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All Journal Heca Journal of Applied Sciences Indonesian Journal of Case Reports Grimsa Journal of Science Engineering and Technology
Adev, Sarra Mutiara
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Engineering Health Professions Medicine & Pharmacology Neuroscience Physics Public Health

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Journal : Grimsa Journal of Science Engineering and Technology

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Hippobroma longiflora L Leaves as a Natural Inhibitor of Cataract Progression: A Comprehensive Study Integrating Ethanol Extract, HPLC, and Molecular Docking Approaches Imelda, Eva; Fitria, Ulfa; Mutia, Ulmiza Putri; Syahrul, Syahrul; Sari, Masitha Dewi; Adev, Sarra Mutiara; Adev, Alya Mutiara; Zakiaturrahmi, Zakiaturrahmi; Toshniwal, Navneet Shamsundar
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.10

Abstract

Cataract remains the highest preventable cause of blindness in the world. The H. longiflora plant (Hippobroma longiflora L) is a plant that has empirically been widely used to treat a variety of eye diseases including cataract. This plant has high antioxidant activity due to its high phenolic and flavonoid content. The H. longiflora plant was extracted using an ethanol solvent and its compound content was analyzed using GCMS and phytochemistry analysis. The extracts obtained were tested with TPC, TFC, antioxidants and quercetine compound with HPLC. From phytochemical and GCMS analysis, it was found that triterpenoid compounds were not found in the sample, and the compound 1-Isobutyl-2,5-dimethyl-4-phenyl-piperidin-4-ol was the most abundant (37.77%), as well as 4-Penten-1-ol, 5-phenyl-3-pperidino (1,30%) were the least abundant in the ethanol extract of the H. longiflora leaves extract. The total phenolic, flavonoid and HPLC results of quercetin were 139.21 mg GAE/g; 11.48 mg QE/G and 0.009 mg/G. Meanwhile, in an antioxidant activity test, it was found that the ethanol extract of the H. longiflora leaves has very strong antioxidants. This finding revealed the potential of ethanol extracts of H. longiflora leaves as a cataract inhibitor through its process as an antioxidant.
Managing the Maze: Advanced Approaches to Pediatric Cataract Complications Imelda, Eva; Jannah, Siti Rain; Adev, Sarra Mutiara; Toshniwal, Nikhil
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 1 (2025): April 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i1.80

Abstract

Complicated cataract is a condition characterized by opacification of the crystalline lens due to intraocular diseases, particularly inflammatory conditions and other abnormalities. It often affects younger age groups, leading to visual impairment that typically requires surgical intervention. A 3-year-old girl presented with complaints of white spots in both eyes for one week. Following a physical examination and ultrasonography, she was diagnosed with bilateral complicated cataracts. The patient was scheduled for procedures including synechiolysis and irrigation-aspiration. However, due to intraoperative complications, additional procedures were necessary. Postoperatively, the patient was treated with antibiotic and anti-inflammatory medications and underwent optical rehabilitation using spectacles. This case highlights the management of pediatric cataracts and the challenges involved, with particular focus on postoperative optical rehabilitation to prevent amblyopia. Prompt and appropriate treatment of cataracts in children is crucial to clear the visual axis and restore a clear retinal image, thereby preventing the development of amblyopia.
Co-Authors Adev, Alya Mutiara Annisa, Thyfa Fitria, Ulfa Imelda, Eva Jannah, Siti Rain Lathifah, Lakaeisya SY Lubis, Dara Amalia Mutia, Ulmiza Putri Nuzhatuddin, Fatimah Raudhatul Jannah Sari, Masitha Dewi Syahrul Syahrul Toshniwal, Navneet Shamsundar Toshniwal, Nikhil Zakiaturrahmi, Zakiaturrahmi