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All Journal Program Kreativitas Mahasiswa - Penelitian Narra J
Fredo Tamara, Fredo
Program Studi Pendidikan Dokter, Fakultas Kedokteran Universitas Brawijaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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POTENSI VAKSIN ATEROSKLEROSIS VIA INDUKSI PROTEIN LECTIN-LIKE OXIDIZED LDL RECEPTOR 1 (LOX-1) TERHADAP AKTIVASI NF-κB, EKSPRESI eNOS DAN KADAR CRP PADA TIKUS DENGAN DIET ATEROGENIK Albaar, Thoha Muhajir; Tamara, Fredo; A, Oktavia Rahayu; Putri, Ardina Pramesti; Nurkhairina, Angi; Yurina, Valentina
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.221 KB)

Abstract

Atherosclerosis is a chronic inflammation condition as a response to the lipoproteins deposition in the artery wall.Oxidized low density lipoprotein (OxLDL) the major of atherosclerosis development. Lectin- like oxidized lo density lipoprotein 1 (LOX-1) is primary  receptor for OxLDL in endothelial cells. Recent studies have shown that LOX-1 might be potential for the atherosclerosis drugs development. This study was designed to investigate the response of LOX-1 vaccination with alum as adjuvant for atherogenesis to prevent increasing of NF-kB , CRP, and decrease of eNOS. This study was experimental laboratory with post test only control group design for 56 days using 28 male Wistar rats. Rats were divided into 7 groups which were negative control with normal diet AIN 93 M, positive control with atherogenic diet AIN 93 M, atherogenic diet AIN 93 M and LOX-1 protein treatment with dosage 1 ng + alum (P1), 10 ng + alum (P2), 100 ng + alum (P3), 1μg + alum (P4) and alum only (P5). On the 57th day, the rats were sacrificed and taken its serum spesimen to measure CRP level with enzyme immunoassay method and aorta tissues to measure NF-kB activation and expression eNOS with immunohistochemical method. Statistical analysis showed that the administration of LOX-1 protein in the treatment groups is significant to prevent NF-kB activation (p=0,00) and prevent decreased expression of eNOS (p=0,00), but not significant to prevent increased CRP level (p=0,83). The conclusion of this study is that the LOX-1 protein vaccination  have potency to prevent atherosclerosis with decreasing NF-kB activation and prevent decreasing eNOS expression. Keywords:  Atherosclerosis vaccine, LOX-1, NF-kB, eNOS, CRP
Global prevalence and determinants associated with the acceptance of monkeypox vaccination Indiastari, Dewi; Fajar, Jonny K.; Tamara, Fredo; Runesi, Odis; Hakim, Lukman N.; Chotimah, Kusnul; Rahmani, Alinda; Saputro, Teguh D.; Afrilla, Dian; Firmansyah, Ervin; Dau, Daniel; Dzhyvak, Volodymyr
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.866

Abstract

Assessing the acceptance of the monkeypox vaccine is crucial for the success of vaccination programs, yet the prevalence reports remain inconclusive. The aim of this study was to determine the global prevalence of monkeypox vaccine acceptance and identify its associated factors. A meta-analysis was conducted with a comprehensive search strategy on the following databases, including Scopus, Embase, and PubMed, for articles published up to April 5, 2024. This study utilizes a single-arm meta-analysis to calculate the pooled prevalence of monkeypox vaccine acceptance. A Z-test was employed to identify factors associated with the vaccine acceptance. Our study analyzed 51 articles encompassing 98,746 participants, revealing an overall monkeypox vaccine acceptance rate of 65%. Notably, the highest acceptance rates were observed among men who have sex with men (MSMs), while healthcare workers (HCWs) showed the lowest acceptance rates. Additionally, our findings indicated an increased acceptance in individuals with educational attainment beyond a bachelor’s degree, a history of COVID-19 and influenza vaccination, homosexual orientation, and HIV-positive status. Conversely, lower acceptance risk was associated with those with educational attainment below a bachelor's degree, heterosexual orientation, and bisexual orientation. In conclusion, our current study has determined the rate of monkeypox vaccine acceptance and identified its associated factors. These findings offer valuable insights as the foundation for targeted policies to manage and increase acceptance rates.
Global prevalence and potential factors influencing willingness for renal transplantation in end-stage renal disease patients: A systematic review and meta-analysis Tamara, Fredo; Fajar, Jonny K.; Susanto, Agung; Enggriani, Yesica T.; Beluan, Maria IS.; Mirino, Reychell; Farida, Lia D.; Hastutya, Diana V.; Puspitasari, Dewi A.; Putri, Yama S.; Susanto, Jefri P.; Dzhyvak, Volodymyr
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.964

