Articles
<![CDATA[Optimasi Formula Tablet Likuisolid Meloksikam Menggunakan PEG 400 Sebagai Pelarut dan Amilum Sagu Pregelatin Sebagai Carrier Material ]]>
<![CDATA[Arina Titami]]>;
<![CDATA[T. N. Saifullah Sulaiman]]>
<![CDATA[ Majalah Farmaseutik Vol 15, No 2 (2019) ]]>
Publisher : <![CDATA[Faculty of Pharmacy, Universitas Gadjah Mada ]]>
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DOI: 10.22146/farmaseutik.v15i2.48181
<![CDATA[Meloksikam termasuk dalam Biopharmaceutics Classification System (BCS) kelas II, memiliki kelarutan rendah dan permeabilitas tinggi. Teknik likuisolid merupakan metode yang dapat meningkatkan kelarutan dan disolusi sediaan. Penelitian ini bertujuan untuk mendapatkan formula optimum sediaan tablet likuisolid meloksikam menggunakan PEG 400 sebagai pelarut dan amilum sagu pregelatin sebagai carrier material. Delapan formula diformulasi dengan berbagai proporsi PEG 400 dan amilum sagu pregelatin. Serbuk dilakukan pengujian sifat alir dan Loss on Drying. Tablet likuisolid meloksikan dilakukan uji yang meliputi: keseragaman kandungan, kekerasan, kerapuhan, waktu hancur, dan disolusi. Hasil penelitian menunjukkan bahwa kombinasi PEG 400 dan amilum sagu pregelatin memberikan pengaruh yang signifikan terhadap sifat fisik serbuk dan sifat fisik tablet likuisolid meloksikam. Kombinasi PEG 400 sebagai pelarut sebanyak 6-8,5% dan amilum sagu pregelatin sebagai carrier material sebanyak 18,5\-21% dapat menghasilkan formula optimum dengan nilai desirability sebesar 0,9.]]>
<![CDATA[Mekanisme Interaksi Obat Pada Pasien Lansia Hipertensi ]]>
<![CDATA[Titami, Arina]]>;
<![CDATA[Dewi, Novia Ariani]]>
<![CDATA[ Jurnal Farmasi SYIFA Vol 2 No 2 (2024): Jurnal Farmasi SYIFA ]]>
Publisher : <![CDATA[CV. Wadah Publikasi Cendekia ]]>
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DOI: 10.63004/jfs.v2i2.460
<![CDATA[Populasi lansia berada pada risiko tinggi terkait drug-related problems (DRPs) karena perubahan farmakokinetik dan farmakodinamik terkait usia. Insiden terkait DRPs dapat dihasilkan dari peningkatan prevalensi multipel penyakit kronis terkait usia yang menyebabkan penggunaan rejimen terapi yang kompleks. Interaksi obat adalah DRPs yang paling banyak terjadi pada penggunaan obat antihipertensi pada pasien lansia. Penelitian bertujuan untuk mengetahui potensi interaksi obat beserta mekanismenya yang mungkin terjadi pada pasien lansia dengan hipertensi. Penelitian ini merupakan review artikel, subjek review yang digunakan adalah artikel yang terindeks secara nasional dan internasional pada 10 tahun terakhir (2013-2023). Data yang diperoleh berasal dari situs web penyedia jurnal elektronik yaitu Google Scholar dan Researchgate. Pencarian artikel berdasarkan kata kunci yang digunakan yaitu interaksi obat, hipertensi, lansia. Potensi terjadi interaksi obat bergantung pada golongan obat dan mekanisme kerja obat tersebut. Terdapat 4 golongan obat yang digunakan sebagai lini pertama pada pengobatan hipertensi yaitu diuretik, B-blocker, ACE Inhibitor, dan ARB. Potensi interaksi obat dapat terjadi antara obat antihipertensi (OAH) dengan obat lainnya berupa obat antihipertensi golongan lain, NSAID, kortikosteroid, dan lainnya.Sebagian besar interaksi obat dapat diprediksi, dicegah dan diminimalisasi efek sampingnya dengan pemahaman yang baik tentang mekanisme interaksi obat. Pengetahuan yang baik tentang interaksi obat akan meningkatkan kesiagaan tenaga kesehatan khususnya apoteker dalam menangani kejadian yang tidakdiinginkan pada terapi farmakologi untuk pasien.]]>
<![CDATA[Review Artikel: Pengaruh Glukokortioid Terhadap Glukosa Darah Pasien Diabetes Melitus Tipe 2 ]]>
<![CDATA[Dewi, Novia Ariani]]>;
<![CDATA[Titami, Arina]]>
