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Pengaruh Pemberian D-Galaktosa Intraperitoneal terhadap Kadar IL-6 pada Tikus Sprague-Dawley Manus, Widya Christine; Pratiwi, Johana Puspasari Dwi; Ardiyan, Yustina Nuke
Bioscientist : Jurnal Ilmiah Biologi Vol 11, No 2 (2023): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i2.7658

As humans age, there is a decline in the function and physiological mechanisms of the body, which can affect quality of life. Chronic inflammation is one of the characteristics found in the aging process, marked by an increase in proinflammatory cytokines in circulation. IL-6 is one of the cytokines that play a role in chronic inflammation. This study aimed to determine serum IL-6 levels using D-galactose induction in Sprague-Dawley rats. The study used a pure experiment with a post-test only control group design, in which 36 male Sprague-Dawley rats were divided into two groups: control and treatment. The research sample was serum, and the control group received a placebo of 0.9% NaCl at a dose of 400 mg/day/kg intraperitoneally. The treatment group, which underwent aging induction, was given D-galactose at the same dose and route. The treatment was administered for 6 weeks, and serum was collected from blood taken in the 6th week. The results indicated that the administration of D-galactose did not have a significant effect on increasing IL-6 levels.

Pengaruh Pemberian D-Galaktosa Intraperitoneal terhadap Kadar IL-6 pada Tikus Sprague-Dawley Manus, Widya Christine; Pratiwi, Johana Puspasari Dwi; Ardiyan, Yustina Nuke
Bioscientist : Jurnal Ilmiah Biologi Vol. 11 No. 2 (2023): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i2.7658

As humans age, there is a decline in the function and physiological mechanisms of the body, which can affect quality of life. Chronic inflammation is one of the characteristics found in the aging process, marked by an increase in proinflammatory cytokines in circulation. IL-6 is one of the cytokines that play a role in chronic inflammation. This study aimed to determine serum IL-6 levels using D-galactose induction in Sprague-Dawley rats. The study used a pure experiment with a post-test only control group design, in which 36 male Sprague-Dawley rats were divided into two groups: control and treatment. The research sample was serum, and the control group received a placebo of 0.9% NaCl at a dose of 400 mg/day/kg intraperitoneally. The treatment group, which underwent aging induction, was given D-galactose at the same dose and route. The treatment was administered for 6 weeks, and serum was collected from blood taken in the 6th week. The results indicated that the administration of D-galactose did not have a significant effect on increasing IL-6 levels.

Profil Pasien Balita Covid-19 di RS Bethesda Tahun 2021 Wikrama, Ketut Wiswa; Indarto, Fx Wikan; Ardiyan, Yustina Nuke; Pratiwi, Johana Puspasari Dwi
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i9.16408

Penelitian bertujuan untuk mengetahui profil pasien balita COVID-19 pada tahun 2021. Menggunakan desain deskriptif observasional dan rancangan cross-sectional. Data sekunder berupa rekam medis didapat dengan teknik total sampling sehingga mencapai n=100 pada rentang waktu 1 januari 2021-31 juli 2022. Data selanjutnya dianalisis univariat kemudian disajikan dalam tabel distribusi frekuensi/ persentase. Hasil menunjukan dari 100 rekam medis didapatkan 53 pasien laki-laki dan 47 perempuan pada mayoritas usia >4 tahun-5 tahun. Enam puluh lima dari total sampel adalah pasien rawat jalan dan 35 rawat inap. Metode diagnostik yang digunakan adalah swab RT-PCR COVID-19. Gejala yang paling sering ditemukan berupa demam (77) disertai dengan keterlibatan sistem gastrointestinal yaitu muntah (21). Tanda pemeriksaan fisik terbanyak adalah peningkatan suhu tubuh (71) dengan tingkat keparahan paling banyak adalah gejala ringan (54) kasus. Pemeriksaan penunjang medis lainnya hanya dilakukan pada pasien dengan tingkat keparahan sedang-kritis yang menjalani rawat inap mencapai 35% dari total subjek penelitian, hasil pemeriksaan darah lengkap sebagian besar normal dan pemeriksaan rontgen pada (24) pasien mengarah ke pneumonia bilateral. Riwayat pengobatan antivirus hanya diberikan pada gejala ringan-kritis yang menjalani rawat inap dan obat yang paling banyak adalah vitamin C dan zink pada (74) pasien dengan luaran klinis hanya dinilai pada pasien rawat inap sebanyak (34) pasien memiliki luaran klinis membaik dan (1) pasien meninggal karena mengalami syok septik dan hipoglikemia berat. Gejala paling banyak adalah demam dan terkait organ lain yaitu gastrointestinal adalah muntah. Tingkat keparahan klinis yang paling banyak adalah gejala ringan. Hasil pemeriksaan fisik paling banyak adalah peningkatan suhu tubuh.

The Relationship between Smoking History with ECOG Score, EGFR Mutation Status, and Clinicopathology Data of NSCLC Patients: Preliminary Study Jayadi, Tejo; Amarantini, Charis; Saputra, Lili Ananta; Pratiwi, Johana Puspasari Dwi; Widowati, Fransiska Galuh
Jurnal Respirologi Indonesia Vol 46 No 1 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v46i1.1044

Background: Patients with non-small cell lung cancer (NSCLC) have a poor outcome. Mutations in the EGFR gene play a crucial role in determining treatment options and prognosis. Smoking history, clinicopathological features, including patient performance, and EGFR gene mutation have served as clinical guidelines for monitoring. This study aims to examine the association between smoking history and ECOG score, EGFR mutation status, and clinicopathological characteristics of patients with NSCLC in Yogyakarta. Methods: An observational and analytic study, with a retrospective cohort design from 32 patients diagnosed with NSCLC. Data on smoking history, clinicopathological characteristics, ECOG performance scores, and EGFR mutation types (Exon 19 deletion and Exon 21 L858R) were extracted and concluded from medical records. The relationship between these variables was analysed using the Chi-square test. Results: The analysis began by exploring the relationship between smoking history and initial ECOG performance scores. It was discovered that non-smokers exhibited poorer initial ECOG scores (P=0.025). Smoking history was significantly associated with specific EGFR mutation types (P=0.009), but not with overall EGFR mutation status. The analysis revealed that deletions on Exon 19 were mainly found in patients who smoked, whereas mutations in Exon 21 were uniquely present in non-smokers. Clinical follow-up also shows an association (P=0.002). This finding suggests that smoking behaviour interferes with the carcinogenesis of NSCLC. Conclusion: The relationship between smoking history, performance status, exon-specific EGFR mutations, and clinical follow-up suggests differences in the carcinogenic mechanisms of NSCLC exon-specific mutations, highlighting biological diversity and emphasizing the need for detailed molecular studies to improve prognostic accuracy.

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