Abstract

The prevalence of willingness to undergo renal transplantation and its potentially associated factors have been documented in multiple prior studies across different regions, yet certain findings are conflicting. The aim of this study was to determine the global prevalence of willingness for renal transplantation and identify its associated factors through meta-analysis methods. Databases such as Scopus, PubMed, and Embase were utilized for the search strategy, covering the period from April to May 2024. Data collection focused on gathering information regarding the prevalence and potential contributing factors of renal transplantation. Statistical analysis involved examining the cumulative prevalence of willingness for renal transplantation using single-arm meta-analysis. Factors associated with willingness for renal transplantation were analyzed using the Mantel–Haenszel test for categorical variables and the inverse variance method for numerical variables. A total of nine articles, covering 3935 patients with end-stage renal disease (ESRD) were included. The pooled estimates revealed that the overall prevalence of willingness to undergo renal transplantation among ESRD patients was 57% (95%CI: 0.46–0.67). Furthermore, we observed a higher likelihood of willingness among men and those of younger age, attainment of at least a bachelor's degree or higher in education, employment status, higher income levels, and a shorter duration of hemodialysis (<5 years). Our study has documented the global prevalence and potential associated factors of willingness to undergo renal transplantation, providing valuable insights for policymakers aiming to enhance the acceptance of renal transplantation.
Insertion/deletion (I/D) polymorphisms of angiotensin-converting enzyme gene and their implications for susceptibility and severity of COVID-19: A systematic review and meta-analysis Fajar, Jonny K.; Tamara, Fredo; Putranto, Wachid; Prabowo, Nurhasan A.; Harapan, Harapan
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.727

Abstract

The insertion or deletion polymorphisms of the angiotensin-converting enzyme gene (ACE I/D) have been the subject of significant research related to coronavirus disease 2019 (COVID-19). Despite this, the findings have remained uncertain and debatable. The aim of this study was to determine the associations between the ACE I/D polymorphisms and the susceptibility as well as the severity of COVID-19. A meta-analysis study (PROSPERO: CRD42022384562) was conducted by searching the articles published on PubMed, Scopus, and Embase as of May 15, 2023. Information regarding the impact of ACE I/D variant on the susceptibility to COVID-19 and its severity was collected and analyzed utilizing the Mantel-Haenszel method with a random effects model or fixed effects model, depending on the presence or absence of heterogeneity. Out of 3,335 articles, 21 articles were included, of which 13 investigated the association between ACE I/D and the risk of COVID-19 infection and 18 of them examined its influence on disease severity. The D allele of ACE increased risk of COVID-19 infection (OR: 1.41; 95%CI: 1.08–1.85; p-Egger: 0.0676; p-Heterogeneity: <0.001; p=0.0120), while ACE I allele (OR: 0.71; 95%CI: 0.54–0.93; p-Egger: 0.0676; p-Heterogeneity: <0.001; p=0.012) and II genotype (OR: 0.55; 95%CI: 0.34–0.87; p-Egger: 0.200; p-Heterogeneity: <0.001; p=0.011) decreased the risk of infection. Additionally, there was a notable association between the ACE ID genotype and an elevated likelihood of experiencing severe COVID-19 within the Asian population (OR: 1.46; 95%CI: 1.15–1.84; p-Egger: 0.092; p-Heterogeneity: 0.116; p=0.002). The presence of ACE I/D polymorphisms significantly influences the likelihood of being susceptible to and experiencing the severity of COVID-19.
Global prevalence and contributing factors of transplant renal artery stenosis in renal transplant recipients: A systematic review and meta-analysis Tamara, Fredo; Fajar, Jonny K.; Gersom, Camoya; Wicaksono, Ramadi S.; Tupamahu, Alvira R.; Huda, Fariz N.; Sari, Fitria R.; Dela, Jamaludin A.; Putri, Irawati E.; Sutrisno, Muhammad A.; Putra, Riyantono; Dwinata, Michael; Friatna, Yudha; Albaar, Thoha M.; Susanto, Agung; Dewi, Ratih TK.; Suseno, Aryo; Samsu, Nur
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1782