<![CDATA[ Jurnal Farmasi SYIFA Vol 2 No 2 (2024): Jurnal Farmasi SYIFA ]]>
Publisher : <![CDATA[CV. Wadah Publikasi Cendekia ]]>
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DOI: 10.63004/jfs.v2i2.463
<![CDATA[Terapi kortikosteroid khususnya glukokortikoid merupakan terapi penting dalam pengobatan dan profilaksis berbagai inflamasi akut dan kronis serta gangguan autoimun. Penggunaan kortikosteroid dengan dosis tinggi dan secara jangka panjang dapat menimbulkan peningkatan glukosa darah pasien bahkan dapat menyebabkan munculnya penyakit diabetes, terutama pada individu yang sebelumnya mengalami resisten insulin atau obesitas. Peningkatan risiko diabetes ini terjadi karena adanya perubahan metabolisme karbohidrat, termasuk resistensi insulin dan penurunan ambilan glukosa perifer terkait dengan penggunaannya. Penelitian ini bertujuan untuk mengetahui pengaruh glukokortikoid terhadap glukosa darah pasien diabetes melitus tipe 2. Penelitian ini merupakan review artikel yang ditulis berdasarkan hasil meninjau beberapa artikel atau literatur terkait. Hasil dari review artikel ini diperoleh delapan artikel untuk selanjutnya dilakukan pembahasan mendalam pada masing-masing jurnal. Penggunaan glukokortikoid semakin luas dibutuhkan pada dunia kesehatan, namun penggunaan glukokortikoid dapat meningkatkan terjadinya hiperglikemia pada pasien. Mekanisme peningkatan glukosa darah akibat penggunaan glukokortikoid yaitu meningkatkan resistensi insulin pada pasien. Pasien dengan atau tanpa diabetes melitus tipe 2 sebelumnya ketika akan mendapatkan terapi kortikosteroid atau glukokortikoid hendaknya dilakukan pemeriksaan terlebih dahulu terkait risiko terjadinya efek samping obat yaitu peningkatan glukosa darah pasien.]]>
<![CDATA[Profil Penggunaan Obat Antihipertensi Pada Pasien Lanjut Usia Yang Dirawat Inap RS Akademik UGM ]]>
<![CDATA[Titami, Arina]]>;
<![CDATA[Wiedyaningsih, Chairun]]>;
<![CDATA[Pratama, I Dewa Putu]]>
<![CDATA[ Majalah Farmaseutik Vol 19, No 3 (2023) ]]>
Publisher : <![CDATA[Faculty of Pharmacy, Universitas Gadjah Mada ]]>
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DOI: 10.22146/farmaseutik.v19i3.78446
<![CDATA[Hypertension is a common disease that is simply defined as a persistent increase in arterial blood pressure. Elderly is correlated with increased blood pressure, which increases the risk of heart disease, stroke, and kidney disease. Intensive treatment of hypertension can significantly reduce the risk of heart and cerebral vascular disease, including target organ damage. This study is an observational study with a retrospective cohort design. The subjects in this study were elderly patients with a diagnosis of hypertension who were hospitalized at the Gadjah Mada University Academic Hospital (RSA UGM) Yogyakarta in the period January 1, 2021–December 31, 2021. The data in this study were sourced from the medical records of the UGM RSA. Data analysis was carried out descriptively to describe the profile of the use of antihypertensive drugs in elderly patients with a diagnosis of hypertension who were hospitalized. The number of patients in that period was found to be 534 patients and then 120 patients who met the inclusion criteria. The 60-69 years age group was the most patient group (71 patients). The proportion of women was more (73 patients) than men. The highest prevalence of comorbidities was diabetes as many as 29 patients. The highest prevalence of length of stay in hospital (LoS) is 1-5 days as many as 66 patients. In this study, the most common use of antihypertensive drugs in elderly patients with hypertension who were treated at UGM RSA was combination therapy (66 patients). Most patients used single therapy with calcium channel blocker (CCB) antihypertensive drugs, namely amlodipine as many as 24 patients and the most combination therapy was amlodipine and candesartan as many as 20 patients.]]>
