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The Role of Plasma Osmolarity in the Mortality of Patients with Covid-19 Indiastari, Dewi; Candradikusuma, Didi; Sutanto, Heri; Budiarti, Niniek; Samsu, Nur
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.12

Covid-19 (Coronavirus disease 2019) is a new infectious disease that attacks the respiratory tract and is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), causing multiorgan failure, often requiring temporary support such as the use of a ventilator or hemodialysis equipment. This condition is related to an imbalance in fluid distribution associated with changes in osmolarity or hyperosmolarity. This research aims to explain the role of plasma osmolarity in Covid-19 patients at dr. Saiful Anwar Hospital, Malang, in patient outcomes, especially death outcomes. The sample for this study was 205 medical records of Covid-19 patients, recorded from September 2021 to May 2022. This study used a retrospective cohort design to describe plasma osmolarity in Covid-19 patients and the outcome of hospitalized patients. There were 205 patient data obtained, with 85 patients dying aged <65 years. Sixty-eight patients of Covid-19 with comorbidities (DM, HT, AKI, CKD, combination) died. There was no difference in plasma osmolarity for living and deceased patients. Repeated plasma osmolarity (retest) had a good degree of accuracy in predicting the outcome of Covid-19 patients, where sensitivity was 71.3% and specificity was 73.4% at a cut-off value of 277.32mOsm/L. The repeat plasma osmolarity value of ≥277.32 had a PPV value of 75%, while plasma osmolarity <277.32 had an NPV value of 69.3%. The OR value was 6.77, meaning that Covid-19 patients with repeated plasma osmolarity levels ≥277.32 would have 6.77 times the risk of mortality compared to Covid-19 patients with repeated plasma osmolarity levels <277.32.

EVALUASI KUALITAS HIDUP DAN SKALA NYERI PADA LANJUT USIA PENYINTAS COVID-19 PASCA RAWAT INAP Soenarti, Sri; Sutanto, Heri; Indiastari, Dewi; Budiarti, Niniek; Hermanto, Djoko Heri; Susanto, Jefri Pratama
Majalah Kesehatan Vol. 10 No. 2 (2023): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2022.010.02.5

COVID-19 menyebabkan banyaknya kematian pada populasi lanjut usia (lansia). Di Indonesia, hingga akhir Mei 2021 terdapat 49% kematian akibat COVID-19 dan pada pasien di atas 60 tahun (lansia) hanya didapatkan 10% kasus sembuh. Lansia dikategorikan sebagai kelompok berisiko terinfeksi virus Corona. Wabah penyakit ini tidak hanya berdampak pada kesehatan fisik tetapi juga kesehatan mental. Pada saat pandemi, memahami kualitas hidup lansia yang sembuh dari COVID-19 pasca perawatan di rumah sakit adalah tantangan global yang baru. Penelitian ini dilakukan dengan mengambil data lansia yang selamat dari COVID-19 pasca rawat inap untuk dinilai kualitas hidupnya dan kesehatan diri. Penilaian dengan wawancara melalui telepon. Data demografi, sosial ekonomi, status kesehatan diambil dari rekam medis pasien. Responden memperoleh rerata skor kualitas hidup (EQ-5D) 0,911 dan rerata skor VAS 89,6. Nyeri sendi memiliki korelasi yang signifikan secara statistik dengan ketidaknyamanan (p < 0,000). Lama rawat inap kurang dari 14 hari memiliki hubungan yang bermakna dengan ketidaknyamanan (p < 0,05). Sedangkan dimensi lain seperti mobilitas, perawatan diri, aktivitas sehari-hari dan kecemasan/depresi tidak berkorelasi dengan ketidaknyamanan secara signifikan. Kesimpulannya, kualitas hidup dan kesehatan diri yang dilaporkan oleh lansia penyintas COVID-19 relatif bagus. Adanya keluhan nyeri sendi dikaitkan dengan kualitas hidup yang lebih buruk (dimensi ketidaknyamanan), sementara risiko ketidaknyamanan meningkat secara signifikan dengan lama rawat yang lebih singkat.

