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Analytical Method Validation of Thorium in Ore Sample Using UV-Vis Spectrophotometer Indryati, Suci; Hidayat, Amalia Ekaputri; Pratama, Afiq Azfar; Laksmana, Roza Indra; Widana, Kurnia Setiawan; Ramlan, Muhammad Alif; Purwanti, Tri; Prassanti, Riesna; Anggraini, Mutia; Rommy, Rommy
EKSPLORIUM Vol 44, No 2 (2023): November 2023
Publisher : Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/eksplorium.2023.6965

Monazite contains several rare earth elements (REE) along with radioactive elements, i.e., thorium (Th) and uranium (U). Thorium content in monazite is several times higher than uranium. Monazite contains around 12% thorium oxide, but the thorium content in this mineral varies depending on location. To determine the thorium content in monazite, an appropriate and validated analytical method is needed so that the reliability of the test results can be trusted. Apart from that, method validation is one of the clauses in SNI ISO/IEC 17025:2017 that must be fulfilled by the laboratory to be certified and produce reliable data. This research aims to validate analytical methods for non-standard and modified methods that are likely to be used outside the scope. In this research, the method used to digest and analyze thorium in mineral samples refers to the ASTM E2941-14 method with several modifications. Therefore, the analysis method needs to be validated. Validation of the analytical method is carried out by testing several parameters such as linearity and working range tests, accuracy, precision (repeatability), Limit of Detection (LOD), and Limit of Quantitation (LOQ). The results of linearity, accuracy, and repeatability tests that meet the acceptance requirements can be used as a method of validation evaluation. The results of the method validation parameter test met the acceptance requirements, with the linearity test showing a coefficient of determination (R2) of 0.997, the accuracy test showing % a recovery value of 106.22%, and the precision (repeatability) test showing %RSD of 3.76% with LOD value is 0.650 mg/L, and LOQ is 0.724 mg/L. Based on the results of these parameter tests, the method for analyzing thorium in mineral samples was validated.

Validation of The Gravimetry Method for Determining Rare Earth Elements Oxides Pratama, Afiq Azfar; Hidayat, Amalia Ekaputri; Rommy, Rommy; Indryati, Suci; Laksmana, Roza Indra; Trinopiawan, Kurnia; Purwanti, Tri; Widana, Kurnia Setiawan; Putra, Aditya Widian; Anggraini, Mutia; Nasrullah, Dzaki Hasan
EKSPLORIUM Vol 45, No 1 (2024): May 2024
Publisher : Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/eksplorium.2024.6972

The demand for minerals to meet technological developments is increasing, including minerals that contain rare earth elements (REE). The levels of REE in solids can be determined using conventional analysis methods (gravimetry) and instruments. Even though the instrument method provides more accurate results with a small amount of analyte, the cost is higher compared to the gravimetric method, which requires more analyte and provides good results. Therefore, the gravimetric method is a solution for areas with limited instruments and budgets. The study aims to validate the gravimetric method for determining REE oxides levels, evaluate its precision and accuracy, and assess its feasibility of use. In this study, two methods were used for REE analysis: the ASTM E2941-14 method with sample weight modification and the addition of acid to increase REE oxides recovery and a precipitation method using oxalic acid. The validation stages include sample dissolution, precipitation, filtration, and ash-making. The research results show that the RSD value is 0.3154, which is smaller than 2/3 of Horwitz's CV, namely 4.1727, which means it meets the precision acceptance requirements of ISO/IEC 17025:2017. The REE oxides recovery value, which indicates accuracy, also increased to 97.74%. Therefore, the gravimetric method can be used as an alternative for determining REE oxides levels.

