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All Journal INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Indonesian Journal of Pharmacy and Natural Product Jurnal Ilmiah Sultan Agung Indonesian Journal of Medical and Pharmaceutical Science Jurnal Kefarmasian Indonesia
Ningrum, Yuyun Darma Ayu
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Pengaruh Lama Fermentasi Terhadap Aktivitas Antioksidan Pada Variasi The Kombucha Dengan Metode ABTS (2,2 Azinobis (3-Ethylbenzotiazolin) 6 Sulphonic Acid) Lusiana, Aprie; Ningrum, Yuyun Darma Ayu; Putri, Chintiana Nindya
Jurnal Ilmiah Penelitian Mahasiswa Vol 3, No 2 (2024): Juni 2024
Publisher : Jurnal Ilmiah Sultan Agung

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Abstract

Flavonoid dan fenol merupakan senyawa antioksidan yang terdapat pada teh kombucha yang telah dikombinasikan dengan teh hitam maupun teh hijau. Namun, adanya senyawa tersebut dipengaruhi oleh lama fermentasi. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh lama fermentasi terhadap aktivitas antioksidan pada variasi teh kombucha dengan metode ABTS (2,2- Azinobis (3-Ethylbenzatiazolin) 6 Sulphonic Acid). Penelitian ini dilakukan secara experimental laboratory. Teh fermentasi kombucha didapat dengan memfermentasikan teh hijau maupun teh hitam dengan kultur kombucha selama 14 hari. Penetapan kadar flavonoid dilakukan dengan metode kolorimetri menggunakan AlCl3 dan fenolik dengan reagen Follin ciocalteau menggunakan spektrofotometri. Uji aktivitas antioksidan dilakukan pada hasil fermentasi teh kombucha 8 dan 14 hari menggunakan metode ABTS secara spektrofotometri UV-Vis pada panjang gelombang 743 nm. Teh kombucha dibuat lima seri konsentrasi 10, 30, 50, 70, dan 90 ppm. Hasil pengujian dianalisis untuk diperoleh nilai IC50, kemudian dianalisis statistik dengan SPPS menggunakan uji One Way Anova yang dilanjutkan dengan uji BNT untuk mengetahui adanya perbedaan yang signifikan antar sampel (p≤0.05). Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan antara pengaruh lama fermentasi dengan aktivitas antioksidan terhadap kombucha teh hijau maupun kombucha teh hitam pada hari ke-8 dan ke-14. Nilai IC50 (µg/mL) pada masing-masing sampel baik teh hitam maupun teh hijau pada hari ke-8 dan ke-14 secara berturut-turut yaitu 28.597; 137.872; 30.975; 40.083. Based on the results of the study, it was concluded that from green tea and black tea kombucha, the longer the fermentation, the flavonoid and phenol content increased, but the antioxidant activity decreased. Kata Kunci: Teh kombucha, Antioksidan, Lama Fermentasi, ABTS, IC50
Formulasi Sabun Padat Ekstrak Etanol Bunga Rosella (Hibiscus sabdariffa L.) dan Uji Stabilitas Fisik Ningrum, Yuyun Darma Ayu; Anggraeni, Nurtias Eka
Indonesian Journal of Pharmacy and Natural Product Vol. 5 No. 2 (2022)
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.452 KB) | DOI: 10.35473/ijpnp.v5i2.1613

