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All Journal Medical Journal of Indonesia Indonesian Journal of Cancer The Indonesian Biomedical Journal Journal of Medicine and Health Molecular and Cellular Biomedical Sciences (MCBS) Syntax Literate: Jurnal Ilmiah Indonesia Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JFL : Jurnal Farmasi Lampung Majalah Kedokteran Andalas Majalah Patologi Indonesia Muhammadiyah Journal of Geriatric Pharmaceutical Sciences and Research (PSR) Indonesian Journal of Medical Chemistry and Bioinformatics Journal of Medicine and Health
Wawaimuli Arozal
Universitas Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Telmisartan inhibits the progression of cardiomyopathy in daunorubicin treated rats: the role of advanced glycation end products Arozal, Wawaimuli; Watanabe, Kenichi; Veeraveedu, Punniyakoti T.; Ma, Meilei; Nafrialdi, Nafrialdi
Medical Journal of Indonesia Vol 20, No 4 (2011): November
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1266.695 KB) | DOI: 10.13181/mji.v20i4.461

Abstract

Background: Anthracyclines have been reported to induce  cardiotoxicity through mechanisms involving formation of  advanced glycation end-products (AGEs), including pentosidine and Nє-(carboxymethyl) lysine (CML). We investigated the  potential utility of telmisartan (TML), an angiotensin II receptor antagonists (ARB) on anthracycline-induced cardiotoxicity.Methods: Three groups of Sprague-Dawley rats were treated as follows: The first group received daunorubicin (DNR) 3 mg/kgBW every alternating day to reach a cumulative dose of 9 mg/kg DNR . The second group received DNR plus TLM at a dose10 mg/kgBW, by oral gavage for 6 weeks, and the third group served as control group (CTL) which only received vehicle of DNR. Mean blood pressure (MBP) peak left ventricular pressure (LVP), LV end-diastolic pressure (LVEDP), and intra-ventricular  contractility (±dP/dt) were recorded by using Powerlab instrumentation. Ejection fraction (EF), and fractional shortening (FS) were measured by echocardiography. Expression of receptor of AGE (RAGE), pentosidine and CML were measured by  immunohistochemistry and Western blot in LV tissue.Results: DNR treatment was associated with significant  weakening of some hemodynamic parameters which couldbe reversed by TML (LVP: 124.3 ± 6.0; 111 ± 7; and 115.1 ± 5.4 mmHg, respectively in CTL, DNR and DNR-TLM groups; LVEDP: 7.5 ± 0.9; 10.7 ± 0.3; 8.7 ± 0.4 mmHg, respectively; +dP/dt: 6813 ± 541; 4800 ± 345; 5950 ± 398 mmHg/s, respectively). The same phenomenons were also observed on echocardiographic parameters (EF: 78.9 ± 1.8; 59.6 ± 1.4; 76.2 ± 2.75 %, resepectively; FS: 42.8 ± 1.7; 29.1 ± 1.3; 41 ± 2.7 %) respectively. Expression of RAGE as well as pentosidine and CML were increased in DNR-rats. TML treatment ameliorated these changes.Conclusion: These results suggested the role of AGE formation in DNR-induced cardiotoxicity and telmisartan could inhibit the progression of cardiac toxicity at least in part by reduction RAGE expressiom. (Med J Indones 2011; 20:255-62)Keywords: advanced glycation end product, anthracyline, cardiotoxicity, daunorubicin, telmisartan
Evaluation of Kidney Injury Molecule-1 (KIM-1) and Neutrophil Gelatinase-Associated Lipocalin (NGAL) Urinary Levels for Detecting Kidney Dysfunction in Patients With Nasopharyngeal Cancer Treated With Cisplatin-Based Treatment Rejeki, Marliana Sri; Arozal, Wawaimuli; Setiabudy, Rianto; Atmakusuma, Djumhana
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (951.677 KB) | DOI: 10.33371/ijoc.v12i2.581