<![CDATA[Evaluation of Percentage of Damaged Drugs at Gondomanan Primary Health Center in Yogyakarta ]]>
<![CDATA[Titami, Arina]]>;
<![CDATA[Andriani, Yuni]]>;
<![CDATA[Saputra, Doni]]>
<![CDATA[ Journal of health research and technology Vol. 3 No. 1 (2025): Journal of health research and techonology ]]>
Publisher : <![CDATA[Sahabat Publikasi Kuu ]]>
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DOI: 10.58439/jhrt.v3i1.266
<![CDATA[Background: The proper storage and distribution of drugs is very important to ensure the effects of drugs in the body and all drugs should be stored in the right storage place. Improper drug storage can cause damage to drugs that can endanger patients and health services themselves. Objective: This study aims to evaluate the drug storage process, specifically the percentage of damaged drugs, at the Gondomanan Primary Health Center in Yogyakarta. Method: The research was conducted using a descriptive observational approach with a cross-sectional design. Data were collected using a checklist referring to Peraturan Menteri Kesehatan Republik Indonesia Nomor 74 Tahun 2016 and Petunjuk Teknis Standar Pelayanan Kefarmasian di Puskesmas Tahun 2019. Result: The percentage of damaged drugs at the Gondomanan Primary Health Center in Yogyakarta is 0%. Conclusion: The percentage of damaged drugs at the Gondomanan Primary Health Center in Yogyakarta is by standards based on Peraturan Pemerintah Kesehatan Republik Indonesia Nomor 74 Tahun 2016 and Petunjuk Teknis Standar Pelayanan Kefarmasian di Puskesmas Tahun 2019.]]>
<![CDATA[Evaluasi Kesesuaian Fasilitas Penyimpanan Obat di Puskesmas Gondomanan Kota Yogyakarta ]]>
<![CDATA[Doni Saputra]]>;
<![CDATA[Arina Titami]]>;
<![CDATA[Yuni Andriani]]>
<![CDATA[ Antigen : Jurnal Kesehatan Masyarakat dan Ilmu Gizi Vol. 2 No. 3 (2024): Agustus : Antigen: Jurnal Kesehatan Masyarakat dan Ilmu Gizi ]]>
Publisher : <![CDATA[LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA ]]>
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DOI: 10.57213/antigen.v2i3.386
<![CDATA[Background: Drug storage regulates drugs received to be safe and free from physical or chemical damage, and their quality is guaranteed, per the established requirements. Improper drug storage in health centers can cause drug damage. Damaged drugs can hurt patients and health services themselves.Objective: To determine the suitability of drug storage facilities at the Puskesmas Gondomanan Kota Yogyakarta.Method: The research method used is descriptive non-experimental with a cross-sectional approach. The data needed in this study are observation data. Findings: The study results at Puskesmas Gondomanan Kota Yogyakarta showed that the drug storage facilities were 100% suitable. Conclusion: The suitability of drug storage facilities at the Puskesmas Gondomanan Kota Yogyakarta is by standards based on Permenkes RI Nomor 74 Tahun 2016 and Petunjuk Teknis Standar Pelayanan Kefarmasiaan di Puskesmas Tahun 2019.]]>
<![CDATA[Evaluasi Kesesuaian Obat Dengan Kartu Stok Di Puskesmas Gondomanan Kota Yogyakarta ]]>
<![CDATA[Titami, Arina]]>;
<![CDATA[Andriani, Yuni]]>;
<![CDATA[Saputra, Doni]]>
<![CDATA[ JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP) ]]>
Publisher : <![CDATA[Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA ]]>
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DOI: 10.30989/jop.v2i2, Special Edition.1465
