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All Journal VALENSI Jurnal Penelitian Tanaman Industri Indonesian Journal of Pharmaceutical Science and Technology Chimica et Natura Acta Indonesian Journal of Chemistry Jambura Journal of Chemistry Bravo's : Jurnal Program Studi Pendidikan Jasmani dan Kesehatan Jurnal Penelitian Tanaman Industri (Littri) MAP (Jurnal Manajemen dan Administrasi Publik)
Achmad Zainuddin
Departemen Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Synthesis N1-Tersier-Butilteobromin from Teobromin and Tersier-Butylbromides Sri Gustini Husein; Achmad Zainuddin; Sani Hoeruman
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.687 KB) | DOI: 10.24198/ijpst.v5i3.17931

Abstract

Xantine derivatives are known to have some pharmacological activity, such as a bronchodilator. The substitution on atoms N1 xantine can improve the activity and selectivity as a tracheaspasm. The purpose of this research was to investigate the influence of concentration sodium hydroxide in sodium acetate as solvent used on the production yield of N1-tert-butilteobromin. The result of the synthesis was isolated using chloroform and purified with the preparative thin layer chromatography. The molecule structure of N1-tert-butilteobromin was confirmed using ultraviolet and infrared spectrophotometry. The result showed that sodium hydroxide concentration could effect the results of yield. The yields of 4%, 8%, and 12% sodium hydroxide concentration were 3.7% (0.074 g), 7.2% (0.144 g), and 1.3% (0.026 g), respectively.Keywords: N1-tert-butylteobromin, sodium hydroxide, tert-butylbromide, theobromine
Co-Authors Ace Tatang Hidayat Ade Kania Ningsih Ahmad Kadir Kilo Andi Rahim Arif Rahman Hakim Arif Rahman Hakim Christina Marpaung Dadan Sumiarsa Darwati Darwati Desi Harneti Putri Huspa Euis Julaeha Euis Julaeha Euis Julaeha Fatimah Riswati Herdanu Rizqullah Hersanti - Ika Wiani Iman Rahayu IRMA KRESNAWATY Izzatul ‘Ainiah Jamaluddin Al Anshori jurnalmap map Lilis Siti Aisyah Lilis Siti Aisyah Muninghar ÔÇì Nur Muhammad Miftah Nurlelasari Nurlelasari Peny Sabila Purwoko, Agus Rani Maharani Rani Maharani Rani Maharani Rani Maharani Ph.D Roekmi-ati Tjokronegoro Sani Hoeruman Sari Purbaya Siska Mulya Octavia Siska Mulya Octavia Sri Gustini Husein Sunit Hendrana Sylvia Rachmawati Meilanie Tati Herlina Tati Herlina Tri Mayanti Tri Reksa Saputra Tri Reksa Saputra Unang Supratman Weny J.A Musa Yenny Febriani Yun Yenny Febriani Yun