Article Per Year (5 Year)
p-Index From 2020 - 2025
0.882
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Santhet: (Jurnal Sejarah, Pendidikan Dan Humaniora) Jurnal Medika Farmaka
Reza Pahlevi, Muhamad
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Other

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Technique Development in Improving the Solubility of Poorly Water Soluble Drugs (BCS II and IV): a Review Study: Pengembangan Teknik dalam Meningkatkan Kelarutan Obat yang Larut Buruk dalam Air (BCS Kelas II dan IV): Studi Review Reza Pahlevi, Muhamad; Sopyan, Iyan; Gozali, Dolih
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.15969

Abstract

Orally active drugs are currently available on the market. API should have adequate solubility and permeability to enhance its therapeutic efficacy when administered orally and obtain optimum bioavailability. Almost 40% of New Chemical Entities had limited solubility or fell into BCS class II and IV. Our review aims to summarize and discuss the development of methods and characterization for increasing the solubility of poorly aqueous drugs from papers published in Google Scholar, NCBI, Science direct, Researchgate, and MDPI. We checked that the methods used such as solid dispersion, cocrystal formation, and coamorphous can increase the solubility of API which has an impact on increasing bioavailability. The successful formation of solid dispersions, cocrystals and coamorphs can be confirmed by the characterization of PXRD, DSC and SEM. In conclusion, drug solubility is an important aspect of pharmacological effects. Drugs with high solubility can provide fast solubility rates and high bioavailability, reducing the dose administered. Solid dispersion, cocrystals, and coamorphous techniques, have succeeded in increasing the solubility of BCS class II and IV drugs.
Review : Pengembangan Sediaan Padat dari Bahan Alam dibuat Mikroenkapsula Helentina B, Maria; Az Zahra, Ulimaz; Zalza Aulia , Reihan; Cahya Marhamka, Salza; Reza Pahlevi, Muhamad; Sutoro, Meylani
Jurnal Medika Farmaka Vol 3 No 1 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i1.53

Abstract

Pendahuluan: Mikroenkapsulasi merupakan teknik pelapisan zat aktif menggunakan agen penyalut, umumnya senyawa polimer, yang berfungsi menjaga stabilitas dan mengontrol pelepasan zat aktif. Bahan penyalut memegang peranan penting karena memengaruhi ukuran dan kestabilan mikrokapsul. Mikroenkapsulasi banyak diterapkan pada bahan alam untuk meningkatkan stabilitas dan memperpanjang umur simpan zat aktif. Metode pembuatan mikroenkapsulasi terbagi menjadi proses kimia, fisika-kimia, dan fisika. Metode: Tinjauan pustaka dilakukan melalui pencarian jurnal di database elektronik seperti Google Scholar, menggunakan kata kunci: “Bahan Alam”, “Mikroenkapsulasi”, dan “Sediaan Padat”. Kriteria inklusi meliputi artikel hasil uji klinis, tinjauan literatur, dan tinjauan sistematis dari jurnal nasional maupun internasional ber-ISSN. Artikel non-relevan, laporan kasus, dan opini ahli dikecualikan. Hasil: Hasil menunjukkan bahwa metode spray drying paling banyak digunakan karena efektif dalam menjaga stabilitas bahan alam dan menghasilkan mikrokapsul berukuran seragam. Kesimpulan: Spray drying menjadi metode mikroenkapsulasi yang dominan untuk bahan alam karena kemudahan, efisiensi, dan kemampuannya dalam meningkatkan kestabilan zat aktif dalam sediaan padat.
Review Artikel: Pengembangan Sediaan Padat dengan Penyalutan Zat Aktif dari Bahan Alam Dilla Chairunnisa, Asa; Purnama Sari Siahaan, Desy; Mega Utami, Wahyuni; Reza Pahlevi, Muhamad; Sutoro, Meylani
Jurnal Medika Farmaka Vol 3 No 1 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i1.55

