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All Journal Jurnal Pengabdian Kesehatan Sriwijaya Journal of Internal Medicine (MJN)
Yulia Ratna Dewi
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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EFFECT OF EDTA AND 3.8% SODIUM CITRATE ON BLOOD SEDIMENTATION RATE BY WESTERGREN METHOD WITH 0.86% NACL Rahmayani Agustin Nanda Kusuma; Emma Ismawatie; Yulia Ratna Dewi
Medical Journal of Nusantara Vol. 4 No. 3 (2025): Medical Journal of Nusantara (MJN)
Publisher : Tahta Media Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55080/mjn.v4i3.1685

Abstract

Background: The erythrocyte sedimentation rate (ESR) is a hematological test used to detect inflammatory processes and blood disorders. ESR values can be influenced by the type of anticoagulant used. Objective: To compare ESR values in venous blood samples using EDTA and 3.8% sodium citrate anticoagulants with the Westergren method modified by the addition of 0.86% NaCl. Methods: This study employed an observational analytical approach with a cross-sectional design, conducted at the Clinical Pathology Laboratory of Politeknik Indonusa Surakarta. A total of 32 venous blood samples were examined using both anticoagulants. Data were analyzed statistically using the Mann–Whitney test. Results: The mean ESR value in samples with EDTA anticoagulant was 18.3 mm/h, while that in samples with 3.8% sodium citrate was 13.1 mm/h. Statistical analysis yielded a p-value of 0.014 (p < 0.05), indicating a significant difference between the two groups. This difference may be attributed to the chemical properties and osmolarity of each anticoagulant, which affect erythrocyte rouleaux formation. Conclusions: The type of anticoagulant significantly affects ESR results. 3.8% sodium citrate remains the preferred anticoagulant for the Westergren method according to standard protocols, without the addition of 0.86% NaCl dilution
INTENSITY OF SECONDHAND SMOKE EXPOSURE IS ASSOCIATED WITH SUBCLINICAL ELEVATION OF SERUM ALT LEVELS IN HEALTHY YOUNG ADULTS Kurnia, Dimas Ardi; Yulia Ratna Dewi; Yulita Maulani
Medical Journal of Nusantara Vol. 4 No. 2 (2025): Medical Journal of Nusantara (MJN)
Publisher : Tahta Media Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55080/mjn.v4i2.1784

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Background: Secondhand smoke exposure contains various toxic compounds that may affect liver function even in young, apparently healthy individuals. Evidence regarding the impact of exposure intensity on liver enzyme activity remains limited. Objective: This study aimed to analyze the association between secondhand smoke exposure intensity and serum alanine aminotransferase (ALT/SGPT) levels among university students. Methods: A cross-sectional study was conducted among 99 university students selected using purposive sampling. Exposure intensity was quantified using a structured questionnaire based on frequency and duration of exposure. Serum ALT levels were measured using an enzymatic method with an automated chemistry analyzer. Data were analyzed using Spearman’s correlation test. Results: A significant positive correlation was observed between secondhand smoke exposure intensity and serum ALT levels (r = 0.293, p = 0.003). Although most ALT values remained within normal reference ranges, higher exposure intensity was associated with a gradual increase in ALT levels. Conclusion: Increased intensity of secondhand smoke exposure is associated with subclinical elevation of serum ALT levels in healthy young adults. These findings highlight the importance of minimizing passive smoke exposure even in non-smoking populations.
MICROBIOLOGICAL CHARACTERISTICS AND ANTIMICROBIAL RESISTANCE IN DIABETIC FOOT ULCERS Yulia Ratna Dewi; Arum Kusuma Putri; Mutia Azahra
Medical Journal of Nusantara Vol. 5 No. 1 (2026): Medical Journal of Nusantara (MJN)
Publisher : Tahta Media Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55080/mjn.v5i1.1950

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Background: Diabetic foot ulcers (DFUs) are among the most severe complications of diabetes mellitus, contributing significantly to morbidity, prolonged hospitalization, and lower-extremity amputations. Infection plays a critical role in the progression of DFUs, with diverse bacterial involvement and increasing antimicrobial resistance posing major challenges to effective treatment. Objective: This study aimed to review and synthesize current evidence on bacterial identification and antimicrobial resistance patterns in diabetic foot ulcers. Methods: A semi-systematic literature review was conducted using electronic databases, including PubMed, Scopus, ScienceDirect, and Google Scholar. The study selection followed PRISMA guidelines. A total of 130 articles were initially identified, of which 30 studies met the inclusion criteria after screening and eligibility assessment. Data were extracted and analyzed using a qualitative descriptive approach with narrative synthesis. Results: The findings revealed that diabetic foot infections are predominantly polymicrobial, with a higher prevalence of Gram-negative bacteria compared to Gram-positive organisms. The most frequently identified pathogens included Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. A significant proportion of isolates exhibited resistance to commonly used antibiotics, particularly penicillin, amoxicillin, and trimethoprim-sulfamethoxazole. Gram-negative bacteria demonstrated more complex resistance mechanisms, including extended-spectrum beta-lactamase (ESBL) and carbapenemase production. Multidrug-resistant (MDR) organisms were commonly reported, further complicating treatment strategies. Conclusion: Diabetic foot infections represent complex polymicrobial conditions with a predominance of Gram-negative bacteria and a growing burden of antimicrobial resistance. Accurate bacterial identification and antibiotic susceptibility testing are essential to guide targeted therapy and improve clinical outcomes. Continuous surveillance and rational antibiotic use are necessary to prevent the further spread of resistant pathogens.
Co-Authors Arum Kusuma Putri Emma Ismawatie Ilyas Syafiq Darul Ridzuan Ismawatie, Emma Kurnia, Dimas Ardi Laela Siti Musrikatun Mutia Azahra Putri, Arum Kusuma Rahmayani Agustin Nanda Kusuma Sunarti Yulita Maulani