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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) PCJN Pharmaceutical and Clinical Journal of Nusantara
Herlina, Tetie
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Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Atypical Antipsychotic Induced Weight Gain in Schizophrenic Patients Tetie Herlina; Dyah A. Perwitasari; Haafizah Dania; Santi Yuliani; Melisa I. Barliana
Indonesian Journal of Clinical Pharmacy Vol 10, No 1 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.1.57

Abstract

Atypical antipsychotics are widely prescribed and have the potential to cause weight gain, which may result in the development of metabolic syndrome. Also, it is important to monitor the use of atypical antipsychotic for metabolic disturbance. The purpose of this study is to determine the side effects of atypical antipsychotics in increasing body weight in schizophrenia patients after 4 weeks of use. Furthermore, a retrospective design was conducted and data were collected based on consecutive sampling in 80 adult psychiatric inpatients (20 women and 60 men) with initial diagnoses of schizophrenia and with the same daily nutrition. The patients were hospitalized from January to March 2019, within the term (over 4 weeks) of initiation atypical antipsychotic. The patient body weight was collected before and 4 weeks after the treatment of atypical antipsychotic. The results showed that patients (20 women and 60 men) receiving atypical antipsychotic had a mean age of 35.6 years and a percentage of 70% women and 56% men had a weight gain of 1–5 kg over 4 weeks. The mean weight observed among our subjects increased from 57.55±10.743 kg to 59.83±12.205 kg after initiating treatment (p=0.001). However, the dual combination of atypical antipsychotics risperidone and clozapine are the most widely atypical antipsychotic used with a percentage equal to 91.25%, 3.75% clozapine, and 5% risperidone. Furthermore, it can be concluded that atypical antipsychotics use for at least 4 weeks can cause weight gain in schizophrenic patients. Pharmacist and doctors are recommended to monitor the metabolic side effects due to the atypical antipsychotic use. Keywords: Atypical antipsycotic, schizophrenia, weight gain  Antipsikotik Atipikal Menginduksi Peningkatan Berat Badan pada Pasien Skizofrenia AbstrakAntipsikotik atipikal banyak diresepkan dan berpotensi menyebabkan kenaikan berat badan yang dapat menyebabkan sindrom metabolik. Ada kebutuhan klinis yang mendesak untuk memantau penggunaan antipsikotik atipikal terhadap gangguan metabolisme. Penelitian ini bertujuan untuk mengetahui efek samping antipsikotik atipikal dalam meningkatkan berat badan pada pasien skizofrenia setelah pemakaian 4 minggu. Melalui desain retrospektif, data dikumpulkan dengan consecutive sampling pada 80 pasien rawat inap psikiatri dewasa (20 wanita dan 60 pria) dengan diagnosis awal skizofrenia dan dengan pengaturan nutrisi harian yang sama. Pasien dirawat di rumah sakit sejak Januari 2019 sampai dengan Maret 2019, dalam jangka menengah (lebih dari 4 minggu) pemberian antipsikotik atipikal. Data berat badan pasien dicatat sebelum dan 4 minggu sesudah pemakaian antipsikotik atipikal. Pasien (20 wanita dan 60 pria) yang menerima antipsikotik atipikal memiliki usia rata-rata 35,6 tahun, semua pasien dengan persentase 70% wanita dan 56% pria memiliki kenaikan berat badan 1–5 kg selama periode 4 minggu. Berat rata-rata yang diamati di antara subyek meningkat dari 57,55±10,743 kg menjadi 59,83±12,205 kg setelah memulai pengobatan (p=0,001). Antipsikotik atipikal yang paling banyak digunakan adalah kombinasi antipsikotik atipikal risperidon clozapin dengan persentase sebesar 91,25%, clozapin 3,75%, risperidon 5%. Kami menyimpulkan bahwa penggunaan antipsikotik atipikal selama setidaknya 4 minggu dapat menyebabkan penambahan berat badan pada pasien skizofrenia. Apoteker dan dokter direkomendasikan untuk memantau efek samping metabolik akibat penggunaan antipsikotik atipikal.Kata kunci: Antipsikotik atipikal, peningkatan berat badan, skizofrenia
Validity and reliability of the world health organisation-five well being index (WHO-5) questionnaire in early detection of depression during Covid-19 pandemic in Yogyakarta Mutmainnah Siradjuddin; Dyah Aryani Perwitasari; Lalu Muhammad Irham; Haafizah Dania; Tetie Herlina
Pharmaciana Vol 13, No 2 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i2.24319

