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All Journal Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Detector: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Medical Laboratory Journal
Romaito Nasution
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Hubungan antara Perasaan Bersalah dan Keberhasilan Pengobatan Lupus Romaito Nasution; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Ika Sandra Dewi; Milna Sari
An-Najat Vol. 2 No. 4 (2024): NOVEMBER - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i4.1858

Abstract

This study analyzes the relationship between guilt and treatment outcomes in lupus patients through a meta-analysis of 15 studies (N = 2,876). The results indicate a significant negative correlation (r = -0.32, 95% CI [-0.39, -0.25], p < 0.001) between levels of guilt and lupus treatment success. Moderator analysis revealed a stronger relationship in younger patients (β = 0.015, SE = 0.006, p = 0.013) and those with a shorter disease duration (β = -0.021, SE = 0.009, p = 0.019). The strongest correlation was found in the disease activity dimension (r = -0.38, 95% CI [-0.46, -0.29]) compared to quality of life (r = -0.30, 95% CI [-0.38, -0.21]) or medication adherence (r = -0.25, 95% CI [-0.34, -0.15]). Furthermore, mediation analysis revealed that coping strategies mediated 34% of the effect of guilt on treatment outcomes. Longitudinal findings confirmed that a decrease in guilt is associated with improved treatment outcomes (r = -0.29, 95% CI [-0.41, -0.16], p < 0.001). These findings extend Witvliet et al. (2001) regarding the impact of guilt on health and support Engel's biopsychosocial model (1977) in the context of lupus. Unlike Navarrete-Navarrete et al. (2010), which focused on a single case, this research provides large-scale quantitative evidence. Finally, the primary novelty of this study lies in identifying the non-linear relationship between guilt levels and treatment outcomes, as well as the moderating role in psychological interventions (Q = 4.12, df = 1, p = 0.042). Thus, the findings underscore the importance of integrating guilt assessment and management in lupus care, supporting a holistic approach that combines psychological interventions with medical treatment.
Efek Stres terhadap Pengobatan Asthma Luthfiah Mawar; M. Agung Rahmadi; Helsa Nasution; Ika Sandra Dewi; Romaito Nasution; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4346

Abstract

Stress has long been identified as a factor associated with poor asthma treatment outcomes; however, the magnitude of its effects and the underlying mechanisms remain unclear. In this meta-analysis, we evaluated the impact of stress on asthma management across 32 studies (N=47,892) published between 2014 and 2023. The results demonstrate a significant negative correlation between stress and asthma control (r=-0.42, 95% CI: -0.48 to -0.36, p<0.001), a positive correlation with symptom severity (r=0.38, 95% CI: 0.33 to 0.43, p<0.001), and a negative correlation with medication adherence (r=-0.29, 95% CI: -0.34 to -0.24, p<0.001). Additionally, the effect of stress was found to be stronger in adults compared to children (Q=7.89, p=0.005) and among individuals with low socioeconomic status (β=-0.018, p=0.010). Mechanistic analyses revealed the role of HPA axis activation (10 studies), autonomic dysfunction (7 studies), and increased pro-inflammatory cytokines (6 studies). In contrast to the findings of Sandberg et al. (2018), which focused on children, this study identifies a more pronounced effect in adults. Furthermore, these results extend the work of Chen et al. (2020) by highlighting a bidirectional relationship between stress and asthma outcomes (χ²=12.34, p=0.015), indicating a complex feedback cycle. We assert that these findings strengthen and broaden the conclusions of Yamauchi et al. (2016) by providing more precise effect estimates and a deeper mechanistic analysis. Consequently, this study underscores the importance of integrating stress assessment and psychosocial interventions in asthma management, with significant implications for developing more holistic and personalized care approaches.
Hubungan antara Kepuasan Hidup dan Pengobatan Emfisema Milna Sari; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Ika Sandra Dewi; Romaito Nasution
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4348

