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All Journal Borneo Journal Of Pharmascientech Jurnal Farmasi Sains dan Praktis Borobudur Pharmacy Review Borneo Journal of Pharmacy
Kartikawati, Nurfina Dian
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Digitalisasi Sebagai Upaya Peningkatan Kepatuhan Penggunaan Obat Pasien Tuberkulosis: Studi Literatur Kartikawati, Nurfina Dian; Febriani, Anisa Putri; Rizki, Rahmania Hafidhotur; Sari, Lutfiana
Borobudur Pharmacy Review Vol 4 No 2 (2024): August-Dec
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/bphr.v4i2.12745

Abstract

Patient adherence to TB treatment regimen is essential to ensure recovery and prevent drug resistance. The use of drug reminder applications in the management of Tuberculosis (TB) is increasingly growing in the digital era. This literature aims to review the effect of drug reminder applications on TB patient adherence. The method used is a systematic literature review by searching various relevant scientific databases, such as Crossref and Google Scholar, for articles published in the last two years. The keywords in this study are: Tuberculosis; Drug Adherence; Drug Reminder Application. The literature search was conducted by combining Boolean search terms ("AND", "OR"). In 6 articles, the results of the literature showed that the use of drug reminder applications has a positive impact on patient adherence, with several studies showing an increase in adherence of up to 30%. Factors such as ease of use, daily reminder features, and support from health workers determine the success of the application. The main conclusion of this study is that digitalization of drug reminder applications has the potential to be an effective solution in improving TB patient adherence, but further research is needed to evaluate the sustainability of its impact in the long term.
PRINCIPLES OF DOSE ADJUSTMENT IN PATIENTS WITH CHRONIC KIDNEY FAILURE Mende, Juniarto; Kartikawati, Nurfina Dian; Titami, Arina; Mahmuda, Hartati
Jurnal Farmasi Sains dan Praktis Vol 11 No 2 (May-August 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i2.9687

Abstract

Chronic renal disease is a kidney illness marked by a progressive decline in kidney function over months or years. The usage of medications in this condition is a crucial aspect of managing kidney disease patients. When done correctly, pharmacotherapy can halt disease development and minimize morbidity and mortality. In patients with kidney illness, decreasing kidney function can drastically change the pharmacokinetics and pharmacodynamics of many medications, increase the risk of drug toxicity if not well treat. Many of these changes must be expected and mitigated by changing the medicine dosage. Complications of chronic kidney disease (CKD) that go untreated can cause significant early morbidity and mortality, as well as aggravate its progression. This literature review is based on a review of the literature and articles related to CKD to determine the principles of dose adjustment in CKD patients. Classification of drugs in CKD patients includes antifungals, anticoagulants, antidiabetics, antihypertensives, antibiotics, and analgesics. The administration of these drugs should be considered for kidney function in CKD patients. The presence of multidisciplinary interventions reduces the risk of progression of CKD severity. Adjustment of the dosage regimen in CKD patients is carried out for certain drugs that have a significant relationship between drug concentration and clinical outcomes in patients.
Interventions on Costs and Survival Rates of Lung Cancer Patients Yuliastuti, Fitriana; Kartikawati, Nurfina Dian; Pradani, Missya Putri Kurnia; Bunga, Cut Dewi; Mahato, Roshan Kumar
Borneo Journal of Pharmacy Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i4.10049

Abstract

Lung cancer is characterized by the uncontrolled growth of cells in the lung tissue, particularly in the lining of the respiratory tract. The disease has a high and alarming mortality rate, requiring prompt and appropriate management. This study aims to examine the costs and one-year survival rates of lung cancer patients at Dharmais Cancer Hospital. Data analysis was conducted in four stages: a retrospective observational study using secondary data from medical records, which described patient characteristics and factors affecting survival and treatment costs; analysis of survival curves by cancer stage and intervention; and testing differences in survival curves using the log-rank test. The results show that higher survival rates are often inversely proportional to shorter survival times, and vice versa. Stage 1 patients exhibited the most extended survival despite low survival rates for inpatients (48 months, 25%) and outpatients (53 months, 15%). Intervention types 4.00 (chemotherapy and radiotherapy) and 7.00 (chemotherapy, radiotherapy, and surgery) effectively extended survival, although associated survival rates remained low. The highest inpatient treatment costs were observed in stage 2 patients, while the highest annual outpatient costs were linked to surgical interventions, highlighting the difference between per-episode and cumulative annual expenditures.
Cost Analysis Pasien Chronic Kidney Diseases di Instalasi Rawat Inap RS Soerojo Magelang Hapsari, Widarika Santi; Kartikawati, Nurfina Dian; Sabaan, Wahid
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.780

Abstract

Chronic Kidney Disease (CKD) is a global health problem with rapidly increasing prevalence and high treatment costs. In developing countries, CKD management is more complex due to the influence of socioeconomic factors and underlying comorbidities. This study aims to obtain an overview of treatment costs and analyze the influence of patient characteristics, comorbidities, and length of stay on direct medical costs for CKD patients at Soerojo Hospital. This study was retrospective using data from CKD patients undergoing inpatient hemodialysis in 2024. Data collected included patient characteristics and direct medical costs. Data analysis was performed descriptively and inferentially using normality tests followed by non-parametric tests (Kruskal-Wallis and Mann-Whitney) to examine cost differences between groups. A total of 87 patients participated in this study. The majority of patients were male (57.74%) and aged ≥60 years (42.53%). Patients with stage 5 CKD dominated (87.36%), most of whom had 1–3 comorbidities (56.32%) with a length of stay ≤5 days (60.92%). The highest direct medical costs were found in patients with stage 5 CKD, especially in the cost of procedures (Rp13,422,222 ± 11,203,121). In general, the cost of procedures was the largest expenditure component. Based on statistical analysis, the variables of the number of comorbidities and length of hospitalization showed a significant relationship (p<.05) with the total cost of care for CKD patients. This study concluded that high clinical complexity due to comorbidities and long LOS were the main predictors of increased direct medical costs.
Co-Authors Bunga, Cut Dewi Febriani, Anisa Putri Fitriana Yuliastuti Hapsari, Widarika Santi Juniarto Mende Mahato, Roshan Kumar Mahmuda, Hartati Pradani, Missya Putri Kurnia Rizki, Rahmania Hafidhotur Sabaan, Wahid Sari, Lutfiana Titami, Arina