REVIEW: INOVASI TEKNOLOGI FARMASI DALAM MENINGKATKAN KEPATUHAN PENGOBATAN PADA PASIEN PEDIATRIK DAN GERIATRIK Deisberanda, Fortunata Saesarria; Rommy, Rommy
Journal Pharmacy Of Tanjungpura Vol 3, No 1 (2025): Oktober
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar

This article reviews innovations in pharmaceutical technologies aimed at improving medication adherence in pediatric and geriatric patients, with a focus on innovative formulations. The purpose of this review was to assess the effectiveness of novel formulations in enhancing therapeutic outcomes and patient adherence, as well as to identify challenges in their clinical implementation. The findings from various studies indicate that technologies such as 3D printing, orally disintegrating tablets (ODTs), and chewable tablets improve therapeutic results and patient compliance by offering flexibility in dose adjustments and drug delivery. Additionally, formulations tailored to patient preferences, such as gummies and orally disintegrating films, have proven effective in enhancing medication acceptance, especially in pediatric and geriatric populations. While these technologies show great potential, challenges related to regulation and manufacturing barriers, such as quality standardization and production scalability, remain major obstacles. Therefore, further and more comprehensive research is required to ensure the widespread implementation of these technologies in pediatric and geriatric patient care.

Strategi Pengembangan Ekowisata Berbasis Ekonomi Lokal di Kawasan Geopark Kabupaten Natuna Rommy, Rommy; Darmanto, Darmanto; Subiyakto , Rudi
Jurnal Pendidikan Indonesia Vol. 6 No. 10 (2025): Jurnal Pendidikan Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/japendi.v6i10.8682

Tourism development trends continue to be developed to encourage and increase local economic growth. The increase in incoming tourists has a positive impact on a region on the foreign exchange received and can increase growth in the hotel, restaurant, and other businesses in the tourism sector. With the recognition of the Natuna area as a National Geopark, it is hoped that it will be able to create real benefits in preserving nature, empowering local communities and improving the economy of local communities in Natuna Regency. However, based on available data, the number of tourists visiting the Geopark area has not shown a large increase and influence in improving the economy of the Natuna community, especially in the Geopark area. The purpose of the research is to analyze the implementation of tourism and tourism development strategies in the Natuna Regency Geopark Area towards improving the economy of the surrounding community. The researcher uses the theory put forward by (Cooper et al., 1993) about tourism development which includes Attractions, Amenities, Accessbility and Ancillary Service. The research uses a qualitative method with a strategy concept including the input stage, the TWOS matrix matching stage, and the decision stage using QSPM. The results of the study show that the Development of Local Economy-Based Ecotourism in the Natuna Regency Geopark Area has not been carried out optimally. The best strategy resulting from the QSPM matrix is to create a stronger and more appropriate narrative and branding regarding Ecotourism and Geoparks both to prospective tourists and other stakeholders and also by exploring potential new attractions and markets.

Analytical Method Validation of Thorium in Ore Sample Using UV-Vis Spectrophotometer Indryati, Suci; Hidayat, Amalia Ekaputri; Pratama, Afiq Azfar; Laksamana, Roza Indra; Widana, Kurnia Setiawan; Ramlan, Muhammad Alif; Purwanti, Tri; Prassanti, Riesna; Anggraini, Mutia; Rommy, Rommy
EKSPLORIUM Vol. 44 No. 2 (2023): NOVEMBER 2023
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/eksplorium.2023.6965

Monazite contains several rare earth elements (REE) along with radioactive elements, i.e., thorium (Th) and uranium (U). Thorium content in monazite is several times higher than uranium. Monazite contains around 12% thorium oxide, but the thorium content in this mineral varies depending on location. To determine the thorium content in monazite, an appropriate and validated analytical method is needed so that the reliability of the test results can be trusted. Apart from that, method validation is one of the clauses in SNI ISO/IEC 17025:2017 that must be fulfilled by the laboratory to be certified and produce reliable data. This research aims to validate analytical methods for non-standard and modified methods that are likely to be used outside the scope. In this research, the method used to digest and analyze thorium in mineral samples refers to the ASTM E2941-14 method with several modifications. Therefore, the analysis method needs to be validated. Validation of the analytical method is carried out by testing several parameters such as linearity and working range tests, accuracy, precision (repeatability), Limit of Detection (LOD), and Limit of Quantitation (LOQ). The results of linearity, accuracy, and repeatability tests that meet the acceptance requirements can be used as a method of validation evaluation. The results of the method validation parameter test met the acceptance requirements, with the linearity test showing a coefficient of determination (R2) of 0.997, the accuracy test showing % a recovery value of 106.22%, and the precision (repeatability) test showing %RSD of 3.76% with LOD value is 0.650 mg/L, and LOQ is 0.724 mg/L. Based on the results of these parameter tests, the method for analyzing thorium in mineral samples was validated.