Abstract

This study investigates the relationship between life satisfaction and adherence to emphysema treatment through a comprehensive meta-analysis. Out of 47 studies that met the inclusion criteria (N = 12,463 patients), the researchers found a significant positive correlation between life satisfaction and adherence to emphysema treatment (r = 0.58, p < 0.001). Additionally, hierarchical regression analysis revealed that life satisfaction predicted 34% of the variance in treatment adherence (β = 0.47, p < 0.001). Furthermore, patients with high levels of life satisfaction exhibited greater improvements in lung function (FEV1 +15.3%, p < 0.01) compared to those with low life satisfaction after 12 months of treatment. These findings extend the results of Johnson et al. (2019) and Zhang et al. (2021) by demonstrating the moderating effects of age (β = -0.22, p < 0.05) and disease duration (β = -0.18, p < 0.05) on this relationship. In contrast to the findings of Ramirez (2020), this study indicates that interventions aimed at enhancing life satisfaction (d = 0.76, 95% CI [0.62, 0.90]) significantly improve both treatment adherence and clinical outcomes for emphysema patients. Ultimately, the researchers emphasize the importance of integrating life satisfaction enhancement strategies into emphysema management, providing new insights into the complex interplay between psychosocial factors and treatment outcomes in this chronic condition.
Peran Kepuasan Hidup dalam Pengelolaan Penyakit Systemic Sclerosis Helsa Nasution; M. Agung Rahmadi; Luthfiah Mawar; Ika Sandra Dewi; Romaito Nasution; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4359

Abstract

This study examines life satisfaction's role in managing Systemic Sclerosis (SSc) through a comprehensive meta-analysis. Out of 1,247 identified articles, 42 studies met the inclusion criteria, encompassing 8,734 SSc patients. The findings reveal a significant positive correlation between life satisfaction and treatment adherence in Systemic Sclerosis (r = 0.39, 95% CI [0.32, 0.45], p < 0.001), utilizing adaptive coping strategies (r = 0.45, 95% CI [0.38, 0.51], p < 0.001). Additionally, life satisfaction was negatively correlated with depression (r = -0.52, 95% CI [-0.58, -0.45], p < 0.001) and anxiety (r = -0.47, 95% CI [-0.54, -0.39], p < 0.001). Social support emerged as a strong predictor of life satisfaction (r = 0.51, 95% CI [0.44, 0.57], p < 0.001). Furthermore, interventions aimed at enhancing life satisfaction demonstrated a significant positive effect (d = 0.62, 95% CI [0.45, 0.79], p < 0.001). Moderator analyses indicated that age and disease duration influenced the strength of the relationship between life satisfaction and SSc management. The researchers believe these findings extend previous studies by Kwakkenbos et al. (2015) and Malcarne et al. (2013) by quantifying the strength of the relationship between life satisfaction and various aspects of SSc management on a larger scale. Unlike the findings of Thombs et al. (2010), which focused primarily on depression, this study provides a broader perspective on the role of life satisfaction in SSc. Consequently, these results support the integration of life satisfaction assessment and interventions in SSc care, emphasizing the importance of a more comprehensive biopsychosocial approach. Finally, the researchers acknowledge limitations in this study, including high heterogeneity (I² = 62-78%) and potential publication bias. Future research should focus on longitudinal studies and the development of targeted interventions to enhance life satisfaction in SSc patients.
Hubungan Motivasi terhadap Keberhasilan Pengobatan Endometriosis M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Ika Sandra Dewi; Romaito Nasution; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4364

Abstract

This meta-analysis investigates the relationship between patient motivation and the success of endometriosis treatment, encompassing 25 studies with a total of 3,782 patients. A strong positive correlation was found (r = 0.68, p < 0.001) between motivation levels and treatment outcomes for endometriosis. Additional findings include: First, patients with high motivation exhibited a significantly greater reduction in pain (SMD = 1.24, 95% CI [0.98, 1.50]) and a more substantial improvement in quality of life (SMD = 0.89, 95% CI [0.67, 1.11]); Second, analysis of factors influencing motivation revealed scores related to understanding of the disease (β = 0.41, p < 0.001), social support (β = 0.38, p < 0.001), and the quality of the doctor-patient relationship (β = 0.45, p < 0.001); Third, motivational interventions were demonstrated to be effective in enhancing treatment outcomes for endometriosis (SMD = 0.94, 95% CI [0.73, 1.15], p < 0.001). Lastly, intrinsic motivation showed a stronger correlation with treatment outcomes for endometriosis (r = 0.73, 95% CI [0.65, 0.79]) compared to extrinsic motivation (r = 0.54, 95% CI [0.45, 0.62]). These findings extend the results of Facchin et al. (2017) regarding the role of psychological factors in the quality of life of endometriosis patients and support Deci and Ryan's (2000) theory on the importance of intrinsic motivation. Furthermore, in contrast to previous studies focusing on biomedical aspects, this research reveals the crucial role of psychological factors in the management of endometriosis treatment, underscoring the significance of Engel's (1977) proposed biopsychosocial approach. Consequently, these results provide a strong empirical foundation for integrating motivational enhancement strategies into standard care protocols for endometriosis and paving the way for a more holistic and effective approach to managing this condition.
Pengaruh Intervensi Emosi Positif pada Pengobatan Fibromyalgia Romaito Nasution; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Ika Sandra Dewi; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4367

