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All Journal Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biological Pharmacy
Putri, Refitha Nurul
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology

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Effect of Combination Herbal Plants Extracts on Diabetes Mellitus Semesta, Cleopatra Diva; Putri, Refitha Nurul; Hadisaputri, Yuni Elsa
Indonesian Journal of Biological Pharmacy Vol 3, No 3 (2023): IJBP (Desember)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v3i3.47737

Abstract

Diabetes is a non-communicable disease with metabolic dysfunction characterized by high glucose levels due to damage to pancreatic β cells so that insulin cannot be secreted normally by the body. Diabetes mellitus cannot be cured, but it can only be controlled with appropriate treatment. Most of the available synthetic antidiabetic treatments have serious side effects and are quite expensive. Therefore, traditional herbal medicine is an alternative which is used for some people in maintaining normal blood sugar levels. The use of herbal therapy with a combination of plant extracts has the potential to be more effective in lowering blood sugar when compared to single plant extracts. The aim of this article review is that to compile and provide a scientific overview of the various studies which have been conducted previously regarding the effectiveness of combinations of herbal plant extracts in diabetes mellitus. A comprehensive literature study was conducted by using various electronic search databases with the keyword “Combination of antidiabetic extracts” and 30 international research journals which were combined into review articles were obtained which shows that combinations of plant extracts proved to be more effective in lowering blood glucose levels compared to single herbal plant extracts.
Hypoglycaemic Properties of The Combination of Roselle Calyx (Hibiscus sabdariffa Linn.) and Stevia Leaves (Stevia rebaudiana B.) in Alloxan-Induced White Rats Febriyanti, Raden Maya; Putri, Refitha Nurul; Diantini, Ajeng; Levita, Jutti
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.59646

Abstract

Roselle (Hibiscus sabdariffa L.) and stevia (Stevia rebaudiana Bertoni) are known to contain phenolic compounds and flavonoids that act as antioxidants and are beneficial in lowering blood sugar levels. This study aimed to determine the phytochemical content and evaluate the hypoglycemic effects of a combined aqueous extract of H. sabdariffa and S. rebaudiana in a 3:1 ratio on diabetic rats. Aqueous extracts were prepared and analyzed for total phenolic and flavonoid contents using the Folin-Ciocalteu and aluminum chloride methods. Diabetes was induced in male Wistar rats by intraperitoneal injection of alloxan (235 mg/kgBW). Rats in the test groups received 500 or 1000 mg/kgBW of the combination, with blood glucose levels measured on the 0th, 7th, and 14th days post-treatment using a glucometer. H. sabdariffa, S. rebaudiana, and their combination contained total phenolic contents of 102.75, 188.053, and 118.856 mgGAE/g, respectively, and flavonoid contents of 3.099, 6.987, and 4.791 mgQE/g, subsequently. Administration of the combination extract at 1000 mg/kgBW showed the highest hypoglycemic effect, reducing blood glucose levels by 35.98% on the 14th day compared to the negative control (p<0.05). The combination of H. sabdariffa and S. rebaudiana extracts demonstrates significant hypoglycemic activity, attributed to their phenolic and flavonoid content.
A Review of the Impact of Stevia Leaf (Stevia rebaudiana Bert.) as a Sweetener in Blood Glucose in Alloxan-Induced Rats Putri, Refitha Nurul; Husni, Patihul
Indonesian Journal of Biological Pharmacy Vol 4, No 2 (2024): IJBP (Agustus)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

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Abstract

Diabetes mellitus (DM) is a chronic condition characterized by elevated blood glucose levels due to insulin-related deficiencies and is often referred to as “The Silent Killer”. Medicinal plants have been widely explored as alternative therapies for managing DM. Among these, Stevia rebaudiana Bert. has garnered significant attention for its potent antidiabetic properties. Known as a natural sweetener 200–300 times sweeter than sucrose, Stevia boasts a zero glycemic index, making it particularly suitable for individuals with diabetes. This review aims to evaluate the antihyperglycemic potential of Stevia rebaudiana Bert. as an alternative to conventional therapies. A systematic review was conducted by acquiring data from scientific databases such as Semantic Scholar, PubMed, Scopus, OpenAlex, Crossref, and ScienceDirect, focusing on literature published between 2020–2024. Studies on diabetic rat models induced with alloxan were analyzed, with doses ranging from 20–1000 mg/kgBW and optimal doses identified between 120–150 mg/kgBW. The results demonstrated that Stevia significantly reduced blood glucose levels in diabetic rats and sustained hyperglycemia, effectively modeling type 1 diabetes. The bioactive constituents, including phenolics, alkaloids, glycosides, steviosides, flavonoids, and tannins, were identified as key contributors to its antihyperglycemic activity. In conclusion, Stevia rebaudiana Bert. exhibits promising efficacy as a natural antidiabetic agent. Its ability to reduce blood glucose levels and its zero glycemic index position it as a viable alternative to conventional antihyperglycemic therapies, especially for managing type 1 DM.
Co-Authors Ajeng Diantini, Ajeng Jutti Levita Patihul Husni Raden Maya Febriyanti Semesta, Cleopatra Diva Yuni Elsa Hadisaputri