Abstract

Transplant renal artery stenosis (TRAS) is a serious complication of renal transplantation, with its prevalence and associated factors remaining inconclusive. The aim of this study was to assess the global prevalence and risk factors associated with TRAS incidence in renal transplant recipients. We conducted a meta-analysis by collecting data on the prevalence and factors associated with TRAS from articles in Scopus, Embase, and PubMed. The prevalence of TRAS was determined using a single-arm meta-analysis. The factors associated with TRAS were determined using Mantel-Haenszel analysis or inverse variance analysis. Out of 28,599 articles from the searches, 31 of them were included in the analysis. The global prevalence of TRAS was 6% among renal transplant recipients. Diabetes mellitus, hypertension, longer duration of dialysis before transplant, deceased donor, acute rejection, delayed graft function, longer cold ischemic time, and prolonged peak systolic velocity were associated with an increased risk of TRAS. Age, gender, peripheral artery disease (PAD) comorbidity, causes of end-stage renal disease (ESRD), previous dialysis modality, and cytomegalovirus infection were not associated with TRAS incidence. In conclusion, the global prevalence of TRAS in renal transplant recipients is relatively high, and some of the contributing factors to the development of TRAS are preventable. These findings could serve as a guideline for informing the management of TRAS in the future.
Outcomes of first-generation versus second-generation drug-eluting stents in calcified coronary lesions: A meta-analysis Rohman, Mohammad S.; Fajar, Jonny K.; Widyaningsih, Melly C.; Aziizah, Yusnia N.; Khasanah, Uswatun A.; Nendro, Farid EB.; Beting, Euphrasiane G.; Tanaem, Vini S.; Jannati, Desi; Putri, Wanda M.; Tamara, Fredo
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.2100

Abstract

The choice between first-generation drug-eluting stents (DES) and second-generation DES in managing calcified coronary lesions remains a topic of debate. The aim of this study was to compare outcomes between first-generation DES and second-generation DES in patients with calcified coronary lesions. This meta-analysis study was conducted from October to November 2024. The databases used were Embase, Scopus, and PubMed. Relevant articles were collated, and data regarding outcomes in patients with calcified coronary lesions treated with first-generation and second-generation DES were included to calculate the pooled effect size. The statistical analysis was performed using the Mantel-Haenszel method. Six articles were included in the study. The results indicated that calcified coronary lesions treated with first-generation DES were associated with increased risks of all-cause mortality (Odd ratios (OR): 1.23; 95% confidence interval (95%CI): 1.05–1.45; p-Egger= 0.9346; p-Heterogeneity: 0.9720; p=0.0120), myocardial infarction (OR: 1.48; 95%CI: 1.22–1.80; p-Egger: 0.6472; p-Heterogeneity: 0.5890; p<0.0001); and target lesion revascularization (TLR) (OR: 1.47; 95%CI: 1.24–1.74; p-Egger: 0.9982; p-Heterogeneity: 0.5950; p<0.0001), in comparison with second-generation DES. In contrast, when comparing first- and second-generation DES in terms of cardiac death and major adverse cardiovascular events, a similar risk was depicted. This study compared the outcomes of first-generation and second-generation DES in the management of patients with calcified coronary lesions, which may serve as a reference for selecting DES in the patient population.
Co-Authors Afrilla, Dian Albaar, Thoha M. Angi Nurkhairina, Angi Ardina Pramesti Putri, Ardina Pramesti Aziizah, Yusnia N. Beluan, Maria IS. Beting, Euphrasiane G. Camoya Gersom Chotimah, Kusnul Dau, Daniel Dela, Jamaludin A. Dewi, Ratih TK. Dwinata, Michael Dzhyvak, Volodymyr Enggriani, Yesica T. Farida, Lia D. Firmansyah, Ervin Friatna, Yudha Hakim, Lukman N. Harapan Harapan Hastutya, Diana V. Huda, Fariz N. Indiastari, Dewi Jannati, Desi Jonny K. Fajar Khasanah, Uswatun A. Mirino, Reychell Mohammad S. Rohman Nendro, Farid EB. Nur Samsu Oktavia Rahayu A, Oktavia Rahayu Prabowo, Nurhasan A. Puspitasari, Dewi A. Putra, Riyantono Putranto, Wachid Putri, Irawati E. Putri, Wanda M. Putri, Yama S. Rahmani, Alinda Runesi, Odis Saputro, Teguh D. Sari, Fitria R. Susanto, Agung Susanto, Jefri P. Suseno, Aryo Sutrisno, Muhammad A. Tanaem, Vini S. Thoha Muhajir Albaar, Thoha Muhajir Tupamahu, Alvira R. VALENTINA YURINA Wicaksono, Ramadi S. Widyaningsih, Melly C.