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All Journal Detector: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Romaito Nasution
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Hubungan antara Perasaan Bersalah dan Keberhasilan Pengobatan Lupus Romaito Nasution; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Ika Sandra Dewi; Milna Sari
An-Najat Vol. 2 No. 4 (2024): NOVEMBER - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i4.1858

Abstract

This study analyzes the relationship between guilt and treatment outcomes in lupus patients through a meta-analysis of 15 studies (N = 2,876). The results indicate a significant negative correlation (r = -0.32, 95% CI [-0.39, -0.25], p < 0.001) between levels of guilt and lupus treatment success. Moderator analysis revealed a stronger relationship in younger patients (β = 0.015, SE = 0.006, p = 0.013) and those with a shorter disease duration (β = -0.021, SE = 0.009, p = 0.019). The strongest correlation was found in the disease activity dimension (r = -0.38, 95% CI [-0.46, -0.29]) compared to quality of life (r = -0.30, 95% CI [-0.38, -0.21]) or medication adherence (r = -0.25, 95% CI [-0.34, -0.15]). Furthermore, mediation analysis revealed that coping strategies mediated 34% of the effect of guilt on treatment outcomes. Longitudinal findings confirmed that a decrease in guilt is associated with improved treatment outcomes (r = -0.29, 95% CI [-0.41, -0.16], p < 0.001). These findings extend Witvliet et al. (2001) regarding the impact of guilt on health and support Engel's biopsychosocial model (1977) in the context of lupus. Unlike Navarrete-Navarrete et al. (2010), which focused on a single case, this research provides large-scale quantitative evidence. Finally, the primary novelty of this study lies in identifying the non-linear relationship between guilt levels and treatment outcomes, as well as the moderating role in psychological interventions (Q = 4.12, df = 1, p = 0.042). Thus, the findings underscore the importance of integrating guilt assessment and management in lupus care, supporting a holistic approach that combines psychological interventions with medical treatment.
Peran Kecerdasan Emosional dalam Pengobatan Cystic fibrosis Luthfiah Mawar; M. Agung Rahmadi; Helsa Nasution; Nurzahara Sihombing; Romaito Nasution; Milna Sari
Detector: Jurnal Inovasi Riset Ilmu Kesehatan Vol. 2 No. 4 (2024): November : Jurnal Inovasi Riset Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/detector.v2i4.4421

Abstract

This study investigates the role of emotional intelligence (EI) in cystic fibrosis (CF) treatment through a comprehensive meta-analysis of 47 studies involving 5,823 CF patients. Results affirm a significant positive correlation between EI and treatment adherence (r = 0.62, p < 0.001), as well as improved quality of life (QoL) for CF patients (β = 0.58, 95% CI [0.49, 0.67]). Regression analysis revealed that EI predicts 37% of the variance in lung function (FEV1) (R² = 0.37, F(1, 5821) = 3421.76, p < 0.001). Furthermore, patients with high EI scores exhibited significantly reduced levels of anxiety (d = -0.79) and depression (d = -0.83) compared to control groups. These findings extend previous research by Salovey et al. (2002) and Ceyhan et al. (2024) by identifying specific EI mechanisms influencing CF treatment outcomes. Unlike Cox et al.'s (2020) study focusing on the general population, our findings specifically demonstrate the effectiveness of EI-based interventions in improving clinical outcomes for CF patients, with an average FEV1 increase of 12% after 6 months of intervention. Lastly, mediation analysis indicated that emotion regulation (β = 0.31, p < 0.001), adaptive health behaviors (β = 0.28, p < 0.001), and utilization of social support (β = 0.22, p < 0.001) mediated the relationship between EI and CF treatment outcomes. These findings underscore the importance of integrating EI training into standard CF care protocols to enhance holistic treatment outcomes.
Efek Kepuasan Hidup pada Pengobatan Sarcoidosis Milna Sari; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Nurzahara Sihombing; Romaito Nasution
Detector: Jurnal Inovasi Riset Ilmu Kesehatan Vol. 2 No. 4 (2024): November : Jurnal Inovasi Riset Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/detector.v2i4.4423

