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All Journal Majalah Farmaseutik Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences)
Niswah, Sukma Uswatun
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Medicine & Pharmacology

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EFEK KOMBINASI EKSTRAK ETANOL DAUN JERUK PURUT (Citrus hystrix D.C.) DAN DAUN KEMANGI (Ocimum sanctum L.) TERHADAP BAKTERI Staphylococcus aureus ATCC 25923 DENGAN METODE PITA KERTAS Niswah, Sukma Uswatun; Ana Indrayati; Ghani Nurfiana Fadma Sari
Majalah Farmasi dan Farmakologi Vol. 27 No. 3 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i3.27092

Abstract

Penyakit infeksi bakteri Staphylococcus aureus dapat diobati dengan menggunakan antibiotik. Resistensi bakteri sering terjadi pada bakteri Staphylococcus aureus. Kekebalan bakteri terhadap antibiotik menyebabkan angka kematian semakin meningkat. Daun jeruk purut dan daun kemangi mengandung senyawa aktif flavonoid, alkaloid, saponin, dan tanin sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas kombinasi ekstrak etanol daun jeruk purut dan daun kemangi terhadap bakteri Staphylococcus aureus ATCC 25923. Daun jeruk purut dan daun kemangi diekstraksi dengan metode maserasi menggunakan pelarut etanol 96% kemudian dilakukan identifikasi golongan senyawa. Ekstrak daun jeruk purut dan daun kemangi dilakukan uji antibakteri dengan metode dilusi. Hasil konsentrasi bunuh minimal dikombinasi dengan perbandingan konsentrasi (1:1), (1:2), dan (2:1). Pengujian aktivitas antibakteri menggunakan metode difusi cakram dan penentuan efek kombinasi menggunakan metode pita kertas. Data dianalisa secara statistik dengan uji Shapiro-wilk, homogenitas Levene, dilanjutkan uji One-Way ANOVA dan uji Least Significant Difference. Hasil penelitian menunjukkan bahwa kombinasi ekstrak etanol daun jeruk purut dan daun kemangi memiliki aktivitas antibakteri terhadap Staphylococcus aureus ATCC 25923. Kombinasi ekstrak paling efektif ditunjukkan pada perbandingan konsentrasi 1:2 dengan rata-rata diameter zona hambat 27,21±0,47 mm dan memberikan efek kombinasi sinergis terhadap Staphylococcus aureus ATCC 25923.
Development of green synthesis silver nanoparticle with Ocimum sanctum leaf extract: characterization and stability study Niswah, Sukma Uswatun; Kusumorini, Nindya; Martien, Ronny
Majalah Farmaseutik Vol 22, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i1.113027

Abstract

This study aimed to synthesize, characterize, and evaluate the stability of silver nanoparticles (AgNPs) produced using Ocimum sanctum L. leaf extract through a green synthesis method. The aqueous extract of fresh basil leaves served as a natural reducing and stabilizing agent in the reduction of 1 mM silver nitrate solution at 80 °C, indicated by a color change from light yellow to brown. Phytochemical screening confirmed the presence of phenolic compounds, saponins, and flavonoids responsible for the reduction and stabilization processes. Characterization by UV–Visible spectrophotometry showed a surface plasmon resonance peak at 450 ± 4.93 nm, while particle size analysis indicated a Z-average of 85.77 ± 0.46 nm and a polydispersity index of 0.222 ± 0.003, reflecting uniform and monodisperse nanoparticles. The zeta potential of –14.23 ± 0.30 mV suggested moderate colloidal stability. After 30 days of refrigerated storage, the nanoparticles exhibited a red shift of the absorption peak, an increased particle size of 111.12 ± 1.24 nm, and a slightly higher zeta potential, indicating partial aggregation. These findings demonstrate that O. sanctum extract can effectively mediate the eco-friendly synthesis of stable silver nanoparticles, although their long-term stability is influenced by physicochemical interactions of surface biomolecules.
Co-Authors Ana Indrayati Ghani Nurfiana Fadma Sari Kusumorini, Nindya Ronny Martien