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Maulidah, Nurul
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Journal : Academia Open

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Inhibition of Propolis on the Growth of Aggregatibacter Actinomycetemcomitans Pratiwi, Novita; Hayati, Anis Khoirin; Maulidah, Nurul
Academia Open Vol 10 No 1 (2025): June (In Progress)
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10589

Abstract

General Background: Periodontitis, a chronic inflammatory disease, leads to tooth loss, with Aggregatibacter actinomycetemcomitans playing a key role in its pathogenesis. Specific Background: The rise of antibiotic resistance necessitates alternative treatments. Propolis, a bee-derived resin, has shown antimicrobial properties. Knowledge Gap: Limited research exists on the inhibitory effects of propolis against A. actinomycetemcomitans at varying concentrations. Aims: This study evaluates the antibacterial activity of propolis extract on A. actinomycetemcomitans in vitro. Results: Propolis exhibited significant antibacterial effects, with a minimum inhibitory concentration of 12.5% (125 mg/mL), attributed to flavonoids and apigenin. Statistical analysis confirmed significant differences across concentrations (p < 0.05). Novelty: This study highlights the concentration-dependent antibacterial efficacy of propolis against A. actinomycetemcomitans, suggesting its potential as a natural therapeutic. Implications: Propolis may serve as a complementary antimicrobial in periodontal therapy, reducing antibiotic reliance and resistance. Highlights: Effective Antibacterial Agent – Propolis inhibits A. actinomycetemcomitans growth at a minimum concentration of 12.5% (125 mg/mL). Bioactive Components – Flavonoids and apigenin in propolis disrupt bacterial membranes and biofilm formation. Clinical Potential – Propolis may serve as a natural alternative to antibiotics in periodontal therapy. Keywords: Periodontitist, Propolis, Aggregatibacter Actinomycetemcomitans, Antimicroba
Bilateral Compound Odontoma in Posterior Maxilla in Dr Wahidin sudirohusodo. Public and Teaching Hospital, Mojokerto, Indonesia : A Case Report Maulidah, Nurul; Wibowo, Mochamad Rizky Rafianto
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.11992

Abstract

Odontoma at 24,9%, is the second most common odontogenic tumors of the jaws after ameloblastoma, and it occurs more in children than adults. It is often asymptomatic and accidentally found on the patients with tooth loss or malposition. There are two types of odontoma based on its form, namely compound odontoma and complex odontoma. Odontoma is treated by conventional surgery. In general, recurrences do not occur in these cases. In this report, odontoma was found bilaterally in posterior maxilla which is a rare case because mostly compound odontoma is reported to occur in the anterior maxilla. Case Report: A 35-year-old man with no oral complaints came for a consultation before undergoing orthodontic treatment. OPG examination was performed and there were lesions that led to the diagnosis of compound odontoma. Furthermore, odontoma excision was performed and impacted teeth were removed from the patient Conclusion: Although most of odontoma cases are asymptomatic, early diagnosis and treatments are required to minimize the occurrence of complications and improve the prognosis of treatment. Highlights: Odontoma is the second most common odontogenic tumor after ameloblastoma. Case involves rare bilateral posterior maxilla compound odontoma. Early diagnosis prevents complications and improves prognosis. Keywords: Odontoma, Hamartroma, Odontogenic tumor, Benign tumor
Co-Authors Anis Khoirin Hayati Ariyanti Putri, Novica Azizah, Balkis Nur Erni Yuliastuti Isnaniah, Isnaniah Nurmiaty, Nurmiaty Pratiwi, Novita Rahmat Kurniawan Restu Marsiwi, Andin Rusmilawaty Wibowo, Mochamad Rizky Rafianto