Abstract

Soap is one of the cosmetic preparations used for skin care and cleansing, the use of rosella flower extract (Hibiscus sabdariffa L) as an antioxidant that functions as an antidote to free radicals. Based on this explanation, the purpose of this study was to determine the best formulation of solid soap preparations Rosella flower extract in terms of the result of physical stability test. Researchers conducted the formulation by comparing the amount of extract used to determine its effect on the physical stability test. The treatments in this study were rosella extract concentrations of 0% (formula F1), 1% (formula F2), 2% (formula F3), and 3% (formula F4). Observations were made on rosella extract solid soap including organoleptic test, pH test, high foam test, foam stability test, and water content test. The results of the analysis showed that Rosella extract solid soap had a pH, foam stability, and water content that were within the safe range. The results of making good rosella extract solid soap are found in F1 and F2, where the less rosella extract is used in making solid soap, the better the soap produced.ABSTRAKSabun merupakan salah satu sediaan kosmetik yang digunakan untuk perawatan dan pembersihan kulit, penggunaan Ekstrak bunga rosella (Hibiscus sabdariffa L) sebagai antioksidan yang berfungsi untuk penangkal radikal bebas. Berdasarkan pemaparan tersebut tujuan dari penelitian ini dilakukan untuk menentukan formulasi terbaik sediaan sabun padat Ekstrak bunga rosella ditinjau dari hasil uji stabilitas fisik. Peneliti melakukan formulasi dengan membandingkan banyaknya Ekstrak yang digunakan untuk mengetahui pengaruhnya terhadap uji stabilitas fisiknya. Perlakuan pada penelitian ini yaitu konsentrasi Ekstrak rosella 0% (formula F1), 1% (formula F2), 2% (formula F3), dan 3% (formula F4). Pengamatan yang dilakukan pada sabun padat Ekstrak rosella meliputi uji organoleptis, uji pH, uji tinggi busa, uji stabilitas busa, dan uji kadar air. Hasil analisis menunjukkan Sabun padat Ekstrak rosella memiliki pH, stabilitas busa, dan kadar air yang masuk dalam rentang aman. Hasil pembuatan sabun padat Ekstrak rosella yang baik yaitu terdapat pada F1 dan F2, dimana Semakin sedikit Ekstrak rosella digunakan pada pembuatan sabun padat maka akan semakin baik sabun yang di hasilkan.
Formulasi Sediaan Lip Balm Minyak Zaitun Halal dan Uji Kestabilan Fisik Ningrum, Yuyun Darma Ayu; Azzahra, Nurul Hidayah
Indonesian Journal of Pharmacy and Natural Product Vol. 5 No. 2 (2022)
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (583.207 KB) | DOI: 10.35473/ijpnp.v5i2.1652

Abstract

Lip Balm is a cosmetic preparation with the main components such as wax, fat and oil from natural or synthesized extracts with the aim of preventing dryness of the lips by increasing lip moisture and protecting the adverse effects of the environment on the lips. Based on the explanation above, the purpose of this study was to formulate lip balm preparations using olive oil and review the results of physical stability tests. Researchers made a modified formulation based on Simplex Lactis Design by using a combination of cera alba and cera flava as the basis of the formulation with a concentration of 16.25% cera alba and  8.75% cera flava. Observations were made on olive oil lip balm including pH test, homogeneity test, melting test of the preparation, adhesion test and stability test of the preparation. The results of the analysis showed that olive oil lip balm had a good pH value, homogeneity, melting preparation and adhesion, and was stable in the stability test. ABSTRAKLip Balm merupakan sediaan kosmetik dengan komponen utama seperti lilin, lemak dan minyak dari ekstrak alami atau yang disintesis dengan tujuan untuk mencegah terjadinya kekeringan pada bibir dengan meningkatkan kelembaban bibir dan melindungi pengaruh buruk lingkungan pada bibir. Berdasarkan pemaparan diatas tujuan dari penelitian ini dilakukan untuk memformulasikan sediaan lip balm dengan menggunakan minyak zaitun dan ditinjau hasil uji stabilitas fisiknya. Peneliti melakukan formulasi dengan modifikasi berdasarkan Simplex Lactis Design dengan menggunakan kombinasi cera alba dan cera flava sebagai basis formulasi dengan konsentrasi cera alba 16,25% dan cera flava 8,75% . Pengamatan yang dilakukan pada lip balm minyak zaitun meliputi uji pH, uji homogenitas, uji lebur sediaan, uji daya lekat dan uji stabilitas sediaan. Hasil analisis yang didapatkan menunjukan lip balm minyak zaitun memiliki nilai pH, Homogenitas, lebur sediaan dan daya lekat yang baik, serta stabil dalam uji stabilitas.
Tingkat Kualitas Pelayanan Kesehatan dalam Perspektif Islam dan Pengetahuan Pasien terhadap Penggunaan Antibiotik di RSI Sultan Agung Semarang Ningrum, Yuyun Darma Ayu; Purnami, Islina Dwi; Virgianti, Mita
Indonesian Journal of Medical and Pharmaceutical Science Vol. 3 No. 1 (2024)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v3i1.179

