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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal of Pharmaceuticals and Natural Sciences
Arifin, Sukmawati
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Effects of Pamelo Orange Peel (Citrus maxima) Ethanol Extract on Macroscopic Kidney and Heart of Hypertensive Rats: Efek Ekstrak Etanol Kulit Jeruk Pamelo (Citrus maxima) pada Makroskopik Ginjal dan Jantung Tikus Hipertensi Arifin, Sukmawati; Emelda, Andi; Santi, Irma; Putrisari, Nur Awaliah; Intan, Tri Rahmaputri Nur; Husain, Nurul Fadillah; Adawiyah, Rabiyah Al
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 1 (2024): (March 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i1.16946

Abstract

Background: Hypertension, characterized by elevated blood pressure (≥140/90 mmHg), leads to kidney and heart damage. Hypertension causes increased heart rate, heart enlargement, risk of heart failure, and damage to kidney blood vessels. One way to treat hypertension is by administering drugs such as herbal medicines. Pamelo oranges (Citrus maxima) are starting to be developed in the treatment of diseases. The ethanol extract of pomelo orange peel (EEKJP) contains flavonoid compounds which have antihypertensive activity as a natural Angiotensin Converting Enzyme (ACE) inhibitor, diuretic, increases Nitric Oxide Synthase (NOS) activity and activates Endothelium Derived Relaxing Factor (EDRF). Objectives: This study aims to examine the effect of ethanol extract of pomelo orange peel on the macroscopic features of the heart and kidneys of hypertensive rats (Rattus norvegicus). Methods: This research uses The Posttest-Only Control Group Design. Thirty rats were divided into six groups, namely naive control, negative control (NaCMC 1%), positive control (Captopril 0,45 mg/200 gramBB), EEKJP 100 mg/KgBW group, EEKJP 150 mg/KgBW group, and EEKJP 200 mg/KgBW group. Hypertension condition through induction with prednisone 1.5 mg/KgBW and NaCl 2% for 21th days. The test preparation was administered orally for 14th days. Next, all rats were dissected to remove the heart and kidney organs for macroscopic observations. Results: The results of the study showed that ethanol extract of pomelo (Citrus maxima) orange peel had a varied effect on the macroscopic appearance of the heart and kidneys of rats with hypertension. The heart organ shows structural improvements, while the kidneys have not shown any improvement. Conclusions: Extract with a dose of 100 mg/KgBW has no changes in the macroscopic appearance of the heart so it is thought to be able to repair damage to the heart organ.
Evaluation of Drug Related Problems of Antihypertensive Drugs in Inpatient Hypertensive Patients at the Latemmamala Regional General Hospital, Soppeng Regency for the January-March 2023 Period Yuliana, Dewi; Salam, Rika Amalia; Arifin, Sukmawati
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 3 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v1i3.8493

Abstract

Hypertension is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg in two measurements taken five minutes apart at rest. Problems caused by drug abuse are called DRPs (Drug Related Problems). The occurrence of DRPs is known to have a detrimental effect on patient quality of life, increased mortality and high medical costs. This study aims to determine the incidence of DRPs and the types of DRPs that occur in hypertensive patients at Latemmamala Hospital, Soppeng Regency. This study is a type of non-experimental descriptive research conducted retrospectively using secondary data in medical records where samples were selected using purposive sampling technique. The results showed that of the 78 samples consisting of 42 women (53.85%) and 36 men (46.15%), all of which met the inclusion and exclusion criteria, showed that the age prevalence was more prone to hypertension at the age of 56-75 years as many as 47 patients (60.26%). There were 46 cases out of 43 patients who had the potential to experience DRPs. The most DRPs that occurred were in the case of C1.4 as many as 26 cases (56.52%), then C1.1 as many as 20 cases (43.48%).
Co-Authors Adawiyah, Rabiyah Al Andi Emelda Dewi Yuliana Husain, Nurul Fadillah Intan, Tri Rahmaputri Nur Irma Santi, Irma Putrisari, Nur Awaliah Salam, Rika Amalia