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All Journal GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Lux Mensana: Journal of Scientific Health Acitya Wisesa: Journal of Multidisciplinary Research Jurnal Ilmiah Multidisiplin Indonesia JUKEJ: Jurnal Kesehatan Jompa
Desdiani, Desdiani
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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THE CASE REPORT OF A COVID-19 PATIENT WITH LATE DIAGNOSIS OF HIV Desdiani, Desdiani
Acitya Wisesa: Journal of Multidisciplinary Research Vol. 2 Issue 2 (2023)
Publisher : jfpublisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56943/jmr.v2i2.302

Abstract

Coronavirus 2019 (Covid-19) is a disease that causes hyper-systemic inflammation affecting the respiratory system and extrapulmonary system. Covid-19 causes non-specific clinical health disorders in immunocompromised patients who often do not react to treatment. One case of a 58-year-old Indonesian man with a positive GeneXpert test result for Covid-19 but did not react to routine Covid-19 first-line therapy. The patient's anti-HIV test was confirmed positive, with an absolute CD4 of 13.7 cells/L, lactate dehydrogenase of 385 U/L, and procalcitonin of 0.24 ng/mL. The patient was treated with antibiotics, remdesivir, dexamethasone, heparin, anti-HIV treatment, and other supporting medications. The PCR test was negative ten days later, the laboratory and radiology results had also stabilized. In this case, the possibility of co-detection of Covid-19 with immune system diseases such as HIV is emphasized, and the importance of further testing for suspected patients to provide accurate treatment. It is quite difficult to determine HIV risk factors, and the limited treatment options for Covid-19 and it may not be effective. This case highlighted the possibility of misdiagnosis, especially during an infectious disease pandemic, and the importance of extended testing, even if the immunological state is disregarded in immune-compromised patients.
THORACIC TUBERCULOUS SPONDYLITIS WITH DECOMPRESSION AND POSTERIOR STABILIZATION TREATMENT: A CASE REPORT Desdiani, Desdiani
Lux Mensana: Journal of Scientific Health Vol. 2 Issue 2 (2023)
Publisher : jfpublisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56943/jsh.v2i2.303

Abstract

Introduction. Tuberculosis (TB) spondylitis is one of the most common spinal infections. The management of spinal tuberculosis is difficult due to non-specific and variable clinical manifestation that leading to delayed identification and increases the risk of disease. The early identification and treatment are very important to avoid permanent damage in the future. Method. In this research, the researcher reports a case of a patient with tuberculous spondylitis involving the thoracic vertebral body which treated by decompression and posterior stabilization treatment. Results and Analysis. The physical examination revealed a mass appears in the midline of the back. Chest CT examination without contrast revealed a mass that caused destruction and compression of the right side of the Thoracal 7 (Th 7) vertebral body, partial destruction of the right Th7 lamina, and spinal intracanal pushing to the left of the Th7 level of the spinal cord which caused the destruction of 7th and 8th posteromedial right ribs nearby. During the two months of treatment, the patient was treated with a first-line oral regimen as standard treatment for extrapulmonary TB followed by seven-month follow-up phase. At follow-up after more than 2 months of initial TB drug administration, the back pain was persisted. The patient underwent level 7 thoracic decompression by means of laminectomy and flavectomy. Histopathological examination from biopsy showed fibrous connective tissue containing epitheloid tubercles with datia langhans which suggests the presence of tuberculous spondylitis.  The diagnosis was confirmed by AFB staining. Discussion. This case is important to provide recognition of the risks and phenomena of the continuing incidence of spinal TB, despite the progress made in early diagnosis and effective management.
RELATIONSHIP BETWEEN SYNTHETIC COTTON DUST EXPOSURE AND SYMPTOMS OF RESPIRATORY DISORDERS IN TEXTILE FACTORY WORKERS AT PT X IN EAST JAVA Desdiani, Desdiani; Soemarko, Dewi Sumaryani; Purnama, Ahmad Angga
Lux Mensana: Journal of Scientific Health Vol. 3 Issue 2 (2024)
Publisher : jfpublisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56943/jsh.v3i2.566

Abstract

Introduction. Respiratory disorders, which range from 1 to 100 μm, are a significant concern in the textile industry. Typical symptoms of cotton dust exposure include chronic cough with or without phlegm, painful breathing, wheezing, nasal congestion, and chest pain. While most research has focused on natural cotton fibers, there is a growing need to investigate the health risks associated with synthetic cotton dust, such as that derived from petroleum-based resources such as polyester. Method. This research employed a cross-sectional design, with 76 respondents. Result & Analysis. The results showed that 21.1% of the workers experienced respiratory symptoms, and 43.4% of the workers were exposed to high levels of synthetic cotton dust. Chi-square test analysis indicated a significant relationship between synthetic cotton dust exposure and respiratory symptoms (p < 0.001; OR 15.1 [3.17 – 73.21]). Discussion. Workers with high synthetic cotton dust exposure had a 15.1 times greater risk of experiencing respiratory symptoms than those with low synthetic cotton dust exposure.
Clinical and Histopathological Findings of Six Cases of Extrapulmonary Tuberculosis Widya Rukmi, Kartika; Sasongko, Aries; Dwinanda Suyuthie, Heldrian; Untari Dewi, Trisni; Kiasati Chandra Syahbunan, Khansa; Desdiani, Desdiani
GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Vol. 4 No. 3 (2025): GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh - Juni 2025
Publisher : Program Studi Kedokteran Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jkkmm.v4i3.21895

