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All Journal Molecular and Cellular Biomedical Sciences (MCBS) JURNAL PENDIDIKAN TAMBUSAI Eksakta : Berkala Ilmiah Bidang MIPA TOFEDU: The Future of Education Journal
Nurjanah, Diana
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Energy Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Social Sciences Other

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Virtual Screening of Indonesian Herbal Compounds with Neuraminidase Inhibitor Activity against N2 Influenza Virus Protein: An in silico Study Nurjanah, Diana; Fadilah, Fadilah; Dharmayanti, Ni Luh Putu Indi
Molecular and Cellular Biomedical Sciences Vol 8, No 2 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i2.468

Abstract

Background: Neuraminidase inhibitor (NAI) is one of anti-influenza drugs recommended for use by the World Health Organization (WHO). However, after treatment with NAI drugs in human, resistance to influenza antiviral drugs is begun to rise. Therefore, identification of compounds from Indonesian herbal plants as natural inhibitors of the influenza virus neuraminidase protein needs to be conducted for the development of new anti-influenza drugs.Materials and methods: The crystal structure of the neuraminidase protein complex used in this study was obtained from the Protein Data Bank (PDB). Structure-based pharmacophore modeling was performed using LigandScout version 4.4.5 software. Indonesian herbal plant compounds were collected from the HerbalDB database. Protein and ligand processing was carried out using Autodock 4.2 software. The 3D interaction visualization was carried out with Autodock software, while 2D interaction visualization was carried out with LigPlot software. To determine the toxicity and drug-likeliness of the ligand, the test ligands that had the best docking results were predicted using SwissADME and AdmetSAR.Results: From the virtual screening results, 24 hits were found, and five compounds had the best binding energy among the 24 tested compounds, these were pollenitin (ΔG=-7.22 kcal/mol), OPC-4:0 (ΔG=-7.11 kcal/mol), 6-hydroxykaempferol (ΔG=-7.08 kcal/mol), 5,8-dihydroxy-7,4'-dimethoxyflavone (ΔG=-7.07 kcal/mol), and 3,5,6,7-tetrahydroxy-4'-methoxyflavone (ΔG=-6.95 kcal/mol). The best five compounds were then chosen for further analysis.Conclusion: OPC-4:0 is found to be the best compound for the NAI based on its binding energy, pharmacokinetics, toxicity, and drug-likeliness. Thus, OPC-4:0 might be a potential candidate as a NAI of HxN2 virus. Keywords: influenza, molecular docking, neuraminidase, resistance, virtual screening
The Evolution of Zoonosis-Related Studies in Indonesia, 1977-2023: Bibliometric Analysis Concepts Nurjanah, Diana; Dharmayanti, Indi; Fadilah, Fadilah
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 01 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss01/465

Abstract

Various zoonotic diseases have been reported as epidemics throughout the world, including in Indonesia. Various studies have been conducted related to gaps in knowledge, especially on disease distribution, etiology, pathogens, hosts, vector biology, dynamics, cycle of transmission, predisposing factors, and risk factors. To find out the dynamics of zoonotic disease study and research in Indonesia, a study was conducted to report a literature analysis that focused on bibliometric analysis of the Scopus database and VOSviewer software to create a visualization map that identified how the evolution of zoonotic diseases studies from 1977-2023 in Indonesia. In co-occurrence analysis, two units of analysis are used, namely "author keywords" and "index keywords" in VOSviewer. It showed that studies related to zoonoses in Indonesia tend to increase every year with a significant increase in 2020 and 2022. Document types are dominated by articles (72%) with subjects or research areas related to “medicine” (29%). From the "author keywords" analysis unit, the words "zoonosis" and "Indonesia" were the words that appeared the most. Meanwhile, from “index keywords” six clusters were found with the word "human" "animals", and "zoonosis" being the word that appears the most in the analysis of the studies conducted.
Analysis of the Challenges and Opportunities of the Merdeka Curriculum at MI Arrahman School Palembang Nurjanah, Diana; Lutfiah Harnum Azzahra; Vivin Stelora; Abdurrahamansyah
The Future of Education Journal Vol 4 No 8 (2025)
Publisher : Lembaga Penerbitan dan Publikasi Ilmiah Yayasan Pendidikan Tumpuan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61445/tofedu.v4i8.1057

