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All Journal JFL : Jurnal Farmasi Lampung Sains Medisina
Harissa, Nola
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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Faktor Yang Berhubungan Dengan Kepatuhan Minum Obat Pada Penderita Skizofrenia Fase Stabil Di Poli Rawat Jalan RS Jiwa Daerah Provinsi Lampung Tahun 2022 Harissa, Nola; Anggriani, Yusi; Sarnianto, Prih; Septa, Tendry
JFL : Jurnal Farmasi Lampung Vol. 12 No. 2 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i2.1110

Abstract

Adherence with antipsychotic treatment is very important to achieve optimal therapeutic results to the people with schizophrenia. The aim of the study is to determine the factors associated with medication adherence in patients with stable phase of paranoid schizophrenia at the Outpatient Polyclinic of the Regional Hospital of Lampung Province in 2022. This study used a crosssectional method with prospective data collection, a sample of 176 and the use of purposive sampling for the sampling technique. The data obtained were analyzed by using the chi square test to find out the relation between the dependent variable which is medication adherence, and the independent variables, namely perceptions of family support, knowledge related to disease, perceptions of drug side effects, and the perceptions of the pharmacist's role. To find out the dominant factors influencing the medicine compliance, the data were analyzed by using ordinal logistic regression. The study obtained of medicine compliance rates in paranoid schizophrenia patients based on the MMAS scale were good in 53 (30.1%), moderate in 62 (35.2%) and poor in 61 (34.7%). There is a relationship between medication adherence and the perception of family support (p value 0.038), knowledge related to disease (p value 0.005), perception of drug side effects (p value 0.003), and perception of the role of pharmacist (p value 0.000). The dominant factor affecting compliance to taking medication is the perception of the pharmacist's role with OR = 2.8, which means patients who get a good pharmacist role are more compliant in taking medication by 2.8 times. Keywords: Medication Compliance, Paranoid Schizophrenia, Stable Phase, Outpatient
FORMULASI SEDIAAN SABUN PADAT KOMBINASI EKSTRAK KULIT NANAS (Ananas comosus L.) DAN KULIT DURIAN (Durio zibethinus) TERHADAP Staphylococcus aureus: FORMULASI SEDIAAN SABUN PADAT KOMBINASI EKSTRAK KULIT NANAS (Ananas comosus L.) DAN KULIT DURIAN (Durio zibethinus) TERHADAP Staphylococcus aureus Wahyu Tri Mulyani, Yuli; Sari, Novita; Nurjanah, Siti; Anasis, Annisa Mulia; Harissa, Nola
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1878

Abstract

Staphylococcus aureus bacteria are bacteria that can cause infections. Prevention can be done by cleaning the body with soap. Soap is a skin cleansing preparation made from a saponification process between oil and organic or inorganic bases. Pineapple and durian peel contain active antibacterial compounds, namely alkaloids, flavonoids, saponins, and tannins. This study aims to determine the antibacterial activity of solid soap combined with pineapple peel and durian peel extracts against Staphylococcus aureus. The research method used was a laboratory experimental method with a solid soap formulation combining pineapple peel and durian peel extracts. Solid soap formulations are tested for bacteria using the hole/well method. The formulations used are F0 (soap base), F1 (0 pineapple peel extract and 4% durian peel), F2 (1% pineapple peel extract and 3% durian peel), F3 (2% pineapple peel extract and 2% durian peel), F4 (pineapple peel 3%, durian peel 1%), F5 (pineapple peel extract 4% and durian peel 0%), and a positive control (solid antibacterial bath soap brand x). A solid soap preparation has been made and has fulfilled the requirements for evaluating the quality of soap preparations, including organoleptic tests, homogeneity tests, pH tests, foam height tests, and stability tests. The results of tests on bacteria showed that the F0 inhibition zone was nonexistent, F1 was 9.72 mm, F2 was 11.31 mm, F3 was 11.73 mm, F4 was 12.15 mm, F5 was 10.34 mm, and the positive control was 14.18 mm. The conclusion of this study was that the best formulation with the largest zone of inhibition was at F3 of 13.73 mm with a strong inhibitory response to Staphylococcus aureus. Keyword: Ananas comosus, Antibacterial soap, Durio zibethinus, Staphylococcus aureus  
STUDI ANALISIS EFEK SAMPING KEMOTERAPI PADA PASIEN KANKER PAYUDARA DI RSUD DR. H. ABDUL MOELOEK PROVINSI LAMPUNG TAHUN 2023: STUDY ANALYSIS OF SIDE EFFECTS OF CHEMOTHERAPY IN BREAST CANCER PATIENTS AT DR. H. ABDUL MOELOEK LAMPUNG PROVINCE YEAR 2023 Widiyastuti, Asih; Handayani, Kartika; Harissa, Nola; Wahidah, Lilik Koernia; Nopiyansyah
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2446

