Article Per Year (5 Year)
p-Index From 2020 - 2025
0.751
P-Index
This Author published in this journals
All Journal The Indonesian Biomedical Journal Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Buletin Kedokteran dan Kesehatan Prima
Sylvana, Dhini
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
The Association of the Neutrophil-Lymphocyte Ratio With Diabetes Mellitus and Diabetic Foot Ulcer: A Review Article Sylvana, Dhini; Santi Syafril
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 4 No. 4 (2022): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v4i4.14689

Abstract

Introduction: Diabetes mellitus (DM) is inappropriately elevated blood glucose levels. Diabetic foot ulcer (DFU) is the most common complication of diabetes mellitus. Many research studies was found that neutrophil lymphocyte ratio (NLR) have positive correlation with HBA1C, blood glucose, and outcome of diabetic foot ulcer. Methods: The literature searches using online databases such as PubMed, ScienceDirect Elsevier, and Google Schoolar. Result: After doing an online search, we found 39 articles were relevant for this review topic. Analysis: Many research studies have found increased HbA1C (≥6,5) and increased blood glucose (random blood glucose ≥ 200mg/dL and/or fasting blood glucose ≥126 mg/dL) in patients with diabetes mellitus have a positive correlation with increased NLR. And there was increased NLR values in patients with diabetic foot ulcer and NLR values was higher (NLR≥6) in non-healing ulcers than in healing ulcers. Conclusion: NLR can be used as screening tool for determining evaluation of diabetes mellitus and as screening tool for determining outcome of diabetic foot ulcers.
The relationship between the implementation of the five pillars of Community-Led Total Sanitation (CLTS) and the incidence of stunting at Sei Bejangkar Community Health Center Sylvana, Dhini; Husna, Fika Amaliza; Rahmadayani, Fanny; Djuang, Michelle Hendriani; Akbar, Khainir; Ibnu, Syahroni; Djohan, Djohan; Hutagalung, Tommy Rizky; Puspawani, Yeni; Napitu, Sabar Hamonangan Victorianus; Baeha, Ferdinando Motuho; Tarigan, Setia Budi
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7435

Abstract

Researchers were interested in studying the impact of Community-based total sanitation on stunting in the service area of the Sei Bejangkar Health Center since the first survey indicated that 90 toddlers were stunted owing to the effects of inadequate sanitation. The study used a quantitative, cross-sectional methodology. This research was carried out near the Sei Bejangkar Health Center. All of the infants and toddlers in the puskesmas's operational region served as the study's population. Total sampling was used during the sampling process. Univariate, Bivariate, and Multivariate tests were utilized to analyze both main and secondary data in this study. Based on the data, it appears that there is no connection between the halt defecation movement and stunting in toddlers in the sei anchor health center's service area (P value of 0.529 or more than 0.05). Toddlers at the Sei Bejangkar Health Center are less likely to be stunted if open defecation is reduced. The p-value is 0.000, which means it's significantly larger than 0.05 (0.000 > 0.05).
Low Serum Nerve Growth Factor Levels Are Associated with Insulin Resistance, Beta Cell Dysfunction, and Neuropathy Screening Scores in Subjects with Type 2 Diabetes Mellitus Sylvana, Dhini; Lindarto, Dharma; Syafril, Santi
The Indonesian Biomedical Journal Vol 17, No 5 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i5.3750

Abstract

BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes mellitus (T2DM), associated with chronic hyperglycemia, insulin resistance, and neuroinflammation. Despite the widespread use of Michigan Neuropathy Screening Instrument (MNSI) for early identification in neuropathy screening, studies assessing its relationship between NGF, insulin resistance, and neuropathy in T2DM patients, particularly in Indonesia, remain limited. Therefore, this study was conducted to evaluate associations between serum NGF, insulin resistance, β-cell function, and MNSI scores in T2DM.METHODS: Seventy-seven T2DM subjects were classified into DPN and non-DPN groups using MNSI. Subjects were excluded if they have comorbidities and conditions potentially affecting metabolic, immune, or organ function. Enzyme-linked immunosorbent assay (ELISA) was used for the measurement of serum NGF, enzymatic hexokinase method for fasting plasma glucose (FPG) and 2-hour postprandial glucose (2HPP), high-performance liquid chromatography (HPLC) for glycated hemoglobin (HbA1c), and chemiluminescent immunoassay for fasting insulin. Homeostatic model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-β) were then calculated.RESULTS: Most of the study subjects had NGF level of <11 pg/mL. NGF concentrations showed inverse correlations with HOMA-IR (r=–0.263, p=0.021) and HOMA-β (r=–0.316, p=0.005). In the DPN subgroup, NGF demonstrated a stronger negative correlation with HOMA-β (r=–0.425, p=0.009), whereas no significant correlation was found in non-DPN. HbA1c was higher in DPN (p=0.014). No significant associations were observed between NGF and HbA1c, FPG, or 2HPP. NGF was significantly associated with MNSI Part B scores (p=0.032), reflecting objective neuropathic findings, but not with MNSI Part A or total scores.CONCLUSION: Lower NGF levels were significantly associated with insulin resistance and β-cell dysfunction in T2DM. The association with MNSI part B suggests that physical examination findings may reflect NGF-related neuropathic alterations better than symptom-based assessments.KEYWORDS: diabetic peripheral neuropathy, HOMA-IR, HOMA-β, Michigan Neuropathy Screening Instrument, nerve growth factor, T2DM
The relationship between the implementation of the five pillars of Community-Led Total Sanitation (CLTS) and the incidence of stunting at Sei Bejangkar Community Health Center Sylvana, Dhini; Husna, Fika Amaliza; Rahmadayani, Fanny; Djuang, Michelle Hendriani; Akbar, Khainir; Ibnu, Syahroni; Djohan, Djohan; Hutagalung, Tommy Rizky; Puspawani, Yeni; Napitu, Sabar Hamonangan Victorianus; Baeha, Ferdinando Motuho; Tarigan, Setia Budi
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7435

Abstract

Researchers were interested in studying the impact of Community-based total sanitation on stunting in the service area of the Sei Bejangkar Health Center since the first survey indicated that 90 toddlers were stunted owing to the effects of inadequate sanitation. The study used a quantitative, cross-sectional methodology. This research was carried out near the Sei Bejangkar Health Center. All of the infants and toddlers in the puskesmas's operational region served as the study's population. Total sampling was used during the sampling process. Univariate, Bivariate, and Multivariate tests were utilized to analyze both main and secondary data in this study. Based on the data, it appears that there is no connection between the halt defecation movement and stunting in toddlers in the sei anchor health center's service area (P value of 0.529 or more than 0.05). Toddlers at the Sei Bejangkar Health Center are less likely to be stunted if open defecation is reduced. The p-value is 0.000, which means it's significantly larger than 0.05 (0.000 > 0.05).
Co-Authors Baeha, Ferdinando Motuho dharma Lindarto, dharma Djohan Djohan Djuang, Michelle Hendriani Husna, Fika Amaliza Hutagalung, Tommy Rizky Ibnu, Syahroni Khainir Akbar, Khainir Napitu, Sabar Hamonangan Victorianus Puspawani, Yeni Rahmadayani, Fanny Santi Syafril Santi Syafril, Santi Tarigan, Setia Budi