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All Journal Arif: Jurnal Sastra dan Kearifan Lokal Junior Medical Journal
Ulviena, Lulu
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Religion Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences

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The Effect of Honey Fermentation on the Cell Appearance in the Seminiferous Tubule Wall of Rats Induced by Cisplatin Ulviena, Lulu; Hadi, Restu Syamsul
Junior Medical Journal Vol. 2 No. 2 (2023): Oktober 2023
Publisher : Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v2i2.3917

Abstract

Background: Cisplatin is the most effective cancer treatment used in chemotherapy. Cisplatin works by inducing oxidative stress, but it also has toxic side effects on healthy cells in the male reproductive organs. Therefore, there is a need for a solution to reduce the side effects of cisplatin. Honey fermentation is a natural substance that can reduce the toxicity of cisplatin. Honey is known as “The food of God” which is a gift of sustenance from Allah SWT due to its extraordinary benefits. Methodology: This study utilized primary data with an experimental posttest-only control group design conducted in vivo. The research involved four experimental groups of rats: a control group without any treatment, a cisplatin group, a 5% honey fermentation group exposed to cisplatin, and a 10% honey fermentation group exposed to cisplatin. All rats were weighed before, during, and after the treatment. Subsequently, HE staining was performed for both descriptive and quantitative observations. Results: Honey fermentation can provide a protective effect on primary spermatocytes and Leydig interstitial cells, almost reaching normal levels. The highest improvement was observed in the 5% honey fermentation group for primary spermatocytes and the 10% group for Leydig interstitial cells. Conclusion: Honey fermentation administration can be protective for testicular organ cells against the side effects of cisplatin. From an Islamic perspective, Allah has created honey for consumption, as mentioned in Surah An-Nahl.
Terapi Budaya: Putus Pengobatan pada Skizofrenia Paranoid Ulviena, Lulu; Frijanto, Agung; Agustina, Citra Fitri
Arif: Jurnal Sastra dan Kearifan Lokal Vol. 5 No. 2 (2026): Arif: Jurnal Sastra dan Kearifan Lokal
Publisher : Fakultas Bahasa dan Seni

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/Arif.052.10

Abstract

Skizofrenia merupakan gangguan jiwa kronis dengan gejala positif, negatif, dan kognitif, dengan tipe paranoid paling sering dijumpai. Kekambuhan dialami sekitar 80% pasien, terutama akibat penghentian obat. Dilaporkan kasus pria 25 tahun dengan riwayat skizofrenia paranoid yang mengalami kekambuhan setelah 1 tahun putus obat. Gejala berupa halusinasi auditorik-visual, waham kejar dan pengendalian, perubahan perilaku, serta peniruan tokoh. Diagnosis ditegakkan sebagai F20.0 Skizofrenia Paranoid dengan GAF 51–60. Terapi diberikan risperidone 3 mg dua kali sehari serta edukasi kepatuhan. Diskusi menekankan bahwa kekambuhan umumnya dipicu putus obat, sehingga kepatuhan merupakan faktor kunci dalam pencegahan relaps. Optimalisasi terapi memerlukan kombinasi antipsikotik, intervensi psikososial, dan dukungan keluarga. Kasus ini menegaskan pentingnya terapi jangka panjang dan edukasi berkelanjutan untuk mempertahankan perbaikan gejala serta kualitas hidup pasien. Selain itu, terapi memerlukan keterlibatan keluarga, masyarakat, dan lingkungan budaya.
Co-Authors Citra Fitri Agustina, Citra Fitri Frijanto, Agung Restu Syamsul Hadi