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All Journal Biology, Medicine, & Natural Product Chemistry JOPS (Journal Of Pharmacy and Science) Jurnal Pharmacopoeia Jurnal Kesehatan Farmasi Herbal Medicine Journal Jurnal Farmasi Indonesia
Rosi, Devahimer Harsep
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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DAMPAK PENGGUNAAN OBAT BERPOTENSI HEPATOTOKSIK TERHADAP LUARAN KLINIS PADA PASIEN SIROSIS HATI Efmisa, Ariesta Kirana; Rosi, Devahimer Harsep; Farnandi, Rido; Rahmi, Azimatur; Deswati, Deswati; Armal, Khairil
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4719

Abstract

Liver cirrhosis is a pathological liver disease characterized by the formation of fibrous tissue and regenerative nodules in liver cells. The potential for hepatotoxicity due to the use of hepatotoxic drugs leads to worsening of the liver disease suffered by these patients. This study aims to assess the impact of using potentially hepatotoxic drugs on patients' clinical outcomes. This study was an observational study with a cross-sectional design. Data were collected retrospectively through the medical records of patients with liver cirrhosis hospitalized in 2021. The clinical outcomes studied were SGOT, SGPT, albumin, total bilirubin and length of hospitalization. The results obtained were tested using the Kruskal-Wallis statistical test. A total of 62 patients with liver cirrhosis met the inclusion criteria as the study sample. The number of potentially hepatotoxic drug prescriptions received by patients based on Likelihood scores with categories A, B, C, D and E was 368 drugs out of 776 total drug prescriptions (47.4%). The most commonly prescribed potentially hepatotoxic drugs were paracetamol, ceftriaxon, and levofloxacin. It can be concluded that potentially hepatotoxic drugs are still prescribed to patients with liver cirrhosis. Age, gender, child pugh-score, number of drugs, and number of potentially hepatotoxic drugs had no significant effect (p>0.1) on SGOT, SGPT, albumin and total bilirubin. However, patients who received more drugs would have a higher.
Uji Aktivitas Antiinflamasi Ekstrak Etanol, Etil Asetat, dan N-heksan Tangkai Daun Kemumu (Colocasia gigantea Hook.f) secara in vitro terhadap Sel Makrofag Peritoneum Rosi, Devahimer Harsep; Qalbi, Abrar Hafidz; Afriani, Tika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.396

Abstract

Kemumu leaf stalks (Colocasia Gigantea Hook.F) are a plant that has many benefits for society, one of which is anti-inflammatory. Inflammation is process in the body to respond to infection or tissue damage. This study aims to test the anti-inflammatory effectiveness of ethanol extract, n-hexane, and ethyl acetate of kemumu leaf stalks in vitro. Kemumu leaf stalks contain flavonoids, alkaloid and tannin which have anti-inflammatory properties. Anti-inflammatory effectiveness testing was carried out on peritoneal macrophage cells to determine the inhibition of NO production in LPS-stimulated peritoneal macrophage cells by quantifying nitrite accumulation in the culture medium using Griess reagent. This research is an experimental study with 5 dose treatments for each extract with 3 replications. The parameters observed included NO production and the percentage of peritoneal macrophage cell inhibition. The results of statistical tests using One Way Anova showed a significant difference in NO levels between the sample group given the extract and the control sample (p=0.000). From the results of the percentage inhibition of NO production in peritoneal macrophage cells, it shows that ethanol extract of kemumu leaf stalks with concentrations of 50 and 100 µg/ml has the best anti-inflammatory effect, namely with NO production of 4.67 and 1.44 µg/ml respectively, and with respective inhibition 80.32% and 89.01% respectively.
Formulasi Sediaan Gel Face Scrub Dari Ekstrak Etanol Bayam Merah (Amaranthus tricolor L) Rosi, Devahimer Harsep
Jurnal Pharmacopoeia Vol 3 No 2 (2024): September 2024
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v3i2.879

Abstract

Telah dilakukan penelitian “Formulasi Sediaan Gel Face Scrub Dari Ekstrak Etanol Bayam Merah (Amaranthus tricolor L).” Tujuan dari penelitian ini untuk mengetahui ekstrak etanol bayam merah dapat diformulasikan sebagai sediaan gel face scrub. Ekstraksi sampel dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Ekstrak yang didapatkan dibuat gel face scrub. Pada penelitian ini dibuat menjadi 3 formulasi sediaan gel face scrub dengan konsentrasi yang berbeda yaitu F1 0,5 g, F2 0,75 g, dan F3 1 g ekstrak. Dilakukan evaluasi sediaan gel face scrub yaitu meliputi uji organoleptis, uji homogenitas, uji pH, uji iritasi, uji daya sebar dan uji daya lekat. Bayam merah yang digunakan telah diidentifikasi sebagai Amaranthus tricolor L. Hasil skrining fitokimia terhadap ekstrak bayam merah menunjukkan ekstrak positif mengandung flavonoid, alkaloid, steroid, saponin, dan tanin. Kesimpulan yang didapat bahwa sediaan gel face scrub dari ekstrak etanol bayam merah dapat diformulasikan menjadi sediaan gel face scrub karena sediaan gel yang diperoleh telah memenuhi parameter uji fisik yaitu uji organoleptis, uji homogenitas, uji pH, uji iritasi kulit, uji daya lekat, namun belum memenuhi persyaratan terhadap uji daya sebar.
Uji Stabilitas dan Uji Aktivitas Antifungi Sediaan Krim Dari Fraksi Etil Asetat Daun Matoa (Pometia pinnata J.R Forst & G. Forst) Terhadap Pertumbuhan Jamur Trichophyton rubrum Rinaldi, Agus Rahman; Rosi, Devahimer Harsep; Hevira, Linda
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.198

