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All Journal JURNAL KESEHATAN YAMASI MAKASSAR Journal of Pharmaceutical Science and Herbal Technology Jurnal Kesehatan Qamarul Huda
Suryanita
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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FORMULATION OF BRIGHTENING GEL WITH ETANOL EXTRACT OF RED PAWPAW LEAVES (Syzygium oleana) AS ANTIOXIDANT Suryanita; Alfiani Am, Fenni; Asri SR, Muhammad; junita, Nurfitria
Journal of Pharmaceutical Science and Herbal Technology Vol. 9 No. 1 (2024): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

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Excessive sun exposure can have a negative impack on the skin. One way that can be done to reduce this impact is to use sunscreen. This research aimed to determine whether the ethanol of red shoot leaves (Syzygium oleana) can be formulated into a gel preparation that is physically and chemically stable and to determine sunscreen activity based on the SPF value using the UV-VIS spectrophotometric method. The method in this research was laboratory experimental. Red shoot leaves were extracted by using the maceration method with a preparation formula designe in three concentration, namely Formula 1 (1%), Formula 2 (3%),and  Formula 3 (5%). Then a stability test was carried out by storing at temperatures of 40C and 400C. Evaluation of preparation qualityincludes organoleptic, homogeneity, pH, viscosity, and spreadability test. An SPF value test was also carried out. The research results that have been carried out show that the ethanol extract of red shoot leaves with concentration of 1% 3% and 5% formulated in gel form produces a stable preparation and meets the quality requirements of the preparation. The SPF value from formula 1 is 2,508349 (minimal protection), formula 2 3,380475 (minimal protection) and formula 3 2,679704 (minimal protection).
THE FORMULATION OF CREAM PREPARATIONS BLUSH ON OF ETANOL EXTRACT FROM MIANA PURPLE LEAVES (Coleus scutellarioides L.) AS BLUSHER Suryanita; Fitrahmia S, Nur; Auliah, Nielma; Bachri, Nurjannah
Journal of Pharmaceutical Science and Herbal Technology Vol. 9 No. 1 (2024): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

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Anthocyanin is a chemical compound found in purple miana leaves and plays an important role in providing color. Purple miana leaf extract can be used as a natural coloring in blush on cream preparations. The aim of this research is to determine whether purple miana leaf extract (Coleus scutellarioides L) can be formulated in the form of a blush cream dosage form that is physically and chemically stable. The research method used was experimental research by making blush on preparation formulations with concentrations of 7.5%, 10% and 12.5% ​​and evaluating the preparations using physicochemical, irritation tests and hedonic tests. The research results showed that blush on formulations with concentrations of 7.5%, 10% and 12.5% ​​were physically and chemically stable and in the hedonic/preference test the most preferred formulation was the formulation with a concentration of 12.5%. The conclusion of this research is that the ethanol extract of purple miana leaves (Coleus Scutellarioides L) can be formulated in the form of a blush cream dosage form that is physically and chemically stable.
STUDI ETNOFARMAKOLOGI TUMBUHAN OBAT HIPERGLIKEMIA PADA MASYARAKAT Suryanita; Indrayani, Ferna
Journal of Pharmaceutical Science and Herbal Technology Vol. 8 No. 2 (2023): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35892/jpsht.v1i1.1422