Abstract

Introduction: Introduction: This study aims to examine natural materials that can be formulated into coated solid preparations in the pharmaceutical world. Coated solid preparations have various benefits, including increasing the stability of active substances, protecting materials from the external environment such as light, heat, oxygen, and covering unpleasant tastes. Methods: This study was conducted through a literature search using the Google Scholar, ScienceDirect, and ResearchGate databases, with inclusion criteria in the form of research journals on natural materials made into coated solid preparations. Results: The study shows that natural materials such as plant extracts, probiotics, aromatic resins, fish oil, and oleoresins can be formulated into several forms of coated solid preparations, including film-coated tablets, film-coated tablets, encapsulates, microcapsules, and microparticles (pellets). Commonly used coating materials include HPMC (Hydroxypropyl methyl cellulose), PVA (Polyvinyl alcohol), opadry AMB, maltodextrin, and kollicoat protect. Some examples of natural ingredients that have been applied are pomegranate peel extract as an antimalarial, gambir leaf extract as an antidyslipidemia, and probiotics from fermented snake fruit. Conclusion: the formulation of solid preparations coated with natural ingredients provides significant benefits in increasing the effectiveness and stability of pharmaceutical preparations, while utilizing natural ingredients that have biological activity. This study is expected to be a reference in the development of pharmaceutical preparations based on natural ingredients.
DEVELOPMENT OF ANDROID-BASES DIGITAL HANDOUT LEARNING MEDIA ON THE NEWS MATERIAL OF THE PROCLAMATION OF INDEPENDENCE IN PALEMBANG CLASS XI AT SMA NEGERI 12 PALEMBANG: Pengembangan Media Pembelajaran Handout Digital Berbasis Android Pada Materi Berita Proklamasi Kemerdekaan di Palembang kelas XI di SMA Negeri 12 Palembang Bening, Dayanara; Reza Pahlevi, Muhamad
Santhet: (Jurnal Sejarah, Pendidikan Dan Humaniora) Vol 9 No 6 (2025): SANTHET: (JURNAL SEJARAH, PENDIDIKAN DAN HUMANIORA)
Publisher : Proram studi pendidikan Sejarah Fakultas Keguruan Dan Ilmu Pendidikan Universaitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/santhet.v9i6.5787

Abstract

This study aimed to develop and evaluate an Android-based digital handout learning media focused on the Proclamation of Independence news in Palembang for 11th-grade history students at SMA Negeri 12 Palembang. The research addressed the need for engaging and locally relevant history learning materials, considering that existing resources were limited and students showed insufficient understanding of local historical events. The study employed a Research and Development (R&D) approach guided by the ADDIE instructional design model, consisting of analysis, design, development, implementation, and evaluation phases. Data collection involved curriculum analysis, interviews, questionnaires, and expert validation. The media was tested through one-on-one, small group, and full-class field trials, using pretests and posttests to measure student learning outcomes. Results showed a significant increase in student learning outcomes, with the average score improving from 45.48 in the pretest to 97.09 in the posttest. The N-gain value of 0.94 indicated high effectiveness of the media. Expert validation confirmed the product’s validity in terms of content, media design, and language. Students responded positively to the media’s clarity, interactivity, and accessibility via smartphones. While the media proved effective and well-received, limitations include the study’s focus on a single school and challenges faced by students without smartphone access. Future research should consider broader samples and alternative access methods to ensure inclusivity and generalizability.
Co-Authors Agung Laksono S, Moch Amalia Putri, Amalia Az Zahra, Ulimaz Bening, Dayanara Cahya Marhamka, Salza Devianti Sagita, Novaliana Dilla Chairunnisa, Asa DOLIH GOZALI Dwi C, Alya Garnadi Jafar, Garnadi Helentina B, Maria Iyan Sopyan Mahran A, Ghani Mega Utami, Wahyuni Purnama Sari Siahaan, Desy Rosyana, Nasywa Sutoro, Meylani Zalza Aulia , Reihan