Abstract

Background: Hospital pharmacy services are a vital component of hospitals that contribute to the provision of high-quality healthcare. Infectious diseases are diseases caused by very dynamic pathogenic microbes, especially in developing countries. Therefore, antibiotics are drugs used for infections caused by bacteria. This research is aimed at determining the level of quality of health services from an Islamic perspective and patient knowledge about antibiotics. Methods: This type of research is quantitative research with descriptive methods. Meanwhile, the data collection technique used was using a questionnaire. Univariate analysis aims to explain or describe the characteristics of each research variable which generally only produces a frequency and percentage distribution of each variable. using a cross sectional descriptive method. Data is processed using the Statistical Product and Servicer Solution (SPSS) application. Results: The results of the research on the level of service quality according to the Islamic perspective for the five dimensions, namely Reliability as much as 64.4%, Responsiveness as much as 63.67%, Assurance as much as 36.67%, as much as 60.67% and Tangibles as much as 61.67% which falls into the sufficient category. , while the research results showed that the level of patient understanding regarding the use of antibiotics reached 56.43%, answering correctly, including in the correct category. Conclusion: There is a significant influence of knowledge regarding the level of health services and knowledge about the use of antibiotics, namely low.
Hubungan Religiusitas Dengan Kepatuhan Penggunaan Obat dan Kualitas Hidup Pasien Hipertensi di Rumah Sakit Islam Sultan Agung Ningrum, Yuyun Darma Ayu; Pratiwi, Agnes Febriyanti; Azzahroh, Nida Fauziyah
Indonesian Journal of Medical and Pharmaceutical Science Vol. 3 No. 1 (2024)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v3i1.180

Abstract

Background: High blood pressure is a non-communicable disease but is called an unnoticeable killer or silent killer. Because the symptoms aren't veritably pronounced, but complications of high blood pressure can beget death and the prevalence of this complaint is adding every time. Someone who suffers from high blood pressure should always take drug regularly so that their blood pressure can be controlled and they can live a good life. Religiusity is the state in which a person behaves and is encouraged to bear in relation to religion. Religion can be used to reduce stress and depression which can lead to high blood pressure. Thus, this experimenters are interested in understanding the relationship between religiusity and drug compliance and quality of life in hypertensive cases at Sultan Agung Islamic Hospital. Methods: The research design used is quantitative correlational research with a cross-sectional approach. The number of samples in this study was 100. Results: The results of the study showed that there was a strong relationship between religiusity and the patients quality of life with p-value = 000 and r-value = 0.690 and there was a strong relationship between adherence to taking medication and the patients quality of life with p-value = 000 and r-value = 0.690. value = 0.552, but the relationship between adherence to taking medication and religiusity has a sufficient relationship with p-value = 000 and r-value = sufficient correlation. 0360. Conclusion: there was a strong relationship between religiusity and the patients quality of life, and between adherence to taking medication and the patients quality of life, but the relationship between adherence to taking medication and religiusity has a sufficient relationship.
Pelatihan dan Praktek Pembuatan Bar Soap di Kecamatan Gajah Mungkur Semarang Ningrum, Yuyun Darma Ayu; Buana Januarti , Ika
Jurnal Dimas Vol 4 No 2 (2022): Jurnal Pengabdian Kepada Masyarakat
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/dimas.v4i2.44