Preliminary Study of Yttrium Extraction from Tin Slag Using Hydrochloric Acid Hidayat, Rachmat Fauzi; Trinopiawan, Kurnia; Mubarok, Mohammad Zaki; Rommy, Rommy; Prassanti, Riesna; Putra, Aditya Widian; Ekaputri Hidayat, Amalia; Setiawan Widana, Kurnia; Purwanti, Tri; Laksmana, Roza Indra; Basuki, Triyono; Pratama, Afiq Azfar; Indryati, Suci
EKSPLORIUM Vol. 46 No. 2 (2025): NOVEMBER 2025
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/eksplorium.2025.13299

Tin slag, a byproduct of tin smelting, comprises several important metals, including yttrium, tantalum, manganese, iron, aluminum, titanium, and others. As an element that is used a lot in advanced materials, the separation of Yttrium becomes one of the most important steps in rare earth elements extraction. By using the alkali fusion process and leaching method, yttrium in the tin slag has been successfully extracted. The tin slag was subjected to an alkali fusion treatment with sodium hydroxide at a temperature of 700 °C, and the frit was ground into several particle sizes of +100 to -325 mesh using a laboratory ball mill and mortar. The frit was then leached using hydrochloric acid, with four parameters used: temperature, acid concentration, particle size, and stirring speed. The extracted yttrium reached a percentage of up to 86.94% at a temperature of 80 °C, acid concentration of 2 M, particle size of -325 mesh, and stirring speed of 150 rpm.

Comparison of The Effectiveness of Intermittent and Continuous Pantoprazole Therapy in Peptic Ulcer Disease Bleeding Wirastuti, Ade; Molidia, Sri Rahmat; Salsabela, Salsabela; Anisya, Kharina; Deisberanda, Fortunata Saesarria; Aqsa, Kathina Deswi; Ajwad, Muhammad Nur; Dermawan, Abdurraafi' Maududi; Fakhruddin, Fakhruddin; Rommy, Rommy
Academic Hospital Journal Vol 8, No 1 (2026)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v8i1.115539

Background: Peptic ulcer disease with melena is commonly encountered in clinical practice. Pantoprazole is widely used to control bleeding and heal ulcers, but there is still debate regarding the effectiveness of intermittent bolus administration compared to continuous infusion.Objective: To review and evaluate the literature on the comparative effectiveness of pantoprazole administered via intermittent bolus versus continuous infusion.Methods: This study employed a narrative literature review design. Literature searches were conducted in the PubMed, Google Scholar, ProQuest, and Sage Journals databases for publications from 2020 to 2025 using the keywords: “pantoprazole,” “continuous infusion,” “intermittent bolus,” “effectiveness,” “bleeding,” and “peptic ulcer disease”.Result: Four articles met the inclusion criteria. Two studies reported no significant difference between intermittent bolus and continuous infusion administration. One study found that intermittent bolus administration was associated with a shorter length of stay, whereas another recommended continuous infusion for patients at high risk of upper gastrointestinal bleeding. There was heterogeneity in study design and reported outcomes.Conclusion: There is no significant difference between continuous infusion and intermittent bolus administration of pantoprazole; given the limited number and quality of studies, further research is needed.

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