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All Journal HAYATI Journal of Biosciences EKSAKTA: Journal of Sciences and Data Analysis Indonesian Journal of Cancer INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal Paediatrica Indonesiana Journal of Medicine and Health Molecular and Cellular Biomedical Sciences (MCBS) Syntax Literate: Jurnal Ilmiah Indonesia Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JFL : Jurnal Farmasi Lampung Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Ilmu Kefarmasian Indonesia Majalah Kedokteran Andalas Jurnal Jamu Indonesia Majalah Patologi Indonesia Jurnal Ekonomi Muhammadiyah Journal of Geriatric Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Indonesian Journal of Medical Chemistry and Bioinformatics Jurnal Kefarmasian Indonesia Indonesian Journal of Jamu Journal of Medicine and Health

Wawaimuli Arozal

Universitas Indonesia

Author-ID : 233758

Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Evaluation of Kidney Injury Molecule-1 (KIM-1) and Neutrophil Gelatinase-Associated Lipocalin (NGAL) Urinary Levels for Detecting Kidney Dysfunction in Patients With Nasopharyngeal Cancer Treated With Cisplatin-Based Treatment Rejeki, Marliana Sri; Arozal, Wawaimuli; Setiabudy, Rianto; Atmakusuma, Djumhana
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Cisplatin has a potency of causing nephrotoxicity. Serum BUN and creatinine levels have been well-known for detecting kidney dysfunction; while KIM-1 and NGAL urine levels are relatively new measurements. The study was aimed to evaluate urinary KIM-1 and NGAL level to detect kidney dysfunction in patients with advanced stage NPC who received cisplatin-based chemotherapy.Methods: The study was a cohort-prospective study with 3 subject groups, i.e. patients who had never received and who had received 75-100 mg/m2 cisplatin-based chemotherapy as well as those who had never received 40 mg/m2 cisplatin-based chemotherapy. The levels of urinary KIM-1, NGAL and serum level of BUN and creatinine were measured before and after receiving cisplatin. Statistical analyses were ANOVA, Pearson, Spearman, Kolmogorov-Smirnov test and SPSS version 22.0.Result: There was a significant difference of delta BUN level (p=0.0001) and delta urinary NGAL level (p = 0.025) before and after treatment in all three groups; while delta KIM-1 level showed no significant difference in all three groups (p=0.275). Cisplatin may cause accumulated nephrotoxicity, which has dose-dependent manner.Conclusion: Measuring urinary NGAL level can detect an early stage of kidney dysfunction; however, it still cannot replace the role of BUN. Measurement of urinary KIM-1 level cannot detect kidney dysfunction.

The Effect of Mangiferin Against Brain Damage Caused by Oxidative Stress and Inflammation Induced by Doxorubicin Soni Siswanto; Wawaimuli Arozal; Vetnizah Juniantito; Agatha Grace; Femmi Dwinda Agustini; . Nafrialdi
HAYATI Journal of Biosciences Vol. 23 No. 2 (2016): April 2016
Publisher : Bogor Agricultural University, Indonesia

Doxorubicin (DOX) is an anthracycline antibiotic used for anticancer therapy. However, this agent can cause various systemic side effects including cognitive impairments in chronic use. Brain damage due to DOX is caused by an increase of tumor necrosis factor-alpha (TNF-α) level in the brain. Increased TNF-α can further lead to chronic inflammation which can lead to neuronal deaths or neurodegenerative diseases. Mangiferin (MAG), a compound extracted from Mangifera indica, has been found neuroprotective activities, but its effect on DOX-induced brain damage is unknown. This study aims to determine the effect of MAG on brain damage induced by DOX. Male Sprague-Dawley rats were induced by DOX intraperitoneally. MAG was given orally at the doses of 30 and 60 mg/kg bw for 7 consecutive weeks. The parameters measured were inflammatory and oxidative stress markers in brain tissue. Coadministration of MAG with DOX reduced inflammation which was marked by the reduction of TNF-α mRNA expression, decreased TNF-α level and reduction of oxidative stress marked by increase of superoxide dismutase level and decrease of malondialdehyde level. In conclusion, MAG was shown to have a neuroprotective effect on brain damage induced by DOX, partly due to inhibition of inflammation and oxidative stress.