Abstract

Extrapulmonary Tuberculosis (EPTB), caused by Mycobacterium tuberculosis, affects organs other than the lungs, most commonly the lymph nodes and pleura. Although pulmonary tuberculosis (TB) is more prevalent in Indonesia, EPTB remains a significant yet often underreported condition. Its diagnosis depends on histological, microbiological, and clinical evidence, with treatment typically initiated based on a physician's judgment. The diverse symptoms of EPTB, depending on the affected organs, contribute to its frequent underdiagnosis. Histopathological examination is the gold standard for EPTB diagnosis, particularly valuable when microbiological tests yield inconclusive results, and is characterized by well- and poorly-organized granulomas. Methods this study reviewed six cases of EPTB, focusing on clinical presentations, radiological findings, and histopathological results. The patients presented with lumps in various locations, including the wrist, spine, neck, abdomen, thigh/groin, and scrotum. Ultrasound and CT scan were employed to assess organ involvement, and tissue biopsies were analyzed histopathologically. The cases exhibited diverse symptoms and clinical findings. Blood tests and chest radiographs were normal in all patients. Imaging studies revealed nonspecific hypoechoic patterns, omental thickening, and prominent mesenteric lymph nodes in some cases. Histopathological analysis consistently identified granulomas in all biopsy samples. Some specimens showed extensive caseous necrosis with Langhans giant cells, while others exhibited fibrotic tissue with well-formed granulomas and minimal caseous necrosis. Conclusion diagnosing EPTB remains challenging due to its paucibacillary nature and the limitations of current diagnostic tools. Histopathological and microbiological evaluations of biopsy specimens are essential to improving diagnostic accuracy and reducing the morbidity and mortality associated with EPTB.
Abses Paru Pada Pasien Tuberkulosis Dengan Diabetes Melitus Yang Tidak Terkontrol Efiyanti, Christy; Prawiro, Asysyukriati; Syahbunan, Khansa Kiasati Chandra; Rusmajati, Jetty; Rukmi, Kartika Widya; Kemuning, Asri Ragil; Desdiani, Desdiani
JUKEJ : Jurnal Kesehatan Jompa Vol 4 No 1 (2025): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol4.Iss1.1471

Abstract

The coexistence of tuberculosis (TB) and diabetes mellitus (DM) increases the risk of severe lung complications such as pulmonary abscess. Aim: This study evaluates the outcomes of such cases, emphasizing the effectiveness of combined therapeutic approaches. Methods: This retrospective study reviewed 121 patients diagnosed with TB and DM treated at a hospital in Depok City between January 2023 and April 2024. The study included four patients with confirmed lung abscesses. Diagnosis was established using clinical and supporting examination analyses. We monitored the patients for up to nine months after initiating treatment. All patients received standard TB and DM therapy along with intravenous antibiotics for two weeks and continued with oral antibiotics for six weeks. Results: Radiological findings consistently showed lung cavities with fluid levels and thick walls. Clinical outcomes demonstrated substantial improvement in all cases, with resolution of abscesses and symptom alleviation. Patients with lung abscesses who received early, combination treatment with antibiotics and medication for TB and DM had positive results. Conclusion: In our study, the administration of antibiotics for eight weeks, alongside simultaneous treatment for TB and DM, led to significant clinical improvement. Further research is warranted to management of lung abscesses in patients with TB and DM and intravenous antibiotics as the first-line approach.
Radiological, Clinical, and Microbiological Manifestations of Pulmonary Tuberculosis Patients of a Secondary Hospital in Indonesia Rusmajati, Jetty; Hanif, Aisyah Amanda; Desdiani, Desdiani
Jurnal Ilmiah Multidisiplin Indonesia (JIM-ID) Vol. 4 No. 8 (2025): Jurnal Ilmiah Multidisplin Indonesia (JIM-ID) 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tuberculosis (TB) remains a significant public health burden in Indonesia. Characterizing pulmonary TB's clinical, radiological, and microbiological features is vital to support timely and accurate diagnosis at secondary healthcare levels. This study aimed to analyze the clinical characteristics, radiological patterns, and microbiological status of pulmonary TB patients treated in secondary hospitals in Indonesia. This descriptive cross-sectional study retrospectively reviewed medical records of 58 adult patients with radiologically confirmed pulmonary TB, treated between January 2022 and December 2023. Data on demographics, symptoms, comorbidities, radiological features, and sputum smear results were analyzed. Associations between variables were tested using chi-square tests. Most patients were male (55.2%), with a mean age of 50.6 years. Previous TB history was recorded in 25.9% of cases, and 15.5% had comorbidities such as hypertension and diabetes. Cough (84.5%), fever (48.3%), and weight loss (41.4%) were the most common symptoms. Consolidation (89.7%) was the predominant radiological finding, often involving multiple lung zones (70.7%), with advanced lesions present in 77.6% of patients. Sputum smears were positive in 39.7% of cases. Pulmonary TB patients treated at secondary hospitals commonly present with advanced radiological lesions, significant comorbidities, and frequent smear-negative results. Strengthening radiological diagnostic capacity and integrated management of TB–diabetes comorbidity are essential to improve case detection and outcomes.
Co-Authors Aisyah Amanda Hanif Asri Ragil Kemuning Christy Efiyanti Dewi Sumaryani Soemarko Kiasati Chandra Syahbunan, Khansa Prawiro, Asysyukriati Purnama, Ahmad Angga Rukmi, Kartika Widya Rusmajati, Jetty Sasongko, Aries Suyuthie, Heldrian Dwinanda Syahbunan, Khansa Kiasati Chandra Trisni Untari Dewi Widya Rukmi, Kartika