Abstract

This meta-analysis investigated the effect of life satisfaction on Sarcoidosis treatment outcomes across 47 studies encompassing 8,932 patients. The findings revealed a significant positive correlation between life satisfaction and treatment success (r = 0.62, p < 0.001). Patients with high life satisfaction scores (>7.5/10) demonstrated a 73% higher likelihood of achieving remission compared to those with low scores (<5/10) (OR = 2.84, 95% CI: 2.31-3.49). Regression analysis indicated that each one-point increase in life satisfaction scores was associated with an 18% reduction in Sarcoidosis relapse rates (β = -0.18, p = 0.002). Treatment adherence and health behaviors were found to mediate the relationship between life satisfaction and Sarcoidosis treatment outcomes, accounting for 42% and 35% of the variance, respectively. Moderator analyses demonstrated stronger effects among patients with disease duration <5 years (p = 0.011) and those with mild to moderate disease severity (p = 0.003). These findings extend the work of Lee et al. (2020) and Martínez-García et al. (2021) by demonstrating a more pronounced effect of life satisfaction on Sarcoidosis treatment compared to other chronic conditions. Notably, contrary to Saketkoo et al (2021) previous study, the effect of life satisfaction remained significant even after controlling for patients' socioeconomic factors (β = 0.41, p < 0.001). These results underscore the crucial role of psychosocial interventions in enhancing Sarcoidosis treatment efficacy, offering new perspectives in the management of this chronic condition.
Hubungan Dukungan Sosial dalam Pengobatan Sklerosis Multipel Helsa Nasution; M. Agung Rahmadi; Luthfiah Mawar; Nurzahara Sihombing; Romaito Nasution; Milna Sari
Detector: Jurnal Inovasi Riset Ilmu Kesehatan Vol. 2 No. 4 (2024): November : Jurnal Inovasi Riset Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/detector.v2i4.4424

Abstract

This meta-analysis examined the relationship between social support and medication adherence among multiple sclerosis (MS) patients through a synthesis of 47 studies (N=12,356). The findings confirmed a significant positive correlation (r=0.42, p<0.001, 95% CI [0.38, 0.46]) with substantial heterogeneity (I²=84.0%). Contrary to Cohen et al.'s (2019) finding that informational support was the strongest predictor, our moderator analyses revealed emotional support as the most robust predictor (β=0.39, p<0.001). Furthermore, this research demonstrated that the effects of social support on MS medication adherence were stronger among women (β=0.18, p=0.023) and patients with longer disease duration (β=0.24, p=0.009), extending Franqueiro et al.'s (2023) findings regarding gender differences in social support effectiveness. Family support showed the largest effect (r=0.48, p<0.001), followed by friends (r=0.40, p<0.001) and healthcare providers (r=0.35, p<0.001). Moreover, mediation modeling revealed a significant role of self-efficacy (indirect effect=0.21, 95% CI [0.17, 0.25]), expanding upon Bandura's (2018) model. Supporting Lavorgna et al.'s (2018) findings, our results confirmed that online social support proved equally effective as offline support (Q=1.87, p=0.171). These findings demonstrated robustness through sensitivity analyses and trim-and-fill procedures, confirming resilience against publication bias (adjusted r=0.39, 95% CI [0.35, 0.43]). The novelty of this research lies in its comprehensive identification of key moderators and underlying mechanisms in the social support-medication adherence relationship and the first empirical testing of an integrated mediation model incorporating social support, self-efficacy, and medication adherence in the MS context.
Peran Harapan dalam Kepatuhan Pengobatan Kanker Kolorektal M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawa; Romaito Nasution; Milna Sari
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 6 (2024): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i6.793

Abstract

This meta-analysis investigates the relationship between hope and medication adherence in colorectal cancer (CRC) patients. Out of 1,247 identified articles, 18 studies met the inclusion criteria, encompassing 3,562 patients. The findings reveal a significant positive correlation between hope and medication adherence (r = 0.42, 95% CI: 0.35-0.49, p < 0.001), with notable heterogeneity (I² = 76.4%, Q = 72.03, df = 17, p < 0.001). Furthermore, subgroup analyses indicate a stronger effect in patients with advanced-stage cancer (r = 0.49, 95% CI: 0.39-0.58) compared to those in various earlier stages (r = 0.38, 95% CI: 0.30-0.46, Q = 4.12, df = 1, p = 0.04). No significant differences were found regarding the influence of hope on medication adherence based on treatment type or the country of the study. Additionally, this research extends the findings of DiMatteo et al. (2000) concerning the impact of depression on medication nonadherence, emphasizing the importance of positive psychological states. Moreover, the larger effect size observed for self-efficacy and adherence (r = 0.31) reported by Hall et al. (2016) underscores the relative significance of hope in CRC medication adherence. The novelty of this research lies in its comprehensive synthesis of the hope-adherence relationship within the CRC context, clarifying the varied and partial findings of Zhu et al. (2017) and García-Torres et al. (2016). Consequently, these results support the development of hope-based interventions to enhance medication adherence, as Snyder (2002) suggested in the specific context of CRC. Future research should focus on longitudinal analyses and intervention trials to clarify causal relationships and the effectiveness of hope-based approaches in improving CRC medication adherence.
Co-Authors Helsa Nasution Ika Sandra Dewi Luthfiah Mawa Luthfiah Mawar M. Agung Rahmadi Milna Sari Nurzahara Sihombing