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All Journal CHEMISTRY PROGRESS Jambura Journal of Educational Chemistry Pedagogika : Jurnal Pedagogik dan Dinamika Pendidikan Journal of Multidisciplinary Applied Natural Science
Yogaswara, Radite
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Physics Social Sciences Other

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POTENSI ANTIOKSIDAN DAN ANTIBAKTERI VIRGIN COCONUT OIL DARI TANAMAN KELAPA ASAL PAPUA Pulung, Maria; Yogaswara, Radite; Sianipar, Fajar Ria
CHEMISTRY PROGRESS Vol 9, No 2 (2016)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.9.2.2016.27992

Abstract

ABSTRAK Penelitian ini bertujuan untuk mengetahui potensi antioksidan dan antibakteri dari minyak kelapa asal Papua. Ekstrak minyak kelapa diperoleh dengan menggunakan metode fermentasi dan pemanasan. Aktivitas antioksidan dilakukan dengan metode DPPH sementara aktivitas antibakteri dengan metode sumuran. Hasil uji aktivitas antibakteri menunjukkan bahwa VCOP lebih baik menghambat pertumbuhan bakteri E.coli, sementara VCO fermentasi lebih baik dalam menghambat pertumbuhan bakteri S.aureus. Uji aktivitas antioksidan menunjukkan bahwa VCO yang diekstrak dengan menggunakan metode pemanasan (VCOP) sangat berpotensi sebagai antioksidan alami.ABSTRACT This research aims to determine the antioksidant and antibacterial potency of virgin coconut oil from Papua. Virgin coconut oil was extracted using fermentation and heated methods. The antibakteria potency was determined using sumuran method, while antioksidant was determined using scavenging DPPH method. Antibacterial activity showed that VCOP extract most inhibition the growth of E.coli, while the VCOF most inhibit the growth of S. aureus. The results showed that virgin coconut oil was extract using heated (VCOP) method most potent as antioksidant nature.
Investigation of New 4-Benzyloxy-2-trichloromethylquinazoline Derivatives as Plasmodium falciparum Dihydrofolate Reductase-thymidylate Synthase Inhibitors: QSAR, ADME, Drug-likeness, Toxicity, Molecular Docking and Molecular Dynamics Simulation Yogaswara, Radite; Pranowo, Harno Dwi; Prasetyo, Niko; Pulung, Maria Ludya
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.258

Abstract

Plasmonium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) is one of the most crucial antimalarial targets. Mutations in the binding pocket of this target lead to resistance to the antifolate. The mutations influence the amino acid residues at points 51, 59, 108 and 164 and contribute significantly to malaria not being treated well. Priority should therefore be given to the development of antifolate-resistance drugs. These studies aim to investigate new 4-benzyloxy-2-trichloromethylquinazoline derivatives as PfDHFR-TS inhibitors using QSAR, ADME, drug-likeness, toxicity, molecular docking studies, and molecular dynamics simulations. The best equation model from the QSAR analysis used MLR and PLS statistics to show that the pIC50 is linearly related to GATS4e, SpMax AEA(ed), and Mor28e, but inverted when compared to ATS6m and ATSC7m. The predictive ability of the model was confirmed by internal and external validation. In addition, the Y-randomization validation showed that the QSAR model was reliable, robust, and stable, with a cRp2 score of over 0.5. ADME and drug-likeness predictions confirmed the new QSAR design for molecules S10, S23 and S64. Based on the toxicity results, three molecules are expected to have moderate and non-toxic properties, starting with S23 and then S10 and S64. Molecular docking studies show that all three molecules have high binding energies, 9.869, 9.589, and 9.565 kcal/mol. The amino acid residues Leu46, Asp54, Ser111, and Thr185 play a major role in ligand-receptor interaction in the binding pocket of quadruple mutant PfDHFR-TS. Furthermore, an evaluation of molecular dynamics simulations of three complexes S10-3JSU, S23-3JSU and S64-3JSU demonstrated stable interactions over 100 ns.
Antiplasmodial and Metabolite Profiling of Hyrtios sp. Sponge Extract from Southeast Sulawesi Marine Using LC-HRMS, Molecular Docking, Pharmacokinetic, Drug-likeness, Toxicity, and Molecular Dynamics Simulation Pulung, Maria Ludya; Swasono, Respati Tri; Sholikhah, Eti Nurwening; Yogaswara, Radite; Primahana, Gian; Raharjo, Tri Joko
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.259