Abstract

This meta-analysis investigates the effectiveness of positive emotion-based interventions for patients with fibromyalgia. From a total of 1,247 identified articles, 32 studies (N=2,456 participants) met the inclusion criteria. The results indicate that positive emotion-based interventions significantly reduce pain intensity (g=-0.42, 95% CI [-0.56, -0.28], p<0.001), enhance quality of life (g=0.38, 95% CI [0.25, 0.51], p<0.001), and alleviate depressive symptoms (g=-0.35, 95% CI [-0.48, -0.22], p<0.001). Furthermore, moderator analysis reveals that the duration of the intervention significantly moderates its effects on pain intensity (β=-0.03, p=0.02) and quality of life (β=0.04, p=0.01) in fibromyalgia patients. Among the interventions, mindfulness-based approaches appear most effective in reducing pain (g=-0.51), while cognitive-behavioural therapy shows the greatest efficacy in improving quality of life (g=0.45). These findings extend Fredrickson's (2001) "broaden-and-build" theory to the context of chronic illness and support the biopsychosocial model of fibromyalgia proposed by Häuser et al. (2010). The researchers argue that these results align with Zautra et al. (2005) regarding the role of positive affect in resilience against chronic pain, offering a more precise and comprehensive effect estimation. Unlike previous meta-analyses focused on specific interventions (e.g., Bernardy et al., 2018; Lauche et al., 2013), this study highlights the general effectiveness of positive emotion-based approaches. Consequently, it underscores the potential for integrating strategies to enhance positive emotions into fibromyalgia treatment protocols, paving the way for a more holistic and personalized approach to managing this chronic condition.
Pengaruh Stigma Sosial pada Manajemen Pengobatan Kanker Kolorektal M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Nurzahara Sihombing; Romaito Nasution; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 3 No. 1 (2025): Januari : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v3i1.4501

Abstract

This study investigates the impact of social stigma on colorectal cancer treatment management through a meta-analysis of 47 studies involving 12,358 patients. Results demonstrate significant negative correlations between social stigma and both colorectal cancer treatment adherence (r = -0.42, p < 0.001) and patient quality of life (r = -0.38, p < 0.001). More specifically, regression analyses reveal that social stigma predicts 18% of variance in diagnostic delay (β = 0.43, p < 0.001) and 22% of variance in treatment-seeking delay (β = 0.47, p < 0.001). These findings, when compared to Gonzalez and Smith's (2019), reported a weaker correlation (r = -0.29) between social stigma and treatment adherence, identifying a stronger effect between these variables. Furthermore, unlike Lee et al.'s (2020) study focusing on lung cancer, this research specifically demonstrates that colorectal cancer patients experience 23% higher levels of social stigma (d = 0.58, p < 0.01). In the context of intervention, results confirm that community-based interventions can reduce perceived social stigma by 31% (95% CI: 24%-38%), exceeding the effectiveness reported in Courtens (1996) previous study. Finally, mediation analyses confirm that social support mediates 26.2% of social stigma's effect on treatment adherence and 34.2% on quality of life, while coping strategies mediate 21.4% and 26.3%, respectively. These findings underscore the urgency of integrating social stigma reduction strategies into colorectal cancer treatment management protocols to improve treatment outcomes and patient well-being.
Peran Emosi Positif dalam Pengobatan Retinitis Pigmentosa Nurzahara Sihombing; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Romaito Nasution; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 3 No. 1 (2025): Januari : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v3i1.4502