<![CDATA[Background: The proper storage and distribution of drugs is very important to ensure the effects of drugs in the body and all drugs should be stored in the right storage place. Improper drug storage can cause damage to drugs that can endanger patients and health services themselves. Objective: This study aims to evaluate drug storage, specifically the accuracy of data on the number of drugs on the stock card, at the Gondomanan Primary Health Center in Yogyakarta. Method: The research was conducted using a descriptive observational approach with a cross-sectional design. Data were collected using a checklist referring to Peraturan Menteri Kesehatan Republik Indonesia Nomor 74 Tahun 2016 and Petunjuk Teknis Standar Pelayanan Kefarmasiaan di Puskesmas Tahun 2019. Result: The accuracy of data on the number of drugs on the stock card at the Gondomanan Primary Health Center in Yogyakarta is 100%. Conclusion: The accuracy of data on the number of drugs on the stock card at the Gondomanan Primary Health Center in Yogyakarta is by standards based on Peraturan Pemerintah Kesehatan Republik Indonesia Nomor 74 Tahun 2016 and Petunjuk Teknis Standar Pelayanan Kefarmasiaan di Puskesmas Tahun 2019.]]>
<![CDATA[Drug-Drug Interactions (DDIs) in Elderly Hypertensive Inpatients ]]>
<![CDATA[Titami, Arina]]>;
<![CDATA[Wiedyaningsih, Chairun]]>;
<![CDATA[Pramantara, I Dewa Putu]]>
<![CDATA[ JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 1 ]]>
Publisher : <![CDATA[Faculty of Pharmacy, Universitas Gadjah Mada ]]>
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DOI: 10.22146/jmpf.101799
<![CDATA[Background: The prevalence of hypertension is higher among the elderly population. Elderly patients are considered a high-risk population for Drug-Drug Interactions (DDIs) due to multi-morbidity-related polypharmacy, age-related physiological changes, as well as pharmacokinetic and pharmacodynamic changes.Objectives: This study conducted a drug use survey in the inpatient department of the Academic Hospital of Universitas Gadjah Mada Yogyakarta to assess Drug-drug interactions (DDIs) in individual prescriptions for elderly hypertensive patients.Methods: This research employs an observational study design with a retrospective cohort approach. This study was conducted at the Academic Hospital of Universitas Gadjah Mada Yogyakarta in January-December, 2021. The inclusion criteria for this study included patients diagnosed with hypertension, aged 60 years or older and those hospitalized. Ethical approval for this research was granted by the Faculty of Medicine, Public Health and Nursing Research Ethics Commission at Universitas Gadjah Mada, Yogyakarta under approval number KE-FK-0500-EC-2022.Results: 120 prescriptions from 120 patients were collected from the medical records maintained by the Academic Hospital of Universitas Gadjah Mada Yogyakarta. This study identified 66 cases of Drug-Drug Interactions (DDIs), mainly due to drug interactions comprising 8 interactions unrelated to hypertension, and 58 related to hypertension. Three actual drug interaction events resulted in increased blood pressure, while the others were potential drug interactions.Conclusion: From this study, it can be concluded that elderly patients are considered a natural high-risk population for DDIs. Each patient should be assessed individually based on their prescriptions, although in many cases, DDIs are unavoidable.Keywords: Drug-Drug Interactions; Elderly; Hypertension; Inpatients]]>
<![CDATA[The Relationship Between Oral Antidiabetic Treatment And Blood Sugar Level Among Type 2 Diabetes Mellitus Patients in Nur Hidayah Hospital Yogyakarta. ]]>
<![CDATA[Pujilestari, Mardiana]]>;
<![CDATA[Titami, Arina]]>;
<![CDATA[Sugiyono, Sugiyono]]>
<![CDATA[ Disease Prevention and Public Health Journal Vol. 19 No. 1 (2025): Disease Prevention and Public Health Journal ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/dpphj.v19i1.11948