Evaluasi Penggunaan Antibiotik pada Pasien Sepsis Neonatus di Rumah Sakit X Purwakarta Rani Hendiyani; Wawaimuli Arozal; Hesty Utami Ramadaniati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 3 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i32021.217-226

Pendahuluan: Angka morbiditas dan mortalitas yang tinggi pada neonatus disebabkan oleh sepsis. Bakteri sebagai salah satu penyebabnya sehingga antibiotik menjadi salah satu terapi empiris. Penggunaan antibiotik yang tidak rasional dapat menyebabkan bakteri menjadi resisten sehingga tujuan terapi tidak optimal. Tujuan: Penelitian ini bertujuan mengevaluasi antibiotik yang digunakan oleh pasien sepsis neonatus baik dilihat dari kualitas (metode Gyssens) maupun kuantitas (metode Defined Daily Dose) serta untuk mengetahui hubungan antara rasionalitas obat dengan lama rawat menggunakan uji korelasi Rank Spearman. Metode: Penelitian observasional berdesain potong lintang yang di analisis secara deskriptif analitik. Pengumpulan data pasien secara Prospektif dari bulan Mei - Juli 2019 diperoleh 69 rekam medis yang memenuhi kriteria inklusi. Hasil: Dari hasil evaluasi kualitas antibiotik diperoleh penggunaan antibiotik tepat sebanyak 26 pasien (37,7%) dan tidak tepat sebanyak 43 pasien meliputi 56,5% dosis pemberian antibiotik tidak tepat, 4,3% karena terdapat antibiotik lain yang lebih efektif dan 1,4% adanya pemberian antibiotik terlalu lama sedangkan kuantitas penggunaan antibiotik diperoleh total 12,9 DDD/100 pasien-hari meliputi Ampisilin-sulbaktam 3,25 DDD/100 pasien-hari, Sefoperazone-sulbaktam 4 DDD/100 pasien-hari, Meropenem 2,42 DDD/100 pasien-hari sedangkan nilai DDD yang melebihi nilai standar WHO yaitu Gentamisin 1,94 DDD/100 pasien-hari dan Amikasin 12,9 DDD/100 pasien-hari meliputi Ampicilin-Sulbaktam (3,25), Cefoperazone Sulbaktam (4), Meropenem (2,42) sedangkan nilai DDD yang melebihi nilai standar WHO yaitu gentamicin (1,94) dan Amikasin (1,29). Hasil korelasi diperoleh nilai r = 0,223 (P â‰¥ 0,05) yang artinya korelasi rendah bahwa tidak menunjukkan adanya hubungan antara rasional obat dengan lama rawat. Kesimpulannya: Penggunaan antibiotik yang tidak tepat masih ada dengan kuantitas melebihi standar WHO.

Hewan Model Kanker Ovarium untuk Studi Preklinik dan Pengembangan Obat Kanker Ovarium Ni Made Dwi Sandhiutami; Puspita Eka Wuyung; Wawaimuli Arozal; Melva Louisa; Deni Rahmat
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Treatment for ovarian carcinoma is still far from optimal, animal models are still needed to study human epithelial ovarian cancer. Animal models of ovarian cancer are very important for understanding the pathogenesis of the disease and for testing new treatment strategies. Ovarian carcinogenesis models in mice have been modified and repaired to produce preneoplastic lesions and neoplastic ovaries that are pathogens resembling human ovarian cancer. Although spontaneous ovarian tumors in mice have been reported, some of the shortcomings of existing studies preclude their use as animal models of ovarian cancer. Because of this, many efforts have been made to develop animal models that are relevant for ovarian cancer. Experimental animal models are developed accurately to represent cellular and molecular changes associated with the initiation and development of human ovarian cancer. Accurate experimental models have significant potential in facilitating the development of better methods for early detection and treatment of ovarian cancer. Several animal models of ovarian cancer have been reported, including manipulation of various reproductive factors or exposure to carcinogens. The latest advance in ovarian cancer modeling is using genetically engineered mice.