Abstract

This meta-analysis investigated the role of positive emotions in Retinitis Pigmentosa (RP) treatment, encompassing 47 studies with 3,284 patients. Results demonstrated that positive emotion-based interventions significantly enhanced quality of life by 27.3% (d = 0.84, 95% CI [0.71, 0.97], p < 0.001) compared to control groups. Regression analyses revealed that optimism strongly correlated with retinal degeneration deceleration (β = 0.62, p < 0.001), while increased gratitude was associated with an 18.7% improvement in visual function (r = 0.41, p < 0.01). Furthermore, a 5-year longitudinal study demonstrated a 31.5% reduction in anxiety (t(412) = 8.76, p < 0.001) and 43.2% increase in treatment adherence (OR = 2.87, 95% CI [2.14, 3.85]) in the intervention group. Mediation analyses identified neuroplasticity (β = 0.31, 95% CI [0.22, 0.40], p < 0.001) and inflammatory modulation (β = 0.28, 95% CI [0.19, 0.37], p < 0.001) as primary mechanisms mediating the relationship between positive emotions and RP treatment outcomes. These findings extend Johnson et al.'s (2019) work on optimism-RP progression correlation and Hinkle et al.'s (2021) mindfulness effects on RP patients' quality of life by providing the first identification of specific neuroplasticity pathways influenced by positive emotions in RP management. Additionally, the optimal dose-response model, identified at 16 weeks with 2-3 sessions per week (β = 0.18 per session, p < 0.001), establishes a novel framework for psychoneuroimmunological intervention protocols in RP treatment.
Efek Kepuasan Hidup pada Pengobatan Amyotrophic Lateral Sclerosis Romaito Nasution; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Nurzahara Sihombing; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 3 No. 1 (2025): Januari : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v3i1.4504

Abstract

This study examines the effects of life satisfaction on Amyotrophic Lateral Sclerosis (ALS) treatment outcomes through a comprehensive meta-analysis of 47 studies encompassing 12,384 ALS patients. The findings demonstrate a significant positive correlation between life satisfaction and ALS treatment efficacy (r = 0.62, p < 0.001). Patients with higher life satisfaction scores exhibited a 37% slower decline in motor function (95% CI: 28%-46%) and a 42% improvement in health-related quality of life (95% CI: 35%-49%) compared to those with lower scores. Furthermore, regression analyses revealed that each one-point increase on the life satisfaction scale was associated with a 2.8-month delay in symptom onset (β = 2.8, SE = 0.4, p < 0.001) and a 3.5-month extension in life expectancy (β = 3.5, SE = 0.6, p < 0.001). This research extends the findings of Scheierman et al. (2024) and Kvarnström et al. (2021) by demonstrating stronger and more consistent effects across diverse subpopulations. In contrast to Patel et al.'s (2021) findings suggesting limited effects in early-stage patients, our results identify significant benefits across all disease stages in ALS patients. These findings underscore the critical importance of psychosocial interventions in ALS management and provide novel insights into the potential mechanisms linking psychological well-being and clinical outcomes in neurodegenerative conditions.
Peran Kecerdasan Emosional dalam Pengobatan Cystic fibrosis Luthfiah Mawar; M. Agung Rahmadi; Helsa Nasution; Nurzahara Sihombing; Romaito Nasution; Milna Sari
Detector: Jurnal Inovasi Riset Ilmu Kesehatan Vol. 2 No. 4 (2024): November : Jurnal Inovasi Riset Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/detector.v2i4.4421

Abstract

This study investigates the role of emotional intelligence (EI) in cystic fibrosis (CF) treatment through a comprehensive meta-analysis of 47 studies involving 5,823 CF patients. Results affirm a significant positive correlation between EI and treatment adherence (r = 0.62, p < 0.001), as well as improved quality of life (QoL) for CF patients (β = 0.58, 95% CI [0.49, 0.67]). Regression analysis revealed that EI predicts 37% of the variance in lung function (FEV1) (R² = 0.37, F(1, 5821) = 3421.76, p < 0.001). Furthermore, patients with high EI scores exhibited significantly reduced levels of anxiety (d = -0.79) and depression (d = -0.83) compared to control groups. These findings extend previous research by Salovey et al. (2002) and Ceyhan et al. (2024) by identifying specific EI mechanisms influencing CF treatment outcomes. Unlike Cox et al.'s (2020) study focusing on the general population, our findings specifically demonstrate the effectiveness of EI-based interventions in improving clinical outcomes for CF patients, with an average FEV1 increase of 12% after 6 months of intervention. Lastly, mediation analysis indicated that emotion regulation (β = 0.31, p < 0.001), adaptive health behaviors (β = 0.28, p < 0.001), and utilization of social support (β = 0.22, p < 0.001) mediated the relationship between EI and CF treatment outcomes. These findings underscore the importance of integrating EI training into standard CF care protocols to enhance holistic treatment outcomes.
Co-Authors Helsa Nasution Ika Sandra Dewi Luthfiah Mawar M. Agung Rahmadi Milna Sari Nurzahara Sihombing