temporal region of the region. On macroscopic examination, a blackish-brown scalp tissue size 2x1x0.5 was received, the surface was uneven, the consistency was springy. Microscopic examination of squamous epithelial coating with round, oval, monotone, smooth chromatin, eosinophilic cytoplasm appear. In the sub-epithelium, there is a mass of tumors consisting of proliferative eccrine glands, in groups forming islands, with cuboidal coatings, with round, oval, monotonous nuclei, fine chromatin, eosinophilic cytoplasm. The stroma consists of fibrous connective tissue and blood vessels. The sebaceous glands, hair follicles and infiltration of lymphocyte cells appear. Discussion and conclusions: Based on the results of histopathological examination, it can be concluded as eccrine poroma. In this case electrosurgery is performed, removal with the help of a carbon dioxide laser, or excision surgery can be performed.