Abstract

Background: Cisplatin has a potency of causing nephrotoxicity. Serum BUN and creatinine levels have been well-known for detecting kidney dysfunction; while KIM-1 and NGAL urine levels are relatively new measurements. The study was aimed to evaluate urinary KIM-1 and NGAL level to detect kidney dysfunction in patients with advanced stage NPC who received cisplatin-based chemotherapy.Methods: The study was a cohort-prospective study with 3 subject groups, i.e. patients who had never received and who had received 75-100 mg/m2 cisplatin-based chemotherapy as well as those who had never received 40 mg/m2 cisplatin-based chemotherapy. The levels of urinary KIM-1, NGAL and serum level of BUN and creatinine were measured before and after receiving cisplatin. Statistical analyses were ANOVA, Pearson, Spearman, Kolmogorov-Smirnov test and SPSS version 22.0.Result: There was a significant difference of delta BUN level (p=0.0001) and delta urinary NGAL level (p = 0.025) before and after treatment in all three groups; while delta KIM-1 level showed no significant difference in all three groups (p=0.275). Cisplatin may cause accumulated nephrotoxicity, which has dose-dependent manner.Conclusion: Measuring urinary NGAL level can detect an early stage of kidney dysfunction; however, it still cannot replace the role of BUN. Measurement of urinary KIM-1 level cannot detect kidney dysfunction.
Model Hewan Coba pada Penelitian Diabetes Husna, Fauzul; Suyatna, Franciscus D; Arozal, Wawaimuli; Purwaningsih, Erni H
Pharmaceutical Sciences and Research Vol. 6, No. 3
Publisher : UI Scholars Hub

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Abstract

The animal model has been widely used and contributed vastly to the scientific research over the years. While it can be used as an alternate subject in a study, the selection of the animal is crucial to assess and investigate the influence of the environment and genes on the pathogenesis of a disease. Many factors contribute to the choosing of the animal. They can be ranged from the similarities with the modelled object, easily looked after with less expensive cost, good reproductive performance, ability to produce blood and tissue samples, well-known genetic composition, and the status of the disease can be explained. Research has been taking place to investigate and find the best approach to prevent and deal with diabetes mellitus (DM) and insulin resistance and its complications. It starts with an initial in vitro method and finished with a clinical trial. Similarly, a series of in vivo studies using the animal model has been done aiming at figuring out its conditions or diseases that are identical to that of humans. This article discusses a variety of animal models frequently used in DM research.
L-citrulline as Alternative Pharmacological Substance in Protecting Against Cardiovascular Disease Laurentius, Andrea; Wikanendra, Gregorius Bhaskara; Cong, Tzeto Han; Arozal, Wawaimuli
Pharmaceutical Sciences and Research Vol. 5, No. 2
Publisher : UI Scholars Hub

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Abstract

Cardiovascular disease (CVD) has taken up to average 30% of death diagnoses in the world. Prevalent attempts of physicians to treat this disease came down to focus on using drugs with their specific mechanism of action. Since the method only cures the symptoms and need to be pharmacologically monitored, physicians and scientists have been struggling to find other treatment strategies. This problem led us to search for another substance dealing with CVD via preventive therapy, which does not require such close monitoring by physicians in its use. The answer relies on using L-citrulline as potential therapeutics in treating and preventing CVDs. This compound, found mostly in Citrus sp., contains chemical traits that could affect other bodily substances with its metabolic pathways. It has several functions, but boosting NO production is the dominant one in the cardiovascular system. By enhancing NO bioavailability, it suppresses the risk of having myocardial oxidative stress due to ischemia, cardiac pressure-overload, and post-infarct reperfusion. Thus, understanding of L-citrulline effects on endothelial NOS pathway in the generation of NO and its uncoupling mechanisms could be used as a foundation in developing alternative treatment and prevention of oxidative stress-induced CVD.
Evaluasi Penerapan Booklet dan Edukasi Apoteker pada Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Mayapada Tangerang Sagala, Radoti Merlin; Arozal, Wawaimuli; Sauriasari, Rani; Keban, Sesilia
Pharmaceutical Sciences and Research Vol. 4, No. 2
Publisher : UI Scholars Hub

