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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Medika Farmaka
Reza Pahlevi, Muhamad
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Journal : Jurnal Medika Farmaka

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Review : Pengembangan Sediaan Padat dari Bahan Alam dibuat Mikroenkapsula Helentina B, Maria; Az Zahra, Ulimaz; Zalza Aulia , Reihan; Cahya Marhamka, Salza; Reza Pahlevi, Muhamad; Sutoro, Meylani
Jurnal Medika Farmaka Vol 3 No 1 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i1.53

Abstract

Pendahuluan: Mikroenkapsulasi merupakan teknik pelapisan zat aktif menggunakan agen penyalut, umumnya senyawa polimer, yang berfungsi menjaga stabilitas dan mengontrol pelepasan zat aktif. Bahan penyalut memegang peranan penting karena memengaruhi ukuran dan kestabilan mikrokapsul. Mikroenkapsulasi banyak diterapkan pada bahan alam untuk meningkatkan stabilitas dan memperpanjang umur simpan zat aktif. Metode pembuatan mikroenkapsulasi terbagi menjadi proses kimia, fisika-kimia, dan fisika. Metode: Tinjauan pustaka dilakukan melalui pencarian jurnal di database elektronik seperti Google Scholar, menggunakan kata kunci: “Bahan Alam”, “Mikroenkapsulasi”, dan “Sediaan Padat”. Kriteria inklusi meliputi artikel hasil uji klinis, tinjauan literatur, dan tinjauan sistematis dari jurnal nasional maupun internasional ber-ISSN. Artikel non-relevan, laporan kasus, dan opini ahli dikecualikan. Hasil: Hasil menunjukkan bahwa metode spray drying paling banyak digunakan karena efektif dalam menjaga stabilitas bahan alam dan menghasilkan mikrokapsul berukuran seragam. Kesimpulan: Spray drying menjadi metode mikroenkapsulasi yang dominan untuk bahan alam karena kemudahan, efisiensi, dan kemampuannya dalam meningkatkan kestabilan zat aktif dalam sediaan padat.
Review Artikel: Pengembangan Sediaan Padat dengan Penyalutan Zat Aktif dari Bahan Alam Dilla Chairunnisa, Asa; Purnama Sari Siahaan, Desy; Mega Utami, Wahyuni; Reza Pahlevi, Muhamad; Sutoro, Meylani
Jurnal Medika Farmaka Vol 3 No 1 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i1.55

Abstract

Introduction: Introduction: This study aims to examine natural materials that can be formulated into coated solid preparations in the pharmaceutical world. Coated solid preparations have various benefits, including increasing the stability of active substances, protecting materials from the external environment such as light, heat, oxygen, and covering unpleasant tastes. Methods: This study was conducted through a literature search using the Google Scholar, ScienceDirect, and ResearchGate databases, with inclusion criteria in the form of research journals on natural materials made into coated solid preparations. Results: The study shows that natural materials such as plant extracts, probiotics, aromatic resins, fish oil, and oleoresins can be formulated into several forms of coated solid preparations, including film-coated tablets, film-coated tablets, encapsulates, microcapsules, and microparticles (pellets). Commonly used coating materials include HPMC (Hydroxypropyl methyl cellulose), PVA (Polyvinyl alcohol), opadry AMB, maltodextrin, and kollicoat protect. Some examples of natural ingredients that have been applied are pomegranate peel extract as an antimalarial, gambir leaf extract as an antidyslipidemia, and probiotics from fermented snake fruit. Conclusion: the formulation of solid preparations coated with natural ingredients provides significant benefits in increasing the effectiveness and stability of pharmaceutical preparations, while utilizing natural ingredients that have biological activity. This study is expected to be a reference in the development of pharmaceutical preparations based on natural ingredients.
Co-Authors Agung Laksono S, Moch Amalia Putri, Amalia Az Zahra, Ulimaz Cahya Marhamka, Salza Devianti Sagita, Novaliana Dilla Chairunnisa, Asa DOLIH GOZALI Dwi C, Alya Garnadi Jafar, Garnadi Helentina B, Maria Iyan Sopyan Mahran A, Ghani Mega Utami, Wahyuni Purnama Sari Siahaan, Desy Rosyana, Nasywa Sutoro, Meylani Zalza Aulia , Reihan