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All Journal Indonesian Journal of Case Reports Grimsa Journal of Science Engineering and Technology
Adev, Alya Mutiara
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Engineering Health Professions Medicine & Pharmacology Neuroscience Physics Public Health

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Hippobroma longiflora L Leaves as a Natural Inhibitor of Cataract Progression: A Comprehensive Study Integrating Ethanol Extract, HPLC, and Molecular Docking Approaches Imelda, Eva; Fitria, Ulfa; Mutia, Ulmiza Putri; Syahrul, Syahrul; Sari, Masitha Dewi; Adev, Sarra Mutiara; Adev, Alya Mutiara; Zakiaturrahmi, Zakiaturrahmi; Toshniwal, Navneet Shamsundar
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.10

Abstract

Cataract remains the highest preventable cause of blindness in the world. The H. longiflora plant (Hippobroma longiflora L) is a plant that has empirically been widely used to treat a variety of eye diseases including cataract. This plant has high antioxidant activity due to its high phenolic and flavonoid content. The H. longiflora plant was extracted using an ethanol solvent and its compound content was analyzed using GCMS and phytochemistry analysis. The extracts obtained were tested with TPC, TFC, antioxidants and quercetine compound with HPLC. From phytochemical and GCMS analysis, it was found that triterpenoid compounds were not found in the sample, and the compound 1-Isobutyl-2,5-dimethyl-4-phenyl-piperidin-4-ol was the most abundant (37.77%), as well as 4-Penten-1-ol, 5-phenyl-3-pperidino (1,30%) were the least abundant in the ethanol extract of the H. longiflora leaves extract. The total phenolic, flavonoid and HPLC results of quercetin were 139.21 mg GAE/g; 11.48 mg QE/G and 0.009 mg/G. Meanwhile, in an antioxidant activity test, it was found that the ethanol extract of the H. longiflora leaves has very strong antioxidants. This finding revealed the potential of ethanol extracts of H. longiflora leaves as a cataract inhibitor through its process as an antioxidant.
From Bright to Brightness: Mastering the Management of Bilateral Congenital Cataracts Imelda, Eva; Nuzhatuddin, Fatimah; Jannah, Siti Rain; Adev, Sarra Mutiara; Adev, Alya Mutiara; Toshniwal, Navneet Shamsundar
Indonesian Journal of Case Reports Vol. 1 No. 2 (2023): December 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v1i2.97

Abstract

Congenital cataract is the leading cause of vision loss in newborns and children, and it is caused by an opacity of the eye's lens that occurs at birth or within the first few months of life. Congenital cataracts may develop as unilateral or bilateral. Around 50% of cases of it are considered as idiopathic. A 4-month-old boy was brought by his parents to the Department of Pediatric Ophthalmology and Strabismus in RSUD dr. Zainoel Abidin Banda Aceh with a chief complaint of a white spot on the patient’s right eye. The spot had appeared since birth and became more visible when he was 2 months old. The patient's overall condition was good. Both eyes' visual acuity was blink reflex. The ocular pressure in both eyes was normal. An ophthalmologic examination revealed a fully clouded right eye lens and aphakia in the left eye. The patient had undergone cataract surgery on his left eye on September 6th, 2023. He was diagnosed with Congenital Cataract Oculus Dexter (OD) and Aphakia Oculus Sinister (OS) before surgery. The patient underwent right eye cataract surgery with aspiration irrigation (AI), Primary Posterior Capsulotomy (PPC), and Anterior Vitrectomy (AV) without Intraocular Lens (IOL) implantation within the next two weeks.  Following the surgery, the patient's visual function improved to fix and follow the object, the pupils looked round in both eyes, aphakia, and no membrane development. The patient was prescribed glasses for optical rehabilitation.
Strategies for Preserving Vision in Secondary Glaucoma Post Congenital Cataract Surgery Imelda, Eva; Gianty, Jauza Aqilla; Adev, Alya Mutiara; Toshniwal, Navneet Shamsundar
Indonesian Journal of Case Reports Vol. 1 No. 2 (2023): December 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v1i2.127

Abstract

Congenital cataract is an eye disorder in the form of impaired lens transparency due to cloudiness that appears at birth or immediately after birth. Post-congenital cataract surgery requires regular monitoring to prevent complications that can reduce visual function. Therefore, this case report aims to describe the incidence of secondary glaucoma in patients with aphakia after congenital cataract surgery with uncontrolled post-operative monitoring regularly. A 4-year-old boy patient was brought by his parents with complaints of reappearance of white spots in the left eye which had become increasingly widespread in the last 2-3 months. Complaints accompanied by a feeling of glare in bright places. The patient's parents said the patient could not focus on seeing objects around him. The patient had a history of congenital cataract surgery in both eyes 2 years ago and did not have routine follow-up after cataract surgery. Congenital cataract is a lens clouding that can occur unilaterally or bilaterally when the child is born or immediately after birth. If monitoring is not carried out routinely, the most common condition that occurs in aphakic after congenital cataract surgery is secondary glaucoma. Regular monitoring after congenital cataract surgery is necessary to achieve successful management and prevent complications.
Co-Authors Adev, Sarra Mutiara Fitria, Ulfa Gianty, Jauza Aqilla Imelda, Eva Jannah, Siti Rain Mutia, Ulmiza Putri Nuzhatuddin, Fatimah Sari, Masitha Dewi Syahrul Syahrul Toshniwal, Navneet Shamsundar Zakiaturrahmi, Zakiaturrahmi