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All Journal Majalah Farmasetika Jurnal Abdimas Madani dan Lestari (JAMALI) Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Binawan Student Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Pharmacon: Jurnal Farmasi Indonesia
Ismyama, Dian Farida
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Agriculture, Biological Sciences & Forestry Humanities Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Edukasi HIV/AIDS dan Teknologi dalam Meningkatkan Kesadaran Kesehatan di Kalangan Siswa SMK Wulandari, Cyntia; Ismyama, Dian Farida; Honifa, Honifa
Abdimas Galuh Vol 7, No 1 (2025): Maret 2025
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v7i1.18096

Abstract

Edukasi mengenai HIV/AIDS sangat penting bagi remaja untuk meningkatkan pemahaman mereka terkait penularan, pencegahan, pengobatan, serta dampak sosialnya. Program Pengabdian Kepada Masyarakat (PKM) oleh Prodi Farmasi Universitas Pakuan ini dilaksanakan di SMK Darus Sa’adah, Kabupaten Bogor, dengan tujuan meningkatkan pemahaman siswa tentang HIV/AIDS serta keterampilan mereka dalam membuat konten video edukasi kesehatan. Metode kegiatan meliputi pemutaran video pendek, diskusi interaktif, pelatihan pembuatan konten video, serta kompetisi pembuatan video edukasi bagi siswa kelas XI. Sebanyak 82 siswa dari berbagai jurusan berpartisipasi dalam program ini. Evaluasi dilakukan melalui pre-test dan post-test untuk mengukur efektivitas edukasi. Hasil menunjukkan peningkatan signifikan dalam pemahaman siswa mengenai HIV/AIDS, termasuk perbedaan HIV dan AIDS, gejala, serta pentingnya terapi antiretroviral (ARV). Selain itu, siswa menjadi lebih sadar akan stigma sosial terhadap Orang Dengan HIV/AIDS (ODHA) dan cara memberikan dukungan teman yang terinfeksi. Sebagai bagian dari inovasi pembelajaran, hasil kompetisi konten edukasi kesehatan dipublikasikan melalui platform EDUMEDIG sebagai media referensi berbasis teknologi. Program ini tidak hanya memperkuat kesadaran tentang HIV/AIDS, tetapi juga memberdayakan siswa untuk menjadi agen perubahan melalui media digital. Diharapkan program ini dapat berkelanjutan guna membentuk generasi muda yang lebih sadar kesehatan dan bebas dari stigma terhadap ODHA.
Evaluation of Calcium and Protein Content in Powder and Gummy Candy from Anchovy Extract (Stolephorus commersonnii) Hermawati, Ema; Ismyama, Dian Farida; Handayani, Marybet Tri Retno
Pharmacon: Jurnal Farmasi Indonesia Vol. 22 No. 1 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i1.10541

Abstract

Anchovies (Stolephorus commersonnii) are a good source of calcium and protein. Intake of these nutrients is associated with child height. According to the Ministry of Health of the Republic of Indonesia's Nutrition Status Study Report, the prevalence of stunting among Indonesian children in 2022 was 21.6%, which is still higher than the World Health Organization's (WHO) standard of <20%. This study aims to optimize the formulation of anchovy extract gummy candies that meet quality standards and contain high levels of calcium and protein. Anchovy powder contains 328.64 mg/kg of calcium, 28.46% protein, 0.12% ash, and 5.3% moisture. The anchovy extract was prepared using the maceration method with a 70% ethanol solvent. Four gummy candy formulations were made based on variations in anchovy extract concentration: 10%, 7.5%, 3%, and 1.5%. Formulation 4 (F4) with 1.5% anchovy extract produced the best physical quality, with a standard deviation (SD) of <5% for the weight uniformity test. The organoleptic test results for F4 are as follows: the anchovy taste is mild, the color is dark purple, the smell is slightly aromatic, the shape is consistent with the mold, and the texture is chewy. F4 gummy candies contain 1,490.64 mg/kg of calcium, 27.49% protein, 9.17% ash, and 3.96% moisture.  A serving size of one gummy (1.5 g) contains 2.24 mg of calcium, 0.41 g of protein, 0.06 g of total fat, 0.07 g of carbohydrates, 0.55 g of sugar, and 4.18 mg of sodium. F4 meets quality standards and is high in calcium and protein.
Pencegahan Penyalahgunaan Suplemen dan Herbal dengan Penyuluhan di Poliklinik Rawat Jalan RS Harapan Sehati, Bogor: indonesia Ismyama, Dian Farida; Kusuma , Ema Nillafita Putri; Sa’adah, Aas; Hermawati , Ema
Jurnal Abdimas Madani dan Lestari (JAMALI) Volume 07, Issue 02, September 2025
Publisher : UII