Increasing Adolescents' Knowledge in Indonesia of HIV and STD in Leading-Up Three Zero HIV/AIDS 2030 Indiastari, Dewi; Setyowati, Lita; Sutanto, Heri; Budiarti, Niniek; Rosandi, Millanitalia; Dwitarahma, Marshandyar
Clinical and Research Journal in Internal Medicine Vol. 5 No. 1 (2024): Volume 5 No 1, May 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.01.06

During the transition period of puberty, adolescents experience physical, psychological, and ways of thinking, which social and environmental changes will have a significant impact on adolescents. Improper self-control becomes a threat that can damage the morale and future of adolescents, including choosing the wrong environment resulting in drug abuse, unwanted pregnancies, abortions, sexually transmitted infections, HIV, and AIDS. This community service activity aims to increase the knowledge and importance of youth awareness in Malang about HIV and STIs. This activity is an online lecture-based activity (webinar) and live event assisting teenagers in Malang area. It is held for seven weeks by providing education about what HIV is, why it must be avoided—the dangers of sexually transmitted infections online followed by a discussion session. The activity was attended by 763 participants aged 10-20 years and 114 guardians of students and laypeople. The results obtained during the activity showed an increase in the post-test scores compared to the values before getting the webinar. A long-term evaluation still needs to be carried out to assess the absorption rate of the material that has been carried out on the quality of life of webinar participants. The conclusion obtained from this activity is that the knowledge of webinar participants, especially teenagers, about HIV/AIDS has increased, and knowledge is a fundamental thing that must be instilled in adolescents as early as possible to prevent HIV transmission in adolescents.

Association of Sociodemographic Factors in Affecting the Knowledge, Attitude, and Behaviour of Tuberculosis and HIV in Malang: A Community-Based Study in Rural Area Rosandy, Milanitalia; Candradikusuma, Didi; Indiastari, Dewi; Fatma, Endah; Budiarti, Niniek; Sutanto, Heri; Abellia, Gaby
Clinical and Research Journal in Internal Medicine Vol. 5 No. 1 (2024): Volume 5 No 1, May 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.01.07

Background: Tuberculosis is the leading cause of death among people with HIV. In Indonesia, the Tuberculosis prevalence in 2021 stood at 969,000 cases with an average of 354 cases per 100,000 people. Nevertheless, tuberculosis is often neglected by many people, whereas in fact, it is a preventable and curable disease. This study aims to assess the knowledge, perception, behaviour, and screening for tuberculosis and their association with sociodemographic factors in a rural area of Malang, Indonesia. Method: A cross-sectional community-based study was conducted. The subjects of this study were adults (≥18 years old) who could comprehend the Indonesian language. We included 462 individuals who were chosen randomly by a multistage stratified sampling technique in rural areas of Malang, Indonesia. A validated questionnaire was asked to be filled in by participants, which were selected randomly using a multistage stratified sampling technique. Collected data were analyzed on SPSS for Windows version 25.0 Results: This study found that most (59.77%) of adults from the study area are still unaware of tuberculosis infection, transmission, prevention, and its risk factors. Only 1.2% were aware of the importance of screening if they had contact with positive tuberculosis patients. Participants in the age groups of 61 to 70 and over 70 years old were 5.5 and 4.0 times more likely to exhibit unsatisfactory behaviour compared to those in the 27 to 30 age group. Conclusion: This study shows that knowledge, perceptions, behaviours and tuberculosis screening toward tuberculosis are still lacking in rural communities in Malang and showed that participant on younger age and higher educational subjects has better knowledge, behaviour, perception and screening towards Tuberculosis and HIV.

