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All Journal Majalah Farmaseutik Jurnal Farmasi Sains dan Praktis
Mahmuda, Hartati
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Immunology & microbiology Medicine & Pharmacology Public Health

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Pola Pemberian Nutrisi Parenteral Pada Neonatus di RSUPN dr. Cipto Mangunkusumo. Indonesia Mahmuda, Hartati; Rahmawati, Fita; Mutiara, Rina
Majalah Farmaseutik Vol 20, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i2.75586

Abstract

Neonatus merupakan pengguna terapi nutrisi parenteral paling banyak karena sebagian besar bayi prematur dan bayi lahir dengan berat sangat rendah akan membutuhkan terapi dukungan nutrisi sesegera mungkin setelah lahir. Pemberian nutrisi parenteral pada neonatus dapat mempengaruhi pertumbuhan pasca-kelahiran, meningkatkan perkembangan saraf, dan mengurangi risiko kematian. Penelitian ini bertujuan untuk mengetahui pola pemberian nutrisi parenteral yang diberikan pada neonatus diawal kelahiran. Penelitian ini menggunakan desain observational cross sectional. Penelusuran riwayat pemberian nutrisi parenteral pada neonatus dilakukan secara retrospektif melalui rekam medik dan sistem informasi manajemen rumah sakit. Sejumlah 118 neonatus memenuhi kriteria inklusi penelitian dengan kriteria berat badan ≤ 2.500 g, mendapatkan nutrisi parenteral di bangsal perinatologi, RSUPN dr. Cipto Mangunkusumo Jakarta. Informasi jenis nutrisi parenteral yang diberikan kepada neonatus pada hari pertama kelahiran dianalisis secara deskriptif. Hasil penelitian menunjukkan jenis nutrisi parenteral yang diberikan meliputi makronutrisi berupa glukosa, protein, dan lipid serta mikronutrisi multivitamin, kalsium, dan fosfat. Sejumlah 35 neonatus mendapatkan nutrisi protein-glukosa dengan atau tanpa mikronutrisi, 23 neonatus dengan nutrisi protein-glukosa-lipid dengan atau tanpa mikronutrisi sejumlah 60 neuonatus dengan nutrisi glukosa dengan atau tanpa mikronutrisi.  Nutrisi parenteral yang diberikan beragam sesuai kebutuhan masing-masing neonatus agar tidak terjadi malnutrisi. 
PRINCIPLES OF DOSE ADJUSTMENT IN PATIENTS WITH CHRONIC KIDNEY FAILURE Mende, Juniarto; Kartikawati, Nurfina Dian; Titami, Arina; Mahmuda, Hartati
Jurnal Farmasi Sains dan Praktis Vol 11 No 2 (May-August 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i2.9687

Abstract

Chronic renal disease is a kidney illness marked by a progressive decline in kidney function over months or years. The usage of medications in this condition is a crucial aspect of managing kidney disease patients. When done correctly, pharmacotherapy can halt disease development and minimize morbidity and mortality. In patients with kidney illness, decreasing kidney function can drastically change the pharmacokinetics and pharmacodynamics of many medications, increase the risk of drug toxicity if not well treat. Many of these changes must be expected and mitigated by changing the medicine dosage. Complications of chronic kidney disease (CKD) that go untreated can cause significant early morbidity and mortality, as well as aggravate its progression. This literature review is based on a review of the literature and articles related to CKD to determine the principles of dose adjustment in CKD patients. Classification of drugs in CKD patients includes antifungals, anticoagulants, antidiabetics, antihypertensives, antibiotics, and analgesics. The administration of these drugs should be considered for kidney function in CKD patients. The presence of multidisciplinary interventions reduces the risk of progression of CKD severity. Adjustment of the dosage regimen in CKD patients is carried out for certain drugs that have a significant relationship between drug concentration and clinical outcomes in patients.
Co-Authors Fita Rahmawati Juniarto Mende Kartikawati, Nurfina Dian Rina Mutiara, Rina Titami, Arina