Abstract

Sabun merupakan bahan pembersih kulit yang mengandung natrium dan asam lemak. Prinsip pembuatan dengan menggunakan proses pelelehan. Bahan-bahan yang dipakai berbentuk cair dan dicampurkan dengan menggunakan kecepatan stabil. Pengabdian masyarakat dilakukan dengan cara memberikan praktek secara langsung kepada peserta dilanjutkan d ngan pembagian kuisioner pemahaman. Hasil pengabdian masyarakat didapatkan pemahaman peserta dalam pembuatan sabun sehingga dapat dijadikan pilihan untuk mengembangkan potensi entrepreneur.
Optimization, Characterization, and Primary Irritation Test of Serum Based on Simplex Lattice Design Widyaningrum, Naniek; Arief, Thendi Abdul; Ningrum, Yuyun Darma Ayu
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Using ingredients in cosmetic serum formulation necessitates meticulous consideration to mitigate potential pharmaceutical and clinical issues, and guarantee their safety for application. Xanthan gum functions as a gelling agent, while sodium metabisulfite is an additional antioxidant capable of enhancing formulation viscosity. This research aimed to ascertain the optimal formula's physical characteristics, stability, and irritation potential. The optimal formula was derived through the utilization of the Simple Lattice Design. Physical characterization encompassed parameters such as pH, viscosity, organoleptic properties, adhesion, spreadability, and homogeneity. Stability testing involved a cycling test performed over 24 hours for six cycles under cold and hot temperatures. Subsequently, an analysis was conducted using the paired t-test. In-vitro primary irritation testing was carried out using rabbits and volunteers. The optimal formula was identified to consist of 0.66% xanthan gum and 0.34% sodium metabisulfite, exhibiting favorable physical quality and meeting the requisite standards. The stability testing results revealed that sig. values <0.05 indicated storage temperature's influence on viscosity enhancement while it did not influence pH with sig. values <0.08. The outcomes of the primary irritation test yielded values of 0, signifying the absence of erythema and edema in both rabbits and volunteers. In conclusion, the optimal formula derived from this study exhibits commendable characteristics, stability, and non-irritating attributes, rendering it safe for application.
Formulasi dan Uji Karakteristik Fisik Sediaan Sampo Ekstrak Air Kelapa Menggunakan Metode Freeze Drying Ningrum, Yuyun Darma Ayu; Roffada, Rizal -; Lara, Savara Purnama
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol. 7 No. 1 (2023)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v7i1.3188

Abstract

Sampo adalah sediaan berbentuk semi cair mengandung surfaktan yang berguna menghilangkan kotoran dan lemak pada kulit kepala. Air kelapa merupakan salah satu bahan alam yang kaya dengan vitamin C sebagai antioksidan, memiliki manfaat menjaga kesehatan kulit kepala, sehingga dapat digunakan sebagai zat aktif sediaan sampo. Air kelapa diekstraksi menggunakan metode Freeze drying. Selain bahan aktif, sampo memiliki bahan kunci yaitu surfaktan. Surfaktan yang digunakan dalam penelitian ini adalah kombinasi Sodium lauril sulfat dan Cocamide DEA.  Tujuan dari penelitian ini adalah untuk memperoleh formulasi optimum dengan karakteristik sifat fisik yang baik dari sampo ekstrak freeze drying air kelapa. Penelitian ini merupakan penelitian eksperimen laboratorium. Optimasi formula menggunakan metode Simplex Lattice Design. Pendekatan membuat 8 formula. Seluruh formula dilakukan uji organoleptik uji tinggi busa, uji pH, dan uji stabilitas. Data yang diperoleh diolah dengan perangkat Design expert versi 13.  Menurut hasil evaluasi fisik sediaan sampo. Hasil uji organoleptik berwarna putih, bau mentol, bentuk semi cair. Hasil uji pH 6,2, tinggi busa 7,9 cm Formula optimal sampo terdiri dari 0,2% ekstrak freeze drying air kelapa, 0% Natirum lauril sulfat, 1% Cocamide DEA, 3% CMC, 0,5% asam sitrat, 0,5% metil paraben, 0,15% mentol, dan aquadest. Sediaan ini memiliki sifat fisik yangmemenuhi persyaratan sediaan sampo yang baik. 
Co-Authors Anggraeni, Nurtias Eka Arief, Thendi Abdul Azzahra, Nurul Hidayah Azzahroh, Nida Fauziyah Buana Januarti , Ika Lara, Savara Purnama Lusiana, Aprie Naniek Widyaningrum Pratiwi, Agnes Febriyanti Purnami, Islina Dwi Putri, Chintiana Nindya Roffada, Rizal - Virgianti, Mita