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Effects of Pamelo Orange Peel (Citrus maxima) Ethanol Extract on Macroscopic Kidney and Heart of Hypertensive Rats: Efek Ekstrak Etanol Kulit Jeruk Pamelo (Citrus maxima) pada Makroskopik Ginjal dan Jantung Tikus Hipertensi Arifin, Sukmawati; Emelda, Andi; Santi, Irma; Putrisari, Nur Awaliah; Intan, Tri Rahmaputri Nur; Husain, Nurul Fadillah; Adawiyah, Rabiyah Al
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 1 (2024): (March 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i1.16946

Abstract

Background: Hypertension, characterized by elevated blood pressure (≥140/90 mmHg), leads to kidney and heart damage. Hypertension causes increased heart rate, heart enlargement, risk of heart failure, and damage to kidney blood vessels. One way to treat hypertension is by administering drugs such as herbal medicines. Pamelo oranges (Citrus maxima) are starting to be developed in the treatment of diseases. The ethanol extract of pomelo orange peel (EEKJP) contains flavonoid compounds which have antihypertensive activity as a natural Angiotensin Converting Enzyme (ACE) inhibitor, diuretic, increases Nitric Oxide Synthase (NOS) activity and activates Endothelium Derived Relaxing Factor (EDRF). Objectives: This study aims to examine the effect of ethanol extract of pomelo orange peel on the macroscopic features of the heart and kidneys of hypertensive rats (Rattus norvegicus). Methods: This research uses The Posttest-Only Control Group Design. Thirty rats were divided into six groups, namely naive control, negative control (NaCMC 1%), positive control (Captopril 0,45 mg/200 gramBB), EEKJP 100 mg/KgBW group, EEKJP 150 mg/KgBW group, and EEKJP 200 mg/KgBW group. Hypertension condition through induction with prednisone 1.5 mg/KgBW and NaCl 2% for 21th days. The test preparation was administered orally for 14th days. Next, all rats were dissected to remove the heart and kidney organs for macroscopic observations. Results: The results of the study showed that ethanol extract of pomelo (Citrus maxima) orange peel had a varied effect on the macroscopic appearance of the heart and kidneys of rats with hypertension. The heart organ shows structural improvements, while the kidneys have not shown any improvement. Conclusions: Extract with a dose of 100 mg/KgBW has no changes in the macroscopic appearance of the heart so it is thought to be able to repair damage to the heart organ.
Pendampingan Kader Posyandu dalam Pemenuhan Gizi Ibu Hamil dan Pencegahan Stunting pada Balita Neni San Agustina Siregar; Sari, Windah Anugerah; Adawiyah, Rabiyah Al; Mukodri, Dewi Mey Lestanti
SEWAGATI: Jurnal Pengabdian Masyarakat Indonesia Vol. 4 No. 2 (2025): Juni : SEWAGATI: Jurnal Pengabdian Masyarakat Indonesia
Publisher : BADAN PENERBIT STIEPARI PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56910/sewagati.v4i2.2226

Abstract

Stunting is one of the major public health problems in Indonesia, including in the working area of Puskesmas Wania SP.1, Mimika Regency. This condition is caused by chronic nutritional deficiencies, primarily occurring during the first 1,000 days of life (HPK), from pregnancy to a child’s second birthday. This community service program aimed to enhance the knowledge and skills of Posyandu cadres in assisting pregnant women and toddlers in meeting balanced nutritional needs as a strategy for stunting prevention. The implementation methods included cadre training, direct education for pregnant women and toddlers, distribution of educational leaflets, and promotion of the EDIFO application as a digital nutrition information platform. The results showed a significant improvement in cadres' understanding of balanced nutrition and their ability to educate and monitor the nutritional status of mothers and children. This activity also succeeded in increasing community participation in the Posyandu program. Collaboration among healthcare workers, village government, and higher education institutions further strengthened the program’s impact. The findings confirm that empowering Posyandu cadres is an effective and sustainable strategy to combat stunting at the community level. Program continuity and policy support from stakeholders are essential to maintain and expand its impact.