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Abstract

Type 2 diabetes mellitus is a degenerative disease with long-term treatment that requires knowledge and self-management to control blood sugar level. The purpose of this study was to evaluate the provision of booklet and pharmacist education in improving knowledge and behavior of self-management of type 2 diabetes mellitus patient at Mayapada Hospital Tangerang. This study respondents were 90 people who were divided into 3 groups. Group 1 got booklet and education, group 2 got booklet only and control group did not get any treatment. Fasting Blood Glucose (FBG) levels before the intervention were in poorly controlled category and after intervention there was no significant change. There was an increase in the level of knowledge and self-management in group 1 and group 2. There was no significant change in FBG. Provision of booklet with education by pharmacist showed a higher increase in knowledge (p=0.02) and self management behavior (p<0.001) than provision of booklet only. There was no relationship between knowledge and self-management behavior with blood sugar levels. It could be concluded that booklet and education by pharmacist could improve knowledge and behavior of self-management of DM type 2 patients in each intervention group. However, there was no relationship between knowledge and self-management behavior with FBG.
Efek Andrographolide Oral Terhadap Biomarker Jantung pada Tikus yang Diinduksi Doxorubicin Silmi Hanifah; Wawaimuli Arozal; Vetnizah Juniantito
Journal of Medicine and Health Vol 5 No 2 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v5i2.5026

Abstract

Doxorubicin remains the most prescribed anticancer agent despite its unintended side effects on non-target organs. A limiting-dose strategy is used to lower incidence of cardiotoxicity. Andrographolide has therapeutic effects including antioxidant and anti-inflammatory. This study aimed to assess cardioprotective effects of andrographolide oral on lactate dehydrogenase (LDH), creatine kinase-myocardial band (CK-MB), and relative cardiac weight in doxorubicin-induced rats. Sixteen male rats Sprague Dawley randomized into four groups: receives saline i.p and vehicle orally (Normal), doxorubicin 16 mg/kgBW i.p and vehicle orally (Dox), doxorubicin 16 mg/kgBW i.p+andrographolide 30 mg/kgBW orally (Dox+And30), doxorubicin 16 mg/kgBW i.p+andrographolide 60 mg/kgBW orally (Dox+And60). Blood was collected via cardiac puncture and cardiac organs were weighed after four-weeks administration. Total LDH and CK-MB measured spectrophotometrically. LDH and CK-MB levels significantly elevated, and signs of acute toxicity in Dox group compared with Normal group. Co-treatment with andrographolide at 30 mg/kgBW and 60 mg/kgBW reduced signs of toxicity and significantly attenuated LDH and CK-MB levels compared with Dox group (P<0.05 and P<0.01). However, body weight and relative cardiac weight were not significantly different in all groups after co-treatment with andrographolide. In conclusion, andrographolide lowered LDH and CK-MB levels, therefore has a protective potency in alleviating toxic effects of doxorubicin.
Analisis Pemberian N-acetylcysteine Dosis Tinggi Terhadap Fungsi Ginjal Pasien yang Didiagnosis Acute Kidney Injury Periode Januari – Desember 2021 di RSPON Jakarta Nurul Ulya; Ros Sumarny; Wawaimuli Arozal; Eka Musridharta
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i8.16797

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh efek pemberian N-acetylcysteine dosis tinggi 5000 mg iv terhadap fungsi ginjal pasien terdiagnosis AKI dilihat dari serum Kreatinin, GFR dan Ureum. Studi ini merupakan penelitian deskriptif analitik dengan cross sectional retrospektif. Penelitian ini menggunakan data rekam medis. Analisa perbedaan fungsi ginjal dengan parameter hasil lab ureum, kreatinin, dan GFR pasien AKI baik kelompok kontrol maupun kelompok uji, sebelum dan sesudah diberikan N-acetylcysteine dosis tinggi 5000 mg iv. Data dianalisis secara bivariat dengan uji T berpasangan dan uji T Independent untuk perbedaan antar kelompok pada p ≤0.05.Terdapat 60 total sampel kemudian terbagi menjadi 30 pasien AKI yang diberikan N-acetylcysteine dan 30 pasien tanpa diberikan N-acetylcysteine. Analisis hubungan sebelum dan sesudah pemberian N-acetyceyteine pada masing-masing kelompok Terjadi perbedaan bermakna pada kelompok uji yaitu pada nilai Serum Kreatinin (p=0,002) dan GFR (p=0,001). Sedangkan pada uji beda pada kedua kelompok didapatkan hasil terjadi perbedaan bermakna pada nilai Serum kreatinin yaitu (p=0,003) dan nilai GFR yaitu (p=0.014). Hasil tersebut menunjukan bahwa ada perbedaan yang bermakna pada perbaikan fungsi ginjal antara kelompok yang diberikan N-acetylcysteine (uji) dengan kelompok pasien tanpa N-acetylcysteine (kontrol) yaitu dilihat pada nilai SCr dan GFR. Kelompok uji memberikan efek perbaikan fungsi ginjal yang lebih baik dibandingkan dengan kelompok Kontrol.
Metabolite Biomarker Discovery for Lung Cancer Using Machine Learning Fajarido, Ariski; Erlina, Linda; Tedjo, Aryo; Fadilah, Fadilah; Arozal, Wawaimuli
Indonesian Journal of Medical Chemistry and Bioinformatics
Publisher : UI Scholars Hub