Global prevalence and determinants associated with the acceptance of monkeypox vaccination Indiastari, Dewi; Fajar, Jonny K.; Tamara, Fredo; Runesi, Odis; Hakim, Lukman N.; Chotimah, Kusnul; Rahmani, Alinda; Saputro, Teguh D.; Afrilla, Dian; Firmansyah, Ervin; Dau, Daniel; Dzhyvak, Volodymyr
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.866

Assessing the acceptance of the monkeypox vaccine is crucial for the success of vaccination programs, yet the prevalence reports remain inconclusive. The aim of this study was to determine the global prevalence of monkeypox vaccine acceptance and identify its associated factors. A meta-analysis was conducted with a comprehensive search strategy on the following databases, including Scopus, Embase, and PubMed, for articles published up to April 5, 2024. This study utilizes a single-arm meta-analysis to calculate the pooled prevalence of monkeypox vaccine acceptance. A Z-test was employed to identify factors associated with the vaccine acceptance. Our study analyzed 51 articles encompassing 98,746 participants, revealing an overall monkeypox vaccine acceptance rate of 65%. Notably, the highest acceptance rates were observed among men who have sex with men (MSMs), while healthcare workers (HCWs) showed the lowest acceptance rates. Additionally, our findings indicated an increased acceptance in individuals with educational attainment beyond a bachelor’s degree, a history of COVID-19 and influenza vaccination, homosexual orientation, and HIV-positive status. Conversely, lower acceptance risk was associated with those with educational attainment below a bachelor's degree, heterosexual orientation, and bisexual orientation. In conclusion, our current study has determined the rate of monkeypox vaccine acceptance and identified its associated factors. These findings offer valuable insights as the foundation for targeted policies to manage and increase acceptance rates.

Treatment challenges of nevirapine-induced Stevens-Johnson syndrome: a case report Rosandy, Milanitalia Gadys; Indiastari, Dewi; Candradikusuma, Didi; Budiarti, Niniek; Sutanto, Heri; Amalia, Dinda
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 4 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i4.13026

Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI), is a crucial component of antiretroviral therapy (ART) in HIV management. However, nevirapine carries a rare but potentially life-threatening risk of Stevens-Johnson syndrome (SJS). We reported a case of severe cutaneous manifestations of extensive necrolysis in an HIV-positive patient on the ARV nevirapine. This case highlights the importance of recognizing nevirapine-induced SJS, particularly in the early stages, to ensure prompt discontinuation of the drug and initiation of appropriate supportive care. Clinicians managing HIV patients on nevirapine-based ART should remain vigilant for early signs of SJS and maintain a high index of suspicion.

Pertimbangan Interaksi Obat dalam Memilih Obat Psikofarmaka pada Pasien HIV dengan Gangguan Mood: Evidence Based Case Report Putri, Frilya Rachma; Indiastari, Dewi; Surya, Michael; Hanum, Anisa Syahfitri
Majalah Kedokteran Indonesia Vol 73 No 4 (2023): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.73.4-2023-1059

Introduction: Mood disorders are one of the most common mental disorders in HIV patients. When used for HIV patients with mood disorders, psychiatric drugs might interact with ARVs. The selection of psychiatric drugs for HIV patients needs to be adjusted to avoid side effects due to adverse drug interactions. Objective: To discuss the interactions between psychiatric drugs and HIV ARVs as a consideration for treatment options.Methods: A literature search was conducted through PubMed and Scopus using keywords with the Boolean operator concept. Selected literature reviews a collection of drug interactions between psychiatric drugs for mood disorders and antiretrovirals used for HIV patients.Results: Out of 88 literatures works obtained, 3 of which reviewed the interactions of various psychiatric drugs with antiretrovirals in HIV patients. Psychopharmaceutical and antiretroviral interactions are related to their metabolism by the Cytochrome P450 (CYP450) enzyme. Psychopharmaceutical and antiretrovirals that are metabolized by the same isoenzyme will cause changes in blood plasma levels which then leads to risks of causing side effects.Conclusion: Although there is no ideal drug option for treating mood disorders in HIV patients, SSRIs are still the first choice because of their fewer interactions with antiretrovirals. The antiretrovirals that interacts the most with psychopharmaceutical are those belonging to PI group. It is recommended to avoid drug combinations that cause a lot of interactions and reduce the treatment benefits.