Abstract

Hyrtios sponge is known to possess alkaloid compounds that may exhibit in vitro activity against Plasmodium falciparum. The aim of this study was therefore to isolate and characterise the antiplasmodial active compounds of Hyrtios sp. Sponges collected from the island of Podang-Podang, South Sulawesi, Indonesia. In addition, the LC-HRMS analysis was performed on the active fractions of methanol and ethyl acetate extract to evaluate their antiplasmodial activity. We also validated the in silico antiplasmodial activity of PfDHFR-TS with molecular docking, pharmacokinetics, drug likeness, toxicity, and molecular dynamics analysis. The molecular docking studies showed that the synthesized extremes would have high binding affinity to PfDHFR-TS, thus confirming their potential as powerful enzyme inhibitors. Moreover, the pharmacokinetic and drug-likeness calculations showed that all compounds met the requirements for sufficient resistance and bioavailability, indicating potential as therapeutic candidates. The results of the toxicity analysis indicated that the compounds had a relatively good safety profile, but some potential adverse reactions in the renal and cardiac vasculature could not be excluded. Molecular dynamics simulations confirmed that the complexes formed between the ligand and the target were stable, and the low RMSD value indicated that the active site interactions were also quite stable. These observations reinforce the notion that the extract from Hyrtios sp. not only shows remarkable antimalarial activity but also exhibits pharmacological properties of a prospective drug candidate, which encourages further work in the development of malaria combination therapy both in clinical assessment and comprehensive mechanism of action investigation.
EFEKTIVITAS MODEL PEMBELAJARAN THINK-PAIR-SHARE DALAM MENINGKATKAN HASIL BELAJAR IKATAN KIMIA PADA ERA KURIKULUM MERDEKA: STUDI KASUS DI SMAS KATOLIK VILLANOVA MANOKWARI Tuapatinaya, Ricki; Parubak, Apriani Sulu; Surbakti, Putri Sarera; Yogaswara, Radite
PEDAGOGIKA: Jurnal Pedagogik dan Dinamika Pendidikan Vol 13 No 1 (2025): Pedagogika : Jurnal Pedagogik dan Dinamika Pendidikan
Publisher : Prodi Pendidikan Guru Sekolah Dasar (PGSD) FKIP Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/pedagogikavol13issue1page1-9

Abstract

Penelitian ini bertujuan untuk mengukur efektivitas model pembelajaran Think-Pair-Share (TPS) dalam meningkatkan hasil belajar siswa pada materi ikatan kimia di era Kurikulum Merdeka. Menggunakan desain pre-eksperimental dengan one-group pretest-posttest, penelitian melibatkan 28 siswa kelas X di SMAS Katolik Villanova Manokwari. Hasil penelitian menunjukkan peningkatan signifikan pada nilai rata-rata pretest (42,29) menjadi posttest (75,29). Analisis statistik dengan uji-t menunjukkan nilai sig. 0,000 (< 0,05), yang mendukung hipotesis bahwa TPS memiliki pengaruh signifikan terhadap hasil belajar. N-Gain sebesar 0,61 (kategori sedang) menunjukkan peningkatan hasil belajar yang baik, dengan kontribusi TPS sebesar 78%. Model TPS terbukti efektif dalam mendukung pembelajaran berbasis siswa, meningkatkan keterampilan berpikir kritis, dan mendukung prinsip-prinsip Kurikulum Merdeka. Penelitian ini memberikan rekomendasi untuk penerapan model TPS secara lebih luas pada materi lainnya dan mendorong pengembangan strategi pembelajaran yang inovatif di era pendidikan modern.
Penggunaan Model Pembelajaran Problem Based Learning Terhadap Minat Hasil Belajar Kimia pada Peserta Didik Murtihapsari, Murtihapsari; Achmad, Fauziah; Larasati, Christiana Niken; Yogaswara, Radite
Jambura Journal of Educational Chemistry Vol 4, No 2 (2022): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jjec.v4i2.14050

Abstract

Penggunaan model pembelajaran sangat memberikan pengaruh terhadap hasil belajar dari peserta didik. Guru masih menggunakan model pembelajaran konvensional dengan metode ceramah dalam menyajikan materi sehingga peserta didik merasa jenuh dan kurang memahami materi. Alternatif penggunaan pembelajaran model Problem Based Learning yang inovatif dan kreatif dapat meningkatkan minat belajar peserta didik di kelas. Metode ulasan ini merupakan kajian dari berbagai artikel yang telah terpublikasi nasional pada jurnal ilmiah terakreditasi. Beberapa literatur dikumpulkan yang terkait tema relevan tentang kajian proses pembelajaran dengan menggunakan model Problem Based Learning. Berdasarkan kriteria data yang diperlukan dalam ulasan ini, maka terdapat 24 (dua puluh empat) artikel yang sesuai dengan tema. Penggunaan model Problem Based Learning dalam proses pembelajaran diharapkan peserta didik dapat aktif, mampu tanggap dalam menyelesaikan masalah tekait materi pelajaran, kreatif dan mandiri dalam menjawab soal serta terjadi peningkatan dalam berfikir kritis.
Co-Authors Achmad Rante Suparman, Achmad Rante Achmad, Fauziah ahmad arifin Apriani Sulu Parubak Eti Nurwening Sholikhah Febiartaty, Riska Apolonia Harno Dwi Pranowo Larasati, Christiana Niken Murtihapsari . Nursyamsu, Muhammad Parubak, Apriani Prasetyo, Niko Prastika, Etni Dewi Primahana, Gian Pulung, Maria Pulung, Maria Ludya Respati Tri Swasono Sianipar, Fajar Ria Surbakti, Putri Sarera Tri Joko Raharjo Tuapatinaya, Ricki