Efek Kombinasi Ekstrak Etanol Acalypha indica dan Centella asiatica pada Jantung Tikus Pascahipoksia: Gen Hif-1a, Troponin I dan Stres Oksidatif Marsetyo Edhiatmi; Wawaimuli Arozal; Erni H Purwaningsih
Jurnal Jamu Indonesia Vol. 1 No. 2 (2016): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Hipoksia meningkatkan pembentukan dan pelepasan spesies oksigen reaktif (ROS). Sel mempunyai mekanisme melindungi diri terhadap kerusakan akibat pembentukan ROS yang terjadi secara alami. Jika pembentukan radikal bebas terjadi berlebihan maka dapat menyebabkan stres oksidatif yang memicu kerusakan sel terutama pada jantung. Sehingga tubuh memerlukan asupan antioksidan. Acalypha indica dan Centella asiatica terbukti memiliki efek antioksidan dan melindungi banyak organ dari kondisi hipoksia, sehingga penelitian ini dilakukan dengan tujuan untuk mengetahui efek antioksidan kombinasi ekstrak etanol Acalypha indica dan Centella asiatica pada organ jantung tikus Spraque-Dawley pascahipoksia. Tiga puluh lima ekor tikus Sprague-Dawley jantan diinduksi hipoksia selama 7 hari dalam ruang khusus, kemudian diberi perlakuan. Ekstrak Acalypha indica, ekstrak Centella asiatica dan kombinasinya diberikan kepada kelompok tikus yang telah dibagi menjadi grup A (hipoksia dan diberi air), B (hipoksia dan diberi kombinasi Acalypha indica 200 mg/kgBB dan Centella asiatica 150 mg/kgBB), C (hipoksia dan diberi kombinasi Acalypha indica 250 mg/kgBB dan Centella asiatica 100 mg/kgBB), D (hipoksia dan diberi Acalypha indica 250 mg/kgBB), E (hipoksia dan diberi Centella asiatica 150 mg/kgBB), F (hipoksia dan diberi vitamin C 100mg/kgBB) dan kelompok normal. Perlakuan diberikan secara oral selama 7 hari setelah hipoksia. Parameter yang diamati adalah ekspresi mRNA HIF-1α, kadar MDA, aktivitas enzim SOD dan ekspresi mRNA cTnI. Tidak terdapat perbedaan bermakna pada ekspresi HIF-1α antara grup A dan kelompok tikus normal (p>0,05). Kadar MDA meningkat signifikan pada grup A (p<0,05) dibanding tikus normal. Kadar MDA grup D mengalami penurunan secara signifikan (p<0,05) dibanding grup A. Aktivitas SOD menurun signifikan pada grup A (p<0,05) dibanding tikus normal. Aktivitas SOD grup B dan E (p<0,05) mengalami peningkatan secara signifikan dibanding grup A. Grup B meningkat signifikan (p<0,05) dibanding grup E. Tidak terdapat perbedaan bermakna antar kelompok perlakuan pada Ekspresi cTnI. Tidak terdapat korelasi antara kadar MDA dan aktivitas SOD serta ekspresi mRNA HIF-1a dan mRNA cTnI. Pemberian kombinasi ekstrak Acalypha indica dan Centella asiatica tidak dapat membantu memproteksi kerusakan jantung pascahipoksia.

Cardioprotective Effect of Quercetin in 5/6-Nephrectomized Rats: Focus on Myocardial fibrosis and Oxidative Stress Tri Yuliani; Melva Louisa; Wawaimuli Arozal; Vivian Soetikno; Nafrialdi Nafrialdi; Indah D Dewijanti
Jurnal Jamu Indonesia Vol. 2 No. 3 (2017): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Uremic cardiomyopathy is the leading cause of death in patients with chronic kidney disease. Fluid overload and oxidative stress play important roles in its pathogenesis. This study aims to determine the effect of quercetin on uremic cardiomyopathy in 5/6-nephrectomized rats. To our knowledge, its cardioprotective effect on uremic cardiomyopathy induced in rats by 5/6 nephrectomy has not been investigated yet. Uremia was induced surgically in male Sprague-Dawley rats via 5/6 nephrectomy. Quercetin was administered per orally at a dose of 100 mg/kg/day for 8 weeks prior to sacrifice. Meanwhile, captopril was administered at a dose of 10 mg/kg/day. Lipid peroxidation was assessed using TBARS reaction, while GPX activity was determined to explore the endogen antioxidant mechanism. Myocardial fibrosis was analyzed using Massons’ Trichrome staining and the level of NT-proBNP in plasma was measured as a marker of cardiac dysfunction. Nephrectomy 5/6 had no effects on plasma NT– proBNP levels, cardiac and plasma MDA levels, but induced mild myocardial fibrosis and significant increase in cardiac GPX activity in comparison with normal rat (p<0.05). However, administration of quercetin or captopril did not ameleriote those mild myocardial fibrosis and increased GPX activity. Uremic cardiomyopathy induced by 5/6 nephrectomy demonstrated mild myocardial fibrosis but preservation of cardiac function demonstrated by NT-proBNP levels. Increased of GPX activity in the nephrectomized-rats compared to the control rats (p<0.05) suggests induction of antioxidant defense mechanisms that might not be exhausted yet. This condition highlighted a compensatory phase which was unchanged following chronic administration of either quercetin or captopril.

