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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Eziefule, Oluebube Magnificient
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Biochemistry, Genetics & Molecular Biology Dentistry Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Andrographis paniculata Ethanolic Extract Improved Doxorubicin-induced Cardiac Inflammation, Alterations in Liver Function Parameters and Anemia Eziefule, Oluebube Magnificient; Arozal, Wawaimuli; Wanandi, Septelia Inawati; Louisa, Melva; Wuyung, Puspita Eka; Dewi, Syarifah; Nafrialdi, Nafrialdi; Dewi, Yulia Ratna; Nabillah, Deya Adiby
Molecular and Cellular Biomedical Sciences Vol 8, No 2 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i2.444

Abstract

Background: Doxorubicin (DOX), an efficacious chemotherapy drug is compromised by cardiotoxicity, myelosuppression, and hepatotoxicity. Due to the limited success of current treatments for DOX toxicity, there is a pressing need to explore alternative medical interventions, particularly from plant sources. This study was conducted to investigate the potential protective effect of ethanolic extract of Andrographis paniculata leaves (EEAP) against DOX-induced cardiac inflammation, liver toxicity, and anemia.Materials and methods: Sprague-Dawley rats were intraperitoneally injected with DOX at a total dose of 16 mg/kgBW. EEAP was administered orally for 4 weeks at doses of 125, 250, and 500 mg/kgBW/day according to the assigned treatment groups. The mRNA expression levels of interleukin-1β (IL-1β) and nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) in the heart tissue, along with the concentrations of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) and calcium level were examined. Additionally, the hematological parameters (including hematocrit, hemoglobin and red blood cells (RBCs)), aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and malondialdehyde (MDA) levels in blood were also analyzed.Results: EEAP dose-dependently decreased the mRNA expressions of IL-1β (p<0.05), tended to decrease mRNA expression of NLRP3 and the concentrations of NFκB and calcium in heart tissue compared with the DOX-only group. Additionally, EEAP dose-dependently decreased ALP values (p<0.0001) and tended to improve hematological parameters, as well as AST and MDA levels in serum.Conclusion: This extract may prevent DOX-induced cardiac inflammation, anemia, and hepatotoxicity. However, further studies are needed to confirm these findings, including the efficacy profile of the extract in cancer rats treated with DOX.Keywords: doxorubicin, Andrographis paniculata, inflammation, anemia, hepatotoxicity, herbal medicine
Associations Between Community Health Worker Capacity and Stunting Reduction Efforts in South Central Timor, Indonesia Pujiyanti, Riny; Irfan, Irfan; Handayani, Fitri; Kleden, Simon Sani; Kambuno, Norma Tiku; Hilaria, Maria; Eziefule, Oluebube Magnificient
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 9 No. 1: JANUARY 2026 - Media Publikasi Promosi Kesehatan Indonesia
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v8i12.8635

Abstract

Introduction: Malnutrition, particularly childhood stunting, remains a critical issue in Indonesia, including the South-Central Timor (SCT) District, East Nusa Tenggara Province. Stunting affects 149.2 million children under five years globally. In the SCT District (2025), stunting prevalence reached 41%. Climatic conditions, food insecurity, and cultural factors contribute to this problem. Prevention efforts involve national strategies, including behavioral change communication campaigns, with Community Health Workers (CHWs) playing crucial roles due to their community credibility and responsiveness. CHW participation is voluntary without continuous commitment obligations. CHW activity and roles in stunting reduction acceleration are paramount, necessitating the investigation of influencing factors. This study aims to identify the factors associated with the roles of Community Health Workers (CHWs) in accelerating stunting reduction in the SCT District in 2025. Methods: This quantitative cross-sectional study included 124 CHWs from 10 community health centers in the SCT District. The study was conducted from January to May 2025. Separate questionnaires measured each variable (CHW role, knowledge, and skills). Ethical approval was obtained from the Kupang Health Polytechnic Research Ethics Committee. Results: Bivariate analysis revealed that knowledge level, education, training history, work duration (all p<0.001), and CHW skills (p=0.002) were significantly associated with CHW roles. The final model showed training history increased CHW role effectiveness by 45.3 times (OR=45.354; 95% CI=1.634-1258.56), CHW skills by 44.3 times (OR=44.393; 95% CI=2.721-724.36), and work duration by 16.9 times (OR=16.934; 95% CI=1.280-224.02). Conclusion: Training, skill level, and work duration were associated with higher CHW role performance, supporting improved stunting prevention efforts. This study provides a new understanding of the importance of enhancing CHW knowledge and skills through structured/routine training programs. Further research comparing CHW capacity in low versus high stunting areas is important for understanding CHW capacity management program improvements.
Co-Authors Dewi, Yulia Ratna Fitri Handayani Kleden, Simon Sani Maria Hilaria Melva Louisa MMSI Irfan ,S. Kom Nabillah, Deya Adiby Nafrialdi Nafrialdi Norma Tiku Kambuno pujiyanti, riny Puspita Eka Wuyung SEPTELIA INAWATI WANANDI Syarifah Dewi Wawaimuli Arozal