Abstract

Etnofarmakologi adalah ilmu yang mempelajari kegunaan tanaman yang memiliki efek farmakologi yang memiliki hubungan dengan pengobatan. Tumbuhan obat dapat diartikan sebagai tanaman ataupun tumbuhan yang secara ilmiah memiliki kemampuan menyembuhkan berbagai penyakit seperti mengurangi rasa sakit, mencegah ataupun menyembuhkan penyakit, dan untuk menjaga kondisi badan agar tetap sehat. Dari sekian banyaknya tanaman yang digunakan sebagai obat, salah satu fungsinya adalah sebagai pengobatan Hiperlikemia atau diabetes mellitus. Penelitian ini bertujuan untuk tingkat pengetahuan masyarakat tentang pengobatan tradisional penyakit Hiperglikemia pada masyarakat. Jenis penelitian ini adalah penelitian observasional bersifat deskriptif dan analitik dan teknik pengambilan sampel yakni menggunakan puposive sampling dengan jumlah responden sebanyak 50 orang dan hanya sebanyak 42 responden yang menggunakan tanaman sebagai pengobatan Hiperglikemia atau Diabetes Mellitus. Berdasarkan observasi lapangan dengan membagikan kuesioner di ketahui bahwa koleksi tumbuhan yang dimanfaatkan oleh masyarakat untuk pengobatan Hiperglikemia adalah daun kelor, daun sambiloto, mengkudu, bawang merah dan lidah buaya. Bagian tumbuhan yang digunakan yaitu daun, buah, dan pelepah dengan cara pengolahan tanaman obat oleh masyarakat setempat yaitu dengan cara direbus, diparut, ditumbuk dan dikonsumsi dua kali sehari tiap pagi dan sore hari.
EFEKTIFITAS SENYAWA FLAVANOID EKSTRAK ETANOL DAN PERASAN DAUN BANDOTAN (Ageratum conyzoides L.) TERHADAP KECEPATAN PEMBEKUAN DARAH PADA MENCIT (Mus musculus) Hasma; Suryanita
Journal of Pharmaceutical Science and Herbal Technology Vol. 10 No. 1 (2025): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

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Pendahuluan: Daun bandotan (Ageratum conyzoides L.) sangat berkhasiat dan dapat diolah serta dimanfaatkan sebagai obat untuk menyembuhkan sekaligus mencegah penyakit seperti demam, malaria, batuk, sakit perut, dan obat luka. Bandotan dapat digunakan sebagai obat tradisional karena mengandung senyawa fitokimia yang bermanfaat yang berperan dalam kecepatan pembekuan darah. Tujuan: Penelitian ini adalah jenis penelitian eksperimen untuk mengetahui kandungan senyawa flavonoid dan efektivitas ekstrak etanol dan air perasan daun bandotan (Ageratum conyzoides L.) terhadap kecepatan pembekuan darah pada mencit. Metode yang digunakan Metode duke. Digunakan mencit jantan sebanyak 12 ekor kemudian dibagi menjadi 4 kelompok, masing-masing kelompok terdiri dari 3 ekor mencit. Kelompok 1 kontrol positif (Asam traneksamat injeksi), kelompok 2 ekstrak etanol daun bandotan (40%), kelompok 3 air perasan daun bandotan (40%), dan kelompok 4 kontrol negatif (Aquadest). Selanjutnya masing-masing dari kelompok mencit tersebut dilakukan perlakuan dengan pengambilan darah melalui pembuluh darah vena mencit, kemudian disimpan digelas arloji masing-masing 3 ml dan diberikan obat sesuai dengan kelompoknya dan dilakukan pengamatan kecepatan pembekuan darah. Hasil: Hasil penelitian menunjukkan ekstrak dan perasan daun bandotan positif mengandung senyawa flavonoid, dan kelompok yang paling cepat terjadi pembekuan darah adalah kelompok 1 kontrol positif (Asam traneksamat injeksi) 70 detik dan kelompok 3 (Ekstrak etanol daun bandotan 40%) yaitu 95 detik. Pemberian ekstrak daun bandotan dengan konsentrasi 40% lebih baik dibandingkan dengan air perasan daun bandotan terhadap kecepatan pembekuan darah.
UJI AKTIVITAS FRAKSI N-HEKSAN, ETIL ASETAT, ETANOL DAUN PARE (Momordica charantia L.) TERHADAP Staphylococcus epidermidis DAN Salmonella thypi Muhammad Asri SR; Suryanita; Kasim, Rezky Amaliah
Jurnal Kesehatan Yamasi Makassar Vol 9 No 2 (2025): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/jurkes.v9i2.380

