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All Journal Biology, Medicine, & Natural Product Chemistry JOPS (Journal Of Pharmacy and Science) Jurnal Pharmacopoeia Jurnal Farmasi Indonesia
Rosi, Devahimer Harsep
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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DAMPAK PENGGUNAAN OBAT BERPOTENSI HEPATOTOKSIK TERHADAP LUARAN KLINIS PADA PASIEN SIROSIS HATI Efmisa, Ariesta Kirana; Rosi, Devahimer Harsep; Farnandi, Rido; Rahmi, Azimatur; Deswati, Deswati; Armal, Khairil
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4719

Abstract

Liver cirrhosis is a pathological liver disease characterized by the formation of fibrous tissue and regenerative nodules in liver cells. The potential for hepatotoxicity due to the use of hepatotoxic drugs leads to worsening of the liver disease suffered by these patients. This study aims to assess the impact of using potentially hepatotoxic drugs on patients' clinical outcomes. This study was an observational study with a cross-sectional design. Data were collected retrospectively through the medical records of patients with liver cirrhosis hospitalized in 2021. The clinical outcomes studied were SGOT, SGPT, albumin, total bilirubin and length of hospitalization. The results obtained were tested using the Kruskal-Wallis statistical test. A total of 62 patients with liver cirrhosis met the inclusion criteria as the study sample. The number of potentially hepatotoxic drug prescriptions received by patients based on Likelihood scores with categories A, B, C, D and E was 368 drugs out of 776 total drug prescriptions (47.4%). The most commonly prescribed potentially hepatotoxic drugs were paracetamol, ceftriaxon, and levofloxacin. It can be concluded that potentially hepatotoxic drugs are still prescribed to patients with liver cirrhosis. Age, gender, child pugh-score, number of drugs, and number of potentially hepatotoxic drugs had no significant effect (p>0.1) on SGOT, SGPT, albumin and total bilirubin. However, patients who received more drugs would have a higher.
Uji Aktivitas Antiinflamasi Ekstrak Etanol, Etil Asetat, dan N-heksan Tangkai Daun Kemumu (Colocasia gigantea Hook.f) secara in vitro terhadap Sel Makrofag Peritoneum Rosi, Devahimer Harsep; Qalbi, Abrar Hafidz; Afriani, Tika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.396

Abstract

Kemumu leaf stalks (Colocasia Gigantea Hook.F) are a plant that has many benefits for society, one of which is anti-inflammatory. Inflammation is process in the body to respond to infection or tissue damage. This study aims to test the anti-inflammatory effectiveness of ethanol extract, n-hexane, and ethyl acetate of kemumu leaf stalks in vitro. Kemumu leaf stalks contain flavonoids, alkaloid and tannin which have anti-inflammatory properties. Anti-inflammatory effectiveness testing was carried out on peritoneal macrophage cells to determine the inhibition of NO production in LPS-stimulated peritoneal macrophage cells by quantifying nitrite accumulation in the culture medium using Griess reagent. This research is an experimental study with 5 dose treatments for each extract with 3 replications. The parameters observed included NO production and the percentage of peritoneal macrophage cell inhibition. The results of statistical tests using One Way Anova showed a significant difference in NO levels between the sample group given the extract and the control sample (p=0.000). From the results of the percentage inhibition of NO production in peritoneal macrophage cells, it shows that ethanol extract of kemumu leaf stalks with concentrations of 50 and 100 µg/ml has the best anti-inflammatory effect, namely with NO production of 4.67 and 1.44 µg/ml respectively, and with respective inhibition 80.32% and 89.01% respectively.
Macroscopic, Microscopic, and Phytochemical Screening Analysis of Medicinal Plants in Nagari Lasi, West Sumatra Afriani, Tika; Rosi, Devahimer Harsep; Mailinda, Winda
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.621-633

Abstract

Indonesia is one of the countries titled “Megabiodiversity”, which has a high level of biodiversity, including medicinal plants. Medicinal plants utilize various parts of plants, such as roots, leaves, stems, and fruits for prevention, treatment, and pain relief. Nagari Lasi has great potential in the diversity of medicinal plants, but their utilization by the community is still limited due to a lack of knowledge. This study aims to identify the content of bioactive compounds in medicinal plants through macroscopic, microscopic, and phytochemical screening. The methods include organoleptic observation, macroscopic and microscopic analysis, and phytochemical tests. Of the 150 plant samples, the results showed that 78 samples contained alkaloids, 115 samples contained phenolics, 129 samples contained flavonoids, 75 samples contained steroids, 21 samples contained triterpenoids, and 119 samples contained saponins. This study provides basic information regarding the phytochemical content of medicinal plants in Nagari Lasi as a first step in developing traditional medicine.
Formulasi Sediaan Gel Face Scrub Dari Ekstrak Etanol Bayam Merah (Amaranthus tricolor L) Rosi, Devahimer Harsep
Jurnal Pharmacopoeia Vol 3 No 2 (2024): September 2024
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v3i2.879

Abstract

Telah dilakukan penelitian “Formulasi Sediaan Gel Face Scrub Dari Ekstrak Etanol Bayam Merah (Amaranthus tricolor L).” Tujuan dari penelitian ini untuk mengetahui ekstrak etanol bayam merah dapat diformulasikan sebagai sediaan gel face scrub. Ekstraksi sampel dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Ekstrak yang didapatkan dibuat gel face scrub. Pada penelitian ini dibuat menjadi 3 formulasi sediaan gel face scrub dengan konsentrasi yang berbeda yaitu F1 0,5 g, F2 0,75 g, dan F3 1 g ekstrak. Dilakukan evaluasi sediaan gel face scrub yaitu meliputi uji organoleptis, uji homogenitas, uji pH, uji iritasi, uji daya sebar dan uji daya lekat. Bayam merah yang digunakan telah diidentifikasi sebagai Amaranthus tricolor L. Hasil skrining fitokimia terhadap ekstrak bayam merah menunjukkan ekstrak positif mengandung flavonoid, alkaloid, steroid, saponin, dan tanin. Kesimpulan yang didapat bahwa sediaan gel face scrub dari ekstrak etanol bayam merah dapat diformulasikan menjadi sediaan gel face scrub karena sediaan gel yang diperoleh telah memenuhi parameter uji fisik yaitu uji organoleptis, uji homogenitas, uji pH, uji iritasi kulit, uji daya lekat, namun belum memenuhi persyaratan terhadap uji daya sebar.
Co-Authors Afriani, Tika Azimatur Rahmi Deswati Deswati Efmisa, Ariesta Kirana Farnandi, Rido Khairil Armal Mailinda, Winda Qalbi, Abrar Hafidz