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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Bioscientist : Jurnal Ilmiah Biologi
Ardiyan, Yustina Nuke
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Social Sciences Other

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Pengaruh Pemberian D-Galaktosa Intraperitoneal terhadap Kadar IL-6 pada Tikus Sprague-Dawley Manus, Widya Christine; Pratiwi, Johana Puspasari Dwi; Ardiyan, Yustina Nuke
Bioscientist : Jurnal Ilmiah Biologi Vol 11, No 2 (2023): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i2.7658

Abstract

As humans age, there is a decline in the function and physiological mechanisms of the body, which can affect quality of life. Chronic inflammation is one of the characteristics found in the aging process, marked by an increase in proinflammatory cytokines in circulation. IL-6 is one of the cytokines that play a role in chronic inflammation. This study aimed to determine serum IL-6 levels using D-galactose induction in Sprague-Dawley rats. The study used a pure experiment with a post-test only control group design, in which 36 male Sprague-Dawley rats were divided into two groups: control and treatment. The research sample was serum, and the control group received a placebo of 0.9% NaCl at a dose of 400 mg/day/kg intraperitoneally. The treatment group, which underwent aging induction, was given D-galactose at the same dose and route. The treatment was administered for 6 weeks, and serum was collected from blood taken in the 6th week. The results indicated that the administration of D-galactose did not have a significant effect on increasing IL-6 levels.
Pengaruh Pemberian D-Galaktosa Intraperitoneal terhadap Kadar IL-6 pada Tikus Sprague-Dawley Manus, Widya Christine; Pratiwi, Johana Puspasari Dwi; Ardiyan, Yustina Nuke
Bioscientist : Jurnal Ilmiah Biologi Vol. 11 No. 2 (2023): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i2.7658

Abstract

As humans age, there is a decline in the function and physiological mechanisms of the body, which can affect quality of life. Chronic inflammation is one of the characteristics found in the aging process, marked by an increase in proinflammatory cytokines in circulation. IL-6 is one of the cytokines that play a role in chronic inflammation. This study aimed to determine serum IL-6 levels using D-galactose induction in Sprague-Dawley rats. The study used a pure experiment with a post-test only control group design, in which 36 male Sprague-Dawley rats were divided into two groups: control and treatment. The research sample was serum, and the control group received a placebo of 0.9% NaCl at a dose of 400 mg/day/kg intraperitoneally. The treatment group, which underwent aging induction, was given D-galactose at the same dose and route. The treatment was administered for 6 weeks, and serum was collected from blood taken in the 6th week. The results indicated that the administration of D-galactose did not have a significant effect on increasing IL-6 levels.
Profil Pasien Balita Covid-19 di RS Bethesda Tahun 2021 Wikrama, Ketut Wiswa; Indarto, Fx Wikan; Ardiyan, Yustina Nuke; Pratiwi, Johana Puspasari Dwi
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i9.16408

Abstract

Penelitian bertujuan untuk mengetahui profil pasien balita COVID-19 pada tahun 2021. Menggunakan desain deskriptif observasional dan rancangan cross-sectional. Data sekunder berupa rekam medis didapat dengan teknik total sampling sehingga mencapai n=100 pada rentang waktu 1 januari 2021-31 juli 2022. Data selanjutnya dianalisis univariat kemudian disajikan dalam tabel distribusi frekuensi/ persentase. Hasil menunjukan dari 100 rekam medis didapatkan 53 pasien laki-laki dan 47 perempuan pada mayoritas usia >4 tahun-5 tahun. Enam puluh lima dari total sampel adalah pasien rawat jalan dan 35 rawat inap. Metode diagnostik yang digunakan adalah swab RT-PCR COVID-19. Gejala yang paling sering ditemukan berupa demam (77) disertai dengan keterlibatan sistem gastrointestinal yaitu muntah (21). Tanda pemeriksaan fisik terbanyak adalah peningkatan suhu tubuh (71) dengan tingkat keparahan paling banyak adalah gejala ringan (54) kasus. Pemeriksaan penunjang medis lainnya hanya dilakukan pada pasien dengan tingkat keparahan sedang-kritis yang menjalani rawat inap mencapai 35% dari total subjek penelitian, hasil pemeriksaan darah lengkap sebagian besar normal dan pemeriksaan rontgen pada (24) pasien mengarah ke pneumonia bilateral. Riwayat pengobatan antivirus hanya diberikan pada gejala ringan-kritis yang menjalani rawat inap dan obat yang paling banyak adalah vitamin C dan zink pada (74) pasien dengan luaran klinis hanya dinilai pada pasien rawat inap sebanyak (34) pasien memiliki luaran klinis membaik dan (1) pasien meninggal karena mengalami syok septik dan hipoglikemia berat. Gejala paling banyak adalah demam dan terkait organ lain yaitu gastrointestinal adalah muntah. Tingkat keparahan klinis yang paling banyak adalah gejala ringan. Hasil pemeriksaan fisik paling banyak adalah peningkatan suhu tubuh.
Hubungan Tingkat Pengetahuan Dan Sikap Terhadap Perilaku Pencegahan Hepatitis B Pada Mahasiswa Fakultas Kedokteran Universitas Kristen Duta Wacana Angkatan 2019 Dan 2020 Trixie Alfreda, Agnes; Ardiyan, Yustina Nuke; Dimasto Kristiyanto, Haryo; Marlene Sooai , Christiane
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i8.61345

Abstract

Background: Hepatitis B is an inflammatory liver disease caused by both infectious and non-infectious causes, with Hepatitis B being a global concern. The WHO estimates 820,000 deaths from Hepatitis B in 2019, with 1.5 million new infections occurring annually. Indonesia has the highest mortality rate, at 2.14 per 100,000 population. Medical students, as future healthcare workers, are at risk of exposure to infectious diseases such as Hepatitis B, so their understanding of and attitudes toward infection prevention are crucial. Objective: The purpose of this study was to determine the relationship between knowledge and attitudes toward Hepatitis B prevention behavior among students of the Faculty of Medicine, Duta Wacana Christian University, intakes of 2019 and 2020. Methods: This study used an observational analytical design and a cross-sectional study. Results: This study involved 61 respondents. Analysis using Spearman correlation test shows correlation coefficient (r) between knowledge and attitude of -0.309 and -0.296 respectively, with significance value (p) of 0.016 and 0.021. Conclusion: The level of students' knowledge of Hepatitis B is classified as good, with an average percentage of answers above 75% and a significance value (p) of 0.016. There is a significant relationship between attitudes and preventive behavior as evidenced by a significance value (p) of 0.021. Knowledge and attitudes towards Hepatitis B preventive behavior also show a significant relationship with significance values (p) of 0.016 and 0.021 respectively.
Co-Authors Dimasto Kristiyanto, Haryo Indarto, Fx Wikan Manus, Widya Christine Marlene Sooai , Christiane Pratiwi, Johana Puspasari Dwi Trixie Alfreda, Agnes Wikrama, Ketut Wiswa