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jamali.vol7.iss2.art16

Abstract

Public awareness of the importance of health is increasingly developing towards a better direction. One method is by consuming supplements and herbal medicines to increase the body's resistance to avoid certain diseases. The consumption of safe, high-quality and useful herbal supplements and medicines needs to be cultivated and preserved by the community. Therefore, community service was carried out which consisted of 3 stages of activities, namely distributing questionnaires before counseling, counseling, and distributing questionnaires after counseling to see whether there was an influence of counseling on knowledge. The aim of this activity is to increase public awareness of the misuse and wrong use of supplements and herbal medicines. Community service was carried out at Harapan Sehati Hospital in the Bojonggede area, Bogor Regency with a total of 30 participants.   are used for the counselling. Data were collected using a questionnaire consisting of demographics, knowledge and behavior of participants regarding the use of supplements and herbal medicines. Data processing uses descriptive analysis methods, and the non-parametric Wilcoxon Signed Rank Test. The majority of participants were women (83.3%) and aged 17-25 years (43.3%). As many as 66.7% of participants were college graduates and 96.7% worked as private employees. The percentage of participants who had good knowledge about supplements and traditional medicine before (pre) counseling was 43.3%. Good knowledge becomes 80% after (post) counseling. The data shows a p-value of 0.001 (<0.05), which means there is an influence of counseling, or there is a significant difference between knowledge before and after being given education. It can be concluded that this series of activities is effective in increasing knowledge about the use of supplements and herbal medicines, so it is hoped that it can prevent misuse.
Pharmacogenomic and Bioinformatic Insights into ACE Gene Variants and Their Influence on ACE Inhibitor Response in Hypertension Amukti, Danang Prasetyaning; Ria Indah Pratami; Ismyama, Dian Farida; Puspitasari, Ade; Herlina, Tetie
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 03 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i02.113

Abstract

Response to angiotensin-converting enzyme inhibitors (ACEIs)-based antihypertensive therapy varies between individuals, which is largely influenced by genetic factors. The ACE gene has several polymorphisms that can affect enzyme levels and therapeutic efficacy. This study aims to explore the relationship between genetic variations in the ACE gene and response to captopril, lisinopril, ramipril, and enalapril in hypertensive patients. This study used a bioinformatics and pharmacogenomics approach by analyzing data from PharmGKB, Ensembl, and GTEx Portal. Genetic polymorphisms were analyzed to evaluate their association with ACEI efficacy using a descriptive statistical approach. Results: Four single nucleotide polymorphisms (SNPs) in the ACE gene were found to be associated with response to ACEI. Variants rs4291 and rs1799752 were associated with captopril efficacy, where the AA genotype showed a decrease in the severity of renal failure. The rs1799752 variant was also associated with lisinopril and enalapril, with the DD genotype providing greater blood pressure reduction. In addition, rs4359 and rs4344 were correlated with the efficacy of ramipril, especially in the CC+TT and AA+GG genotypes. Genetic variation in the ACE gene plays a role in determining the response to ACEI therapy. Pharmacogenetic approaches have the potential to improve the efficacy and safety of antihypertensive treatment.
Analisis Kuantitatif Flavonoid Total dalam Ekstrak Daun Bidara (Ziziphus mauritiana) sebagai Dasar Pengembangan Produk Farmasi Alami: Quantitative Analysis of Total Flavonoids in Bidara (Ziziphus mauritiana) Leaf Extract as a Basis for Natural Pharmaceutical Product Development Christian, Yulius Evan; Chandra, Pra Panca Bayu; Hermawati, Ema; Ismyama, Dian Farida
Binawan Student Journal Vol. 7 No. 2 (2025)
Publisher : Direktorat Penelitian, Pengabdian Masyarakat, Dan Kerjasama Universitas Binawan (DPPMK Universitas Binawan)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54771/v2zj1q78