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Abstract

Lung cancer is the leading cause of cancer death worldwide. About 2.1 million lung cancer patients were diagnosed in 2018, accounting for about 11.6% of all newly diagnosed cancer cases. For lung cancer, blood is the first choice as a source of screening biomarker candidates. Blood biomarkers provide a snapshot of the patient's entire body, including the primary tumor, metastatic disease, immune response, and peritumoral stroma. However, sputum sampling, bronchial lavage or aspiration, exhaled breath (EB), and airway epithelial sampling represent unique samples for lung cancer and other airway cancers as potential sources for alternative biomarkers. Metabolites are products of cell metabolism that are unique biomarkers in a disease. In this article, we aim to find metabolite biomarkers using machine learning. Metabolite data were obtained from Metabolomic workbench, while detection and identification were performed in silico. From 82 samples, controls and cancers, we found 158 metabolites and analyzed them. From the analysis, we found 3 metabolites that play an important role in lung cancer and found 1 metabolite that is the most influential. From there we found that glutamic acid is one of the best biomarker candidates we provide for detecting lung cancer. However, this simulation still needs to be improved in order to find other biomarkers that can provide a better detection of lung cancer
Potensi Moringa Oleifera sebagai Agen Neuroprotektif pada Kondisi Penuaan di Otak Safutra, Muhamad Sadam; Barinda, Agian Jeffilano; Arozal, Wawaimuli
Muhammadiyah Journal of Geriatric Vol. 4 No. 2 (2023): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mujg.4.2.138-151

Abstract

Penyakit neurodegeneratif merupakan penyakit yang banyak menimbulkan kejadian morbiditas dan mortalitas pada lansia. Selama proses penuaan, secara progresif kemampuan fungsional otak akan menurun. Penuaan otak dapat dimanifestasikan sebagai penurunan memori dan kognitif, yang biasanya terjadi oleh karena perubahan plastisitas struktural dendritik yang dapat berkembang menjadi penyakit neurodegeneratif. Sampai saat ini, belum ada pengobatan yang efektif untuk penyakit neurodegeneratif. Beberapa obat digunakan untuk menghilangkan gejala meskipun biasanya menimbulkan banyak efek samping. Oleh karena itu penelitian dan pengembangan obat dari berbagai tumbuhan yang memiliki efek neuroprotektif sebagai suplemen untuk memperbaiki fungsi otak banyak dilakukan. Kelor (Moringa oleifera (MO)) diketahui mempunyai aktivitas anti inflamasi, antiapoptosis, disamping juga memiliki nilai gizi yang baik. Komponen bioaktif yang terdapat dalam ekstrak MO diantaranya polifenol, saponin, tannin, isothiocyanate dan flavonoid diduga berperan sebagai neuroprotektif. Mekanisme molekuler yang terlibat pada MO sebagai neuroprotektif adalah jalur Nuclear factor kappa-beta (NF‐kB) dan Nuclear erythroid 2-related factor 2 (Nrf2), glukosinolat yang terdapat dalam MO akan terhidrolisis menjadi isothiocyanate yang akan  secara langsung berinteraksi dengan Kelch-like ECH-associated protein 1 (Keap1) di sitoplasma dan menyebabkan translokasi Nrf2 ke nukleus, selanjutnya Nrf2 akan berikatan dengan Antioxidant response element (ARE) yang akan menghasilkan enzim-enzim detoksifikasi. Selain itu Nrf2 juga menghambat translokasi NFkB ke nukleus sehingga menekan ekspresi sitokin Interleukin (IL) dan Tumor nuclear factor-α (TNF-α) yang berperan dalam inflamasi. Mekanisme lain yang mungkin adalah jalur pensinyalan Tropomyosin receptor kinase B (TrkB). Dengan demikian MO berpotensi kuat sebagai agen neuroprotektif pada penuaan otak.
Moringa oleifera as the potential herb medicine for neurodegenerative diseases: a narrative review Dewi, Yulia Ratna; Barinda, Agian Jeffilano; Arozal, Wawaimuli
Muhammadiyah Journal of Geriatric Vol. 5 No. 1 (2024): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mujg.5.1.1-13