Abstract

The Covid-19 pandemic in Indonesia, including Yogyakarta, has created a psychological impact on the community. One of the psychological impacts is depression. This issue can be overcome by early detecting depression using an instrument called the World Health Organization-Five Well-Being Index (WHO-5). Unfortunately, this instrument is currently unavailable in the Indonesian version. Therefore, this study aims to obtain a valid and reliable Indonesian version of the WHO-5, which can later be used by pharmacists as an instrument to early detect depression in Indonesia, especially in Yogyakarta. This research employed a cross-sectional design. The research subjects were people who visited Apotek UAD 1 and 2, who met the inclusion and were not included in the exclusion criteria. The WHO-5 questionnaire proceeded through a translation process from the English version to the Indonesian version. The original version of the WHO-5 questionnaire, which was the final translated version, was tested on 40 respondents to gain its validity and reliability. The analysis of the validity test using the Pearson Correlation of five questions on the WHO-5 questionnaire has revealed an average value of r = 1, indicating that the questionnaire is valid. The result of the reliability test with Cronbach Alpha is 0.853. In conclusion, the Indonesian version of the WHO-5 questionnaire meets the validity and reliability criteria so that the questionnaire can apply to the community.
Pharmacogenomic and Bioinformatic Insights into ACE Gene Variants and Their Influence on ACE Inhibitor Response in Hypertension Amukti, Danang Prasetyaning; Ria Indah Pratami; Ismyama, Dian Farida; Puspitasari, Ade; Herlina, Tetie
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i02.113

Abstract

Response to angiotensin-converting enzyme inhibitors (ACEIs)-based antihypertensive therapy varies between individuals, which is largely influenced by genetic factors. The ACE gene has several polymorphisms that can affect enzyme levels and therapeutic efficacy. This study aims to explore the relationship between genetic variations in the ACE gene and response to captopril, lisinopril, ramipril, and enalapril in hypertensive patients. This study used a bioinformatics and pharmacogenomics approach by analyzing data from PharmGKB, Ensembl, and GTEx Portal. Genetic polymorphisms were analyzed to evaluate their association with ACEI efficacy using a descriptive statistical approach. Results: Four single nucleotide polymorphisms (SNPs) in the ACE gene were found to be associated with response to ACEI. Variants rs4291 and rs1799752 were associated with captopril efficacy, where the AA genotype showed a decrease in the severity of renal failure. The rs1799752 variant was also associated with lisinopril and enalapril, with the DD genotype providing greater blood pressure reduction. In addition, rs4359 and rs4344 were correlated with the efficacy of ramipril, especially in the CC+TT and AA+GG genotypes. Genetic variation in the ACE gene plays a role in determining the response to ACEI therapy. Pharmacogenetic approaches have the potential to improve the efficacy and safety of antihypertensive treatment.
Tren Global Penelitian Toll-like receptor 4 pada Penyakit Kardiovaskular: Analisis Bibliometrik 2017-2025 Amukti, Danang; Estiningsih, Daru; Herlina, Tetie; Kusumawardani, Nurul; Puspitasari, Ade; Amalia, Latifa; Suminingtyas, Ifa Aris; Nurinda, Eva; Nuryanti, Sundari Desi; Wulandari, Ari Susiana; Pratami, Ria Indah
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol 9, No 1 (2025)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v9i1.5989