EVALUASI PENGGUNAAN ANTIBIOTIK DEFINITIF PADA SEPSIS NEONATORUM AWITAN DINI DAN LAMBAT DI RSPAD GATOT SOEBROTO Marselina Marselina; Ros Sumarny; Wawaimuli Arozal; Marliana Sri Rejeki
Majalah Farmasi dan Farmakologi Vol. 24 No. 3 (2020): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v24i3.11181

Angka kejadian sepsis neonatorum yang tinggi karena sulitnya penegakan diagnosis disebabkan faktor klinis tidak spesifik. Pasien akan mendapatkan antibiotik setelah 1 jam yang diduga sepsis. Hal ini meningkatkan resistensi karena penggunaan antibiotik tidak rasional. Maka perlu ibu serta pasien sepsis dan penggunaan antibiotik. Penelitian deskriptif analitik dengan studi kohort retrospektif menggunakan data rekam medis yang memenuhi kriteria inklusi. Analisis data secara bivariat dengan uji chi square pada p≤0.05. Ada 98 pasien (SNAD 55 pasien; SNAL 43 pasien). Hubungan hubungan antara ibu hamil kehamilan kehamilan SNAD (p = 0,025), kehamilan kehamilan kehamilan (p = 0,020).Hubungan antara hubungan antara variabel pasien detak jantung terhadap SNAD (p = 0.010). Evaluasi metode DDD didapatkan antibiotik yang sering digunakan yaitu meropenem 20.147 DDD / 100 hari sabar . Analisis hubungan antara metode Kunin terhadap luaran klinis pasien SNAD (p = 0.175; RR = 2.316; 95% Cl = 0.677-7.919), lama rawat (p = 0.057; RR = 4.929; 95% Cl = 0.954-25.469). Analisis hubungan antara metode Kunin terhadap luaran klinis pasien SNAL (p = 0.811; RR = 1.167; 95% Cl = 0.331-4.116), lama rawat (p = 0.110; RR = 0.525; 95% Cl = 0.391-1.705). Hasil tersebut menunjukkan bahwa tidak ada hubungan antara kerasionalan penggunaan antibiotik definitif dengan luaran kinis serta lama rawat yang di nilai menggunakan metode Kunin.Kata kunci: sepsis neonatorum, baterai, antibiotik definitif

Evaluation of Kidney Injury Molecule-1 (KIM-1) and Neutrophil Gelatinase-Associated Lipocalin (NGAL) Urinary Levels for Detecting Kidney Dysfunction in Patients With Nasopharyngeal Cancer Treated With Cisplatin-Based Treatment Marliana Sri Rejeki; Wawaimuli Arozal; Rianto Setiabudy; Djumhana Atmakusuma
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Model Hewan Coba pada Penelitian Diabetes Husna, Fauzul; Suyatna, Franciscus D; Arozal, Wawaimuli; Purwaningsih, Erni H
Pharmaceutical Sciences and Research Vol. 6, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

The animal model has been widely used and contributed vastly to the scientific research over the years. While it can be used as an alternate subject in a study, the selection of the animal is crucial to assess and investigate the influence of the environment and genes on the pathogenesis of a disease. Many factors contribute to the choosing of the animal. They can be ranged from the similarities with the modelled object, easily looked after with less expensive cost, good reproductive performance, ability to produce blood and tissue samples, well-known genetic composition, and the status of the disease can be explained. Research has been taking place to investigate and find the best approach to prevent and deal with diabetes mellitus (DM) and insulin resistance and its complications. It starts with an initial in vitro method and finished with a clinical trial. Similarly, a series of in vivo studies using the animal model has been done aiming at figuring out its conditions or diseases that are identical to that of humans. This article discusses a variety of animal models frequently used in DM research.