<![CDATA[Background: Diabetes mellitus is a chronic disease that poses a global health threat, with type 2 diabetes mellitus accounts for 90% of all cases. In Indonesia, diabetes mellitus is among the causes of high mortality due to non-communicable diseases. If not treated properly, type 2 diabetes mellitus can lead to various complications, potentially worsening the patient's condition. To address this, blood glucose levels must be controlled through the use of oral antidiabetic medications, either as monotherapy or in combination therapy. This study aims to the accuracy of oral antidiabetic drugs use and its therapy outcomes (blood sugar levels) in type 2 diabetes mellitus patients at Nur Hidayah Hospital Yogyakarta. Method: This study is an observational study with retrospective data collection, carried out using the purposive sampling method. A total of 75 samples were obtained from 298 populations that met the specified criteria. Univariate data analysis methods are presented in the form of percentages and tables, including analyses of patient characteristics, treatment characteristics, and therapy outcomes. Subsequently, bivariate analysis was conducted using the chi-square test to determine the relationship between the accuracy of oral antidiabetic drugs use and therapy outcomes, specifically blood sugar levels of patients with type 2 diabetes mellitus. Results: The findings of the analysis performed using the chi-square test revealed a correlation between the accuracy of oral antidiabetic medication and blood sugar levels in patients (p-value=0.012). Conclusion: proper use of oral antidiabetics shows that the patient's blood sugar levels are controlled.]]>
<![CDATA[Education and Socialization of DAGUSIBU Programs for Chronic Diseases in Titang, Sumberagung, Bantul ]]>
<![CDATA[Syahyeri, Afrizal]]>;
<![CDATA[Titami, Arina]]>;
<![CDATA[Novela, Silvia Nadia]]>;
<![CDATA[Widane, Made]]>
<![CDATA[ The Journal of Innovation in Community Empowerment Vol 7 No 1 (2025): Journal of Innovation in Community Empowerment (JICE) ]]>
Publisher : <![CDATA[Universitas Jenderal Achmad Yani Yogyakarta ]]>
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DOI: 10.30989/jice.v7i1.1437
<![CDATA[Diabetes Mellitus (DM) merupakan salah satu kasus penyakit kronis dengan prevalensi terbesar di Daerah Istimewa Yogyakarta. Obat-obatan dan alat kesehatan sering digunakan oleh penderita DM maupun penyakit kronis lainnya. Tenaga kefarmasian berperan dalam meningkatkan kesehatan masyarakat melalui pengelolaan obat dengan program Dapatkan, Gunakan, Simpan dan Buang (DAGUSIBU). Tujuan kegiatan pengabdian masyarakat ini adalah untuk meningkatkan pengetahuan dan pemahaman masyarakat Padukuhan Titang, Sumberagung, Bantul tentang pengelolaan obat melalui edukasi dan sosialisasi program DAGUSIBU (Dapatkan, Gunakan, Simpan dan Buang) obat yang baik dan benar serta meningkatkan status kesehatan masyarakat melalui pemeriksaan kesehatan gratis yaitu glukosa darah dan pengukuran tekanan darah. Kegiatan pengabdian dilakukan dengan metode penyuluhan secara langsung sesuai dengan roadmap pengabdian dosen pada tahun 2024. Sasaran masyarakat pengabdian ini ditujukan pada masyarakat lanjut usia dan pralansia. Kegiatan pengabdian ini dimulai dengan sosialisasi edukasi DAGUSIBU dengan media leaflet dan powerpoint. Evaluasi pengabdian dilaksanakan berupa pretest dan posttest untuk mengukur pengetahuan masyarakat terkait materi DAGUSIBU yang sampaikan. Berdasarkan hasil analisis pemberian edukasi dan sosialisasi dapat meningkatkan pengetahuan masyarakat dari 40% menjadi 76% tentang Dapatkan, Gunakan, Simpan dan Buang (DAGUSIBU)]]>
