Garuda - Garba Rujukan Digital

The Dynamics of NS1 Antigen and Platelet Levels in the Acute Phase of Dengue Hemorrhagic Fever Ismawatie, Emma; Ilyas Syafiq Darul Ridzuan; Yulia Ratna Dewi; Sunarti
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.149

Introduction: Dengue hemorrhagic fever (DHF) is a significant global health concern, particularly in tropical and subtropical regions. The early diagnosis and effective management of DHF are crucial to reduce morbidity and mortality. The NS1 antigen and platelet count are two key laboratory parameters used in the diagnosis and monitoring of DHF. This study aimed to investigate the dynamics of NS1 antigen and platelet levels during the acute phase of DHF and their correlation with disease severity. Methods: A prospective cohort study was conducted at a tertiary care hospital in Central Java, Indonesia. Patients presenting with suspected DHF were enrolled and followed up during their hospitalization. Blood samples were collected at admission and at regular intervals to measure NS1 antigen levels and platelet counts. Clinical and laboratory data were collected to assess disease severity. Results: A total of 150 patients were included in the study. The majority of patients were adults (median age, 32 years) with a female predominance (58%). The median duration of fever at presentation was 4 days. NS1 antigen levels were significantly higher in patients with DHF compared to those with dengue fever (DF) (p < 0.001). Platelet counts were significantly lower in patients with DHF compared to those with DF (p < 0.001). NS1 antigen levels showed a negative correlation with platelet counts (r = -0.62, p < 0.001). The levels of NS1 antigen and platelet count were also significantly associated with disease severity. Conclusion: The dynamics of NS1 antigen and platelet levels during the acute phase of DHF provide valuable insights into disease pathogenesis and can aid in the early diagnosis and prediction of disease severity. The negative correlation between NS1 antigen and platelet levels suggests a potential role of NS1 in the development of thrombocytopenia in DHF. Further studies are needed to elucidate the exact mechanisms underlying these observations.

Diabetes Mellitus, Blood Sugar Levels, Healthy Lifestyle Putri, Arum Kusuma; Emma Ismawatie; Yulia Ratna Dewi; Laela Siti Musrikatun
JURNAL PENGABDIAN KESEHATAN Vol. 3 No. 2 (2025): MEI
Publisher : Gayaku Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58222/jupengkes.v3i2.1336

Diabetes Mellitus (DM) is non-communicable diseases (NCDs) that is a problem in the world. DM is a chronic metabolic disorder characterized by high-blood sugar levels. Support a healthy lifestyle with Early detection of DM and checking the current blood sugar (GDS). Uncontrolled GDS levels will cause complications in the body's organs. The method used is socialization with lecturer and discussion as well as checking the current blood sugar (GDS) at Balai RW 3 Dukuh, Ngemplak. The number of participants in this community service was attended by 11 participants. The results of this service 82% normal, 18% upnormal and average of 148.36 mg/dL (normal GDS, <200mg/dL). The result if education on management of DM, the community was anthusiastic and able to answer several questions during the discussion session.

Gerakan Cegah Diabetes: Pemeriksaan Gula Darah dan Sosialisasi Pola Hidup Sehat Putri, Arum Kusuma; Emma Ismawatie; Yulia Ratna Dewi; Laela Siti Musrikatun
JURNAL PENGABDIAN KESEHATAN Vol. 4 No. 1 (2025): NOVEMBER
Publisher : Gayaku Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58222/jupengkes.v4i1.1372

Diabetes Mellitus (DM) is non-communicable diseases (NCDs) that is a problem in the world. DM is a chronic metabolic disorder characterized by high-blood sugar levels. Support a healthy lifestyle with Early detection of DM and checking the current blood sugar (GDS). Uncontrolled GDS levels will cause complications in the body's organs. The method used is socialization with lecturer and discussion as well as checking the current blood sugar (GDS) at Balai RW 3 Dukuh, Ngemplak. The number of participants in this community service was attended by 11 participants. The results of this service 82% normal, 18% upnormal and average of 148.36 mg/dL (normal GDS, <200mg/dL). The result if education on management of DM, the community was anthusiastic and able to answer several questions during the discussion session.

EFFECT OF EDTA AND 3.8% SODIUM CITRATE ON BLOOD SEDIMENTATION RATE BY WESTERGREN METHOD WITH 0.86% NACL Rahmayani Agustin Nanda Kusuma; Emma Ismawatie; Yulia Ratna Dewi
Medical Journal of Nusantara Vol. 4 No. 3 (2025): Medical Journal of Nusantara (MJN)
Publisher : Tahta Media Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55080/mjn.v4i3.1685

Background: The erythrocyte sedimentation rate (ESR) is a hematological test used to detect inflammatory processes and blood disorders. ESR values can be influenced by the type of anticoagulant used. Objective: To compare ESR values in venous blood samples using EDTA and 3.8% sodium citrate anticoagulants with the Westergren method modified by the addition of 0.86% NaCl. Methods: This study employed an observational analytical approach with a cross-sectional design, conducted at the Clinical Pathology Laboratory of Politeknik Indonusa Surakarta. A total of 32 venous blood samples were examined using both anticoagulants. Data were analyzed statistically using the Mann–Whitney test. Results: The mean ESR value in samples with EDTA anticoagulant was 18.3 mm/h, while that in samples with 3.8% sodium citrate was 13.1 mm/h. Statistical analysis yielded a p-value of 0.014 (p < 0.05), indicating a significant difference between the two groups. This difference may be attributed to the chemical properties and osmolarity of each anticoagulant, which affect erythrocyte rouleaux formation. Conclusions: The type of anticoagulant significantly affects ESR results. 3.8% sodium citrate remains the preferred anticoagulant for the Westergren method according to standard protocols, without the addition of 0.86% NaCl dilution

INTENSITY OF SECONDHAND SMOKE EXPOSURE IS ASSOCIATED WITH SUBCLINICAL ELEVATION OF SERUM ALT LEVELS IN HEALTHY YOUNG ADULTS Kurnia, Dimas Ardi; Yulia Ratna Dewi; Yulita Maulani
Medical Journal of Nusantara Vol. 4 No. 2 (2025): Medical Journal of Nusantara (MJN)
Publisher : Tahta Media Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55080/mjn.v4i2.1784

Background: Secondhand smoke exposure contains various toxic compounds that may affect liver function even in young, apparently healthy individuals. Evidence regarding the impact of exposure intensity on liver enzyme activity remains limited. Objective: This study aimed to analyze the association between secondhand smoke exposure intensity and serum alanine aminotransferase (ALT/SGPT) levels among university students. Methods: A cross-sectional study was conducted among 99 university students selected using purposive sampling. Exposure intensity was quantified using a structured questionnaire based on frequency and duration of exposure. Serum ALT levels were measured using an enzymatic method with an automated chemistry analyzer. Data were analyzed using Spearman’s correlation test. Results: A significant positive correlation was observed between secondhand smoke exposure intensity and serum ALT levels (r = 0.293, p = 0.003). Although most ALT values remained within normal reference ranges, higher exposure intensity was associated with a gradual increase in ALT levels. Conclusion: Increased intensity of secondhand smoke exposure is associated with subclinical elevation of serum ALT levels in healthy young adults. These findings highlight the importance of minimizing passive smoke exposure even in non-smoking populations.

Title

Found 5 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 5 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 5 Documents
Search