Abstract

The Merdeka Curriculum represents a breakthrough in Indonesia's education system, designed to create more flexible and student-centered learning. However, its implementation at the Madrasah Ibtidaiyah (MI) level faces various challenges. This study aims to analyze the challenges and opportunities in implementing the Merdeka Curriculum at MI Arrahman Palembang. The research employs a qualitative approach with a case study method. Data were collected through in-depth interviews with the principal and two teachers, participatory observation, and document analysis. The findings reveal that the main challenges lie in the limitations of facilities and infrastructure, particularly reading spaces, information technology devices, and digital learning media, which hinder teachers' ability to utilize independent learning platforms. On the other hand, the Merdeka Curriculum provides opportunities for teachers to design more creative and contextual learning, as well as to develop a student-centered learning culture. The study concludes that the successful implementation of the Merdeka Curriculum requires enhancing educators' capabilities, systemic support from all stakeholders, and specific strategies to address infrastructure limitations. The implications of these findings recommend the importance of continuous mentoring and optimization of available resources to realize more adaptive and meaningful education.
Administrasi dan Supervisi Pendidikan Islam dalam Deep Learning Penerapan Bermuatan Ethno Kurikulum Berbasis Cinta pada Madrasah Ibtidaiyah Nurjanah, Diana; Aisa, Aisa; Zainuri, Ahmad
Jurnal Pendidikan Tambusai Vol. 9 No. 3 (2025): Desember
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pendidikan Islam di Indonesia menghadapi tantangan signifikan dalam era transformasi digital yang memerlukan integrasi komprehensif antara administrasi, supervisi, dan pembelajaran bermakna. Penelitian ini bertujuan menganalisis dan mendeskripsikan pelaksanaan administrasi serta supervisi pendidikan Islam dalam penerapan pembelajaran mendalam bermuatan etnopedagogi berbasis Kurikulum Berbasis Cinta di Madrasah Ibtidaiyah. Metode penelitian menggunakan pendekatan kualitatif dengan teknik kajian pustaka yang mengintegrasikan temuan dari berbagai sumber literatur. Data dikumpulkan melalui dokumentasi sistematis dari basis data Google Scholar dan publikasi akademik kredibel dengan kriteria inklusi tahun publikasi 2021 hingga 2025. Populasi penelitian adalah keseluruhan literatur relevan tentang topik penelitian, sedangkan sampel ditentukan melalui purposive sampling dengan kriteria memiliki Digital Object Identifier (DOI) aktif. Teknik analisis data menggunakan metode analisis konten dengan tahapan reduksi data, penyajian data, verifikasi, dan coding secara sistematis. Hasil penelitian menunjukkan bahwa administrasi pendidikan Islam memainkan peran sentral dalam kelancaran operasional dan peningkatan kualitas pembelajaran melalui manajemen sumber daya efektif dan pengawasan komprehensif. Supervisi akademik yang terencana dapat meningkatkan kompetensi guru dan kualitas pembelajaran, meskipun masih terdapat tantangan dalam tindak lanjut yang optimal. Pembelajaran mendalam menawarkan pendekatan efektif untuk mengembangkan keterampilan abad ke-21, namun memerlukan dukungan administratif dan supervisi yang kuat. Integrasi etnopedagogi dengan Kurikulum Berbasis Cinta menciptakan pengalaman belajar kontekstual dan bermakna yang meningkatkan motivasi serta pembentukan karakter siswa sambil memperkuat identitas kultural dan nilai-nilai spiritual. Kesimpulan penelitian adalah bahwa model integrasi komprehensif antara administrasi, supervisi, dan pembelajaran bermakna berbasis etnopedagogi merupakan pendekatan penting untuk menciptakan Madrasah Ibtidaiyah berkualitas yang responsif terhadap kebutuhan masyarakat lokal dan tantangan abad ke-21.
Co-Authors Abdurrahamansyah Ahmad Zainuri Aisa, Aisa Fadilah Fadilah, Fadilah Indi Dharmayanti Lutfiah Harnum Azzahra NI LUH PUTU INDI DHARMAYANTI Vivin Stelora