Abstract

Neurodegenerative diseases, such as Alzheimer's and Parkinson's, significantly burden the global older adult population. These diseases are characterized by the degeneration of nerve cells and subsequent damage, leading to the gradual loss of neurological function and subsequently affecting the quality of life of older adult people. This study explores the potential role of Moringa oleifera (MO) on neurological diseases. MO, a plant rich in bioactive compounds such as flavonoids, polyphenols, saponins, and tannins, has been proven to possess potent antioxidant effects. Oxidative stress is a primary contributor to the pathogenesis of neurodegenerative diseases, and MO can protect nerve cell damage by enhancing antioxidant activity. In the context of Parkinson's disease, MO has demonstrated the ability to reduce cataleptic symptoms and protect dopaminergic neurons, which are crucial in preventing a decline in dopamine production in the brain. In Alzheimer's disease, MO can improve memory function, reduce oxidative stress, and inhibit the activity of Acetylcholinesterase (AChE) enzymes involved in neurotransmitter dysfunction. While further research is needed to gain a deeper understanding of MO's mechanisms and more specific therapeutic potential, the existing evidence suggests that its constituents and effects hold significant promise as a natural solution for combating the effects of neurodegenerative diseases. As the number of individuals affected by these diseases continues to rise worldwide, further investigation into MO as a neuroprotective agent could pave the way for developing more effective therapies for these conditions.
Co-Authors Agian Jeffilano Barinda Antarianto, Radiana Dhewayani Arleni Bustami Aryo Tedjo Barinda, Again Jeffilano Cong, Tzeto Han Dewi Sukmawati Dewi, Yulia Ratna Djumhana Atmakusuma, Djumhana Dwita, Nounik Cheri Eka Musridharta Erlina, Linda Erni H Purwaningsih, Erni H Erni Hernawati Purwaningsih, Erni Hernawati Ernie Purwaningsih Eziefule, Oluebube Magnificient Fadhillah, Muhamad Rizqy Fadilah Fadilah, Fadilah Fajarido, Ariski Franciscus D. Suyatna Gusti Khatimah, Nurul Hedi R. Dewoto Heri Wibowo Husna, Fauzul Jusman, Sri Widia Azraki Kapuangan, Christopher Kartika, Kartika Handayani Kenichi Watanabe Khatimah, Nurul Gusti Kuncoro, Daviet Dwi Kurniasari Kurniasari Kusmardi Kusmardi Laurentius, Andrea Lee, Hee Jae Meilei Ma Melva Louisa Nabillah, Deya Adiby Nafrialdi Nafrialdi Novi Silvia Hardiany Nur Azizah Nurul Ulya Primadhani, Suci Widya Punniyakoti T. Veeraveedu Puspita Eka Wuyung Putri, Rizky Clarinta Radiana Dhewayani Radoti Merlin Rani Sauriasari Rani Sauriasari, Rani Raymond R. Tjandrawinata Rejeki, Marliana Sri Rianto Setiabudy Riski Amanda, Clara Ros Sumarny ROS SUMARNY Rosyidah, Citra Safutra, Muhamad Sadam Safutra, Sadam Sagala, Radoti Merlin SEPTELIA INAWATI WANANDI Sesilia Keban Sesilia Keban, Sesilia Shimizu, Ippei Silmi Hanifah Sumiati, Yati Supraja Dwiyono Suyatna, Franciscus D Syarifah Dewi Triana, Novi Ulfa T Wahyuni Vetnizah Juniantito Wahyunia Likhayati Septiana Wikanendra, Gregorius Bhaskara