Abstract

Toll-like receptor 4 (TLR4) memiliki peran penting dalam patogenesis penyakit kardiovaskular (PKV) melalui mediasi respons inflamasi. Meskipun peran molekul ini semakin dikenal, belum ada kajian bibliometrik komprehensif yang mengulas tren global publikasi terkait TLR4 dalam konteks PKV secara sistematis. Tujuan penelitian ini bertujuan untuk menganalisis dinamika publikasi ilmiah global tentang TLR4 pada PKV dalam kurun waktu 2017–2025 menggunakan pendekatan bibliometrik. Data dikumpulkan dari database Scopus dengan kata kunci “Toll-like receptor 4” dan “cardiovascular”, difilter berdasarkan judul, abstrak, dan kata kunci, serta dibatasi pada dokumen berbahasa Inggris. Sebanyak 1.939 dokumen dianalisis menggunakan perangkat lunak Bibliometrix (R) dan VOSviewer untuk mengevaluasi tren publikasi, produktivitas penulis, kontribusi negara dan institusi, pemetaan kata kunci, dan artikel yang paling berpengaruh. Tiongkok mendominasi jumlah publikasi (592 dokumen), sementara Amerika Serikat mencatat pengaruh ilmiah tertinggi melalui kolaborasi internasional dan jumlah sitasi. Penulis paling produktif adalah Li Y dan Wang Y, sedangkan institusi teratas adalah Mashhad University dan Capital Medical University. Peta kata kunci menunjukkan empat klaster utama: inflamasi-imunitas, stres oksidatif-apoptosis, metabolisme, dan model hewan. Artikel paling disitasi berasal dari jurnal bereputasi tinggi seperti Signal Transduction and Targeted Therapy dan Nature Reviews Rheumatology. TLR4 merupakan target utama dalam penelitian multidisipliner dan translasi pada penyakit kardiovaskular. Hasil studi ini dapat menjadi acuan penting untuk perumusan strategi riset lanjutan dan kolaborasi global yang lebih terarah.
Review Artikel: Perilaku Masyarakat dalam Penggunaan Jamu untuk Pengobatan Suminingtyas, Ifa Aris; Herlina, Tetie; Suprapti, Sri
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol 9, No 1 (2025)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v9i1.5555

Abstract

Jamu merupakan bagian obat tradisional yang penggunaannya dilakukan secara turun temurun merupakan warisan leluhur yang sampai saat ini kelestariannya tetap terjaga. Pemerintah telah mengeluarkan peraturan tentang saintifikasi jamu nasional sebagai upaya untuk mendukung pemanfaatan jamu yang aman, efektif dan bermutu. Tujuan penelitian ini adalah melakukan studi literatur terhadap penelitian yang menyelidiki tentang perilaku masyarakat dalam penggunaan jamu dan efektifitas penggunaan jamu bila digunakan dalam pengobatan. Metode yang digunakan adalah pelaporan naratif. Pencarian artikel diambil dari database online di web https://garuda.kemdikbud.go.id , penelitian hanya dilakukan di Indonesia pada tahun 2016 hingga tahun 2024. Kata kunci yang digunakan dalam penelitian adalah: penggunaan jamu, jamu untuk pengobatan, penggunaan jamu tradisional. Hasil penelitian menunjukkan perilaku masyarakat dalam penggunaan jamu dalam pengobatan dipengaruhi oleh beberapa faktor yaitu tingkat pendidikan, pekerjaan, informasi, sumber informasi, usia dan dukungan dari orang lain. Tingkat kepatuhan terhadap penggunaan jamu dapat meningkatkan keberhasilan terapi. Peran pemerintah dalam program otonomi daerah merupakan hal yang sangat penting dalam meningkatkan inovasi pengelolaan jamu
Co-Authors Amalia, Latifa Amukti, Danang Danang Prasetyaning Amukti Dyah A. Perwitasari Dyah Aryani Perwitasari Estiningsih, Daru Haafizah Dania Ismyama, Dian Farida Kusumawardani, Nurul Lalu Muhammad Irham Melisa I. Barliana Mutmainnah Siradjuddin Nurinda, Eva Nuryanti, Sundari Desi Pratami, Ria Indah Puspitasari, Ade Ria Indah Pratami Santi Yuliani Suminingtyas, Ifa Aris Suminingtyas, Ifa Aris Suprapti, Sri Wulandari, Ari Susiana