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All Journal Smart Medical Journal Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Siallagan, Delpiana
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Correlation between Apolipoprotein B Levels with Coronary Lesion Area Based on the Gensini Scores in Coronary Heart Disease Patients Siallagan, Delpiana; Siregar, Jelita; Hasan, Refli
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 3 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i3.14396

Abstract

Background: Coronary heart disease (CHD) is caused by atherosclerosis. apolipoprotein B (Apo B) is a large glycoprotein, that plays a role in lipoprotein metabolism and human lipid transport, reflecting atherogenic cholesterol transport. The Gensini scoring system has the highest correlation with the severity of coronary artery stenosis as assessed by angiography. This study aims to determine the correlation between apolipoprotein B levels with the area of ​​coronary lesions based on the Gensini score in patients with CHD Methods: This research is an observational study with cross cross-sectional data collection method of 76 coronary heart disease patients who were treated at H. Adam Malik General Hospital Medan (December 2021 – April 2022). Examination of the Apo B value was carried out by the immunoturbidimetry method (Architect). Coronary lesion area calculated from coronary angiography with Gensini score. The research was conducted after obtaining ethical approval and informed consent. Result: There were 57 male subjects (75 %). The mean age of the subjects was 56.17 years with the youngest age being 24 years and the oldest being 77 years. Most of the subjects who experienced STEMI amounted to 38 people (50 %). The mean Apo B level was 89.18 mg/dL. The mean Gensini score was 62.84. By using the Pearson correlation test, it was found that a significant correlation was found between Apo B and Gensini score, r = 0,288 (p = 0.012) Conclusions: There was a significant correlation between the levels of Apo B and coronary artery lesions based on the Gensini score. Apo B examination and Gensini score can be used as a risk assessment of severity in CHD patients. Further research is needed to involve a larger number of coronary heart disease patients.
The Correlation Between Interleukin-6 (IL-6) Levels and the Extent of Coronary Lesions Based on SYNTAX Scores in Patients with Acute Coronary Syndrome (ACS) Siallagan, Delpiana; Loesnihari, Ricke; Hasan, Refli
Smart Medical Journal Vol 7, No 1 (2024): April
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v7i1.80649

Abstract

Introduction: Atherosclerosis plays an important role in the pathogenesis of acute coronary syndrome (ACS). Inflammation plays a causal role in atherosclerosis. There are many inflammatory markers related to ACS, including C-reactive protein (CRP), homocysteine, matrix metal loproteinases, interleukin (IL)-6, IL-8, and IL-27. IL-6 is the sign of synthesis of acute phase proteins. Recently, the clinical trials related to ACS showed that IL-6 may be an indicator of increased risk for ACS.  An Interleukin-6 (IL-6) examination is can be used  to assess risk factors for acute coronary syndrome (ACS). Interleukin-6 is a marker of local inflammation of coronary plaque and peripheral blood circulation which increases the occurrence of coronary heart disease causing plaque instability and rupture. The SYNTAX scoring system has   correlation assessed through angiography assessing the complexity of the severity of coronary artery stenosis. This study aims to determine the between Interleukin-6 (IL-6) levels and the extent of coronary lesions based on the SYNTAX score in patients with acute coronary syndrome (ACS).Methods: This is a cross-sectional study of 45 patients with acute coronary syndrome (ACS) who were treated at H. Adam Malik General Hospital, Medan (February 2023 – May 2023). IL-6 levels were examined using the Electrochemiluminescent Immunoassay (ECLIA) method using Cobas e 411. The extent of the coronary lesion was calculated based on the SYNTAX score from coronary angiography which was calculated by two invasive cardiologist as suggested before using an online calculator. We used the Spearman correlation test and Mann Whitney test to analyze the data.Results: There were 39 male subjects (86.7%) total.  The mean age of the subjects was 54.89 ± 10.3 years old. Most of the subjects experienced STEMI in total 28 people (62.2%). The Median IL-6  levels was  19.22 pg/mL  while the median of SYNTAX score level was 13.00. By using cross-sectional study and the spearman correlationa test, there is a significant correlation between IL-6 and the SYNTAX score with the correlation value obtained r = 0.343 (p = 0.021).Conclusion: There is a significant relationship between IL-6 and the extent of coronary lesions based on the SYNTAX score in patients with acute coronary syndrome. 
Co-Authors Hasan, Refli Ricke Loesnihari Siregar, Jelita