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All Journal Narra J Deka in Medicine
Dzhyvak, Volodymyr
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Global prevalence and determinants associated with the acceptance of monkeypox vaccination Indiastari, Dewi; Fajar, Jonny K.; Tamara, Fredo; Runesi, Odis; Hakim, Lukman N.; Chotimah, Kusnul; Rahmani, Alinda; Saputro, Teguh D.; Afrilla, Dian; Firmansyah, Ervin; Dau, Daniel; Dzhyvak, Volodymyr
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.866

Abstract

Assessing the acceptance of the monkeypox vaccine is crucial for the success of vaccination programs, yet the prevalence reports remain inconclusive. The aim of this study was to determine the global prevalence of monkeypox vaccine acceptance and identify its associated factors. A meta-analysis was conducted with a comprehensive search strategy on the following databases, including Scopus, Embase, and PubMed, for articles published up to April 5, 2024. This study utilizes a single-arm meta-analysis to calculate the pooled prevalence of monkeypox vaccine acceptance. A Z-test was employed to identify factors associated with the vaccine acceptance. Our study analyzed 51 articles encompassing 98,746 participants, revealing an overall monkeypox vaccine acceptance rate of 65%. Notably, the highest acceptance rates were observed among men who have sex with men (MSMs), while healthcare workers (HCWs) showed the lowest acceptance rates. Additionally, our findings indicated an increased acceptance in individuals with educational attainment beyond a bachelor’s degree, a history of COVID-19 and influenza vaccination, homosexual orientation, and HIV-positive status. Conversely, lower acceptance risk was associated with those with educational attainment below a bachelor's degree, heterosexual orientation, and bisexual orientation. In conclusion, our current study has determined the rate of monkeypox vaccine acceptance and identified its associated factors. These findings offer valuable insights as the foundation for targeted policies to manage and increase acceptance rates.
Global prevalence and potential factors influencing willingness for renal transplantation in end-stage renal disease patients: A systematic review and meta-analysis Tamara, Fredo; Fajar, Jonny K.; Susanto, Agung; Enggriani, Yesica T.; Beluan, Maria IS.; Mirino, Reychell; Farida, Lia D.; Hastutya, Diana V.; Puspitasari, Dewi A.; Putri, Yama S.; Susanto, Jefri P.; Dzhyvak, Volodymyr
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.964

Abstract

The prevalence of willingness to undergo renal transplantation and its potentially associated factors have been documented in multiple prior studies across different regions, yet certain findings are conflicting. The aim of this study was to determine the global prevalence of willingness for renal transplantation and identify its associated factors through meta-analysis methods. Databases such as Scopus, PubMed, and Embase were utilized for the search strategy, covering the period from April to May 2024. Data collection focused on gathering information regarding the prevalence and potential contributing factors of renal transplantation. Statistical analysis involved examining the cumulative prevalence of willingness for renal transplantation using single-arm meta-analysis. Factors associated with willingness for renal transplantation were analyzed using the Mantel–Haenszel test for categorical variables and the inverse variance method for numerical variables. A total of nine articles, covering 3935 patients with end-stage renal disease (ESRD) were included. The pooled estimates revealed that the overall prevalence of willingness to undergo renal transplantation among ESRD patients was 57% (95%CI: 0.46–0.67). Furthermore, we observed a higher likelihood of willingness among men and those of younger age, attainment of at least a bachelor's degree or higher in education, employment status, higher income levels, and a shorter duration of hemodialysis (<5 years). Our study has documented the global prevalence and potential associated factors of willingness to undergo renal transplantation, providing valuable insights for policymakers aiming to enhance the acceptance of renal transplantation.
Assessing corticosteroid utilization and mortality risk in septic shock: insights from network meta-analysis Sutrisno, Wibowo; Dzhyvak, Volodymyr
Deka in Medicine Vol. 1 No. 1 (2024): April 2024
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.v1i1.5

Abstract

BACKGROUND: Despite current guidelines recommending corticosteroid administration in septic shock management, there is ongoing controversy regarding their impact on mortality rates and the most effective corticosteroid type. OBJECTIVES: To assess corticosteroid use and mortality risk in septic shock via network meta-analysis. METHODS: A comprehensive network meta-analysis was undertaken by retrieving articles from PubMed, Embase, and Scopus databases. Pertinent data encompassing baseline characteristics of articles, definitions of sepsis, types of corticosteroids employed, and mortality rates were systematically extracted from each article. The Manthel Hanzhel method alongside a network meta-analysis approach was employed to evaluate the influence of corticosteroid administration on mortality risk among individuals diagnosed with septic shock. RESULTS: Our analysis comprised a total of 50 articles. While indirect comparison failed to yield statistically significant results regarding the reduction in mortality risk, direct comparison indicated that corticosteroid administration was linked to a decreased risk of mortality among septic shock individuals (OR: 0.80; 95%CI: 0.68, 0.93; p Egger: 0.0550; p Heterogeneity: 0.0010; p: 0.0040). Furthermore, among all the types of corticosteroids analyzed, only the hydrocortisone and fludrocortisone combination demonstrated an association with reduced mortality risk in septic shock patients. Individuals receiving this combination therapy exhibited decreased likelihood of mortality compared to those receiving a placebo (OR: 0.78; 95%CI: 0.64, 0.96; p Egger: 0.3082; p Heterogeneity: 0.8570; p: 0.0190). CONCLUSION: Our study emphasizes the significance of corticosteroid therapy, particularly highlighting the hydrocortisone and fludrocortisone combination, for septic shock management.
Co-Authors Afrilla, Dian Beluan, Maria IS. Chotimah, Kusnul Dau, Daniel Enggriani, Yesica T. Farida, Lia D. Firmansyah, Ervin Fredo Tamara, Fredo Hakim, Lukman N. Hastutya, Diana V. Indiastari, Dewi Jonny K. Fajar Mirino, Reychell Puspitasari, Dewi A. Putri, Yama S. Rahmani, Alinda Runesi, Odis Saputro, Teguh D. Susanto, Agung Susanto, Jefri P. Sutrisno, Wibowo