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All Journal JMM (Jurnal Masyarakat Mandiri) Jurnal Kreativitas PKM PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang
Amalia, Thia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Anti-Aging Potential and Quercetin Determination of Melastoma malabathricum L. Leaves Extract Amalia, Thia
Pharmaceutical Journal of Indonesia Vol. 10 No. 1 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.010.01.6

Abstract

Background: Melastoma malabathricum L. is a wild shrub that traditionally used in South-East Asia as wound healing. Plant extracts contain phenolic, flavonoid and tannin. The leaves extract also has many pharmacological activity but the anti-aging activity of the leaves extract has not been studied. Methods: The leaves of M. malabathricum was defatted with chloroform and then refluxed by ethanol. Quercetin content of the leaves extract was determined by HPLC. Anti-aging activity was evaluated by anti-elastase, and anti collagenase inhibitor activity of the leaves extract by a fluorometric method. Results: Percentage yield of the M. malabathricum leaves extract was 16.53% w/w. Quercetin content of the leaves extract was 9.20 mg/g extract. The leaves extract of M. malabathricum L. has anti-elastase and anti collagenase activity with IC50 80.39±2.36 ppm and 63.3±3.32 ppm, respectively. Conclusions: M. Malabathricum leaves extract was potential as an anti-aging cosmetic raw material.
Co-Authors Abda Abda ANISYAH ACHMAD Ayuk Lawuningtyas Hariadini Azis, Umar Abdul Azzahra, Sarrah Syifa Destrity, Nia Ashton Fatkhiya, Norma Inayatul Fauzan, Evan Firdaus, Favian Rafif Fitriani, Annisa Nur Hadiwasito, Agustina Dwi Ilmi Maitri, Ni Made Ajeng Gayatri Paramitha Maya Diah Nirwana Mukaromah, Faizatul Nabilah, Varna Amalia Nurrahmah, Queen Intan Prameswari, Putri Indrasti Sutiyono, Bershiella Amandari Tamara Gusti Ebtavanny Wibowo, Andriani Abigail Widarson, Widarson