Association Between Personal Hygiene Practices and Peripheral Blood Profiles in Agrarian Workers: An Analysis with Socio-demographic and Helminthiasis Considerations Indiastari, Dewi; Didi Candradikusuma; Milanitalia Gadys Rosandy; Niniek Budiarti; Heri Sutanto; Sinta Silvia
The Indonesian Journal of Occupational Safety and Health Vol. 14 No. 2 (2025): The Indonesian Journal of Occupational Safety and Health
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijosh.v14i2.2025.164-179

Introduction: Helminthiasis remains a significant public health issue in Indonesia, negatively impacting nutrition and cognitive development, particularly among individuals who are in direct contact with soil. To mitigate this issue, improving personal hygiene and awareness of infection prevention is essential. This study aims to examine the correlation between sociodemographic factors and personal hygiene with blood profiles among workers in agrarian areas. Methods: A cross-sectional approach was used, with 144 samples collected through purposive sampling in the agrarian area of Malang Regency. Data were gathered using questionnaires covering sociodemographic factors and personal hygiene, as well as through hematology tests results obtained from blood samples taken from respondents, which were tested at the dr. Saiful Anwar Malang General Hospital. For data analysis, the Chi-square test was utilized for bivariate analysis, while logistic regression was employed for multivariate analysis. Results: The mean age of respondents was 48.1 ± 14.1 years, with a majority having attained only an elementary education (51.4%) and primarily working as farmers (66.7%). Approximately 38.2% of respondents demonstrated poor personal hygiene. Significant associations were found between personal hygiene and hemoglobin levels (p=0.031), as well as eosinophil counts (p=0.007). Multivariate analysis showed that respondents who did not wash their hands before eating had 1.8 times higher odds of having abnormal blood profiles compared to those who practiced handwashing. Conclusion: The results of this study suggest that sociodemographic factors and personal hygiene are associated with the quality of blood profile among respondents. Enhanced education is needed to raise community awareness regarding personal hygiene.

The Role of Plasma Osmolarity in the Mortality of Patients with Covid-19 Indiastari, Dewi; Candradikusuma, Didi; Sutanto, Heri; Budiarti, Niniek; Samsu, Nur
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.12

Covid-19 (Coronavirus disease 2019) is a new infectious disease that attacks the respiratory tract and is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), causing multiorgan failure, often requiring temporary support such as the use of a ventilator or hemodialysis equipment. This condition is related to an imbalance in fluid distribution associated with changes in osmolarity or hyperosmolarity. This research aims to explain the role of plasma osmolarity in Covid-19 patients at dr. Saiful Anwar Hospital, Malang, in patient outcomes, especially death outcomes. The sample for this study was 205 medical records of Covid-19 patients, recorded from September 2021 to May 2022. This study used a retrospective cohort design to describe plasma osmolarity in Covid-19 patients and the outcome of hospitalized patients. There were 205 patient data obtained, with 85 patients dying aged <65 years. Sixty-eight patients of Covid-19 with comorbidities (DM, HT, AKI, CKD, combination) died. There was no difference in plasma osmolarity for living and deceased patients. Repeated plasma osmolarity (retest) had a good degree of accuracy in predicting the outcome of Covid-19 patients, where sensitivity was 71.3% and specificity was 73.4% at a cut-off value of 277.32mOsm/L. The repeat plasma osmolarity value of ≥277.32 had a PPV value of 75%, while plasma osmolarity <277.32 had an NPV value of 69.3%. The OR value was 6.77, meaning that Covid-19 patients with repeated plasma osmolarity levels ≥277.32 would have 6.77 times the risk of mortality compared to Covid-19 patients with repeated plasma osmolarity levels <277.32.

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