Abstract

The high mortality rate in breast cancer and with the most malignancy attacking women, therapy is needed in the treatment of breast cancer by chemotherapy. Chemotherapy works by killing rapidly dividing cancer cells. However, due to its non-selective nature, chemotherapy also affects healthy cells and causes side effects that affect the patient's quality of life. This study aims to determine the side effects of chemotherapy in breast cancer patients at Dr. H. Abdul Moeloek Hospital, Lampung Province in 2023. This type of research is a qualitative descriptive observational study with a cross-sectional design and accidental sampling data collection techniques. Data analysis was done descriptively in the form of a percentage. The sample in this study was 41 patients. The results of the study based on the characteristics of female gender were 41 patients (100%) and male patients were 0 patients (0%), the age of the diagnosed patients was in the age range of 36-45 years as many as 13 patients (31.7%), 46-55 years as many as 13 patients (31.7%), and 56-65 years as many as 13 patients (13.7%), based on the patient's occupation with the occupation of a housewife (IRT) as many as 24 patients (58.5%), treatment with the TdCar regimen (Taxane (docetaxel), Carboplatin) as many as 13 patients (26.9%) and the AC regimen (Doxorubicin, Cyclophosphamide) as many as 11 patients (21.2%). The conclusion of this study is the side effects using the Naranjo algorithm, the score obtained is between 1-4 (possible) which means that there may be an ADR. The most common side effects suffered by breast cancer chemotherapy patients at Dr. Soetomo Hospital. H. Abdul Moeloek Lampung Province in 2023 was hair loss (87.8%). Keywords: Side Effects, Breast Cancer, Chemotherapy, Cross-sectional
Uji Aktivitas Analgesik Infusa Herba Pegagan (Centella asiatica) Terhadap Mencit Putih Jantan (Mus musculus) Sari, Novita; Harissa, Nola; Abdillah, Muhammad Hafidz
Sains Medisina Vol 4 No 2 (2025): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v4i2.866

Abstract

Nyeri merupakan tanda bahwa terjadi kerusakan jaringan pada tubuh manusia yang menimbulkan perasaan tidak menyenangkan. Penggunaan obat analgesik dapat mengurangi atau menghilangkan rasa nyeri. Herba pegagan (Centella asiatica) adalah tanaman yang mengandung senyawa aktif berupa flavonoid, tanin, alkaloid dan terpenoid yang diketahui dapat dimanfaatkan untuk menghilangkan rasa nyeri.  Tujuan penelitian ini untuk menguji aktivitas analgesik infusa herba pegagan (Centella asiatica) terhadap mencit putih jantan (Mus musculus). Penelitian ini bersifat eksperimental dengan menggunakan 25 ekor mencit putih jantan yang terbagi menjadi 5 kelompok perlakuan yaitu kelompok yang diberi aquades sebagai kontrol negatif, Ibuprofen 26 mg/KgBB sebagai kontrol positif dan infusa herba pegagan dengan dosis 300, 400 dan 500 mg/KgBB sebagi kelompok percobaan. Setelah 15 menit, kelompok percobaan diberikan penginduksi nyeri asam asetat 1% secara intraperitoneal. Kemudian diamati jumlah geliat mencit tiap 5 menit selama 60 menit, kemudian ditentukan persentase proteksi dan aktivitas analgesiknya. Data yang diperoleh kemudian dianalisis menggunakan uji one way ANOVA. Hasil analisis fitokimia diketahui infusa herba pegagan (Centella asiatica) positif mengandung flavonoid, alkoloid, tanin, dan terpenoid. Hasil analisis statistik LSD pada taraf kepercayaan 95 % menunjukkan perbedaan bermakna antar kelompok perlakuan kecuali pada infusa herba pegagan (Centella asiatica) dosis dosis 400 dan 500 mg/KgBB dengan kelompok kontrol positif karena jumlah geliat pada mencit tidak jauh berbeda dengan kelompok kontrol positif, sehingga dapat dikatakan bahwa daya analgesik dosis dosis 400 dan 500 mg/KgBB setara dengan kelompok kontrol positif (Ibuprofen).
HUBUNGAN EFEK SAMPING OBAT TERHADAP KEPATUHAN MINUM OBAT PADA PASIEN HIV/AIDS DI PUSKESMAS SUKARAJA BANDAR LAMPUNG TAHUN 2025: The Relationship Between Drug Side Effects And Medication Adherence In Hiv/Aids Patients At Sukaraja Health Center, Bandar Lampung, In 2025 Harissa, Nola; Wahidah, Lilik Koernia; Salsabila, Jauza
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/cbwvq431

Abstract

HIV/AIDS is one of the top infectious diseases that cause death. Side effects of drug use are associated with decreased adherence to medication, where according to the literature, patients who experience unpleasant reactions after taking medication show reduced adherence. Adherence to Antiretroviral treatment is very important to achieve optimal therapeutic results in HIV/AIDS sufferers. The purpose of this study was to determine the relationship between side effects of taking medication and adherence to medication in HIV/AIDS patients at Sukaraja Health Center, Bandar Lampung in 2025. This study used a cross-sectional method with prospective data collection, a sample of 74 patients and the use of purposive sampling for the sampling technique.The Data obtained were analyzed by using the chi-square test to find out the relation between the dependent variable which is medication adherence  and the independent variable, namely of drug side effects. The results of the analysis showed that most respondents were aged 26-35 years 34 patients, (45.9%), male 61 patients ( 82.4%), had the highest education level of high school 40 patients (54.1%), and were employed 55 patients (74.3%)This study found medication adherence rates in HIV/AIDS patients based on the MMAS scale, with 48 (64.9%) being adherent and 26 (35.1%) being non-adherent. Twenty-eight (33.8%) patients experienced side effects, while 49 (66.2%) did not. There was a relationship between medication side effects and medication adherence in HIV/AIDS patients with a p-value of 0.030.
Co-Authors Abdillah, Muhammad Hafidz Annisa Mulia Anasis Kartika Handayani Lilik Koernia Wahidah Nopiyansyah Novita Sari Salsabila, Jauza Sarnianto, Prih Septa, Tendry Siti Nurjanah Wahyu Tri Mulyani, Yuli Widiyastuti, Asih Yusi Anggriani