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All Journal JOPS (Journal Of Pharmacy and Science) Jurnal Kesehatan Farmasi
Efmisa, Ariesta Kirana
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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DAMPAK PENGGUNAAN OBAT BERPOTENSI HEPATOTOKSIK TERHADAP LUARAN KLINIS PADA PASIEN SIROSIS HATI Efmisa, Ariesta Kirana; Rosi, Devahimer Harsep; Farnandi, Rido; Rahmi, Azimatur; Deswati, Deswati; Armal, Khairil
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4719

Abstract

Liver cirrhosis is a pathological liver disease characterized by the formation of fibrous tissue and regenerative nodules in liver cells. The potential for hepatotoxicity due to the use of hepatotoxic drugs leads to worsening of the liver disease suffered by these patients. This study aims to assess the impact of using potentially hepatotoxic drugs on patients' clinical outcomes. This study was an observational study with a cross-sectional design. Data were collected retrospectively through the medical records of patients with liver cirrhosis hospitalized in 2021. The clinical outcomes studied were SGOT, SGPT, albumin, total bilirubin and length of hospitalization. The results obtained were tested using the Kruskal-Wallis statistical test. A total of 62 patients with liver cirrhosis met the inclusion criteria as the study sample. The number of potentially hepatotoxic drug prescriptions received by patients based on Likelihood scores with categories A, B, C, D and E was 368 drugs out of 776 total drug prescriptions (47.4%). The most commonly prescribed potentially hepatotoxic drugs were paracetamol, ceftriaxon, and levofloxacin. It can be concluded that potentially hepatotoxic drugs are still prescribed to patients with liver cirrhosis. Age, gender, child pugh-score, number of drugs, and number of potentially hepatotoxic drugs had no significant effect (p>0.1) on SGOT, SGPT, albumin and total bilirubin. However, patients who received more drugs would have a higher.
A EVALUASI PENGGUNAAN ANTIBIOTIK PADA BRONKOPNEUMONIA ANAK DI RSUD MUKOMUKO 2024 Mutiara, Elsa Febria; Efmisa, Ariesta Kirana; Rosi, Devahimer Harsep
Jurnal Kesehatan Farmasi Vol 7 No 2 (2025): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v7i2.3612

Abstract

Latar Belakang: Bronkopneumonia adalah kondisi inflamasi paru-paru yang berdampak pada satu atau lebih lobus, ditandai dengan tambalan infiltratif yang dihasilkan dari bakteri, virus, jamur, dan zat asing.Tujuan penelitian ini untuk memperoleh gambaran dan analisa ketepatan penggunaan antibiotik. Metode: Penelitian ini adalah penelitian observasional deskriptif dengan pendekatan retrospektif menggunakan data sekunder rekam medis. Penelitian ini melakukan sampling terhadap 58 rekam medis pasien bronkopneumonia anak yang dirawat inap dan mendapat terapi antibiotik. Analisis kualitatif menggunakan metode Gyssens untuk menilai ketepatan indikasi, pemilihan jenis, dosis, interval, dan lama terapi. Analisis kuantitatif menggunakan metode ATC/DDD untuk menghitung konsumsi antibiotik per 100 pasien-hari Hasil: Antibiotik yang paling sering digunakan adalah seftriakson (53,4%), sefotaksim (27,6%), dan meropenem (19,0%). Evaluasi Gyssens menunjukkan 79,3% penggunaan rasional (kategori 0), 19% kategori IV A, dan 1,7% kategori III B. Total konsumsi antibiotik sebesar 25,57 DDD/100 hari rawat dengan nilai tertinggi seftriakson (18,06 DDD/100 hari). Sedangkan nilai terendah terlihat untuk Meropenem sebesar 2,09 DDD per 100 hari dan Sefotaksim sebesar 5,42 DDD per 100 hari rawat inap. Kesimpulan: Sebagian besar penggunaan antibiotik pada pasien bronkopneumonia anak di RSUD Mukomuko sudah rasional dan efektif, namun diperlukan pengawasan berkelanjutan untuk mencegah resistensi dan meningkatkan mutu pelayanan.
Co-Authors Azimatur Rahmi Deswati Deswati Farnandi, Rido Khairil Armal Mutiara, Elsa Febria Rosi, Devahimer Harsep