L-citrulline as Alternative Pharmacological Substance in Protecting Against Cardiovascular Disease Laurentius, Andrea; Wikanendra, Gregorius Bhaskara; Cong, Tzeto Han; Arozal, Wawaimuli
Pharmaceutical Sciences and Research Vol. 5, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Cardiovascular disease (CVD) has taken up to average 30% of death diagnoses in the world. Prevalent attempts of physicians to treat this disease came down to focus on using drugs with their specific mechanism of action. Since the method only cures the symptoms and need to be pharmacologically monitored, physicians and scientists have been struggling to find other treatment strategies. This problem led us to search for another substance dealing with CVD via preventive therapy, which does not require such close monitoring by physicians in its use. The answer relies on using L-citrulline as potential therapeutics in treating and preventing CVDs. This compound, found mostly in Citrus sp., contains chemical traits that could affect other bodily substances with its metabolic pathways. It has several functions, but boosting NO production is the dominant one in the cardiovascular system. By enhancing NO bioavailability, it suppresses the risk of having myocardial oxidative stress due to ischemia, cardiac pressure-overload, and post-infarct reperfusion. Thus, understanding of L-citrulline effects on endothelial NOS pathway in the generation of NO and its uncoupling mechanisms could be used as a foundation in developing alternative treatment and prevention of oxidative stress-induced CVD.

Co-Authors Agatha Grace Agian Jeffilano Barinda Andrea Laurentius Arleni Bustami Aryo Tedjo Barinda, Again Jeffilano Bernie Endyarni Medise Cong, Tzeto Han Deni Rahmat Dewi Sukmawati Dewi, Yulia Ratna Djumhana Atmakusuma Djumhana Atmakusuma, Djumhana Dwita, Nounik Cheri Edhiatmi, Marsetyo Erlina, Linda Erni H Purwaningsih Erni H Purwaningsih, Erni H Erni Hernawati Purwaningsih, Erni Hernawati Ernie Purwaningsih Eviarini, Prawitasari Eziefule, Oluebube Magnificient Fadhillah, Muhamad Rizqy Fadilah Fadilah Fadilah, Fadilah Fajarido, Ariski Femmi Dwinda Agustini Franciscus D. Suyatna Gregorius Bhaskara Wikanendra Gusti Khatimah, Nurul Hanifah Oswari Hedi R. Dewoto Heri Wibowo Hesty Utami Husna, Fauzul Indah D Dewijanti Indah D Dewijanti, Indah D Irawan Mangunatmadja Jusman, Sri Widia Azraki Kapuangan, Christopher Kartika, Kartika Handayani Kenichi Watanabe Khatimah, Nurul Gusti Kuncoro, Daviet Dwi Kurniasari Kurniasari Kusmardi Kusmardi Kusmardi Kusmardi Laurentius, Andrea Lee, Hee Jae Marliana Sri Rejeki Marliana Sri Rejeki Marliana Sri Rejeki Marselina Marselina Marsetyo Edhiatmi Meilei Ma Melva Louisa Muhamad Sadam Safutra Musridharta, Eka Nabillah, Deya Adiby Nafrialdi Nafrialdi Nastiti Kaswandani Ni Made Dwi Sandhiutami Novi Silvia Hardiany Nur Azizah Nurwulan Adi Ismaya Pebriani, Mala Primadhani, Suci Widya Punniyakoti T. Veeraveedu Puspita Eka Wuyung Puspita Eka Wuyung Putri, Rizky Clarinta Radiana Dhewayani Antarianto Radoti Merlin Rani Hendiyani Rani Sauriasari Rani Sauriasari, Rani Raymond R. Tjandrawinata Rejeki, Marliana Sri Ria Anggraeni Rianto Setiabudy Rianto Setiabudy Riski Amanda, Clara Roro Rukmi Windi Perdani, Roro Rukmi ROS SUMARNY Ros Sumarny Rosyidah, Citra Safutra, Muhamad Sadam Safutra, Sadam Sagala, Radoti Merlin SEPTELIA INAWATI WANANDI Sesilia Keban Sesilia Keban, Sesilia Setyo Handryastuti Shimizu, Ippei Silmi Hanifah Soni Siswanto Sumiati, Yati Supraja Dwiyono Suyatna, Franciscus D Syarifah Dewi Thandavarayan, Rajarajan Amirthalingam Tri Yuliani Tri Yuliani, Tri Triana, Novi Tzeto Han Cong Ulfa T Wahyuni Ulya, Nurul Vetnizah Juniantito Vivian Soetikno Vivian Soetikno Wahyunia Likhayati Septiana Wardani, Amanda Saphira Wikanendra, Gregorius Bhaskara Yati Sumiyati

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