Abstract

Matoa (Pometia pinnata) is one of the endemic plants of Papua that has pharmacological antifungal activity. This study aimed to determine whether the ethyl acetate fraction of Matoa leaves can be formulated into a cream preparation that meets the requirements for stability testing and antifungal activity testing. This study is an experimental study which includes stability testing and antifungal activity testing of the cream preparation made from the Matoa leaf fraction against the growth of the fungus Trichophyton rubrum. The yield of ethanol extract from Matoa leaves was 21.272%, which had organoleptic properties that did not differ among each cream formula. The cream formulas were homogeneous, with no coarse granules observed during homogeneity testing. The pH of the cream preparations was between 4 and 5. The adhesive and spreading power of the cream preparations met the requirements, except for formula F3. The antifungal activity of the ethyl acetate fraction cream preparations against Trichophyton rubrum showed inhibition zones as follows: F1: 18.28 mm, F2: 11.19 mm, and F3: 18.81 mm. All formulas (F1, F2, and F3) met the physical and stability requirements for a good cream preparation, except that the spreading power test for F3 did not meet the criteria for good cream physical properties. The best antifungal activity against Trichophyton rubrum was observed in formula F3, with an inhibition zone of 18.81 mm, categorized as strong antifungal activity.
A EVALUASI PENGGUNAAN ANTIBIOTIK PADA BRONKOPNEUMONIA ANAK DI RSUD MUKOMUKO 2024 Mutiara, Elsa Febria; Efmisa, Ariesta Kirana; Rosi, Devahimer Harsep
Jurnal Kesehatan Farmasi Vol 7 No 2 (2025): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v7i2.3612

Abstract

Latar Belakang: Bronkopneumonia adalah kondisi inflamasi paru-paru yang berdampak pada satu atau lebih lobus, ditandai dengan tambalan infiltratif yang dihasilkan dari bakteri, virus, jamur, dan zat asing.Tujuan penelitian ini untuk memperoleh gambaran dan analisa ketepatan penggunaan antibiotik. Metode: Penelitian ini adalah penelitian observasional deskriptif dengan pendekatan retrospektif menggunakan data sekunder rekam medis. Penelitian ini melakukan sampling terhadap 58 rekam medis pasien bronkopneumonia anak yang dirawat inap dan mendapat terapi antibiotik. Analisis kualitatif menggunakan metode Gyssens untuk menilai ketepatan indikasi, pemilihan jenis, dosis, interval, dan lama terapi. Analisis kuantitatif menggunakan metode ATC/DDD untuk menghitung konsumsi antibiotik per 100 pasien-hari Hasil: Antibiotik yang paling sering digunakan adalah seftriakson (53,4%), sefotaksim (27,6%), dan meropenem (19,0%). Evaluasi Gyssens menunjukkan 79,3% penggunaan rasional (kategori 0), 19% kategori IV A, dan 1,7% kategori III B. Total konsumsi antibiotik sebesar 25,57 DDD/100 hari rawat dengan nilai tertinggi seftriakson (18,06 DDD/100 hari). Sedangkan nilai terendah terlihat untuk Meropenem sebesar 2,09 DDD per 100 hari dan Sefotaksim sebesar 5,42 DDD per 100 hari rawat inap. Kesimpulan: Sebagian besar penggunaan antibiotik pada pasien bronkopneumonia anak di RSUD Mukomuko sudah rasional dan efektif, namun diperlukan pengawasan berkelanjutan untuk mencegah resistensi dan meningkatkan mutu pelayanan.
Antifungal Activity of the Ethyl Acetate Fraction of Matoa Leaves (Pometia pinnata J. R. Forst & G. Forst) Against Trichophyton rubrum Afriani, Tika; Rosi, Devahimer Harsep; Cania, Reka
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.299-303

Abstract

Dermatophytosis is a prevalent skin infection in tropical regions like Indonesia, predominantly caused by the fungus Trichophyton rubrum. While Matoa leaves (Pometia pinnata) are known for their medicinal properties, their specific antifungal potency requires optimization through fractionation. This study aimed to evaluate the antifungal activity of the ethyl acetate fraction of Matoa leaves and determine its effective concentration against T. rubrum. This experimental study employed the disc diffusion method using Sabouraud Dextrose Agar (SDA). The ethyl acetate fraction was tested at concentrations of 10% and 20%, with 2% Ketoconazole as the positive control and DMSO as the negative control. The results demonstrated that the ethyl acetate fraction exhibited strong antifungal activity, yielding inhibition zones of 18.25 mm at 10% concentration and 19.75 mm at 20% concentration. Statistical analysis using the Kruskal-Wallis and Mann-Whitney tests indicated significant antifungal activity compared to the negative control (p < 0.05), though no significant difference was observed between the 10% and 20% concentrations. These findings suggest that the semi-polar ethyl acetate fraction of Matoa leaves is a potent natural antifungal agent, showing strong efficacy even at lower concentrations.
Co-Authors Afriani, Tika Azimatur Rahmi Cania, Reka Deswati Deswati Efmisa, Ariesta Kirana Farnandi, Rido Hevira, Linda Khairil Armal Mutiara, Elsa Febria Qalbi, Abrar Hafidz Rinaldi, Agus Rahman