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All Journal Jurnal Farmasi Media Farmasi Indonesia
Nanda Saifullah Sulaiman, Teuku
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Pengaruh Konsentrasi Gelling Agent dan Ratio Fase Minyak Dan Surfaktan Terhadap Formulasi Gel Mikroemulsi Ketoprofen : Ramadhani, Untia Kartika Sari; Nanda Saifullah Sulaiman, Teuku; Hernawan Nugroho, Bambang
Media Farmasi Indonesia Vol. 17 No. 2 (2022): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v17i2.200

Abstract

Ketoprofen adalah obat golongan anti inflamasi non steroid yang dibuat dalam gel mikroemulsi untuk meminimalkan efek samping gastrointestinal. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi gelling agent Natrium karboksimetilselulosa (Na CMC) dan rasio fase minyak Isopropil Miristat (IPM) dengan surfaktan (tween 80 dan span 80) terhadap sifat dan stabilitas fisik gel mikroemulsi ketoprofen. Gel mikroemulsi ketoprofen dibuat menjadi mikroemulsi ketoprofen yang kemudian ditambahkan gelling agent NaCMC dengan perbandingan rasio fase IPM : Surfaktan (Tween 80 dan Span 80) / NaCMC yaitu FI (1:5/3%), FII (2:5/3%), FIII (1:5/3,5%), FIV (2:5/3,5%). Gel mikroemulsi ketoprofen disimpan pada suhu 4°C, 25°C, 40°C selama 4 minggu dengan parameter sifat dan stabilitas fisik yang diuji setiap minggunya yaitu uji organoleptis, homogenitas, pH, viskositas, daya sebar dan daya lekat. Uji ukuran globul dilakukan sebelum dan sesudah penambahan NaCMC pada mikroemulsi ketoprofen. Penetapan kadar gel mikroemulsi ketoprofen ditetapkan dengan spektrofotometri UV-Vis. Variasi rasio fase minyak isopropil miristat : surfaktan (tween 80 dan span 80) dan konsentrasi Na CMC mempengaruhi sifat fisik dan stabilitas fisik gel mikroemulsi ketoprofen yang terlihat dari organoleptis, homogenitas dan viskositas gel mikroemulsi ketoprofen selama 4 minggu penyimpanan di suhu 4°C,25°C,40°C. Gel mikroemulsi ketoprofen stabil secara fisik ketika disimpan pada suhu 25°C.
Pengaruh Amilum Singkong (Manihot esculenta, Crantz) Native dan Pregelatinized Terhadap Laju Disolusi Tablet Parasetamol Ngurah Agung Dewantara Putra, I Gusti; Murwanti, Retno; Rohman, Abdul; Nanda Saifullah Sulaiman, Teuku
Jurnal Farmasi (Journal of Pharmacy) Vol. 7 No. 1 (2018): Jurnal Farmasi (Journal of Pharmacy), October 2018
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Amylum is widely used as an excipient in pharmaceutical formulations, one of which is inert and can be mixed with any drug without causing a chemical reaction. The aim of this research is to know the preparation method of cassava amylum (Manihot esculenta, Crantz) native and pregelatinized which is used as binder to dissolution rate of paracetamol tablet with granulation method. The native and pregelatinized amylum produced from cassava is carried out by a preliminary test to determine the nature of physical characteristics and to know the ability as a binder of the tablet. The paracetamol tablets produced from the two methods were tested dissolution using medium buffer phosphate at 37 ± 0,5 ° C (pH 5.8, 50 rpm). The results showed that cassava starch preparation method had an effect on dissolution rate of tablet. Pregelatinized amylum as binder on paracetamol tablet showed Q value (93,17 ± 0,01)% while native amylum showed value of Q (81,76 ± 0,20)%. The use of pregelatinized cassava starch as a binder on paracetamol tablet has better characteristic properties compared with native starch.
Co-Authors Abdul Rohman Hernawan Nugroho, Bambang Ngurah Agung Dewantara Putra, I Gusti Ramadhani, Untia Kartika Sari Retno Murwanti