Abstract

Bidara leaves (Ziziphus mauritiana) are a herbal plant that is known to be rich in bioactive compounds, especially flavonoids, which have antioxidant, anti-inflammatory and antimicrobial activities. This study aims to determine the total flavonoid content in bidara leaf extract and evaluate the potential of its secondary metabolites for pharmaceutical and cosmetic applications. Phytochemical screening was carried out to identify secondary metabolite content, which included flavonoids, alkaloids, saponins, tannins and phenolics. Extraction was carried out using the maceration method with 96% ethanol solvent, followed by filtering and evaporation of the solvent using a rotary vacuum evaporator at a temperature of 40°C to produce a thick extract. Determination of total flavonoid levels was carried out using the UV-Vis spectrophotometric method with aluminum chloride reagent at a wavelength of 441 nm, using quercetin as a standard. The results showed that the total flavonoid content in bidara leaf extract reached 3202.43 mg QE/100 g dry extract. This high flavonoid content supports antioxidant activity through the mechanism of capturing free radicals, chelating transition metal ions, and inhibiting lipid peroxidation. In addition, the flavonoids in the extract have the potential to be anti-inflammatory by inhibiting pro-inflammatory enzymes and modulating cytokines, as well as antimicrobial through disrupting microbial membranes. The conclusion of this research is that bidara leaf extract has great potential to be developed as an active ingredient in pharmaceutical and cosmetic formulations.
Evaluasi Aktivitas Antiinflamasi Nanoemulsi Teripang (Stichopus variegatus) Secara In Vitro dengan Metode Denaturasi Bovine Serum Albumin Hermawati, Ema; Ismyama, Dian Farida; Christian, Yulius Evan; Chandra, Pra Panca Bayu
Majalah Farmasetika Vol. 11 No. 2, Tahun 2026 (In Press)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v11i2.69257

Abstract

Teripang atau dikenal juga dengan sebutan gamat (Stichopus variegatus) merupakan bahan alam kelautan yang banyak dimanfaatkan di berbagai negara Asia, termasuk Indonesia. Teripang berpotensi dikembangkan di bidang obat maupun bidang kosmetik, karena mengandung berbagai macam bioaktif.  Salah satu kandungan teripang adalah saponin yang berpotensi memiliki aktivitas sebagai antiinflamasi dan aktibakteri. Tantangan dari pembuatan produk kosmetik yang terbuat dari bahan aktif bahan alam adalah stabilitas dan penetrasi bahan aktif ke dalam kulit. Teknologi nanopartikel digunakan untuk meningkatkan stabilitas dan bioavabilitas bahan aktif. Ekstrak teripang diperoleh melalui metode maserasi dengan rendemen 5,3%. Kadar saponin pada ekstrak teripang yang ditetapkan secara kuantitatif menggunakan spektrofotometer UV-Vis menunjukkan kadar sebesar 6,14 mg/g sampel. Nanoemulsi ekstrak teripang diformulasikan menggunakan metode gelasi ionik dengan kitosan sebagai polimer pembentuk. Hasil karakterisasi menunjukkan ukuran partikel rata-rata 733,7 nm, polydispersity index (PDI) 0,584, serta zeta potensial +29,14 mV, yang mengindikasikan stabilitas koloid yang baik. Aktivitas antiinflamasi diuji menggunakan metode denaturasi Bovine Serum Albumin (BSA) dan diperoleh nilai IC₅₀ sebesar 144,34 bpj, yang menunjukkan kemampuan penghambatan denaturasi protein.
Co-Authors Chandra, Pra Panca Bayu Danang Prasetyaning Amukti Handayani, Marybet Tri Retno Herlina, Tetie Hermawati , Ema Hermawati, Ema Honifa, Honifa Kusuma , Ema Nillafita Putri Puspitasari, Ade Ria Indah Pratami Sa’adah, Aas Wulandari, Cyntia Yulius Evan Christian