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Andi Ratihsekarningrum Siradje
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Medicine & Pharmacology Public Health

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Antihyperlipidemic and Antiinflammatory Activity of Crude Oil Anguilla Marmorata [Q.] Gaimard in White Rats (Rattus Norvegicus) Jamaluddin, Jamaluddin; Khildah Khaerati; Ihwan, Ihwan; Yusriadi, Yusriadi; Andi Ratihsekarningrum Siradje; Apriyana Soputra; Novita Christiana Ponganan; Klerensia Defneir Titing; Novianti Batti; Andi Mustika; Andi Alfianto; Moh. Rifki; Janes Krisly; Finta Amalinda
Journal of Public Health and Pharmacy Vol. 4 No. 1: MARCH 2024
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v4i1.4817

Abstract

Fish oil has omega-3 and omega-6 fatty acids, which provide health benefits such as prevention of an increase in total cholesterol, triglycerides, and a decrease in blood HDL, as well as being anti-inflammatory agents in humans. The present study was conducted to determine the antihyperlipidemic and anti-inflammatory activities of eel fish (Anguilla marmorata [Q.] Gaimard) oil extracts on white rats (Rattus norvegicus). To test hyperlipidemia, 25 rats were divided into 5 groups and treated with; 1.5 % PEG 400 (negative control), 20 mg simvastatin (positive control), test doses of 18, 36, and 72 mg/kg. The treatments were carried out for 39 days. In investigating the anti-inflammatory activity, 25 white rats were divided into 5 groups; negative control, positive control, three-dose treatments of 22, 44, and 88 mg/200 g. Blood cholesterol levels were measured and percent inflammation was determined. The results showed that the eel oil extracts led to a decreased of total cholesterol levels 49.60 %, triglycerides 31.15 %, and HDL 14.3 %. The percentage of inflammation values ranged from 31.73 to 54.48 %. The findings indicated that the most effective doses for the antihyperlipidemic effect were 72 mg/ kg, while 22 mg/200 g for the anti-inflammatory activity.
Co-Authors Andi Alfianto Andi Mustika Apriyana Soputra Finta Amalinda Heni Pujiastuti Jamaluddin Jamaluddin Janes Krisly Khildah Khaerati Klerensia Defneir Titing Moh. Rifki Novianti Batti Novita Christiana Ponganan Yusriadi Yusriadi