Abstract

Bitter melon leaves (Momordica charantia L.) contain compounds such as flavonoids, saponins, triterpenoids, glycosides and alkaloids. This study aims to determine the difference in antibacterial activity of the N-hexane, Ethyl acetate and Ethanol 96% fractions fram bitter melon leaves (Momordica charantia L.) against the bacteria Staphylococcus epidermidis and Salmonella thypi. The research method is an experimental study to see the antibacterial activity of the N-hexane, ethyl acetate and etanol 96% fractions at concentrations of 5%, 10% and 15% using the disc diffusion method. The results of the research showed that Staphylococcus epidermidis bacteria obtained an inhibitory power of 5% (5,95 mm), 10% (12,23 mm), 15% (14,05 mm) for the N-hexane fraction. Ethyl acetate fraction 5% (6,08 mm), 10% (7,37 mm), 15% (10,93 mm). Ethanol fraction of 5% (6,37 mm), 10% (12,8 mm), 15% (13,98 mm). Salmonella thypi bacteria against the N-hexane fraction obtained an inhibitory power of 5% (7,83 mm), 10% (12,47 mm), 15% (13,88 mm). The ethyl acetate fraction is 5% (5,43 mm), 10% (10,85 mm), 15% (13,88 mm). Ethanol fraction of 5% (7,77 mm), 10% (10,27 mm), 15% (15,5 mm). It can be concluded that the N-hexane, ethyl acetate and ethanol 96% fractions have antibacterial activity.
Aktivitas Imunodulator Fraksi Etil Asetat Daun Jamblang (Syzgium cumini L) Pada Tikus Putih Jantan (Rattus norvegicus L) Yang Telah Diinfeksi Staphylococcus aureus Muhammad Asri SR; Rudia Tamaria; Suryanita
Jurnal Kesehatan Qamarul Huda Vol. 12 No. 2 (2024): Desember 2024
Publisher : Universitas Qamarul Huda Badaruddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37824/jkqh.v12i2.2024.672

Abstract

The immune system functions to protect the body from foreign substances such as microorganisms, bacteria, viruses and parasites. The immune system can be enhanced by administering immunomodulators. This study aims to determine the immunomodulatory activity of the jamblang leaf fraction (Syzgium cumini L) in male white rats (Rattus norvegicus L) that have been infected with Staphylococcus aureus. The extract was prepared by fractionation using ethyl acetate, ethanol, and n-hexane as solvents. Testing of immunomodulatory activity was carried out by calculating the phagocytic activity value of peritoneal macrophage cells using the Giemsa staining method with 100X magnification on a microscope. Fifteen rats tested were divided into five treatment groups, namely negative control (Na-CMC), positive control (Stimuno® 50 mg), and the extract dose group of 140 mg/kg BW, 210 mg/kg BW, 280 mg/kg BW. The treatment was given orally for 7 consecutive days and intraperitoneal injection of Staphylococcus aureus bacteria was given on day 8 for each group. The results of peritoneal fluid smear studies are used to determine the activity of macrophage cells. Data were analyzed by one way ANOVA test and followed by the HSD post hoc test. Immunomodulatory activity test showed that doses of 140 mg/kg BW, 210 mg/kg BW and 280 mg/kg BW had immunomodulatory activity by showing significant differences with the negative control and positive control groups (p<0.05). Based on the results of the study, it was shown that the immunomodulatory activity test at a dose of 280 mg/kg BW had greater immunomodulatory activity due to the greater number of activated macrophage cells.
Co-Authors Alfiani Am, Fenni Asri SR, Muhammad Auliah, Nielma Fitrahmia S, Nur Hasma Indrayani, Ferna Junita, Nurfitria Kasim, Rezky Amaliah Muhammad Asri SR Nurjannah Bachri, Nurjannah Rudia Tamaria